Three essays on subjective performance evaluation

Ph.DDOCTOR OF PHILOSOPH

A catalog of collected debris disks: properties, classifications and correlations between disks and stars/planets

We have collected a catalog of 1095 debris disks with properties and classification (resolved, planet, gas) information. From the catalog, we defined a less biased sample with 612 objects and presented the distributions of their stellar and disk properties to search for correlations between disks and stars. We found debris disks were widely distributed from B to M-type stars while planets were mostly found around solar-type stars, gases were easier to detect around early-type stars and resolved disks were mostly distributed from A to G- type stars. The fractional luminosity dropped off with stellar age and planets were mostly found around old stars while gas-detected disks were much younger. The dust temperature of both one-belt systems and cold components in two-belt systems increased with distance while decreasing with stellar age. In addition, we defined a less biased planet sample with 211 stars with debris disks but no planets and 35 stars with debris disks and planets and found the stars with debris disks and planets had higher metallicities than stars with debris disks but no planets. Among the 35 stars with debris disks and planets, we found the stars with disks and cool Jupiters were widely distributed with age from 10 Myr to 10 Gyr and metallicity from -1.56 to 0.28 while the other three groups tended to be old (> 4Gyr) and metal-rich (> -0.3). Besides, the eccentricities of cool Jupiters are distributed from 0 to 0.932 wider than the other three types of planets (< 0.3).Comment: 34 pages, 12 figures, 3 tables, Accepted for publication in RA

Optical and Gamma-Ray Variability Behaviors of 3C 454.3 from 2006 to 2011

We present our photometric monitoring of a flat spectrum radio quasar (FSRQ) 3C 454.3 at Yunnan observatories from 2006 to 2011. We find that the optical color of 3C 454.3 shows obvious redder-when-brighter trend, which reaches a saturation stage when the source is brighter than 15.15 mag at V band. We perform a simulation with multiple values of disk luminosity and spectral index to reproduce the magnitude-color diagram. The results show that the contamination caused by the disk radiation alone is difficult to produce the observed color variability. The variability properties during the outburst in December 2009 are also compared with $\gamma$-ray data derived from Fermi $\gamma$-ray space telescope. The flux variation of these two bands follow a linear relation with $F_{\gamma} \propto F_R^{1.14\pm0.07}$, which provides an observational evidence for external Compton process in 3C 454.3. Meanwhile, this flux correlation indicates that electron injection is the main mechanism for variability origin. We also explore the variation of the flux ratio $F_{\gamma}/F_R$ and the detailed structures in the lightcurves, and discuss some possible origins for the detailed variability behaviors.Comment: accepted for publication in The Astrophysical Journal, 5 figures, 2 table

PinX1 regulation of telomerase activity and apoptosis in nasopharyngeal carcinoma cells

<p>Abstract</p> <p>Background</p> <p>Human interacting protein X1 (PinX1) has been identified as a critical telomerase inhibitor and proposed to be a putative tumor suppressor gene. Loss of PinX1 has been found in a large variety of malignancies, however, its function in inhibiting telomerase activity of tumor cells is not well documented. Here we show that PinX1 is essential for down-regulation telomerase activity of nasopharyngeal carcinoma.</p> <p>Methods</p> <p>Expression vectors of human PinX1 (pEGFP-C3-PinX1) and its small interfering RNA (PinX1-FAM-siRNA) were constructed and transfected into NPC. Their effects on mRNA of telomerase catalytic subunit (hTERT), telomerase activity, cell proliferation, cell migration, wound healing, cell cycles and apoptosis were examined using semi-quantitative RT-PCR, stretch PCR, MTT assay, Transwell, scratch assay and flow cytometry, respectively.</p> <p>Results</p> <p>Transfection of pEGFP-C3-PinX1 and PinX1-FAM-siRNA increased and reduced PinX1 mRNA by 1.6-fold and 70%, respectively. Over-expression of PinX1 decreased hTERT mRNA by 21%, reduced telomerase activity, inhibited cell growth, migration and wound healing ability, arrested cells in G0/G1 phase, and increased apoptotic index. In contrast, down-regulation of PinX1 did not alter the above characteristics.</p> <p>Conclusions</p> <p>PinX1 may play important roles in NPC proliferation, migration and apoptosis and has application potential in tumor-targeted gene therapy.</p

