Assessment of P-Delta Effect on High Rise Buildings

P-delta effect is secondary effect on structure .it is also known as ‘Geometric nonlinearity effect’. As number of stories increases, P-delta effect becomes more important. If the change in bending moments and displacements is more than 10%, P-delta effect should be considered in design. In this study the P-delta effect on high rise building is studied. Linear static analysis (without P-delta effect) on high rise building having different number of stories is carried out. For the analysis G+14, G+19, G+24, (i.e 15, 20, and 25storey) R.C.C. framed building are modeled. Earthquake load is applied on model of structure as per IS-18939(2002) for zone III in E-Tab software. Load combination for analysis is set as per IS-456(2000).All analysis is carried out in software ETAB. Bending moment, story displacement with and without p-delta effect is calculated and compared for all the models. Then by trial and error method suitable cross-section are provided for unsafe building to bring within acceptable limit by increasing stiffness of a building. The result shows that it is essential to consider the P-delta effect for 25storey building. So buildings having height more than or equal to 75m, should be designed considering P-delta effect. Also we can say that up to 25storey building, it is not necessary to consider P-delta effect in design and primary or first order analysis is sufficient for design. By increasing stiffness of building by providing suitable cross section or by increasing stiffness building can bring within acceptable limit.[7] DOI: 10.17762/ijritcc2321-8169.150515

Solid Waste Management and Route OptimizationBy Using GIS-A Case Study of Indapur City

: In today’s world solid waste management is a global environmental issue. In India this issue is not taken seriously. There is a tremendous amount of loss in terms of environmental degradation, health hazards and loss due to direct disposal of waste. There has to be appropriate planning for proper solid waste management by means of analysis of the waste situation of the area. The growth in the urban population and activity has resulted in an increased solid waste generation. In the process of solid waste management, more attention needs to be paid towards collection as it itself requires 60-70% of the total cost. For effective management, the municipal corporation of Indapur has divided the entire region into seventeen wards which are further divided into six health units to collect the solid waste. Two alternate disposal systems are considered. In first case the entire solid waste of the city of Indapur is dumped at one dumping site. In next case there are three sites proposed at different locations in the city Indapur city. A comparison is made considering transportation cost, site maintenance cost, labour cost, and diesel cost. This study would deal with, how Geographical Information System (GIS) can be used as a decision support tool for planning waste management and for route optimization. Hence an attempt is made in this study to second optimum route for solid waste transportation in Indapur city. DOI: 10.17762/ijritcc2321-8169.150516

Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment.

The currently available techniques for the safety evaluation of candidate drugs are usually cost-intensive and time-consuming and are often insufficient to predict human relevant cardiotoxicity. The purpose of this study was to develop an in vitro repeated exposure toxicity methodology allowing the identification of predictive genomics biomarkers of functional relevance for drug-induced cardiotoxicity in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). The hiPSC-CMs were incubated with 156 nM doxorubicin, which is a well-characterized cardiotoxicant, for 2 or 6 days followed by washout of the test compound and further incubation in compound-free culture medium until day 14 after the onset of exposure. An xCELLigence Real-Time Cell Analyser was used to monitor doxorubicin-induced cytotoxicity while also monitoring functional alterations of cardiomyocytes by counting of the beating frequency of cardiomyocytes. Unlike single exposure, repeated doxorubicin exposure resulted in long-term arrhythmic beating in hiPSC-CMs accompanied by significant cytotoxicity. Global gene expression changes were studied using microarrays and bioinformatics tools. Analysis of the transcriptomic data revealed early expression signatures of genes involved in formation of sarcomeric structures, regulation of ion homeostasis and induction of apoptosis. Eighty-four significantly deregulated genes related to cardiac functions, stress and apoptosis were validated using real-time PCR. The expression of the 84 genes was further studied by real-time PCR in hiPSC-CMs incubated with daunorubicin and mitoxantrone, further anthracycline family members that are also known to induce cardiotoxicity. A panel of 35 genes was deregulated by all three anthracycline family members and can therefore be expected to predict the cardiotoxicity of compounds acting by similar mechanisms as doxorubicin, daunorubicin or mitoxantrone. The identified gene panel can be applied in the safety assessment of novel drug candidates as well as available therapeutics to identify compounds that may cause cardiotoxicity

