77 research outputs found
Gold nanoparticles improve metabolic profile of mice fed a high-fat diet
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/02/2018
- Field of study
© 2018 The Author(s). Background: Obesity is a high risk for multiple metabolic disorders due to excessive influx of energy, glucose and lipid, often from a western based diet. Low-grade inflammation plays a key role in the progression of such metabolic disorders. The anti-inflammatory property of gold compounds has been used in treating rheumatoid arthritis in the clinic. Previously we found that pure gold nanoparticles (AuNPs, 21 nm) also possess anti-inflammatory effects on the retroperitoneal fat tissue following intraperitoneal injection, by downregulating tumor necrosis factor (TNF) α. However, whether such an effect can change the risk of metabolic disorders in the obese has not been well studied. The study employed C57BL/6 mice fed a pellet high fat diet (HFD, 43% as fat) that were treated daily with AuNPs [low (HFD-LAu) or high (HFD-HAu) dose] via intraperitoneal injection for 9 weeks. In the in vitro study, RAW264.7 macrophages and 3T3-L1 adipocytes were cultured with low and high concentrations of AuNPs alone or together. Results: The HFD-fed mice showed a significant increase in fat mass, glucose intolerance, dyslipidemia, and liver steatosis. The HFD-LAu group showed an 8% reduction in body weight, ameliorated hyperlipidemia, and normal glucose tolerance; while the HFD-HAu group had a 5% reduction in body weight with significant improvement in their glucose intolerance and hyperlipidemia. The underlying mechanism may be attributed to a reduction in adipose and hepatic local proinflammatory cytokine production, e.g. TNFα. In vitro studies of co-cultured murine RAW264.7 macrophage and 3T3-L1 adipocytes supported this proposed mechanism. Conclusion: AuNPs demonstrate a promising profile for potential management of obesity related glucose and lipid disorders and are useful as a research tool for the study of biological mechanisms
Members of the chloride intracellular ion channel protein family demonstrate glutaredoxin-like enzymatic activity
- Author
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 12/01/2015
- Field of study
© 2015 Al Khamici et al. The Chloride Intracellular Ion Channel (CLIC) family consists of six evolutionarily conserved proteins in humans. Members of this family are unusual, existing as both monomeric soluble proteins and as integral membrane proteins where they function as chloride selective ion channels, however no function has previously been assigned to their soluble form. Structural studies have shown that in the soluble form, CLIC proteins adopt a glutathione S-transferase (GST) fold, however, they have an active site with a conserved glutaredoxin monothiol motif, similar to the omega class GSTs. We demonstrate that CLIC proteins have glutaredoxin-like glutathione-dependent oxidoreductase enzymatic activity. CLICs 1, 2 and 4 demonstrate typical glutaredoxin-like activity using 2-hydroxyethyl disulfide as a substrate. Mutagenesis experiments identify cysteine 24 as the catalytic cysteine residue in CLIC1, which is consistent with its structure. CLIC1 was shown to reduce sodium selenite and dehydroascorbate in a glutathione-dependent manner. Previous electrophysiological studies have shown that the drugs IAA-94 and A9C specifically block CLIC channel activity. These same compounds inhibit CLIC1 oxidoreductase activity. This work for the first time assigns a functional activity to the soluble form of the CLIC proteins. Our results demonstrate that the soluble form of the CLIC proteins has an enzymatic activity that is distinct from the channel activity of their integral membrane form. This CLIC enzymatic activity may be important for protecting the intracellular environment against oxidation. It is also likely that this enzymatic activity regulates the CLIC ion channel function
Enterocyte Shedding and Epithelial Lining Repair Following Ischemia of the Human Small Intestine Attenuate Inflammation
- Author
- A Patel
- B de Vries
- B De Vries
- BR Lucchesi
- Cornelis H. C. Dejong
- CT Taylor
- D Salvemini
- Dian Kuipers
- DM Yellon
- H de Groot
- H Yaoita
- I Engelberts
- J Laufer
- JL Romson
- Joep P. M. Derikx
- JPM Derikx
- K Wada
- M Bergeron
- M Takada
- MA Daemen
- MA Daemen
- ME Bianchi
- MH Schoenberg
- ML Hart
- ML Huynh
- MR Grotz
- MR Litt
- MT Lotze
- NB Vedder
- NG Frangogiannis
- NP Restifo
