1,269 research outputs found
Synthesis and Characterization of ÎČ-Cyclodextrin/alginate Nanoparticle as a Novel Drug Delivery System
The aim of this work was to study a novel nanoparticle system formed from alginate and ÎČ-cyclodextrin by ionotropic gelation method and to evaluate their potential for the association and delivery of drugs. The nanoparticles were prepared by electrostatic interactions between Ca2+/alginate gel and ÎČ-cyclodextrin. Morphology and structure characterization of nanoparticles was investigated by scanning electron micrographs (SEM), transmission electron microscope (TEM), Fourier transform infrared spectra (FTIR). The nanoparticle size was about 50 â 80 nm and their structure quite regular and consistent.
Ketoprofen, chosen as a model drug, was incorporated into the nanocarriers with association efficiency of 50.7 % and loading efficiency of 5.7 %. Ketoprofen released from the nanoparticles was 57 % at pH 7.4 and 69 % at pH 5.0 for 4 h
Sersiclets - A Matched Filter Extension of Shapelets for Weak Lensing Studies
The precision study of dark matter using weak lensing by large scale
structure is strongly constrained by the accuracy with which one can measure
galaxy shapes. Several methods have been devised but none have demonstrated the
ability to reach the level of precision required by future weak lensing
surveys. In this Letter we explore new avenues to the existing Shapelets
approach, combining a priori knowledge of the galaxy profile with the power of
orthogonal basis function decomposition. This Letter discusses the new issues
raised by this matched filter approach and proposes promising alternatives to
shape measurement techniques. In particular it appears that the use of a
matched filter (e.g. Sersic profile) restricted to elliptical radial fitting
functions resolves several well known Shapelet issues.Comment: 6 pages, 6 figures. MNRAS Accepte
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Geometric semi-automatic analysis of radiographs of Collesâ fractures
Fractures of the wrist are common in Emergency Departments, where some patients are treated with a procedure called Manipulation under Anaesthesia. In some cases, this procedure is unsuccessful and patients need to revisit the hospital where they undergo surgery to treat the fracture. This work describes a geometric semi-automatic image analysis algorithm to analyse and compare the x-rays of healthy controls and patients with dorsally displaced wrist fractures (Collesâ fractures) who were treated with Manipulation under Anaesthesia. A series of 161 posterior-anterior radiographs from healthy controls and patients with Collesâ fractures were acquired and analysed. The patientsâ group was further subdivided according to the outcome of the procedure (successful/unsuccessful) and pre- or post-intervention creating five groups in total (healthy, pre-successful, pre-unsuccessful, post-successful, post-unsuccessful). The semi-automatic analysis consisted of manual location of three landmarks (finger, lunate and radial styloid) and automatic processing to generate 32 geometric and texture measurements, which may be related to conditions such as osteoporosis and swelling of the wrist. Statistical differences were found between patients and controls, as well as between pre- and post-intervention, but not between the procedures. The most distinct measurements were those of texture. Although the study includes a relatively low number of cases and measurements, the statistical differences are encouraging
Measurement of Cosmic-ray Muons and Muon-induced Neutrons in the Aberdeen Tunnel Underground Laboratory
We have measured the muon flux and production rate of muon-induced neutrons
at a depth of 611 m water equivalent. Our apparatus comprises three layers of
crossed plastic scintillator hodoscopes for tracking the incident cosmic-ray
muons and 760 L of gadolinium-doped liquid scintillator for producing and
detecting neutrons. The vertical muon intensity was measured to be cmssr. The yield of
muon-induced neutrons in the liquid scintillator was determined to be
neutrons/(gcm). A fit to the recently measured neutron
yields at different depths gave a mean muon energy dependence of for liquid-scintillator targets.Comment: 14 pages, 17 figures, 3 table
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Big bottlenecks in cardiovascular tissue engineering.
Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges
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