1,087 research outputs found
Computation of leading-edge vortex flows
The simulation of the leading edge vortex flow about a series of conical delta wings through solution of the Navier-Stokes and Euler equations is studied. The occurrence, the validity, and the usefulness of separated flow solutions to the Euler equations of particular interest. Central and upwind difference solutions to the governing equations are compared for a series of cross sectional shapes, including both rounded and sharp tip geometries. For the rounded leading edge and the flight condition considered, viscous solutions obtained with either central or upwind difference methods predict the classic structure of vortical flow over a highly swept delta wing. Predicted features include the primary vortex due to leading edge separation and the secondary vortex due to crossflow separation. Central difference solutions to the Euler equations show a marked sensitivity to grid refinement. On a coarse grid, the flow separates due to numerical error and a primary vortex which resembles that of the viscous solution is predicted. In contrast, the upwind difference solutions to the Euler equations predict attached flow even for first-order solutions on coarse grids. On a sufficiently fine grid, both methods agree closely and correctly predict a shock-curvature-induced inviscid separation near the leeward plane of symmetry. Upwind difference solutions to the Navier-Stokes and Euler equations are presented for two sharp leading edge geometries. The viscous solutions are quite similar to the rounded leading edge results with vortices of similar shape and size. The upwind Euler solutions predict attached flow with no separation for both geometries. However, with sufficient grid refinement near the tip or through the use of more accurate spatial differencing, leading edge separation results. Once the leading edge separation is established, the upwind solution agrees with recently published central difference solutions to the Euler equations
Capabilities of the Skylab-A spectrometer (S191) for remote sensing of surface targets in the thermal-infrared spectral region
The effects of some of the factors which fundamentally limit the amount of information which can be deduced from spectrometer (S191) measurements, made from the orbital altitude of Skylab-A, of the thermal-infrared power radiated into space from typical surface targets are discussed. The particular significance of this spectral region is that the power radiated at night is comparable in intensity to that in daylight. Calculations were made which simulate the quality of spectrometer data that could be expected from spectral measurements made in space, of the thermal-infrared radiation emitted from typical rocks on the surface. The results indicate that the reststrahlen structure in these spectra is not distinctive enough to permit reliable identification of the rocks. This conclusion is confirmed by relevant data which have already been obtained from aircraft and spacecraft
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Effectiveness of UK optometric enhanced eye care services: a realist review of the literature
PURPOSE: UK demographic and legislative changes combined with increasing burdens on National Health Service manpower and budgets have led to extended roles for community optometrists providing locally-commissioned enhanced optometric services (EOS). This realist review's objectives were to develop programme theories that implicitly or explicitly explain quality outcomes for eye care provided by optometrists via EOS and to test these theories by investigating the effectiveness of services for cataract, glaucoma, and primary eye care.
METHODS: The review protocol was published on PROSPERO, and RAMESES publication standards were followed. Programme theories were formulated via scoping literature searches and expert consultation. The searching process involved all relevant electronic databases and grey literature, without restrictions on study design. Data synthesis focussed on questioning the integrity of each theory by considering supportive and refuting evidence from the source literature.
RESULTS: Good evidence exists for cataract, glaucoma and primary eye care EOS that: with appropriate training, accredited optometrists manage patients commensurate with usual care standards; genuine partnerships can exist between community and hospital providers for cataract and glaucoma EOS; patient satisfaction with all three types of service is high; cost-effectiveness of services is unproven for cataract and primary eye care, while glaucoma EOS cost-effectiveness depends on service type; contextual factors may influence service success.
