Geração de modelos de rastreabilidade de informação industrial : análise de um caso prático

Dissertação de mestrado em Engenharia e Gestão de Sistemas de InformaçãoAs organizações esforçam-se cada vez mais para maximizar a sua produtividade, para produzir com mais eficiência e mais qualidade, e para reduzir os seus custos. Para conseguir isso, é necessário implementar um sistema de rastreabilidade. A rastreabilidade é a capacidade de rastrear o histórico de um produto, em qualquer momento. Esta capacidade permite melhorar a qualidade dos processos de produção e dos produtos, evitando perda de confiança dos consumidores e perdas financeiras. A implementação e a manutenção de um sistema de rastreabilidade enfrentam diversos desafios, entre os quais: 1) a falta de entendimento e acordo sobre o significado do conceito de rastreabilidade, as suas exigências concretas e a natureza do processo de rastreabilidade; e 2) a distribuição da informação por diversas aplicações informáticas heterogéneas e independentes. A aquisição, a manutenção e o acesso aos dados de rastreabilidade relevantes são aspetos basilares para implementar um sistema de rastreabilidade eficaz. Esta implementação está assente na capacidade de os sistemas heterogéneos inter-operarem de modo a oferecer uma visão completa da rastreabilidade. As normas internacionais são um dos elementos cruciais para esta eficácia. Nesta dissertação, é utilizada a norma global de rastreabilidade da GS1 para identificar regras de negócio e requisitos mínimos de um sistema de rastreabilidade. Esta norma internacional, o apoio dos stakeholders e a revisão da literatura são os mecanismos adotados no exercício de levantamento de requisitos para a modelação do processo de rastreabilidade da Bosch Car Multimédia Portugal, S.A.. O método Four-Step-Rule-Set (4SRS) é aplicado para transformar os requisitos resultantes da modelação do processo de rastreabilidade numa arquitetura lógica. Esta arquitetura constitui o principal resultado desta dissertação. Um dos seus benefícios é fornecer um melhor entendimento das exigências e da natureza deste processo. Esta dissertação também contribui com propostas para melhorar a rastreabilidade num processo específico da Bosch Car Multimédia Portugal, S.A, propondo: 1) locais e momentos onde devem ser recolhidos alguns dados de rastreabilidade relevantes; e 2) dados de rastreabilidade relevantes a recolher na proposta 1.Organizations strive increasingly to maximize their productivity, in order to produce more efficiently and with higher quality, and to reduce their costs. To achieve this, it is necessary to implement a traceability system. Traceability is the ability to track the history of a product at any time. This capability improves the quality of production processes and products, avoiding losing consumer’s confidence as well as financial losses. The implementation and maintenance of a traceability system faces several challenges, including: 1) the lack of understanding and agreement on the meaning of the concept of traceability, its specific requirements and the nature of the process itself, and 2) the distribution of information by several heterogeneous and independent software applications. The acquisition, maintenance and access to relevant traceability data are fundamental to implement an effective traceability system. This implementation is based on the ability of heterogeneous systems to inter-operate in order to provide a complete overview of traceability. International standards are one of the key elements for this effectiveness. In this dissertation, the GS1 global traceability standard is used to identify business rules and minimum requirements of a traceability system. This international standard, the support of stakeholders and the literature review are the mechanisms adopted in the exercise of elicitation requirements for modeling the traceability process Bosch Car Multimedia Portugal, S.A.. The Four-Step-Rule-Set (4SRS) is used to transform the requirements resulting from the modeling of the traceability process in a logical architecture. This architecture is the main result of this dissertation. One of its benefits is to provide a better understanding of the requirements and the nature of this process. This dissertation also contributes with proposals to improve the traceability of a specific process of Bosch Car Multimedia Portugal, S.A., proposing: 1) places and moments where some relevant traceability data must be collected and 2) relevant traceability data to collect proposal 1

Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study

© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Purpose: To evaluate complete blood count (CBC) parameters in the first week of life as predictive biomarkers for the development of retinopathy of prematurity (ROP). Methods: Multicenter, prospective, observational study of a cohort of preterm infants born with gestational age (GA) < 32 weeks or birth weight < 1500 g in eight Portuguese neonatal intensive care units. All demographic, clinical, and laboratory data from the first week of life were collected. Univariate logistic regression was used to assess risk factors for ROP and then multivariate regression was performed. Results: A total of 455 infants were included in the study. The median GA was 29.6 weeks, and the median birth weight was 1295 g. One hundred and seventy-two infants (37.8%) developed ROP. Median values of erythrocytes (p < 0.001), hemoglobin (p < 0.001), hematocrit (p < 0.001), mean corpuscular hemoglobin concentration (p < 0.001), lymphocytes (p = 0.035), and platelets (p = 0.003) of the group of infants diagnosed with ROP any stage were lower than those without ROP. Mean corpuscular volume (MCV) (p = 0.044), red blood cell distribution width (RDW) (p < 0.001), erythroblasts (p < 0.001), neutrophils (p = 0.030), neutrophils-lymphocytes ratio (p = 0.028), and basophils (p = 0.003) were higher in the ROP group. Higher values of MCV, erythroblasts, and basophils remained significantly associated with ROP after multivariate regression. Conclusion: In our cohort, the increase in erythroblasts, MCV, and basophils in the first week of life was significantly and independently associated with the development of ROP. These CBC parameters may be early predictive biomarkers for ROP.Open access funding provided by FCT|FCCN (b-on). This work was supported by the Laboratório de Genética and the Instituto de Saúde Ambiental (ISAMB) of the Faculdade de Medicina of Universidade de Lisboa and the Instituto de Investigação Científica Bento da Rocha Cabral. The writing of the manuscript was also supported by funds from Fundação para a Ciência e a Tecnologia to ISAMB (ref. UIDB/04295/2020 and UIDP/04295/2020). This work was also part of a doctoral project funding by the company CUF with a PhD grant in Medicine awarded in 2021 and by the Portuguese Society of Ophthalmology with a PhD grant awarded in 2019.info:eu-repo/semantics/publishedVersio

