The stability of fish populations: how changes in the environment may affect people with epilepsy

Universidade Presbiteriana Mackenzie Centro de Ciências Biológicas e da Saúde Programa de Pós-Graduação em Distúrbios do DesenvolvimentoUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de FisiologiaUniversidade de São Paulo Faculdade de Medicina de Ribeirão Preto Departamento de Neurociências e Ciências do ComportamentoUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUNIFESP, EPM, Depto. de FisiologiaUNIFESP, EPMSciEL

Sudden unexpected death in Parkinson's disease: Insights from clinical practice

Classified as the second most common neurodegenerative disorder associated with aging after Alzheimer's disease, Parkinson's disease (PD) is the most common movement disorder. In the last decade, despite advances in treatment, mortality rates linked with PD continued to reach significant figures. Available studies have shown that compared with healthy controls, patients with PD are accompanied by high rates of premature death. This is usually caused by factors such as pneumonia and cerebrovascular and cardiovascular diseases. Recently, it has been demonstrated that a significant proportion of patients with PD die suddenly. This is referred to as a sudden and unexpected death in PD (SUDPAR). Here, we focus on the magnitude of SUDPAR. Finally, it is important to learn more about SUDPAR for the implementation of effective prevention strategies

Sudden unexpected death in Parkinson’s disease (SUDPAR): a review of publications since the decade of the brain

FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo)CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)FAPESP/CNPq/MCT (Instituto Nacional de Neurociencia Translacional)Univ Fed Sao Paulo EPM UNIFESP, Escola Paulista Med, Disciplina Neurociencia, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Biblioteca Campus Sao Paulo, Sao Paulo, SP, BrazilPUC SP, Programa Estudos Posgrad Fonoaudiol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo EPM UNIFESP, Escola Paulista Med, Dept Fonoaudiol, Sao Paulo, SP, BrazilKrankenanstalt Rudolfstiftung Wien, Dept Neurol, Vienna, AustriaUniv Fed Sao Paulo EPM UNIFESP, Escola Paulista Med, Dept Neurol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo EPM UNIFESP, Escola Paulista Med, Disciplina Neurociencia, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Biblioteca Campus Sao Paulo, Sao Paulo, SP, BrazilUniv Fed Sao Paulo EPM UNIFESP, Escola Paulista Med, Dept Fonoaudiol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo EPM UNIFESP, Escola Paulista Med, Dept Neurol, Sao Paulo, SP, BrazilWeb of Scienc

Sudden unexpected death in Parkinson's disease (SUDPAR): a review of publications since the decade of the brain

FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo)CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)FAPESP/CNPq/MCT (Instituto Nacional de Neurociencia Translacional)Univ Fed Sao Paulo EPM UNIFESP, Escola Paulista Med, Disciplina Neurociencia, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Biblioteca Campus Sao Paulo, Sao Paulo, SP, BrazilPUC SP, Programa Estudos Posgrad Fonoaudiol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo EPM UNIFESP, Escola Paulista Med, Dept Fonoaudiol, Sao Paulo, SP, BrazilKrankenanstalt Rudolfstiftung Wien, Dept Neurol, Vienna, AustriaUniv Fed Sao Paulo EPM UNIFESP, Escola Paulista Med, Dept Neurol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo EPM UNIFESP, Escola Paulista Med, Disciplina Neurociencia, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Biblioteca Campus Sao Paulo, Sao Paulo, SP, BrazilUniv Fed Sao Paulo EPM UNIFESP, Escola Paulista Med, Dept Fonoaudiol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo EPM UNIFESP, Escola Paulista Med, Dept Neurol, Sao Paulo, SP, BrazilWeb of Scienc

Fish Oil Supplementation Reduces Heart Levels of Interleukin-6 in Rats with Chronic Inflammation due to Epilepsy