- P Libby
- RA Matthijsen
- RA Matthijsen
- RF Guo
- Robert A. Matthijsen
- Ronald M. van Dam
- S Cuzzocrea
- S Donath
- S Yamasaki
- Stefan Bereswill
- T Kanda
- T Murohara
- T Tsuruma
- TV Arumugam
- W Zhou
- Wim A. Buurman
- XL Ma
- Z Cai
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2009
- Field of study
BACKGROUND: Recently, we observed that small-intestinal ischemia and reperfusion was found to entail a rapid loss of apoptotic and necrotic cells. This study was conducted to investigate whether the observed shedding of ischemically damaged epithelial cells affects IR induced inflammation in the human small gut. METHODS AND FINDINGS: Using a newly developed IR model of the human small intestine, the inflammatory response was studied on cellular, protein and mRNA level. Thirty patients were consecutively included. Part of the jejunum was subjected to 30 minutes of ischemia and variable reperfusion periods (mean reperfusion time 120 (+/-11) minutes). Ethical approval and informed consent were obtained. Increased plasma intestinal fatty acid binding protein (I-FABP) levels indicated loss in epithelial cell integrity in response to ischemia and reperfusion (p<0.001 vs healthy). HIF-1alpha gene expression doubled (p = 0.02) and C3 gene expression increased 4-fold (p = 0.01) over the course of IR. Gut barrier failure, assessed as LPS concentration in small bowel venous effluent blood, was not observed (p = 0.18). Additionally, mRNA expression of HO-1, IL-6, IL-8 did not alter. No increased expression of endothelial adhesion molecules, TNFalpha release, increased numbers of inflammatory cells (p = 0.71) or complement activation, assessed as activated C3 (p = 0.14), were detected in the reperfused tissue. CONCLUSIONS: In the human small intestine, thirty minutes of ischemia followed by up to 4 hours of reperfusion, does not seem to lead to an explicit inflammatory response. This may be explained by a unique mechanism of shedding of damaged enterocytes, reported for the first time by our group
The effects of integrated care: a systematic review of UK and international evidence
- Author
- A Beacon
- A Best
- A Boyle
- A Cameron
- A Cameron
- A MacLean
- A Mason
- A Paulus
- A Paulus
- A Taylor
- A Theodoridou
- A Xyrichis
- AA Abdul
- AA Boyle
- ABM Steventon
- AL Huntley
- AM Epstein
- Andrew Booth
- Anthea Sutton
- AS Kuhlmann
- B Janse
- B Janse
- BD Loader
- BW Jack
- BW Lamb
- C Boult
- C Boult
- C Boult
- C Boult
- C Callahan
- C Chen
- C Ham
- C Hullick
- C Imison
- C Kammerlander
- C Letton
- C Nicholson
- C Richings
- C Smith
- CH Colla
- CH Colla
- CJ Hajewski
- CJ Homer
- CM Kautz
- D Allen
- D Allen
- D Gray
- D Lyon
- D Peikes
- D Simmons
- D Trivedi
- DA Dorr
- DE Wennberg
- Department of Health
- DM Gravelle Hugh
- DR Rittenhouse
- Duncan Chambers
- E Belanger
- E Cohen
- E Levelt
- E Smith
- E Suter
- EG Guerrero
- Elizabeth Goyder
- F Ahmad
- F Ahmed
- F Beland
- F Beland
- F Béland
- F Paize
- FM Weaver
- G Hawthorne
- G Jackson
- G Johansson
- G Powell Davies
- GH Guyatt
- H Hildebrandt
- H Robertson
- H Tucker
- IJ Higginson
- J Barnett
- J Dodd
- J Farmer
- J Graffy
- J Hockley
- J Kinley
- J Stokes
- J Tieman
- JA Alexander
- JA Roberts
- JM Brokel
- JM Hartgerink
- JM Morales-Asencio
- JM Pettie
- JPM Stokes
- K Eklund
- K Footman
- K Laver
- KA Myors
- KG Sahlen
- L Roberts
- L Sinclair
- L Veerbeek
- L-E Olsson
- L-F Low
- LA Blewett
- LL Berry
- LS Aiken
- M Battersby
- M Breton
- M Brännström
- M Butler
- M Coupe
- M Harris
- M Hussain
- M MacAdam
- M Martinussen
- M McGregor
- M Offredy
- M Ouwens
- M Parsons
- M Petticrew
- M Soljak
- M Stampa
- M Stewart
- M Wilberforce
- MA van der Marck
- Maxine Johnson
- MJ Grant
- MJ Stewart
- N Genet
- N Khanna
- NA Martinez-Gonzalez
- National Audit Office
- National Health Institute
- ND Bakerly
- NHS England
- P Clarkson
- P Fagan
- P Kent
- PA Brawer
- PH Rowlandson
- R Addicott
- R Hebert
- R Hébert
- R Johnstone
- R Pawson
- R Pineault
- R Rosenheck
- R Wedel
- RB Salmon
- RF van Gils
- RL Fuller
- RP Johnstone
- RS Brown
- S Bird
- S Counsell
- S Cunningham
- S Jha
- S Julian
- S Mackie
- S Roberts
- S Tucker
- SC Mertes
- SE Maslin-Prothero
- SK Baxter
- SL Ettner
- SL Waller
- SM Ng
- SR Bird
- SR Bird
- SR Counsell
- SR de Bruin
- Susan Baxter
- T Callaly
- T Choo
- T Hammar
- T McConnell
- T Ryan
- V Pearson
- W Hogg
- W Katon
- WE Hoogendoom
- Z Munn
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/05/2018
- Field of study
