7,333 research outputs found
Fluorescein angiography compared to three-dimensional measurements by the retinal thickness analyzer in classic choroidal neovascularization
Purpose: To compare and correlate imaging of classic subfoveal choroidal neovascularization (CNV) with noninvasive 3-dimensional imaging by the retinal thickness analyzer (RTA) to conventional fluorescein angiography (FA). Methods: A total of 29 eyes of 29 consecutive patients with predominantly classic CNV eligible for photodynamic therapy underwent FA and RTA imaging. The FA dimensions of the CNV were measured independently by two graders. With the RTA, masked to FA the size of the CNV itself as imaged in 3-dimensional reconstruction, the size of significantly thickened retina overlying the CNV and the maximum retinal thickness were measured. Results: The mean diameter of the CNV determined from 3-dimensional RTA reconstructions showed an excellent correlation with measurements from FA (r = 0.91, p < 0.001). The area of retinal thickening was by a mean of 0.7 mm in diameter larger and correlated moderately well with the size of the CNV on FA (r = 0.65, p < 0.001). In contrast, there was no correlation between the absolute retinal thickness and the CNV size on FA. Conclusions: Noninvasive quantitative mapping of predominantly classic CNV by RTA is feasible and also allows 3-dimensional measurement of the lesion itself. The results correlate well with FA assessment but visualize different properties of the disease. Copyright (c) 2007 S. Karger AG, Basel
Concentric left ventricular remodeling and aortic stiffness: A comparison of obesity and hypertension
Licensed under the Creative Commons Attribution Non-Commercial No Derivatives Licens
Sorafenib prevents human retinal pigment epithelium cells from light-induced overexpression of VEGF, PDGF and PlGF
Background
Cumulative light exposure is significantly associated with progression of age-related macular degeneration (AMD). Inhibition of vascular endothelial growth factor is the main target of current antiangiogenic treatment strategies in AMD. However, other growth factors, such as platelet-derived growth factor (PDGF) and placenta growth factor (PlGF), have a substantial impact on development of AMD. Previous reports indicate that sorafenib, an oral multikinase inhibitor, might have beneficial effects on exudative AMD. This study investigates the effects of sorafenib on light-induced overexpression of growth factors in human retinal pigment epithelial (RPE) cells. Methods
Primary human RPE cells were exposed to white light and incubated with sorafenib. Viability, expression, and secretion of VEGF-A, PDGF-BB, and PlGF and their mRNA were determined by reverse transcription-polymerase chain reactions, immunohistochemistry and enzyme-linked immunosorbent assays.
Results
Light exposure decreased cell viability and increased expression and secretion of VEGF-A, PDGF-BB and PlGF. These light-induced effects were significantly reduced when cells were treated with sorafenib at a dose of 1 mu g/ml.
Conclusion
The results show that sorafenib has promising properties as a potential antiangiogenic treatment for AMD
Obese Subjects Show Sex-Specific Differences in Right Ventricular Hypertrophy
As right ventricular (RV) remodeling in obesity remains underinvestigated, and the impact of left ventricular (LV) diastolic dysfunction on RV hypertrophy is unknown, we aimed to investigate whether (1) sex-specific patterns of RV remodeling exist in obesity and (2) LV diastolic dysfunction in obesity is related to RV hypertrophy.Seven hundred thirty-nine subjects (women, n=345; men, n=394) without identifiable cardiovascular risk factors (body mass index [BMI], 15.3-59.2 kg/m2) underwent cardiovascular magnetic resonance (1.5 T) to measure RV mass (g), RV end-diastolic volume (mL), RV mass/volume ratio, and LV diastolic peak filling rate (mL/s). All subjects were normotensive (average, 119±11/73±8 mm Hg), normoglycaemic (4.8±0.5 mmol/L), and normocholesterolaemic (4.8±0.9 mmol/L) at the time of scanning. Across both sexes, there was a moderately strong positive correlation between BMI and RV mass (men, +0.8 g per BMI point increase; women, +1.0 g per BMI point increase; both P<0.001). Whereas women exhibited RV cavity dilatation (RV end-diastolic volume, +1.0 mL per BMI point increase; P<0.001), BMI was not correlated with RV end-diastolic volume in men (R=0.04; P=0.51). Concentric RV remodeling was present in both sexes, with RV mass/volume ratio being positively correlated to BMI (men, R=0.41; women, R=0.51; both P<0.001). Irrespective of sex, the LV peak filling rate was negatively correlated with both RV mass (men, R=-0.43; women, R=-0.44; both P<0.001) and RV mass/volume ratio (men, R=-0.37; women, R=-0.35; both P<0.001).A sex difference in RV remodeling exists in obesity. Whereas men exhibit concentric RV remodeling, women exhibit a mixed pattern of eccentric and concentric remodeling. Regardless of sex, reduced LV diastolic function is associated with concentric RV remodeling
