Risk factors for uterine fibroids in women of reproductive age

Целью исследования была оценка факторов риска развития миомы матки у женщин репродуктивного возраста. Показано, что в условиях гинекологического стационара ГУ «Дорожная больница» ГП «Одесская железная дорога» миома матки по частоте в структуре обращений занимает третье место после воспалительных процессов придатков матки и эндометриоза. Наиболее частая локализация миомы — интерстициальная, при этом в 49,8 % случаев опухоль локализуется в теле матки. К основным факторам риска возникновения миомы относятся гормональный дисбаланс, возраст до 45 лет и наследственная предрасположенностьUterine fibroids and their complications remain one of the main reasons for surgical interventions in gynecological practice in all developed countries. The frequency of this pathology in the structure of gynecological diseases is high and comprise by different authors data, from 10 to 27%, the results of autopsies of about 50%, according to U.S. researchers more than 70%. Approximately 30–45 % of cases of uterine fibroids are diagnosed in women of reproductive age: 15–17 % in women older than 30 years, and 30–35% at the premenopausal age. Recently there was determined a trend towards the rejuvenation of the disease. After 30 years the risk of uterine fibroids increases to 70–80 %, and the incidence continues to be very common pathology in women in the perimenopause period. However, it is impossible to determine the true incidence due to asymptomatic course in more than 70 % of uterine fibroids. The study was aimed to evaluate risk factors for uterine fibroids in women of reproductive age. The research was conducted at the SI “Road Hospital” of SE “Odessa Railway” during 2008–2013. There was conducted a retrospective analysis of medical records of women of reproductive age suffering from uterine fibroids (code ICD-10 D25). Statistical analysis performed using the software Statistica 7.0 (USA)

Impact of the «Simbiter» group multiprobiotics on the contents of monomers of bindweb structures in the periodontal tissues in conditions of prolonged hypoacidity

In conditions of prolonged omeprazole-induced hypoacidity in the periodontal tissues of rats an increased catabolism of collagenous and non- collagenous proteins is occurred, The "Simbiter acidophilic concentrated" and "Simbiter-omega" multiprobiotics prevent depolymerization of collagenous and non-collagenous structures of periodontal connective tissues of rats in conditions of prolonged hypoacidity

Effect of glutamate-induced obesity on the NO-ergic system in tissues of rats’ salivary glands

На експериментальній моделі глутамат-індукованого ожиріння досліджено стан NO-ергічної системи в слинних залозах щурів. За умов глутамат-індукованого ожиріння в слинних залозах щурів відбулось підвищення активності NO-ергічної системи і одночасне накопичення NO2–, метаболіту циклічних перетворень оксиду азоту та можливого субстрату для утворення NO за рахунок нітритредуктазних систем; На экспериментальной модели глутамат-индуцированного ожирения изучено состояние NO-эргической системы в слюнных железах крыс. В условиях глутамат-индуцированного ожирения в слюнных железах крыс произошло повышение активности NO-ергической системы и одновременное накопление в слюнных железах крыс NO2–, метаболита циклических превращений оксида азота, и возможного субстрата для образования NO за счет нитритредуктазных систем; Under experimental model of obesity induced by monosodium glutamate it was studied the state of NO-ergic system in the salivary glands of rats. Under monosodium glutamate-induced obesity there is activation of the NO-ergic system in the salivary glands of rats and there is accumulation of NO2– in salivary glands of rats, which is a metabolite of cyclic transformations of nitric oxide and a substrate for the synthesis of NO by nitrite reductase systems

Корекція патологічних змін у тканинах слинних залоз за умов глутамат-індукованого ожиріння нанокристалічним діоксином церію

За умов глутамат-індукованого ожиріння в слинних залозах щурів вірогідно підвищується активність NO-ергічної системи. Нанокристалічний діоксид церію нормалізує активність NO-ергічної системи за умов глутамат-індукованого ожиріння

Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study

Purpose: To accommodate the unprecedented number of critically ill patients with pneumonia caused by coronavirus disease 2019 (COVID-19) expansion of the capacity of intensive care unit (ICU) to clinical areas not previously used for critical care was necessary. We describe the global burden of COVID-19 admissions and the clinical and organizational characteristics associated with outcomes in critically ill COVID-19 patients. Methods: Multicenter, international, point prevalence study, including adult patients with SARS-CoV-2 infection confirmed by polymerase chain reaction (PCR) and a diagnosis of COVID-19 admitted to ICU between February 15th and May 15th, 2020. Results: 4994 patients from 280 ICUs in 46 countries were included. Included ICUs increased their total capacity from 4931 to 7630 beds, deploying personnel from other areas. Overall, 1986 (39.8%) patients were admitted to surge capacity beds. Invasive ventilation at admission was present in 2325 (46.5%) patients and was required during ICU stay in 85.8% of patients. 60-day mortality was 33.9% (IQR across units: 20%–50%) and ICU mortality 32.7%. Older age, invasive mechanical ventilation, and acute kidney injury (AKI) were associated with increased mortality. These associations were also confirmed specifically in mechanically ventilated patients. Admission to surge capacity beds was not associated with mortality, even after controlling for other factors. Conclusions: ICUs responded to the increase in COVID-19 patients by increasing bed availability and staff, admitting up to 40% of patients in surge capacity beds. Although mortality in this population was high, admission to a surge capacity bed was not associated with increased mortality. Older age, invasive mechanical ventilation, and AKI were identified as the strongest predictors of mortality

Co-infection and ICU-acquired infection in COIVD-19 ICU patients: a secondary analysis of the UNITE-COVID data set

Background: The COVID-19 pandemic presented major challenges for critical care facilities worldwide. Infections which develop alongside or subsequent to viral pneumonitis are a challenge under sporadic and pandemic conditions; however, data have suggested that patterns of these differ between COVID-19 and other viral pneumonitides. This secondary analysis aimed to explore patterns of co-infection and intensive care unit-acquired infections (ICU-AI) and the relationship to use of corticosteroids in a large, international cohort of critically ill COVID-19 patients.Methods: This is a multicenter, international, observational study, including adult patients with PCR-confirmed COVID-19 diagnosis admitted to ICUs at the peak of wave one of COVID-19 (February 15th to May 15th, 2020). Data collected included investigator-assessed co-infection at ICU admission, infection acquired in ICU, infection with multi-drug resistant organisms (MDRO) and antibiotic use. Frequencies were compared by Pearson's Chi-squared and continuous variables by Mann-Whitney U test. Propensity score matching for variables associated with ICU-acquired infection was undertaken using R library MatchIT using the "full" matching method.Results: Data were available from 4994 patients. Bacterial co-infection at admission was detected in 716 patients (14%), whilst 85% of patients received antibiotics at that stage. ICU-AI developed in 2715 (54%). The most common ICU-AI was bacterial pneumonia (44% of infections), whilst 9% of patients developed fungal pneumonia; 25% of infections involved MDRO. Patients developing infections in ICU had greater antimicrobial exposure than those without such infections. Incident density (ICU-AI per 1000 ICU days) was in considerable excess of reports from pre-pandemic surveillance. Corticosteroid use was heterogenous between ICUs. In univariate analysis, 58% of patients receiving corticosteroids and 43% of those not receiving steroids developed ICU-AI. Adjusting for potential confounders in the propensity-matched cohort, 71% of patients receiving corticosteroids developed ICU-AI vs 52% of those not receiving corticosteroids. Duration of corticosteroid therapy was also associated with development of ICU-AI and infection with an MDRO.Conclusions: In patients with severe COVID-19 in the first wave, co-infection at admission to ICU was relatively rare but antibiotic use was in substantial excess to that indication. ICU-AI were common and were significantly associated with use of corticosteroids

Peculiarities of teaching of biological and bioorganic chemistry on the stomatologic faculty in the introduction of inculcation of credit-modular system

В статті наведено аналіз досвіду впровадження кредитно-модульної системи навчання на кафедрі медичної, біологічної та біоорганічної хімії Вищого державного навчального закладу України «Українська медична стоматологічна академія»; В статье приведен анализ опыта внедрения кредитно-модульной системы обучения на кафедре медицинской, биологической и биоорганической химии Высшего государственного учебного заведения Украины «Украинская медицинская стоматологическая академия»; In article analysis of experience of credit based modular system learning at the department of medical, biological and bioorganic chemistry of Higher State Institution of Ukraine “Ukrainian Medical Stomatological Academy” is cited

Modeling of emotional stress in animals

In ex ament on 40 rats it was determined that the influence of stressor reactions is realize by typological peculiarities of the organism. This is illustrated on the example of changes parodentium in rats which where typed in the "opened field". It was revealed that least firm animals the content of caleium decreases in comparision with control group. The average in dex exposed to stress factor and not differ from intact group of rats