BACKGROUND: Healthcare systems around the world have been responding to the demand for better integrated models of service delivery. However, there is a need for further clarity regarding the effects of these new models of integration, and exploration regarding whether models introduced in other care systems may achieve similar outcomes in a UK national health service context. METHODS: The study aimed to carry out a systematic review of the effects of integration or co-ordination between healthcare services, or between health and social care on service delivery outcomes including effectiveness, efficiency and quality of care. Electronic databases including MEDLINE; Embase; PsycINFO; CINAHL; Science and Social Science Citation Indices; and the Cochrane Library were searched for relevant literature published between 2006 to March 2017. Online sources were searched for UK grey literature, and citation searching, and manual reference list screening were also carried out. Quantitative primary studies and systematic reviews, reporting actual or perceived effects on service delivery following the introduction of models of integration or co-ordination, in healthcare or health and social care settings in developed countries were eligible for inclusion. Strength of evidence for each outcome reported was analysed and synthesised using a four point comparative rating system of stronger, weaker, inconsistent or limited evidence. RESULTS: One hundred sixty seven studies were eligible for inclusion. Analysis indicated evidence of perceived improved quality of care, evidence of increased patient satisfaction, and evidence of improved access to care. Evidence was rated as either inconsistent or limited regarding all other outcomes reported, including system-wide impacts on primary care, secondary care, and health care costs. There were limited differences between outcomes reported by UK and international studies, and overall the literature had a limited consideration of effects on service users. CONCLUSIONS: Models of integrated care may enhance patient satisfaction, increase perceived quality of care, and enable access to services, although the evidence for other outcomes including service costs remains unclear. Indications of improved access may have important implications for services struggling to cope with increasing demand. TRIAL REGISTRATION: Prospero registration number: 42016037725
Measurements of Higgs bosons decaying to bottom quarks from vector boson fusion production with the ATLAS experiment at √=13TeV
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Agullo PM
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ahnen JV
- Ai X
- Aielli G
- Akatsuka S
- Akbiyik M
- Akilli E
- Akimov AV
- Al Khoury K
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Ali S
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alves FLL
- Alviggi MG
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amoroso S
- Amrouche CS
- Anastopoulos C
- Andari N
- Andeen T
- Anders JK
- Andrean SY
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparo MA
- Aranda CP
- Aranzabal N
- Araya ST
- Arcangeletti C
- Arce ATH
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Armbruster AJ
- Armstrong A
- Arnaez O
- Arnold H
- Artoni G
- Asada H
- Asai K
- Asai S
- Asawatavonvanich T
- Asbah NA
- Asimakopoulou EM
- Asquith L
- Assahsah J
- Assamagan K
- Astalos R
- Astigarraga MEP
- Atkin RJ
- Atkinson M
- Atlay NB
- Atmasiddha PA
- Augsten K
- Austrup VA
- Avolio G
- Ayoub MK
- Azuelos G
- Babal D
- Bachacou H
- Bachas K
- Backman F
- Bagnaia P
- Bahilo JJL
- Bahrasemani H
- Bailey AJ
- Bailey VR
- Baines JT
- Bakalis C
- Baker OK
- Bakker PJ
- Bakos E
- Balaji S
- Balasubramanian R
- Baldin EM
- Balek P
- Balli F
- Balunas WK
- Balz J
- Banas E
- Bandieramonte M
- Bandyopadhyay A
- Barak L
- Barbe WM
- Barberio EL
- Barberis D
- Barbero M
- Barbour G
- Barillari T
- Barisits M-S
- Barkeloo J
- Barklow T
- Barnett BM
- Barnett RM
- Barnovska-Blenessy Z
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro F
- Barron U
- Barsov S
- Bartels F
- Bartoldus R
- Bartolini G
- Barton AE
- Bartos P
- Basalaev A
- Basan A
- Bassalat A
- Basso MJ
- Basson CR
- Bates RL
- Batlamous S
- Batley JR
- Batool B
- Battaglia M
- Bauce M
- Bauer F
- Bauer P
- Bawa HS
- Bayirli A
- Beacham JB
- Beau T
- Beauchemin PH
- Becherer F
- Bechtle P
- Beck HP
- Becker K
- Becot C
- Beddall AJ
- Bednyakov VA
- Bee CP
- Beermann TA
- Begalli M
- Begel M
- Behera A
