Robust spatially resolved pressure measurements using MRI with novel buoyant advection-free preparations of stable microbubbles in polysaccharide gels

MRI of fluids containing lipid coated microbubbles has been shown to be an effective tool for measuring the local fluid pressure. However, the intrinsically buoyant nature of these microbubbles precludes lengthy measurements due to their vertical migration under gravity and pressure-induced coalescence. A novel preparation is presented which is shown to minimize both these effects for at least 25 min. By using a 2% polysaccharide gel base with a small concentration of glycerol and 1,2-distearoyl-sn-glycero-3-phosphocholine coated gas microbubbles, MR measurements are made for pressures between 0.95 and 1.44 bar. The signal drifts due to migration and amalgamation are shown to be minimized for such an experiment whilst yielding very high NMR sensitivities up to 38% signal change per bar

Expression of MAGE-1 and -3 genes and gene products in human hepatocellular carcinoma

MAGE gene family encodes peptides recognized by autologous cytotoxic T lymphocytes in a major histocompatibility complex (MHC) class-I restricted fashion. In the present study, we have performed reverse-transcription polymerase chain reaction (RT-PCR) for the genes, as well as immunohistochemical analysis and Western blotting of MAGE-1 and -3 proteins in 33 surgically resected hepatocellular carcinomas (HCCs). MAGE-1 and -3 mRNAs were constitutively expressed exclusively in 78 and 42% of HCCs respectively. On immunohistochemistry with monoclonal antibodies, 77B for MAGE-1 and 57B for MAGE-3, MAGE-1 and -3 proteins were recognized in cytoplasm of only six among 33 (18%) and two of 29 HCCs (7%) respectively. The distribution pattern was mostly focal in HCC nodules. By contrast, the Western blot analysis revealed that the MAGE-1 (46 kDa) and -3 proteins (48 kDa) were expressed in 80 and 60% of 15 HCCs examined respectively. The proteins of MAGE-1 and -3 were also expressed exclusively in HCCs regardless of the histological grading and clinical staging. Our results indicate that the detection of the genes by RT-PCR or the proteins by Western blotting is useful for differentiating early HCCs from non-cancerous lesions, and that the peptides derived from MAGE-1 and -3 proteins might be suitable targets for immunotherapy of human HCC. © 1999 Cancer Research Campaig

Soda and Tobacco Industry Corporate Social Responsibility Campaigns: How Do They Compare?

In an article that forms part of the PLoS Medicine series on Big Food, Andrew Cheyne and colleagues compare soda companies' corporate social responsibility (CSR) campaigns - which are designed to bolster the image and popularity of their products and to prevent regulation - with the tobacco industry's CSR campaigning

Nombre de la investigación Informe sobre creación de Valor Compartido Nestlé

Esta es la primera vez que Nestlé publica un informe global sobre la Creación de valor compartido y trata los temas de responsabilidad social y sostenibilidad corporativas. Forma parte del conjunto de la información relativa a la empresa y acompaña a nuestro Informe de Gestión de 2007. La información abarca las operaciones de Nestlé en todo el mundo para el año terminado en diciembre de 2007 y ha sido sometido a verificación externa. El informe analiza las repercusiones de las actividades de negocio que más preocupan a nuestros grupos de interé

Eskimo Pie Boy (full front view)

Full front view of Eskimo Pie Boy advertising icon. Eskimo boy on ice cream cart with umbrella, made from die cast metal and cold cast figure.https://scholarscompass.vcu.edu/brandcenter_icons/1041/thumbnail.jp

Eskimo Pie Boy (full rear view)

Full back view of Eskimo Pie Boy advertising icon. Eskimo boy on ice cream cart with umbrella, made from die cast metal and cold cast figure.https://scholarscompass.vcu.edu/brandcenter_icons/1042/thumbnail.jp

Little Hans (full front view)

Full front view of Little Hans (the Nestlé chocolate maker) advertising icon. Bearded figure in overalls.https://scholarscompass.vcu.edu/brandcenter_icons/1294/thumbnail.jp