Primary extra-cranial meningioma in the right submandibular region of an 18-year-old woman: a case report

<p>Abstract</p> <p>Introduction</p> <p>Extra-cranial meningioma or ectopic meningioma is a rare tumor. This tumor has been reported in various anatomic sites in the head and neck, mediastinum, skin and soft tissues. We report a rare case of ectopic meningioma in the submandibular region detected by using fine-needle aspiration cytology, histopathology and immunohistochemistry. This case represents another unusual site for extra-cranial meningioma, which prompted us to report it.</p> <p>Case presentation</p> <p>An 18-year-old Dravidian woman presented with swelling in the right submandibular region. The computed tomographic scan findings were suggestive of a neoplastic mass lesion in the right submandibular region. Fine-needle aspiration cytology led to the differential diagnosis of a monomorphic adenoma of a salivary gland or an ectopic meningioma. The patient underwent excision of the submandibular gland and tumor. The histological examination and immunohistochemistry studies confirmed that the lesion was an extra-cranial meningioma. At her two-year follow-up examination, there was no recurrence of the tumor.</p> <p>Conclusion</p> <p>Our experience with this case indicates that, although rare, meningioma should be entertained in the differential diagnosis of a mass lesion in the head and neck region.</p

Study and Evaluation for Quality Improvement of Object Oriented System at Various Layers of Object Oriented Matrices

Abstract-The fundamental of any engineering discipline is measurement. For making quality management decisions object-oriented design metrics can be used which is considerable evidence. This leads to saving substantious costs of allocated resources in testing or estimate a maintenance effort of project. Many object-oriented metrics have been designed for C++ which is most preferred language for many object-oriented systems. This paper focuses on an evaluation of object oriented metrics in C++. For this, two projects considered as inputs for the study -The first project is a library management system for college and the second is a graphical editor which can be used to describe and create a scene. The metric values have been calculated by semi automated tool. The resulting values have been analyzed to provide significant insight about object oriented characteristics of projects. The metric values have been calculated using a semi automated tool. The resulting values have been analyzed to provide significant insight about the object oriented characteristics of the projects. This is very long process. This project will be applicable in well compiled java program and it should have valid comments to measure the cohesion .The objective of this project is to create a common platform for all design quality metrics to make the application software more scalable and maintainable. In this paper, we include the system design of my work, solution steps according to the problem definition statement. Finally conclude by testing C++ and Java project

Feasibility of hydraulic separation in a novel anaerobic-anoxic upflow reactor for biological nutrient removal

ABSTRACT : This contribution deals with a novel anaerobic-anoxic reactor for biological nutrient removal (BNR) from wastewater, termed AnoxAn. In the AnoxAn reactor, the anaerobic and anoxic zones for phosphate removal and denitrification are integrated in a single continuous upflow sludge blanket reactor, aiming at high compactness and efficiency. Its application is envisaged in those cases where retrofitting of existing wastewater treatment plants for BNR, or the construction of new ones, is limited by the available surface area. The environmental conditions are vertically divided up inside the reactor with the anaerobic zone at the bottom and the anoxic zone above. The capability of the AnoxAn configuration to establish two hydraulically separated zones inside the single reactor was assessed by means of hydraulic characterization experiments and model simulations. Residence time distribution (RTD) experiments in clean water were performed in a bench-scale (48.4 L) AnoxAn prototype. The required hydraulic separation between the anaerobic and anoxic zones, as well as adequate mixing in the individual zones, was obtained through selected mixing devices. The observed behaviour was described by a hydraulic model consisting of continuous stirred tank reactors and plug-flow reactors. The impact of the denitrification process in the anoxic zone on the hydraulic separation was subsequently evaluated through model simulations. The desired hydraulic behaviour proved feasible, involving little mixing between the anaerobic and anoxic zones (mixing flowrate 40.2% of influent flowrate) and negligible nitrate concentration in the anaerobic zone (less than 0.1 mgN L-1) when denitrification was considered