- Behr JK
- Beisiegel F
- Belfkir M
- Bella G
- Bella LA
- Bellagamba L
- Bellerive A
- Bello FAD
- Bellos P
- Beloborodov K
- Belotskiy K
- Belyaev NL
- Benchekroun D
- Benekos N
- Benhammou Y
- Benjamin DP
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Berger N
- Bergmann B
- Bergsten LJ
- Beringer J
- Berlendis S
- Berlingen JM
- Bernardi G
- Bernius C
- Bernlochner FU
- Berry T
- Berta P
- Berthold A
- Bertram IA
- Bethke S
- Betti A
- Bevan AJ
- Bhatta S
- Bhattacharya DS
- Bhattarai P
- Bhopatkar VS
- Bi R
- Bianchi RM
- Biebel O
- Biedermann D
- Bielski R
- Bierwagen K
- Biesuz NV
- Biglietti M
- Billoud TRV
- Bindi M
- Bingul A
- Bini C
- Biondi S
- Birch-sykes CJ
- Birman M
- Bisanz T
- Biswal JP
- Biswas D
- Bitadze A
- Bittrich C
- Bjørke K
- Blazek T
- Bloch I
- Blocker C
- Blue A
- Blumenschein U
- Bobbink GJ
- Bobrovnikov VS
- Boeriu OEV
- Bogavac D
- Bogdanchikov AG
- Bohm C
- Boisvert V
- Bokan P
- Bolanos GR
- Bold T
- Bomben M
- Bona M
- Bonilla JS
- Boonekamp M
- Booth CD
- Borbély AG
- Borecka-Bielska HM
- Borgna LS
- Borisov A
- Borissov G
- Bortoletto D
- Bosca SR
- Boscherini D
- Bosman M
- Bostanabad MG
- Bouaouda K
- Boudreau J
- Bouhova-Thacker EV
- Boumediene D
- Bouquet R
- Bourdarios CA
- Boveia A
- Boyd J
- Boye D
- Boyko IR
- Bozson AJ
- Bracinik J
- Brahimi N
- Brandt G
- Brandt O
- Braren F
- Brau B
- Brau JE
- Brendlinger K
- Brener R
- Brenner L
- Brenner R
- Bressler S
- Bret MC
- Brickwedde B
- Briglin DL
- Britton D
- Britzger D
- Brock I
- Brock R
- Brooijmans G
- Brooks WK
- Brost E
- Bruncko D
- Bruni A
- Bruni G
- Bruschi M
- Bruscino N
- Bryngemark L
- Brüers B
- Buanes T
- Buat Q
- Buchholz P
- Buckley AG
- Budagov IA
- Buddenbrock SEV
- Bugge MK
- Bulekov O
- Bullard BA
- Burch TJ
- Burdin S
- Burgard CD
- Burger AM
- Burghgrave B
- Burr JTP
- Burton CD
- Burzynski JC
- Buschmann E
- Bussey PJ
- Butler JM
- Buttar CM
- Butterworth JM
- Buttinger W
- Buzykaev AR
- Bylund OB
- Büscher V
- Cabras G
- Caforio D
- Cai H
- Cairo VMM
- Cakir IT
- Cakir O
- Calace N
- Calafiura P
- Calderini G
- Calfayan P
- Callea G
- Caloba LP
- Caltabiano A
- Calvet D
- Calvet S
- Calvet TP
- Calvetti M
- Camarda S
- Camarri P
- Camelia EA
- Camerlingo MT
- Cameron D
- Camincher C
- Campanelli M
- Camplani A
- Canale V
- Canesse A
- Cantero J
- Cao Y
- Capriles FGD
- Capua M
- Cardarelli R
- Cardillo F
- Carducci G
- Carli T
- Carlino G
- Carlson BT
- Carlson EM
- Carminati L
- Carney RMD
- Caron S
- Carquin E
- Carratta G
- Carrá S
- Carter JWS
- Carter TM
- Casado MP
- Casha AF
- Castiglia EG
- Castillo FL
- Castillo LRF
- Castro NF
- Catinaccio A
- Catmore JR
- Cattai A
- Cavaliere V
- Cavasinni V
- Celebi E
- Celli F
- Cerny K
- Cerqueira AS
- Cerri A
- Cerrito L
- Cerutti F
- Cervelli A
- Cetin SA
- Chadi Z
- Chakraborty D
- Chan J
- Chan WS
- Chan WY
- Chapman JD
- Chargeishvili B
- Charlton DG
- Charman TP
- Chatterjee M
- Chau CC
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chen B
- Chen C
- Chen CH
- Chen H
- Chen H
- Chen J
- Chen J
- Chen J
- Chen S
- Chen SJ
- Chen X
- Chen Y
- Chen Y-H
- Cheng HC
- Cheng HJ
- Cheplakov A
- Cheremushkina E
- Cheu E
- Cheung K
- Chevalier L
- Chevalérias TJA
- Chiarella V
- Chiarelli G
- Chiodini G
- Chisholm AS
- Chitan A
- Chiu I
- Chiu YH
- Chizhov MV
- Choi K
- Chomont AR
- Chou Y
- Chow YS
- Christopher LD
- Chu MC
- Chu X
- Chudoba J
- Chwastowski JJ
- Ciaccio AD
- Ciaccio LD
- Cieri D
- Ciesla KM
- Cindro V
- Cioară IA
- Ciocio A
- Cirotto F
- Citron ZH
- Citterio M
- Ciubotaru DA
- Ciungu BM
- Clark A
- Clark PJ
- Clawson SE
- Clement C
- Clissa L
- Coadou Y
- Cobal M
- Coccaro A
- Cochran J
- Codina EP
- Cohen H
- Coimbra AEC
- Cole B
- Collot J
- Connell SH
- Connelly IA
- Conventi F
- Cooper-Sarkar AM
- Cormier F
- Cornell SD
- Corpe LD
- Corradi M
- Correia AMH
- Corrigan EE
- Corriveau F
- Costa MJ
- Costanza F
- Costanzo D
- Coutinho YA
- Cowan G
- Cowley JW
- Crane J
- Cranmer K
- Creager RA
- Crescioli F
- Cristinziani M
- Cristoforetti M
- Croft V
- Crosetti G
- Crépé-Renaudin S
- Cueto A
- Cui H
- Cukierman AR
- Cunningham WR
- Czekierda S
- Czodrowski P
- Czurylo MM
- Da Costa AMMJ
- da Costa JBG
- Da Cunha Sargedas De Sousa MJ
- Da Fonseca Pinto JV
- Da Via C
- Daalen TRV
- Dabrowski W
- Dachs F
- Dado T
- Dahbi S
- Dai T
- Dallapiccola C
- Dam M
- Damazio DO
- Damp J
- Dandoy JR
- Daneri MF
- Danninger M
- Dao V
- Darbo G
- Dartsi O
- Dattagupta A
- David C
- Davidek T
- Davis DR
- Dawson I
- de Andrade Filho LM