Spin Transfer Torques in MnSi at Ultra-low Current Densities
Spin manipulation using electric currents is one of the most promising
directions in the field of spintronics. We used neutron scattering to observe
the influence of an electric current on the magnetic structure in a bulk
material. In the skyrmion lattice of MnSi, where the spins form a lattice of
magnetic vortices similar to the vortex lattice in type II superconductors, we
observe the rotation of the diffraction pattern in response to currents which
are over five orders of magnitude smaller than those typically applied in
experimental studies on current-driven magnetization dynamics in
nanostructures. We attribute our observations to an extremely efficient
coupling of inhomogeneous spin currents to topologically stable knots in spin
structures
A Hot Helium Plasma in the Galactic Center Region
Recent X-ray observations by the space mission Chandra confirmed the
astonishing evidence for a diffuse, hot, thermal plasma at a temperature of 9.
K (8 keV) found by previous surveys to extend over a few hundred parsecs
in the Galactic Centre region. This plasma coexists with the usual components
of the interstellar medium such as cold molecular clouds and a soft (~0.8 keV)
component produced by supernova remnants, and its origin remains uncertain.
First, simple calculations using a mean sound speed for a hydrogen-dominated
plasma have suggested that it should not be gravitationally bound, and thus
requires a huge energy source to heat it in less than the escape time. Second,
an astrophysical mechanism must be found to generate such a high temperature.
No known source has been identified to fulfill both requirements. Here we
address the energetics problem and show that the hot component could actually
be a gravitationally confined helium plasma. We illustrate the new prospects
this opens by discussing the origin of this gas, and by suggesting possible
heating mechanisms.Comment: 9 pages, accepted for publication in APJ
Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis
Background
A non-invasive method to grade the severity of steatohepatitis and liver fibrosis is magnetic resonance imaging (MRI) based corrected T1 (cT1). We aimed to identify genetic variants influencing liver cT1 and use genetics to understand mechanisms underlying liver fibroinflammatory disease and its link with other metabolic traits and diseases.
Methods
First, we performed a genome-wide association study (GWAS) in 14,440 Europeans in UK Biobank with liver cT1 measures. Second, we explored the effects of the cT1 variants on liver blood tests, and a range of metabolic traits and diseases. Third, we used Mendelian randomisation to test the causal effects of 24 predominantly metabolic traits on liver cT1 measures.
Results
We identified six independent genetic variants associated with liver cT1 that reached GWAS significance threshold (p<5x10-8). Four of the variants (rs75935921 in SLC30A10, rs13107325 in SLC39A8, rs58542926 in TM6SF2, rs738409 in PNPLA3) were also associated with elevated transaminases and had variable effects on liver fat and other metabolic traits. Insulin resistance, type 2 diabetes, non-alcoholic fatty liver and BMI were causally associated with elevated cT1 whilst favourable adiposity (instrumented by variants associated with higher adiposity but lower risk of cardiometabolic disease and lower liver fat) was found to be protective.
Conclusion
The association between two metal ion transporters and cT1 indicates an important new mechanism in steatohepatitis. Future studies are needed to determine whether interventions targeting the identified transporters might prevent liver disease in at risk individuals
Long-range crystalline nature of the skyrmion lattice in MnSi
We report small angle neutron scattering of the skyrmion lattice in MnSi
using an experimental set-up that minimizes the effects of demagnetizing fields
and double scattering. Under these conditions the skyrmion lattice displays
resolution-limited Gaussian rocking scans that correspond to a magnetic
correlation length in excess of several hundred {\mu}m. This is consistent with
exceptionally well-defined long-range order. We further establish the existence
of higher-order scattering, discriminating parasitic double-scattering with
Renninger scans. The field and temperature dependence of the higher-order
scattering arises from an interference effect. It is characteristic for the
long-range crystalline nature of the skyrmion lattice as shown by simple mean
field calculations.Comment: 4 page
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