Sudden unexpected death in epilepsy (SUDEP) is a major cause of premature death related to epilepsy. The causes of SUDEP remain unknown, but cardiac arrhythmias and asphyxia have been suggested as a major mechanism of this event. Inflammation has been implicated in the pathogenesis of both epilepsy and ventricular arrhythmia, with interleukin-6 (IL-6) being recognized as a crucial orchestrator of inflammatory states. Our group previously reported that levels of IL-6 were increased in the hearts of epileptic rats. In this scenario, anti-inflammatory actions are among the beneficial effects of fish oil dietary supplementation. This investigation revealed that elevated levels of IL-6 in the heart were markedly reduced in epileptic rats that were treated in the long-term with fish oil, suggesting protective anti-inflammatory actions against dangerously high levels of IL-6. Based on these findings, our results suggest beneficial effects of long-term intake of fish oil in reducing the inflammation associated with chronic epilepsy.FAPESPCAPESCNPqFAPESP/CNPq/MCT-Instituto Nacional de Neurociencia TranslacionalFAPEMIGCEPID/FAPESPUniv Fed Sao Paulo, Escola Paulista Med, Disciplina Neurociencia, UNIFESP, Sao Paulo, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Dept Fisiol, UNIFESP, Sao Paulo, BrazilUniv Fed Sao Joao Del Rei UFSJ, Dept Engn Biossistemas, Sao Joao Del Rei, BrazilUniv Presbiteriana Mackenzie, Programa Posgrad Disturbios Desenvolvimento, Ctr Ciencias Biol & Saude, Sao Paulo, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Disciplina Neurociencia, UNIFESP, Sao Paulo, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Dept Fisiol, UNIFESP, Sao Paulo, BrazilFAPESPCAPESCNPqFAPESP/CNPq/MCT-Instituto Nacional de Neurociencia TranslacionalFAPEMIGCEPID/FAPESPWeb of Scienc

More children with epilepsy are dying suddenly

Universidade Federal de São Paulo EPM UNIFESP, Escola Paulista Med, Disciplina Neurol Expt, São Paulo, BrazilHCL, Dept Funct Neurol & Epileptol, Lyon, FranceUCBL, CNRS 5292, INSERM U1028, TIGER,CRNL, Lyon, FranceCHU Vaudois, Dept Clin Neurosci, Lausanne, SwitzerlandUniversidade Federal de São Paulo EPM UNIFESP, Escola Paulista Med, Disciplina Neurol Expt, São Paulo, BrazilWeb of Scienc

c-FOS Expression After Hippocampal Deep Brain Stimulation in Normal Rats

ObjectivesWe studied the effects of Hip-deep brain stimulation (DBS) on the expression of the inducible transcription factor c-FOS in the brain of normal rats.Materials and MethodsTen Wistar rats were anesthetized, and nine were implanted with epidural and hippocampal electrodes for brain activity recording; one animal was used as sham. Bipolar stimulating electrodes were implanted in the left hippocampus. Three animals were used as control (implanted but not stimulated), one as sham (not implanted, not stimulated), and six as the study group. Stimulation was carried out using square wave pulses with 0.8V, 300 mu sec, and 130 Hz (similar to 25 mu C/cm2) on the left hippocampus through the implanted bipolar hippocampal lead. Three animals were submitted to a one-hour and three to a six-hour stimulation session. Immunohistochemistry was employed to visualize c-FOS distribution in the rat's brain. the presence of seizures and electrocorticographic findings also were observed.ResultsIn animals submitted to both one-hour or six-hour unilateral hippocampal stimulation sessions, there was a significant bilateral overexpression of c-FOS in the hippocampus proper, dentate gyrus, and hylus. in the CA1 and CA3 regions, although activation was bilateral, c-FOS hyperexpression prevailed at the stimulated side over time; this was not true for the hilar and dentate gyrus regions where a more symmetric activation occurred over time. A significant c-FOS activation occurred after one hour of Hip-DBS in the ipsilateral amygdala; there was no contralateral amygdala activation, and by six hours, no amygdala activation was noted. No c-FOS activation was noted in other brain areas.DiscussionOur data showed that unilateral Hip-DBS was able to cause widespread and persistent bilateral activation of the normal rat limbic system, although in some, nuclei activation prevailed over the stimulated side. Cortical activation outside the limbic system was not noted. Our data represent a first approach to study the mechanistic paradigm involved in Hip-DBS.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo, BR-04544000 São Paulo, BrazilUniversidade Federal de São Paulo, EPM, São Paulo, BrazilWeb of Scienc