- De Asmundis R
- De Beurs M
- De Carvalho ALM
- De Castro S
- De Groot N
- de Jong P
- de la Hoz SG
- De la Torre H
- De Lima RT
- De Maria A
- De Pedis D
- de Renstrom PAB
- De Sa RCL
- De Salvo A
- De Sanctis U
- De Santis M
- De Santo A
- De Vivie De Regie JB
- De K
- Dedovich DV
- Deiana AM
- Delgove D
- Deliot F
- Delitzsch CM
- Dell’Acqua A
- Dell’Asta L
- Delmastro M
- Delporte C
- Delsart PA
- Demers S
- Demichev M
- Demontigny G
- Denisov SP
- Derendarz D
- Derkaoui JE
- Derue F
- Dervan P
- Desch K
- Dette K
- Deutsch C
- Deviveiros PO
- Diaconu C
- Dias FA
- Diaz LP
- Diaz MA
- Diaz YD
- Dickinson J
- Didenko M
- Diehl EB
- Dietrich J
- Dimitrievska A
- Ding W
- Dingfelder J
- Dittmeier SJ
- Dittus F
- Djama F
- Djobava T
- Djuvsland JI
- Do Vale MAB
- Dobre M
- Dodsworth D
- Doglioni C
- Dolejsi J
- Dolezal Z
- Dominguez LP
- Don MMR
- Donadelli M
- Donaldson CP
- Donato CD
- Donell DMM
- Dong B
- Donini J
- Donszelmann TC
- Dopke J
- Doria A
- Dova MT
- Doyle AT
- Drechsler E
- Dreyer E
- Dreyer T
- Drobac AS
- du Pree TA
- Du D
- Duan Y
- Dubinin F
- Dubovsky M
- Dubreuil A
- Duchovni E
- Duckeck G
- Ducu OA
- Duda D
- Dudarev A
- Dudder AC
- Duflot L
- Dumancic M
- Dumitriu AE
- Dunford M
- Dungs S
- Duperrin A
- Durglishvili A
- Dutta B
- Duvnjak D
- Dyckes GI
- Dyndal M
- Dysch S
- Dziedzic BS
- Dührssen M
- Dülsen C
- Düren M
- D’amen G
- D’Amico V
- D’Auria S
- D’Eramo L
- D’onofrio A
- D’Onofrio M
- D’uffizi M
- Eggleston MG
- Eifert T
- Eigen G
- Einsweiler K
- Ekelof T
- El Jarrari H
- El Moussaouy A
- Ellajosyula V
- Ellert M
- Ellinghaus F
- Elliot AA
- Ellis N
- Elmsheuser J
- Elsing M
- Emeliyanov D
- Emerman A
- Enari Y
- Erdmann J
- Ereditato A
- Erland PA
- Errenst M
- Escalier M
- Escobar C
- Estevez MA
- Etzion E
- Evans G
- Evans H
- Evans MO
- Ezhilov A
- Fabbri F
- Fabbri L
- Fabiani V
- Facini G
- Fakhrutdinov RM
- Falciano S
- Falke PJ
- Falke S
- Faltova J
- Fang Y
- Fang Y
- Fanourakis G
- Fanti M
- Faraj M
- Farbin A
- Farilla A
- Farina EM
- Farooque T
- Farrington SM
- Farthouat P
- Fassi F
- Fassouliotis D
- Fawcett WJ
- Fayard L
- Fedin OL
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 23/06/2021
- Field of study
The paper presents a measurement of the Standard Model Higgs Boson decaying to b-quark pairs in the vector boson fusion (VBF) production mode. A sample corresponding to 126 fb−1 of s√=13TeV proton–proton collision data, collected with the ATLAS experiment at the Large Hadron Collider, is analyzed utilizing an adversarial neural network for event classification. The signal strength, defined as the ratio of the measured signal yield to that predicted by the Standard Model for VBF Higgs production, is measured to be 0.95+0.38−0.36 , corresponding to an observed (expected) significance of 2.6 (2.8) standard deviations from the background only hypothesis. The results are additionally combined with an analysis of Higgs bosons decaying to b-quarks, produced via VBF in association with a photon
Muon reconstruction and identification efficiency in ATLAS using the full Run 2 pp collision data set at \sqrt{s}=13 TeV
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Agullo PM
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ahnen JV
- Ai X
- Aielli G
- Akatsuka S
- Akbiyik M
- Akesson TPA
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
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- Alhroob M
- Ali B
- Ali S
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
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- Allport PP
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- Alviggi MG
- Ambler A
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- Amelung C
- Amidei D
- Amoroso S
- Amrouche CS
- An F
- Anastopoulos C
- Andari N
- Andeen T
- Anders JK
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- Zemaityte G
- Zeng JC
- Zenin O
- Zenis T
- Zerwas D
- Zgubic M
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- Zhang DF
- Zhang G
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- Zhang X
- Zhang X
- Zhang Y
- Zhang Z
- Zhang Z
- Zhao P
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
- Zhou C
- Zhou H
- Zhou M
- Zhou N
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- Zhu C
- Zhu CG
- Zhu H
- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zwalinski L
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/01/2021
- Field of study
