Discovery and Early Evolution of ASASSN-19bt, the First TDE Detected by TESS

We present the discovery and early evolution of ASASSN-19bt, a tidal disruption event (TDE) discovered by the All-Sky Automated Survey for Supernovae (ASAS-SN) at a distance of $d\simeq115$ Mpc and the first TDE to be detected by TESS. As the TDE is located in the TESS Continuous Viewing Zone, our dataset includes 30-minute cadence observations starting on 2018 July 25, and we precisely measure that the TDE begins to brighten $\sim8.3$ days before its discovery. Our dataset also includes 18 epochs of Swift UVOT and XRT observations, 2 epochs of XMM-Newton observations, 13 spectroscopic observations, and ground data from the Las Cumbres Observatory telescope network, spanning from 32 days before peak through 37 days after peak. ASASSN-19bt thus has the most detailed pre-peak dataset for any TDE. The TESS light curve indicates that the transient began to brighten on 2019 January 21.6 and that for the first 15 days its rise was consistent with a flux $\propto t^2$ power-law model. The optical/UV emission is well-fit by a blackbody SED, and ASASSN-19bt exhibits an early spike in its luminosity and temperature roughly 32 rest-frame days before peak and spanning up to 14 days that has not been seen in other TDEs, possibly because UV observations were not triggered early enough to detect it. It peaked on 2019 March 04.9 at a luminosity of $L\simeq1.3\times10^{44}$ ergs s$^{-1}$ and radiated $E\simeq3.2\times10^{50}$ ergs during the 41-day rise to peak. X-ray observations after peak indicate a softening of the hard X-ray emission prior to peak, reminiscent of the hard/soft states in X-ray binaries.Comment: 23 pages, 14 figures, 5 tables. A machine-readable table containing the host-subtracted photometry presented in this manuscript is included as an ancillary fil

An Amusing Look at the Host of the Periodic Nuclear Transient ASASSN-14ko Reveals a Second AGN

We present Multi-Unit Spectroscopic Explorer (MUSE) integral-field spectroscopy of ESO 253$-$G003, which hosts a known Active Galactic Nucleus (AGN) and the periodic nuclear transient ASASSN-14ko, observed as part of the All-weather MUse Supernova Integral-field of Nearby Galaxies (AMUSING) survey. The MUSE observations reveal that the inner region hosts two AGN separated by $1.4\pm0.1~\rm{kpc}$ (\approx 1.\!\!^{\prime\prime}7). The brighter nucleus has asymmetric broad, permitted emission-line profiles and is associated with the archival AGN designation. The fainter nucleus does not have a broad emission-line component but exhibits other AGN characteristics, including $v_{\rm{FWHM}}\approx 700~\rm{km}~\rm{s}^{-1}$ forbidden line emission, $\log_{10}(\rm{[OIII]}/\rm{H}\beta) \approx 1.1$, and high excitation potential emission lines such as [Fe$~$VII]$~\lambda6086$ and He$~$II$~\lambda4686$. The host galaxy exhibits a disturbed morphology with large kpc-scale tidal features, potential outflows from both nuclei, and a likely superbubble. A circular relativistic disk model cannot reproduce the asymmetric broad emission-line profiles in the brighter nucleus, but two non-axisymmetric disk models provide good fits to the broad emission-line profiles: an elliptical disk model and a circular disk + spiral arm model. Implications for the periodic nuclear transient ASASSN-14ko are discussed.Comment: 20 pages, 16 figures, and 2 tables. Accepted by MNRA

Swine flu: lessons we need to learn from our global experience

There are important lessons to be learnt from the recent ‘Swine Flu’ pandemic. Before we call it a pandemic, we need to have appropriate trigger points that involve not only the spread of the virus but also its level of virulence. This was not done for H1N1 (swine flu). We need to ensure that we improve the techniques used in trying to decrease the spread of infection—both in the community and within our hospitals. This means improved infection control and hygiene, and the use of masks, alcohol hand rubs and so on. We also need to have a different approach to vaccines. Effective vaccines were produced only after the epidemic had passed and therefore had relatively little impact in preventing many infections. Mass population strategies involving vaccines and antivirals also misused large amounts of scarce medical resources

