Occurrence of SARS-CoV-2 viremia is associated with genetic variants of genes related to COVID-19 pathogenesis

IntroductionSARS-CoV-2 viral load has been related to COVID-19 severity. The main aim of this study was to evaluate the relationship between SARS-CoV-2 viremia and SNPs in genes previously studied by our group as predictors of COVID-19 severity.Materials and methodsRetrospective observational study including 340 patients hospitalized for COVID-19 in the University Hospital La Princesa between March 2020 and December 2021, with at least one viremia determination. Positive viremia was considered when viral load was above the quantifiable threshold (20 copies/ml). A total of 38 SNPs were genotyped. To study their association with viremia a multivariate logistic regression was performed.ResultsThe mean age of the studied population was 64.5 years (SD 16.6), 60.9% patients were male and 79.4% white non-Hispanic. Only 126 patients (37.1%) had at least one positive viremia. After adjustment by confounders, the presence of the minor alleles of rs2071746 (HMOX1; T/T genotype OR 9.9 p < 0.0001), rs78958998 (probably associated with SERPING1 expression; A/T genotype OR 2.3, p = 0.04 and T/T genotype OR 12.9, p < 0.0001), and rs713400 (eQTL for TMPRSS2; C/T + T/T genotype OR 1.86, p = 0.10) were associated with higher risk of viremia, whereas the minor alleles of rs11052877 (CD69; A/G genotype OR 0.5, p = 0.04 and G/G genotype OR 0.3, p = 0.01), rs2660 (OAS1; A/G genotype OR 0.6, p = 0.08), rs896 (VIPR1; T/T genotype OR 0.4, p = 0.02) and rs33980500 (TRAF3IP2; C/T + T/T genotype OR 0.3, p = 0.01) were associated with lower risk of viremia.ConclusionGenetic variants in HMOX1 (rs2071746), SERPING1 (rs78958998), TMPRSS2 (rs713400), CD69 (rs11052877), TRAF3IP2 (rs33980500), OAS1 (rs2660) and VIPR1 (rs896) could explain heterogeneity in SARS-CoV-2 viremia in our population

Cuentos de nunca acabar. Aproximaciones desde la interculturalidad

Cuentos de nunca acabar. Aproximaciones desde la interculturalidad, surge después de la pandemia y su imposibilidad de socializar “en persona” con los compañeros de eventuales encuentros, porque la Comprensión Lectora tenía que reinventarse para su nueva reflexión cognitiva, adaptación contextual y reconstrucción del conocimiento. Este renovado enfoque de la realidad postpandemia, concebido en el marco de la educación intercultural comunitaria, busca potencializar los entornos naturales, sociales y culturales como recursos de aprendizaje multidisciplinario a través del lenguaje animado de los cuentos. En este marco, había que dinamizar la asignatura de Comunicación Oral y Escrita, que se dicta en los Primeros Niveles de los Centros de Apoyo de Otavalo, Cayambe, Latacunga y Riobamba, mediante un eje transversal donde los estudiantes escriban fundamentados en valores de la cosmovisión andina, considerando que provienen de varios lugares de la sierra y amazonía ecuatoriana. Todo surgió del encuentro presencial de un sábado cualquiera donde los estudiantes realizaban ejercicios narrativos, logrando una apreciable respuesta de imaginación, más emotiva que la clásica tarea de las Unidades, tanto así que, pasados unos días, seguían llegando sus escritos a mi correo. Entonces nos pusimos manos a la obra, cada estudiante tendría dos opciones como Actividad Integradora, la primera consistía en escribir un cuento de su propia inspiración, y la segunda analizar un clásico para comentar sus valores y antivalores. La mayor parte de estudiantes decidió escribir su propio cuento, de donde se escogieron algunas participaciones que podrían considerarse originales, para una edición que, respetando la transcripción de la tradición oral que prima en los sectores comunitarios, nos concretamos en revisar la puntuación y ortografía para publicarlos. Con esto buscamos innovar la Actividad Integradora, por algo más práctico y operativo para configurar los Objetos de Aprendizaje que buscamos. Así nació, en medio del camino, este libro de Cuentos de nunca acabar. Aproximaciones desde la interculturalidad, que ponemos en sus manos. Hernán Hermosa Mantilla Quito, junio de 202