This article documents the muon reconstruction and identification efficiency obtained by the ATLAS experiment for 139 \hbox {fb}^{-1} of pp collision data at \sqrt{s}=13 TeV collected between 2015 and 2018 during Run 2 of the LHC. The increased instantaneous luminosity delivered by the LHC over this period required a reoptimisation of the criteria for the identification of prompt muons. Improved and newly developed algorithms were deployed to preserve high muon identification efficiency with a low misidentification rate and good momentum resolution. The availability of large samples of Z\rightarrow \mu \mu and J/\psi \rightarrow \mu \mu decays, and the minimisation of systematic uncertainties, allows the efficiencies of criteria for muon identification, primary vertex association, and isolation to be measured with an accuracy at the per-mille level in the bulk of the phase space, and up to the percent level in complex kinematic configurations. Excellent performance is achieved over a range of transverse momenta from 3 GeV to several hundred GeV, and across the full muon detector acceptance of |\eta |<2.7
The ATLAS inner detector trigger performance in pp collisions at 13 TeV during LHC Run 2
- Author
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
The design and performance of the inner detector trigger for the high level trigger of the ATLAS experiment at the Large Hadron Collider during the 2016-2018 data taking period is discussed. In 2016, 2017, and 2018 the ATLAS detector recorded 35.6 fb(-1), 46.9 fb(-1), and 60.6 fb(-1) respectively of proton-proton collision data at a centre-of-mass energy of 13TeV. In order to deal with the very high interaction multiplicities per bunch crossing expected with the 13TeV collisions the inner detector trigger was redesigned during the long shutdown of the Large Hadron Collider from 2013 until 2015. An overview of these developments is provided and the performance of the tracking in the trigger for the muon, electron, tau and b-jet signatures is discussed. The high performance of the inner detector trigger with these extreme interaction multiplicities demonstrates how the inner detector tracking continues to lie at the heart of the trigger performance and is essential in enabling the ATLAS physics programme
Direct constraint on the Higgs–charm coupling from a search for Higgs boson decays into charm quarks with the ATLAS detector
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- Suarez RG
- Tame ZPA
- Toro RC
- Torregrosa EF
- Urbán SC
- Vazquez CJB
- Verzini MJA
- Volpe DD
- Walls FMG
- Yildiz HD
- Zagazeta LFG
- Åkesson TPA
- Öncel ÖO
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/08/2022
- Field of study
A search for the Higgs boson decaying into a pair of charm quarks is presented. The analysis uses proton–proton collisions to target the production of a Higgs boson in association with a leptonically decaying W or Z boson. The dataset delivered by the LHC at a centre-of-mass energy of and recorded by the ATLAS detector corresponds to an integrated luminosity of 139 fb−1. Flavour-tagging algorithms are used to identify jets originating from the hadronisation of charm quarks. The analysis method is validated with the simultaneous measurement of WW, WZ and ZZ production, with observed (expected) significances of 2.6 (2.2) standard deviations above the background-only prediction for the (W/Z)Z(→cc¯) process and 3.8 (4.6) standard deviations for the (W/Z)W(→cq) process. The (W/Z)H(→cc¯) search yields an observed (expected) upper limit of 26 (31) times the predicted Standard Model cross-section times branching fraction for a Higgs boson with a mass of , corresponding to an observed (expected) constraint on the charm Yukawa coupling modifier |κc|<8.5 (12.4), at the 95% confidence level. A combination with the ATLAS (W/Z)H,H→bb¯ analysis is performed, allowing the ratio κc/κb to be constrained to less than 4.5 at the 95% confidence level, smaller than the ratio of the b- and c-quark masses, and therefore determines the Higgs-charm coupling to be weaker than the Higgs-bottom coupling at the 95% confidence level
Measurements of Higgs bosons decaying to bottom quarks from vector boson fusion production with the ATLAS experiment at s√=13TeV
- Author
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- Abbott B
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- Abeling K
- Abhayasinghe DK
- Abidi SH
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- Zacharis G
- Zaffaroni E
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- Zahreddine J