Discovery and Follow-up of ASASSN-19dj: An X-ray and UV Luminous TDE in an Extreme Post-Starburst Galaxy

We present observations of ASASSN-19dj, a nearby tidal disruption event (TDE) discovered in the post-starburst galaxy KUG 0810+227 by the All-Sky Automated Survey for Supernovae (ASAS-SN) at a distance of d $\simeq$ 98 Mpc. We observed ASASSN-19dj from $-$21 to 392 days relative to peak UV/optical emission using high-cadence, multi-wavelength spectroscopy and photometry. From the ASAS-SN $g$-band data, we determine that the TDE began to brighten on 2019 February 6.8 and for the first 25 days the rise was consistent with a flux $\propto$ $t^2$ power-law. ASASSN-19dj peaked in the UV/optical on 2019 March 6.5 (MJD = 58548.5) at a bolometric luminosity of $L = (6.2 \pm 0.2) \times 10^{44} \text{ erg s}^{-1}$. Initially remaining roughly constant in X-rays and slowly fading in the UV/optical, the X-ray flux increased by over an order of magnitude $\sim$225 days after peak, resulting from the expansion of the X-ray emitting surface. The late-time X-ray emission is well-fit by a blackbody with an effective radius of $\sim 1 \times 10^{12} \text{ cm}$ and a temperature of $\sim 6 \times 10^{5} \text{ K}$. Analysis of Catalina Real-Time Transient Survey images reveals a nuclear outburst roughly 14.5 years earlier with a smooth decline and a luminosity of $L_V$ $\geq$ $1.4 \times 10^{43}$ erg s$^{-1}$, although the nature of the flare is unknown. ASASSN-19dj occurred in the most extreme post-starburst galaxy yet to host a TDE, with Lick H$\delta_{A}$ = $7.67 \pm 0.17$ \AA.Comment: 25 pages, 14 figures. Will be submitted to MNRAS. For a short video description please see https://youtu.be/WjTZwO7vcF

An AMUSING look at the host of the periodic nuclear transient ASASSN-14ko reveals a second AGN

We present Multi-Unit Spectroscopic Explorer (MUSE) integral-field spectroscopy of ESO 253-G003, which hosts a known active galactic nucleus (AGN) and the periodic nuclear transient ASASSN-14ko, observed as part of the All-weather MUse Supernova Integral-field of Nearby Galaxies survey. The MUSE observations reveal that the inner region hosts two AGN separated by 1.4±0.1 kpc (≍1 ′′. 7). The brighter nucleus has asymmetric broad permitted emission-line profiles and is associated with the archival AGN designation. The fainter nucleus does not have a broad emission-line component but exhibits other AGN characteristics, including vFWHM≈700 km~s−1 forbidden line emission, log10([OIII]/Hβ)≈1.1 , and high-excitation potential emission lines, such as [Fe VII] λ6086 and He II λ4686. The host galaxy exhibits a disturbed morphology with large kpc-scale tidal features, potential outflows from both nuclei, and a likely superbubble. A circular relativistic disc model cannot reproduce the asymmetric broad emission-line profiles in the brighter nucleus, but two non-axisymmetric disc models provide good fits to the broad emission-line profiles: an elliptical disc model and a circular disc + spiral arm model. Implications for the periodic nuclear transient ASASSN-14ko are discussed.MAT acknowledges support from the DOE CSGF through grant no. DE-SC0019323. BJS and CSK are supported by NSF grant no. AST-1907570. BJS is also supported by NASA grant no. 80NSSC19K1717 and NSF grants AST-1920392 and AST-1911074. CSK is supported by NSF grant no. AST-181440. KAA is supported by the Danish National Research Foundation (DNRF132). Support for JLP is provided in part by FONDECYT through grant n.1191038 and by the Ministry for the Economy, Development, and Tourism’s Millennium Science Initiative through grant no. IC120009, awarded to The Millennium Institute of Astrophysics, MAS. LG acknowledges financial support from the Spanish Ministry of Science, Innovation and Universities (MICIU) under the 2019 Ramón y Cajal program RYC2019-027683 and from the Spanish MICIU project PID2020-115253GA-I00. Parts of this research were supported by the Australian Research Council Centre of Excellence for All Sky Astrophysics in 3 Dimensions (ASTRO 3D), through project number CE170100013. LG was funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 839090, and partially supported by the Spanish grant no. PGC2018-095317-B-C21 within the European Funds for Regional Development (FEDER). Support for TW-SH was provided by NASA through the NASA Hubble Fellowship grant no. #HST-HF2-51458.001-A awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., for NASA, under contract NAS5-26555. Based on observations collected at the European Organization for Astronomical Research in the Southern Hemisphere under ESO programme 096.D-0296(A).Peer reviewe