CONCLUSIONS: The EOS reviewed are clinically effective and provide patient satisfaction but limited data is available on cost-effectiveness
Disinfection of football protective equipment using chlorine dioxide produced by the ICA TriNova system
<p>Abstract</p> <p>Backround</p> <p>Community-associated methicillin-resistant <it>Staphylococcus aureus </it>outbreaks have occurred in individuals engaged in athletic activities such as wrestling and football. Potential disease reduction interventions include the reduction or elimination of bacteria on common use items such as equipment. Chlorine dioxide has a long history of use as a disinfectant. The purpose of this investigation was to evaluate the ability of novel portable chlorine dioxide generation devices to eliminate bacteria contamination of helmets and pads used by individuals engaged in football.</p> <p>Methods</p> <p>In field studies, the number of bacteria associated with heavily used football helmets and shoulder pads was determined before and after overnight treatment with chlorine dioxide gas. Bacteria were recovered using cotton swabs and plated onto trypticase soy agar plates. In laboratory studies, <it>Staphylococcus aureus </it>was applied directly to pads. The penetration of bacteria into the pads was determined by inoculating agar plates with portions of the pads taken from the different layers of padding. The ability to eliminate bacteria on the pad surface and underlying foam layers after treatment with chlorine dioxide was also determined.</p> <p>Results</p> <p>Rates of recovery of bacteria after treatment clearly demonstrated that chlorine dioxide significantly (p < 0.001) reduce and eliminated bacteria found on the surface of pads. For example, the soft surface of shoulder pads from a university averaged 2.7 × 10<sup>3 </sup>recoverable bacteria colonies before chlorine dioxide treatment and 1.3 × 10<sup>2 </sup>recoverable colonies after treatment. In addition, the gas was capable of penetrating the mesh surface layer and killing bacteria in the underlying foam pad layers. Here, 7 × 10<sup>3 </sup>to 4.5 × 10<sup>3 </sup>laboratory applied <it>S. aureus </it>colonies were recovered from underlying layers before treatment and 0 colonies were present after treatment. Both naturally occurring bacteria and <it>S. aureus </it>were susceptible to the treatment process.</p> <p>Conclusion</p> <p>Results of this study have shown that chlorine dioxide can easily and safely be used to eliminate bacteria contamination of protective pads used by football players. This could serve to reduce exposure to potential pathogens such as the methicillin-resistant <it>Staphylococcus aureus </it>among this group of individuals.</p
Translating the potential of the urine steroid metabolome to stage NAFLD (TrUSt-NAFLD): study protocol for a multicentre, prospective validation study.
INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) affects approximately one in four individuals and its prevalence continues to rise. The advanced stages of NAFLD with significant liver fibrosis are associated with adverse morbidity and mortality outcomes. Currently, liver biopsy remains the 'gold-standard' approach to stage NAFLD severity. Although generally well tolerated, liver biopsies are associated with significant complications, are resource intensive, costly, and sample only a very small area of the liver as well as requiring day case admission to a secondary care setting. As a result, there is a significant unmet need to develop non-invasive biomarkers that can accurately stage NAFLD and limit the need for liver biopsy. The aim of this study is to validate the use of the urine steroid metabolome as a strategy to stage NAFLD severity and to compare its performance against other non-invasive NAFLD biomarkers. METHODS AND ANALYSIS: The TrUSt-NAFLD study is a multicentre prospective test validation study aiming to recruit 310 patients with biopsy-proven and staged NAFLD across eight centres within the UK. 150 appropriately matched control patients without liver disease will be recruited through the Oxford Biobank. Blood and urine samples, alongside clinical data, will be collected from all participants. Urine samples will be analysed by liquid chromatography-tandem mass spectroscopy to quantify a panel of predefined steroid metabolites. A machine learning-based classifier, for example, Generalized Matrix Relevance Learning Vector Quantization that was trained on retrospective samples, will be applied to the prospective steroid metabolite data to determine its ability to identify those patients with advanced, as opposed to mild-moderate, liver fibrosis as a consequence of NAFLD. ETHICS AND DISSEMINATION: Research ethical approval was granted by West Midlands, Black Country Research Ethics Committee (REC reference: 21/WM/0177). A substantial amendment (TrUSt-NAFLD-SA1) was approved on 26 November 2021. TRIAL REGISTRATION NUMBER: ISRCTN19370855
The potential impact of a cataract surgery programme on the care of orphans and vulnerable children in Swaziland