- Zaitsev AM
- Zakareishvili T
- Zakharchuk N
- Zambito S
- Zanzi D
- Zeitnitz C
- Zeißner SV
- Zemaityte G
- Zeng JC
- Zenin O
- Zenz S
- Zerradi S
- Zerwas D
- Zgubič M
- Zhang B
- Zhang DF
- Zhang G
- Zhang J
- Zhang K
- Zhang L
- Zhang L
- Zhang M
- Zhang R
- Zhang S
- Zhang X
- Zhang X
- Zhang Y
- Zhang Z
- Zhao P
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
- Zhou C
- Zhou H
- Zhou M
- Zhou N
- Zhou Y
- Zhu C
- Zhu CG
- Zhu H
- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/06/2021
- Field of study
Observation of electroweak production of two jets in association with an isolated photon and missing transverse momentum, and search for a Higgs boson decaying into invisible particles at 13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adam L
- Adamczyk L
- Adamek L
- Addepalli SV
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Agarwala J
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Agullo PM
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ahnen JV
- Ai X
- Aielli G
- Aizenberg I
- Akatsuka S
- Akbiyik M
- Akimov AV
- Alberghi GL
- Albert J
- Albicocco P
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Ali S
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alves FLL
- Alviggi MG
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amoroso S
- Amrouche CS
- Anastopoulos C
- Andana RYG
- Andari N
- Andeen T
- Anders JK
- Andrean SY
- Andreazza A
- Angelidakis S
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparo MA
- Aranda CP
- Aranzabal N
- Araya ST
- Arcangeletti C
- Arce ATH
- Arena E
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Armbruster AJ
- Armstrong A
- Arnaez O
- Arnold H
- Artoni G
- Asada H
- Asai K
- Asai S
- Asbah NA
- Asimakopoulou EM
- Asquith L
- Assahsah J
- Assamagan K
- Astalos R
- Astigarraga MEP
- Atkin RJ
- Atkinson M
- Atlay NB
- Atmani H
- Atmasiddha PA
- Augsten K
- Auricchio S
- Austrup VA
- Avner G
- Avolio G
- Ayoub MK
- Azuelos G
- Babal D
- Bachacou H
- Bachas K
- Bachiu A
- Backman F
- Badea A
- Bagnaia P
- Bahilo JJL
- Bahrasemani H
- Bailey AJ
- Bailey VR
- Baines JT
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- Bandyopadhyay A
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- Barisits M-S
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- Barreiro F
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- Barrue RFC
- Barsov S
- Bartels F
- Bartoldus R
- Bartolini G
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- Basalaev A
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- Briglin DL
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- Bryngemark L
- Brüers B
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- Buchholz P
- Buckley AG
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- Butterworth JM
- Buttinger W
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- Büscher V
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- Caforio D
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- Cairo VMM
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- Calafiura P
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- Calfayan P
- Callea G
- Caloba LP
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- Camelia EA
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- Cardillo F
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- Carlson EM
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- Carminati L
- Carnesale M
- Carney RMD
- Caron S
- Carquin E
- Carratta G
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- Carter JWS
- Carter TM
- Casadei D
- Casado MP
- Casha AF
- Castiglia EG
- Castillo FL
- Castillo LRF
- Castro NF
- Catinaccio A
- Catmore JR
- Cattai A
- Cavaliere V
- Cavalli N
- Cavasinni V
- Celebi E
- Celli F
- Centonze MS
- Cerny K
- Cerqueira AS
- Cerri A
- Cerrito L
- Cerutti F
- Cervelli A
- Cetin SA
- Chadi Z
- Chakraborty D
- Chala M
- Chan J
- Chan WS
- Chan WY
- Chapman JD
- Chargeishvili B
- Charlton DG
- Charman TP
- Chatterjee M
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chen A
- Chen B
- Chen B
- Chen C
- Chen CH
- Chen H
- Chen H
- Chen J
- Chen J
- Chen S
- Chen SJ
- Chen X
- Chen X
- Chen Y
- Chen Y-H
- Cheng CL
- Cheng HC
- Cheplakov A
- Cheremushkina E
- Cherepanova E
- Cheu E
- Cheung K
- Chevalier L
- Chiarella V
- Chiarelli G
- Chiodini G
- Chisholm AS
- Chitan A
- Chiu YH
- Chizhov MV
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- Chou Y
- Chow YS
- Chowdhury T
- Christopher LD
- Chu MC
- Chu X
- Chudoba J