Type-Ia Supernova Rates to Redshift 2.4 from Clash: The Cluster Lensing and Supernova Survey with Hubble

We present the supernova (SN) sample and Type-Ia SN (SN Ia) rates from the Cluster Lensing And Supernova survey with Hubble (CLASH). Using the Advanced Camera for Surveys and the Wide Field Camera 3 on the Hubble Space Telescope (HST), we have imaged 25 galaxy-cluster fields and parallel fields of non-cluster galaxies. We report a sample of 27 SNe discovered in the parallel fields. Of these SNe, approximately 13 are classified as SN Ia candidates, including four SN Ia candidates at redshifts z greater than 1.2.We measure volumetric SN Ia rates to redshift 1.8 and add the first upper limit on the SN Ia rate in the range z greater than 1.8 and less than 2.4. The results are consistent with the rates measured by the HST/ GOODS and Subaru Deep Field SN surveys.We model these results together with previous measurements at z less than 1 from the literature. The best-fitting SN Ia delay-time distribution (DTD; the distribution of times that elapse between a short burst of star formation and subsequent SN Ia explosions) is a power law with an index of 1.00 (+0.06(0.09))/(-0.06(0.10)) (statistical) (+0.12/0.08) (systematic), where the statistical uncertainty is a result of the 68% and 95% (in parentheses) statistical uncertainties reported for the various SN Ia rates (from this work and from the literature), and the systematic uncertainty reflects the range of possible cosmic star-formation histories. We also test DTD models produced by an assortment of published binary population synthesis (BPS) simulations. The shapes of all BPS double-degenerate DTDs are consistent with the volumetric SN Ia measurements, when the DTD models are scaled up by factors of 3-9. In contrast, all BPS single-degenerate DTDs are ruled out by the measurements at greater than 99% significance level

Adenosine A2A receptors in Parkinson’s disease treatment

Latest results on the action of adenosine A2A receptor antagonists indicate their potential therapeutic usefulness in the treatment of Parkinson’s disease. Basal ganglia possess high levels of adenosine A2A receptors, mainly on the external surfaces of neurons located at the indirect tracts between the striatum, globus pallidus, and substantia nigra. Experiments with animal models of Parkinson’s disease indicate that adenosine A2A receptors are strongly involved in the regulation of the central nervous system. Co-localization of adenosine A2A and dopaminergic D2 receptors in striatum creates a milieu for antagonistic interaction between adenosine and dopamine. The experimental data prove that the best improvement of mobility in patients with Parkinson’s disease could be achieved with simultaneous activation of dopaminergic D2 receptors and inhibition of adenosine A2A receptors. In animal models of Parkinson’s disease, the use of selective antagonists of adenosine A2A receptors, such as istradefylline, led to the reversibility of movement dysfunction. These compounds might improve mobility during both monotherapy and co-administration with L-DOPA and dopamine receptor agonists. The use of adenosine A2A receptor antagonists in combination therapy enables the reduction of the L-DOPA doses, as well as a reduction of side effects. In combination therapy, the adenosine A2A receptor antagonists might be used in both moderate and advanced stages of Parkinson’s disease. The long-lasting administration of adenosine A2A receptor antagonists does not decrease the patient response and does not cause side effects typical of L-DOPA therapy. It was demonstrated in various animal models that inhibition of adenosine A2A receptors not only decreases the movement disturbance, but also reveals a neuroprotective activity, which might impede or stop the progression of the disease. Recently, clinical trials were completed on the use of istradefylline (KW-6002), an inhibitor of adenosine A2A receptors, as an anti-Parkinson drug