Comparative analysis of SOFC-MGT top-level and new bottom-level system performance

In order to make the SOFC-MGT system more widely used, the mathematical simulation models of the SOFC-MGT top-level circulatory system and the new bottom circulatory system were first established, and then the performance of the two systems was analyzed and compared using Matlab/Simulink simulation software. The research results show that the output performance of the SOFC-MGT top-level circulation system is due to the new bottom-level circulation system, and the stack output performance of the two systems is not much different

Anti-Proliferation and Anti-Invasion Effects of Diosgenin on Gastric Cancer BGC-823 Cells with HIF-1α shRNAs

Drug resistance is a major factor for the limited efficacy of chemotherapy in gastric cancer treatment. Hypoxia-inducible factor-1α (HIF-1α), a central transcriptional factor in hypoxia, is suggested to participate in the resistance. Here, we identified a hypoxia-mimic (cobalt chloride) sensitive gastric cell line BGC-823 to explore whether diosgenin, an aglycone of steroidal saponins, can inhibit cancer cell invasion and survival of solid tumor in a hypoxic mimic microenvironment. We have shown that diosgenin is a potent candidate for decreasing the ability of invasion and survival in cobalt chloride treated BGC-823 cells. In addition, when combined with HIF-1α specific short hairpin RNA (shRNA), diosgenin can inhibit BGC-823 cells more effectively. The anti-invasion role of diosgenin may be related to E-cadherin, integrinα5 and integrin β6. These results suggest that diosgenin may be a useful compound in controlling gastric cancer cells in hypoxia condition, especially when combined with down-regulated HIF-1α

Perivascular macrophages in health and disease

Macrophages are a heterogeneous group of cells that are capable of carrying out distinct functions in different tissues, as well as in different locations within a given tissue. Some of these tissue macrophages lie on, or close to, the outer (abluminal) surface of blood vessels and perform several crucial activities at this interface between the tissue and the blood. In steady-state tissues, these perivascular macrophages maintain tight junctions between endothelial cells and limit vessel permeability, phagocytose potential pathogens before they enter tissues from the blood and restrict inappropriate inflammation. They also have a multifaceted role in diseases such as cancer, Alzheimer disease, multiple sclerosis and type 1 diabetes. Here, we examine the important functions of perivascular macrophages in various adult tissues and describe how these functions are perturbed in a broad array of pathological conditions

Bottled Water or Tap Water? A Comparative Study of Drinking Water Choices on University Campuses

A cross-regional comparative study was conducted to survey the drinking behaviors of university students, in Singapore, Hong Kong, and Macau. In particular, I tested students’ preference for bottled water over filtered tap water, in a context where the latter option is widely accessible, free of charge, and meets drinking standards. It was found that Singapore has a relatively low rate of bottled water consumption within the young population of university students, while in Hong Kong and Macau one-fourth of the students still drink bottled water more frequently than tap water. Using the Theory of Planned Behavior framework, the perceptions and factors that determine the choices were studied. In terms of determinants of the drinking water choices, “Safety and Hygiene” and “Convenience and Availability” ranked highest for all three regions. “Taste”, “Price”, and “Personal and Family Habits” were valued next by different subsamples. Respondents from Singapore rated relatively high in the accessibility of filtered tap water, safety of tap water transfer, and trust in government, and these factors are considerably significant in driving the result of having the lowest consumption of bottle water on campus. Gender and the behaviors of students who stay in campus dorms were also explored

Ambiguity, bureaucracy and certainty: The ABCs of enabling water self-sufficiency

10.1016/j.polsoc.2016.05.001Policy and Society352165-17