We aimed to evaluate the potential impact of a cataract surgery programme at the Good Shepherd Hospital, Siteki, Swaziland, on the care of orphans and vulnerable children in Swaziland. We studied consecutive patients aged 50 years and older undergoing surgery for age-related cataract who reported having children living in their household. Of 131 subjects recruited, 65 (49.6%) were the primary caregivers for the child(ren) in their household. Visual acuities measured 2 weeks after surgery significantly improved. Four weeks after surgery, there was a sizable increase in the proportions of subjects who were able to undertake self-care activities, attend to activities of daily living, undertake income-generating activities and care for children. Cataract surgery on elderly visually impaired patients has the potential to impact positively on the care of orphans and vulnerable children
South Korea's automotive labour regime, Hyundai Motors’ global production network and trade‐based integration with the European Union
This article explores the interrelationship between global production networks(GPNs) and free trade agreements (FTAs) in the South Korean auto industry and its employment relations. It focuses on the production network of the Hyundai Motor Group (HMG) — the third biggest automobile manufacturer in the world — and the FTA between the EU and South Korea. This was the first of the EU’s ‘new generation’ FTAs, which among other things contained provisions designed to protect and promote labour standards. The article’s argument is twofold. First, that HMG’s production network and Korea’s political economy (of which HMG is a crucial part) limited the possibilities for the FTA’s labour provisions to take effect. Second, that the commercial provisions in this same FTA simultaneously eroded HMG’s domestic market and corporate profitability, leading to adverse consequences for auto workers in the more
insecure and low-paid jobs. In making this argument, the article advances a multiscalar conceptualization of the labour regime as an analytical intermediary between GPNs and FTAs. It also provides one of the first empirical studies of the EU–South Korea FTA in terms of employment relations, drawing on 105 interviews with trade unions, employer associations, automobile companies and state officials across both parties
Gapless spinons and a field-induced soliton gap in the hyper-honeycomb Cu oxalate framework compound [(CH)NH]Cu(CO)
We report a detailed study of the specific heat and magnetic susceptibility
of single crystals of a spin liquid candidate: the hyper-honeycomb Cu oxalate
framework compound [(CH)NH]Cu(CO). The specific
heat shows no anomaly associated with a magnetic transition at low temperatures
down to 180 mK in zero magnetic field. We observe a large linear-in-
contribution to the specific heat , mK/mol K,
at low temperatures, indicative of the presence of fermionic excitations
despite the Mott insulating state. The low- specific heat is strongly
suppressed by applied magnetic fields , which induce an energy gap, , in the spin-excitation spectrum. We use the four-component relativistic
density-functional theory (DFT) to calculate the magnetic interactions,
including the Dzyaloshinskii-Moriya antisymmetric exchange, which causes an
effective staggered field acting on one copper sublattice. The magnitude and
field dependence of the field-induced gap, , are
accurately predicted by the soliton mass calculated from the sine-Gordon model
of weakly coupled antiferromagnetic Heisenberg chains with all parameters
determined by our DFT calculations. Thus our experiment and calculations are
entirely consistent with a model of
[(CH)NH]Cu(CO) in which anisotropic magnetic
exchange interactions due to Jahn-Teller distortion cause one copper sublattice
to dimerize, leaving a second sublattice of weakly coupled antiferromagnetic
chains. We also show that this model quantitatively accounts for the measured
temperature-dependent magnetic susceptibility. Thus
[(CH)NH]Cu(CO) is a canonical example of a
one-dimensional spin-1/2 Heisenberg antiferromagnet and not a
resonating-valence-bond quantum spin liquid, as previously proposed.Comment: 8 pages, 6 figure
Can Monkeys Choose Optimally When Faced with Noisy Stimuli and Unequal Rewards?
We review the leaky competing accumulator model for two-alternative forced-choice decisions with cued responses, and propose extensions to account for the influence of unequal rewards. Assuming that stimulus information is integrated until the cue to respond arrives and that firing rates of stimulus-selective neurons remain well within physiological bounds, the model reduces to an Ornstein-Uhlenbeck (OU) process that yields explicit expressions for the psychometric function that describes accuracy. From these we compute strategies that optimize the rewards expected over blocks of trials administered with mixed difficulty and reward contingencies. The psychometric function is characterized by two parameters: its midpoint slope, which quantifies a subject's ability to extract signal from noise, and its shift, which measures the bias applied to account for unequal rewards. We fit these to data from two monkeys performing the moving dots task with mixed coherences and reward schedules. We find that their behaviors averaged over multiple sessions are close to optimal, with shifts erring in the direction of smaller penalties. We propose two methods for biasing the OU process to produce such shifts
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