Weekly reports for R.V. Polarstern expedition PS103 (2016-12-16 - 2017-02-03, Cape Town - Punta Arenas), German and English version

Priming is arguably one of the key phenomena in contemporary social psychology. Recent retractions and failed replication attempts have led to a division in the field between proponents and skeptics and have reinforced the importance of confirming certain priming effects through replication. In this study, we describe the results of 2 preregistered replication attempts of 1 experiment by Förster and Denzler (2012). In both experiments, participants first processed letters either globally or locally, then were tested using a typicality rating task. Bayes factor hypothesis tests were conducted for both experiments: Experiment 1(N = 100) yielded an indecisive Bayes factor of 1.38, indicating that the in-lab data are 1.38 times more likely to have occurred under the null hypothesis than under the alternative. Experiment 2 (N = 908) yielded a Bayes factor of 10.84, indicating strong support for the null hypothesis that global priming does not affect participants' mean typicality ratings. The failure to replicate this priming effect challenges existing support for the GLOMOsys model

Information science and cognitive psychology: a theoretical approach

Information, as a human and social phenomenon, is the object of study of an emergent scientific field named Information Science (IS), which we put forward as unitary and transdisciplinary and open to a rich interdisciplinarity with other fields of knowledge. In face of the new reality, baptized the Information Society', and the emergence of a new paradigm, that we name "post-custodial, scientific and informational", as opposed to the previous one, "historicist, custodial and technicist", it is urgent to consolidate the theoretical and methodological foundations of IS in order to develop research, both pure and applied, and to contribute to a definition of its boundaries as a scientific area, in the scope of Social Sciences. Starting from an operative definition of Information, this paper aims to discuss the cognitive and emotional dimension of the info-communicational phenomenon and, for that, it is crucial to start a profound and hard dialogue with Cognitive Sciences. The label of 'cognitivist' given, in IS literature, to some authors like Bertram Brookes, because of the emphasis he put on the passage from a state of knowledge to a new state through an addition of knowledge coming from an increase of information, sounds quite equivocal, because knowledge and cognition are not synonymous and cognitive and emotional activity is not reducible to formalities. It is necessary to compare concepts and to understand the neuropsychological roots of the production, the organization and the info-communicational behaviour, so the contribution of Neurosciences and Cognitive Sciences, namely Cognitive Psychology, is indispensable

Track E Implementation Science, Health Systems and Economics

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138412/1/jia218443.pd

Efficacy and safety of ciclosporin versus methotrexate in the treatment of severe atopic dermatitis in children and young people (TREAT): a multicentre parallel group assessor-blinded clinical trial

Background Conventional systemic drugs are used to treat children and young people (CYP) with severe atopic dermatitis (AD) worldwide, but no robust randomized controlled trial (RCT) evidence exists regarding their efficacy and safety in this population. While novel therapies have expanded therapeutic options, their high cost means traditional agents remain important, especially in lower-resource settings. Objectives To compare the safety and efficacy of ciclosporin (CyA) with methotrexate (MTX) in CYP with severe AD in the TREatment of severe Atopic Eczema Trial (TREAT) trial. Methods We conducted a parallel group assessor-blinded RCT in 13 UK and Irish centres. Eligible participants aged 2–16 years and unresponsive to potent topical treatment were randomized to either oral CyA (4 mg kg–1 daily) or MTX (0.4 mg kg–1 weekly) for 36 weeks and followed-up for 24 weeks. Co-primary outcomes were change from baseline to 12 weeks in Objective Severity Scoring of Atopic Dermatitis (o-SCORAD) and time to first significant flare (relapse) after treatment cessation. Secondary outcomes included change in quality of life (QoL) from baseline to 60 weeks; number of participant-reported flares following treatment cessation; proportion of participants achieving ≥ 50% improvement in Eczema Area and Severity Index (EASI 50) and ≥ 75% improvement in EASI (EASI 75); and stratification of outcomes by filaggrin status. Results In total, 103 participants were randomized (May 2016–February 2019): 52 to CyA and 51 to MTX. CyA showed greater improvement in disease severity by 12 weeks [mean difference in o-SCORAD –5.69, 97.5% confidence interval (CI) –10.81 to –0.57 (P = 0.01)]. More participants achieved ≥ 50% improvement in o-SCORAD (o-SCORAD 50) at 12 weeks in the CyA arm vs. the MTX arm [odds ratio (OR) 2.60, 95% CI 1.23–5.49; P = 0.01]. By 60 weeks MTX was superior (OR 0.33, 95% CI 0.13–0.85; P = 0.02), a trend also seen for ≥ 75% improvement in o-SCORAD (o-SCORAD 75), EASI 50 and EASI 75. Participant-reported flares post-treatment were higher in the CyA arm (OR 3.22, 95% CI 0.42–6.01; P = 0.02). QoL improved with both treatments and was sustained after treatment cessation. Filaggrin status did not affect outcomes. The frequency of adverse events (AEs) was comparable between both treatments. Five (10%) participants on CyA and seven (14%) on MTX experienced a serious AE. Conclusions Both CyA and MTX proved effective in CYP with severe AD over 36 weeks. Participants who received CyA showed a more rapid response to treatment, while MTX induced more sustained disease control after discontinuation

On the likelihood of "encapsulating all uncertainty"

This paper is part of the Virtual Special Issue entitled: Measuring and Reporting the Precision of Forensic Likelihood Ratios, [http://www.sciencedirect.com/science/journal/ 13550306/vsi]The assignment of personal probabilities to form a forensic practitioner's likelihood ratio is a mental operation subject to all the frailties of human memory, perception and judgment. While we agree that beliefs expressed as coherent probabilities are neither 'right' nor 'wrong' we argue that debate over this fact obscures both the requirement for and consideration of the 'helpfulness' of practitioner's opinions. We also question the extent to which a likelihood ratio based on personal probabilities can realistically be expected to 'encapsulate all uncertainty'. Courts cannot rigorously assess a forensic practitioner's bare assertions of belief regarding evidential strength. At a minimum, information regarding the uncertainty both within and between the opinions of practitioners is required.Kristy A. Martire, Gary Edmond, Daniel J. Navarro, Ben R. Newel

Philosophical conceptions of information

“The original publication is available at www.springerlink.com” Copyright Springer'I love information upon all subjects that come in my way, and especially upon those that are most important.' Thus boldly declares Euphranor, one of the defenders of Christian faith in Berkley’s Alciphron (Berkeley, (1732), Dialogue 1, Section 5, Paragraph 6/10). Evidently, information has been an object of philosophical desire for some time, well before the computer revolution, Internet or the dot.com pandemonium (see for example Dunn (2001) and Adams (2003)). Yet what does Euphranor love, exactly? What is information? The question has received many answers in different fields. Unsurprisingly, several surveys do not even converge on a single, unified definition of information (see for example Braman 1989, Losee (1997), Machlup and Mansfield (1983), Debons and Cameron (1975), Larson and Debons (1983)).Peer reviewe