- Chwastowski JJ
- Ciaccio AD
- Ciaccio LD
- Cieri D
- Ciesla KM
- Cindro V
- Cioară IA
- Ciocio A
- Cirotto F
- Citron ZH
- Citterio M
- Ciubotaru DA
- Ciungu BM
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- Clement C
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- Cochran J
- Codina EP
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- Coimbra AEC
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- Connell SH
- Connelly IA
- Conroy EI
- Conventi F
- Cooke HG
- Cooper-Sarkar AM
- Cormier F
- Cornell SD
- Corpe LD
- Corradi M
- Correia AMH
- Corrigan EE
- Corriveau F
- Costa MJ
- Costanza F
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- Cote BM
- Coutinho YA
- Cowan G
- Cowley JW
- Cranmer K
- Crescioli F
- Cristinziani M
- Cristoforetti M
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- Crosetti G
- Crépé-Renaudin S
- Cueto A
- Cui H
- Cukierman AR
- Cunningham WR
- Curcio F
- Czodrowski P
- Czurylo MM
- Da Costa AMMJ
- da Costa JBG
- Da Cruz E Silva CB
- Da Cunha Sargedas De Sousa MJ
- Da Fonseca Pinto JV
- Da Via C
- Daalen TRV
- Dabrowski W
- Dado T
- Dahbi S
- Dai T
- Dallapiccola C
- Dam M
- Damazio DO
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- Dandoy JR
- Daneri MF
- Danninger M
- Dao V
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- Darmora S
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- David C
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- Davis DR
- Davis-Purcell B
- Dawson I
- de Andrade Filho LM
- De Araujo MV
- De Asmundis R
- De Beurs M
- De Carvalho ALM
- De Castro S
- De Groot N
- de Jong P
- de la Hoz SG
- De la Torre H
- De Lima RT
- De Maria A
- De Pedis D
- de Renstrom PAB
- De Sa RCL
- De Salvo A
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- De Santo A
- De Souza EEP
- De Vivie De Regie JB
- De K
- Dedovich DV
- Degens J
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- Delitzsch CM
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- Dell’Asta L
- Delmastro M
- Delsart PA
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- Demichev M
- Denisov SP
- Derendarz D
- Derkaoui JE
- Derue F
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- Deutsch C
- Deviveiros PO
- Diaconu C
- Dias FA
- Diaz LP
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- Diehl EB
- Dietrich J
- Dimitrievska A
- Ding W
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- Djuvsland JI
- Dodsworth D
- Doglioni C
- Dolejsi J
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- Domenico AD
- Dominguez LP
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- Donaldson CP
- Donato CD
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- Zenin O
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
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- Ziolkowski M
- Zoccoli A
- Zoch K
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- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- EUROPEAN PHYSICAL JOURNAL C
- Publication date
- 01/01/2022
- Field of study
This paper presents the measurement of the electroweak production of two jets
in association with a Zγ pair with the Z boson decaying into two
neutrinos. It also presents the search for invisible or partially invisible
decays of a Higgs boson with a mass of 125 GeV produced through vector-boson
fusion with a photon in the final state. These results use data from LHC
proton-proton collisions at s = 13 TeV collected with the ATLAS
detector corresponding to an integrated luminosity of 139 fb−1. The event
signature, shared by all benchmark processes considered for measurements and
searches, is characterized by a significant amount of unbalanced transverse
momentum and a photon in the final state, in addition to a pair of forward
jets. For electroweak production of Zγ in association with two jets, the
background-only hypothesis is rejected with an observed (expected) significance
of 5.2 (5.1) standard deviations. The measured fiducial cross-section for this
process is 1.31±0.29 fb. Observed (expected) upper limit of 0.37 (0.34) at
95% confidence level is set on the branching ratio of a 125 GeV Higgs boson to
invisible particles, assuming the Standard Model production cross-section. The
signature is also interpreted in the context of decays of a Higgs boson to a
photon and a dark photon. An observed (expected) 95% CL upper limit on the
branching ratio for this decay is set at 0.018 (0.017), assuming the 125 GeV
Standard Model Higgs boson production cross-section
- …