Mortalidad de cáncer gástrico en México 2005-2015: perfil epidemiológico

Objective: To characterize the behavior of gastric cancer, by educational level, area of residence (rural/urban), age group and mortality in the Mexican population that attended the IMSS from 2005 to 2015. Material and methods: by means of registration of Family Medical Units and data platform Non-Communicable Disease Analysis System (SANENT) we analyzed the patients with registry according to ICD-10: C16; The general characteristics of the population (sex, schooling and type of housing), the incidence and mortality in the years included were described. Statistical analysis: We calculated the average and standard deviation of quantitative variables and proportions for qualitative variables. To compare the incidence and mortality rates between the years analyzed, and the characteristics of the population was by Chi square test. SPSS v.17.0 was used for statistical analysis. Results: In the period from 2005 to 2015, which equals 10 years, a total of 21,761 deaths secondary to gastric cancer with an average death rate of 8.1 × 100,000 members of the IMSS. The overall mortality rate of gastric cancer has declined steadily (year 2005: rate 8.08 × 100,000 vs. 2015: rate of 6.9 × 100,000 p<0.001). This decline has been at the expense of the decline in the mortality rate in women, while in men the mortality rate remained high from 2005 to 2015 (8.2 and 8.5 × 100,000 affiliated to the IMSS, respectively). With regard to educational level,and rural or urban housing, it was consistently demonstrated in 2005, 2010 and 2015 that there was a greater proportion of deceased subjects with a low school level and living in an urban environment. Conclusions: A decline in the overall mortality rate was observed, men were the sex most affected in the mortality rate, and did not change over time. It is essential to continue and implement national programs for the timely detection of this disease, with a greater focus on males because they are the most affected and have an impact on the mortality rate.Objetivo: Caracterizar el comportamiento del cáncer gástrico, por nivel educacional, área de residencia (rural/urbana), grupo de edad y la mortalidad en la población mexicana que asistió al IMSS del 2005 al 2015. Material y métodos: mediante la plataforma de datos Sistema de Análisis de Enfermedades no transmisibles (SANENT 03-2017-013112122900-01) del Instituto Mexicano del Seguro Social, se analizaron los registros de derechohabientes, de acuerdo a la CIE-10: C16; las variables descritas son: sexo, escolaridad y tipo de vivienda, así como la incidencia y mortalidad. Análisis estadístico: Se calculó la media y la desviación estándar de las variables cuantitativas y proporciones para variables cualitativas. Para comparar las tasas de incidencia y mortalidad entre los años analizados, y las características de la población mediante la prueba Chi cuadrada. SPSS v.17.0. Resultados: En el periodo del 2005 al 2015 (10 años), se registró un total de 21,761 defunciones secundarias a cáncer gástrico con una tasa de mortalidad en promedio de 8.1 × 100,000 afiliados al IMSS. La tasa mortalidad global del cáncer gástrico ha presentado un descenso paulatino (año 2005: tasa 8.08 × 100,000 vs. 2015: tasa de 6.9 × 100,000 p<0.001). Este descenso ha sido a expensas de la disminución en la tasa de mortalidad en mujeres, mientras que en los varones la tasa de mortalidad de mantuvo del 2005 al 2015 (8.2 y 8.5 × 100,000 afiliados al IMSS, respectivamente). Con respecto al nivel educativo, y vivienda rural o urbana, se demostró consistentemente en el año 2005, 2010 y 2015 que hubo una mayor proporción de sujetos fallecidos con un bajo nivel escolar, pertenecientes al ambiente urbano. Conclusiones: Se observó un descenso en la tasa de mortalidad global, los hombres, tuvieron mayor mortalidad, no modificándose con el tiempo. Es indispensable implementar programas en México para la detección oportuna de esta enfermedad

Usefulness of Procalcitonin Levels for Predicting the Microbiological Orientation in Patients with Sepsis

The main objective of the study was to verify whether levels of procalcitonin (PCT) could guide us toward determining the type of bacteria causing the sepsis and to identify the discriminatory cut-off point in the first urgent laboratory test. This study is a single center retrospective analysis that includes 371 patients with a mean age of 71.7 ± 15.6 years who were diagnosed with sepsis or septic shock. The yield of blood cultures in demonstrating the causative microbiological agent was 24.3% (90), and it was 57, 1% (212) when evaluating all types of cultures. Statistically significant positive differences were observed in the mean value of the PCT between the group that obtained positive cultures and the group that did not (p p p < 0.0001). The PCT value that showed the best diagnostic characteristic for predicting sepsis was 3.6 ng/mL

Data_Sheet_1_Occurrence of SARS-CoV-2 viremia is associated with genetic variants of genes related to COVID-19 pathogenesis.docx

IntroductionSARS-CoV-2 viral load has been related to COVID-19 severity. The main aim of this study was to evaluate the relationship between SARS-CoV-2 viremia and SNPs in genes previously studied by our group as predictors of COVID-19 severity.Materials and methodsRetrospective observational study including 340 patients hospitalized for COVID-19 in the University Hospital La Princesa between March 2020 and December 2021, with at least one viremia determination. Positive viremia was considered when viral load was above the quantifiable threshold (20 copies/ml). A total of 38 SNPs were genotyped. To study their association with viremia a multivariate logistic regression was performed.ResultsThe mean age of the studied population was 64.5 years (SD 16.6), 60.9% patients were male and 79.4% white non-Hispanic. Only 126 patients (37.1%) had at least one positive viremia. After adjustment by confounders, the presence of the minor alleles of rs2071746 (HMOX1; T/T genotype OR 9.9 p ConclusionGenetic variants in HMOX1 (rs2071746), SERPING1 (rs78958998), TMPRSS2 (rs713400), CD69 (rs11052877), TRAF3IP2 (rs33980500), OAS1 (rs2660) and VIPR1 (rs896) could explain heterogeneity in SARS-CoV-2 viremia in our population.</p