Evaluation of Cholinesterase Activities During in Vivo Intoxication Using an Electrochemical Sensor Strip – Correlation With Intoxication Symptoms

Cholinesterase activity in blood of laboratory rats was monitored. Rats were intoxicated with paraoxon at dosis of 0 – 65 – 125 – 170 – 250 – 500 nmol. The 250 nmol dose was found to be the LD50. An electrochemical sensor was found useful to provide information about cholinesterase activity. The decrease of cholinesterase activity was correlated to intoxication symptoms and mortality level. It was found that the symptoms of intoxication are not observed while at least 50% of cholinesterase activity in blood remains. The minimal cholinesterase activity essential to survival is around 10%, when compared with the initial state. No changes in levels of low moleculary weight antioxidants were observed

The 'Sound' Phenomenon Paradigm as Musical and Educational Challenge

Sound phenomenon is an object studied in different fields of scientific knowledge: from the formation of Universal structures to a person's inner world. Command of sound's culture (in different epochs, peoples, musical directions, styles and schools) presents different images of the world in its correlation to a human. That is why mastering the culture of sound in performance and composing practices Achieving this aim can only be possible under one condition: the sound phenomenon and worldview are treated in the framework of paradigm approach. That is when models of sound and the outlook reflect common stance in posing problems by the society and understanding the ways of their treatment. This poses the problem of researching sound phenomenon paradigm shift and outlook as a complex process before musical education theory (Glazyrina, 2001). It is impossible to consider the sound phenomenon in theory of musical training out of context of understandings and attitudes of this or that artistic epoch (direction, style)-artistic and aesthetical concepts, theories of musical training, values and ideals, sound images and so on. However, it should be taken into account that in musical training, culture and art the shift of sound paradigms is much more complex than in science. That is why theory of musical training while studying the repertoire of concepts, technologies and teaching methods in the offgoing sequence of sound phenomenon paradigms should focus on their philosophical content. (C) 2018 Published by Future Academy www.FutureAcademy.org.U

Dietary supplementation with the tribomechanically activated zeolite clinoptilolite in immunodeficiency: effects on the immune system

Natural zeolites are crystalline aluminosilicates with unique adsorption, cation-exchange, and catalytic properties that have multiple uses in industry and agriculture. TMAZ, a natural zeolite clinoptilolite with enhanced physicochemical properties, is the basis of the dietary supplements Megamin and Lycopenomin, which have demonstrated antioxidant activity in humans. The aim of this prospective, open, and controlled parallel-group study was to investigate the effects of supplementation with TMAZ on the cellular immune system in patients undergoing treatment for immunodeficiency disorder. A total of 61 patients were administered daily TMAZ doses of 1.2 g (Lycopenomin) and 3.6 g (Megamin) for 6 to 8 weeks, during which the patients' primary medical therapy was continued unchanged. Blood and lymphocyte counts were performed at baseline and at the end of the study. Blood count parameters were not relevantly affected in either of the two treatment groups. Megamin administration resulted in significantly increased CD4+, CD19+, and HLA-DR+ lymphocyte counts and a significantly decreased CD56+ cell count. Lycopenomin was associated with an increased CD3+ cell count and a decreased CD56+ lymphocyte count. No adverse reactions to the treatments were observed