Current treatment strategies in malignant pleural mesothelioma with a treatment algorithm

Malignant pleural mesothelioma (MPM) is a rare disease with a poor prognosis. The main therapeutic options for MPM include surgery, chemotherapy, and radiation therapy (RT). Although multimodality therapy has been reported to improve survival, not every medically operable patient is able to undergo all recommended therapy. With improvements in surgical techniques and systemic therapies, as well as advancements in RT, there has been a potential new paradigm in the management of this disease. In this review, we discuss the current literature on MPM management and propose a functional treatment algorithm

The Level of Knowledge About Radiation Safety and the Frequency of the Use of Protective Equipment Among Healthcare workers Exposed to Radiation in Different Units

WOS: 000443459600003OBJECTIVE We aimed to investigate the level of knowledge about radiation safety, the frequency of the use of protective equipment, and the reasons for not using it among healthcare workers. METHODS The data were collected by administering a standard cross-sectional survey via the internet to 443 healthcare workers exposed to radiation. The chi-square test was used to compare groups. RESULTS The median age of participants was 30 years, and 52.8% were females. Participants comprised radiology (61.4%), radiation oncology (21.4%), cardiology (7.2%), fluoroscopy use (5.9%), and nuclear medicine (4.1%) workers. In total, 90.1% of the workers had dosimeters. Of those who used fluoroscopy, only 11.5% had dosimeters. A total of 20.3% of the workers stated that dosimetry is reliable, and 89.7% of the workers in the cardiology and fluoroscopy use groups knew that they had to wear lead aprons (p<0.05). The rate of thyroid protector use was 100% in the cardiology group, whereas 23.1% of the fluoroscopy use group did not use a thyroid protector and 7.7% were not aware of its presence (p<0.05). Additionally, the protective goggles use in all groups was 6.3%. Of the workers, 20.8% believed in the protection of protective equipment. The most common reason for not using protective equipment was the restraint of mobility capability. CONCLUSION Exposure to radiation is an important issue in terms of work health and occupational diseases. For this reason, workers' knowledge about radiation safety and protective equipment should be increased, and the hospital administration should inspect the implementation of protective measures regularly

Modeling the drug release from reduced graphene oxide-reinforced hyaluronic acid/gelatin/poly(ethylene oxide) polymeric films

Herein, electroconductive polymeric films consisting of hyaluronic acid (HyA), gelatin (Gel), poly(ethylene oxide) (PEO) reinforced by reduced graphene oxide (RGO) were used in drug release studies to investigate usability of the films as drug carrier in the future. Irbesartan (IRB) used for the treatment of cardiovascular diseases was loaded to the polymeric films and its release kinetic was investigated. Afterwards, the obtained controlled drug release data were simulated using different dynamic differential mathematical models such as 1st, 2nd, 3rd degree and Higuchi model. In addition, a novel approach considering the drug release rate to be inversely proportional to the drug release percentage was presented to reproduce the experimental drug release percentage results. Thus, the approach used in this work covers different aspects of drug release kinetics to assure that HyA/Gel/PEO films w/out RGO could be considered as a potential carrier for controlled drug delivery systems

An extraneural primary anaplastic ependymoma at the subcutaneous inguinal region: Report of a rare case

Ependymomas commonly arise in the central nervous system. Extraneural presentation is quite rare. Herein, we describe a primary extraneural ependymoma in a young female. The mass was located in the right inguinal area. The cut surface of the 7.5 mm × 6.5 mm × 4.5 mm sized tumor was brownish-yellow in color. Histologically, it was hypercellular exhibiting pseudorosette or rosette formations and some papillary structures. Mitosis was counted as high as 10 per 10 high power fields. Neither necrosis nor vascular endothelial proliferation within the tumor was observed. Tumor cells showed strong glial fibrillary acidic protein immunoreactivity. On epithelial membrane antigen, intracytoplasmic dot-like immunostaining was observed. This is the first report presenting a primary extraneural anaplastic ependymoma arising in the inguinal subcutaneous region

Radiotherapy facilities after the Turkiye-Syria earthquakes: lessons from the tragedy

[No Abstract Available