Nationwide access to endovascular treatment for acute ischemic stroke in portugal

Publisher Copyright: Copyright Ordem dos M dicos 2021.Introduction: Since the publication of endovascular treatment trials and European Stroke Guidelines, Portugal has re-organized stroke healthcare. The nine centers performing endovascular treatment are not equally distributed within the country, which may lead to differential access to endovascular treatment. Our main aim was to perform a descriptive analysis of the main treatment metrics regarding endovascular treatment in mainland Portugal and its administrative districts. Material and Methods: A retrospective national multicentric cohort study was conducted, including all ischemic stroke patients treated with endovascular treatment in mainland Portugal over two years (July 2015 to June 2017). All endovascular treatment centers contributed to an anonymized database. Demographic, stroke-related and procedure-related variables were collected. Crude endovascular treatment rates were calculated per 100 000 inhabitants for mainland Portugal, and each district and endovascular treatment standardized ratios (indirect age-sex standardization) were also calculated. Patient time metrics were computed as the median time between stroke onset, first-door, and puncture. Results: A total of 1625 endovascular treatment procedures were registered. The endovascular treatment rate was 8.27/100 000 inhabitants/year. We found regional heterogeneity in endovascular treatment rates (1.58 to 16.53/100 000/year), with higher rates in districts closer to endovascular treatment centers. When analyzed by district, the median time from stroke onset to puncture ranged from 212 to 432 minutes, reflecting regional heterogeneity. Discussion: Overall endovascular treatment rates and procedural times in Portugal are comparable to other international registries. We found geographic heterogeneity, with lower endovascular treatment rates and longer onset-to-puncture time in southern and inner regions. Conclusion: The overall national rate of EVT in the first two years after the organization of EVT-capable centers is one of the highest among European countries, however, significant regional disparities were documented. Moreover, stroke-onset-to-first-door times and in-hospital procedural times in the EVT centers were comparable to those reported in the randomized controlled trials performed in high-volume tertiary hospitalspublishersversionpublishe

Acesso a Tratamento Endovascular para Acidente Vascular Cerebral Isquémico em Portugal

Introduction: Since the publication of endovascular treatment trials and European Stroke Guidelines, Portugal has re-organized stroke healthcare. The nine centers performing endovascular treatment are not equally distributed within the country, which may lead to differential access to endovascular treatment. Our main aim was to perform a descriptive analysis of the main treatment metrics regarding endovascular treatment in mainland Portugal and its administrative districts. Material and Methods: A retrospective national multicentric cohort study was conducted, including all ischemic stroke patients treated with endovascular treatment in mainland Portugal over two years (July 2015 to June 2017). All endovascular treatment centers contributed to an anonymized database. Demographic, stroke-related and procedure-related variables were collected. Crude endovascular treatment rates were calculated per 100 000 inhabitants for mainland Portugal, and each district and endovascular treatment standardized ratios (indirect age-sex standardization) were also calculated. Patient time metrics were computed as the median time between stroke onset, first-door, and puncture. Results: A total of 1625 endovascular treatment procedures were registered. The endovascular treatment rate was 8.27/100 000 inhabitants/year. We found regional heterogeneity in endovascular treatment rates (1.58 to 16.53/100 000/year), with higher rates in districts closer to endovascular treatment centers. When analyzed by district, the median time from stroke onset to puncture ranged from 212 to 432 minutes, reflecting regional heterogeneity. Conclusion: The overall national rate of EVT in the first two years after the organization of EVT-capable centers is one of the highest among European countries, however, significant regional disparities were documented. Moreover, stroke-onset-to-first-door times and in-hospital procedural times in the EVT centers were comparable to those reported in the randomized controlled trials performed in high-volume tertiary hospitals.Introdução: A aprovação do tratamento endovascular para o acidente vascular cerebral isquémico obrigou à reorganização dos cuidados de saúde em Portugal. Os nove centros que realizam tratamento endovascular não estão distribuídos equitativamente pelo território, o que poderá causar acesso diferencial a tratamento. O principal objetivo deste estudo é realizar uma análise descritiva da frequência e métricas temporais do tratamento endovascular em Portugal continental e seus distritos. Material e Métodos: Estudo de coorte nacional multicêntrico, incluindo todos os doentes com acidente vascular cerebral isquémico submetidos a tratamento endovascular em Portugal continental durante um período de dois anos (julho 2015 a junho 2017). Foram colhidos dados demográficos, relacionados com o acidente vascular cerebral e variáveis do procedimento. Taxas de tratamento endovascular brutas e ajustadas (ajuste indireto a idade e sexo) foram calculadas por 100 000 habitantes/ano para Portugal continental e cada distrito. Métricas de procedimento como tempo entre instalação, primeira porta e punção foram também analisadas. Resultados: Foram registados 1625 tratamentos endovasculares, indicando uma taxa bruta nacional de tratamento endovascular de 8,27/100 000 habitantes/ano. As taxas de tratamento endovascular entre distritos variaram entre 1,58 e 16,53/100 000/ano, com taxas mais elevadas nos distritos próximos a hospitais com tratamento endovascular. O tempo entre sintomas e punção femural entre distritos variou entre 212 e 432 minutos. Conclusão: Portugal continental apresenta uma taxa nacional de tratamento endovascular elevada, apresentando, contudo, assimetrias regionais no acesso. As métricas temporais foram comparáveis com as observadas nos ensaios clínicos piloto

Remote Sensing in Human Health: A 10-Year Bibliometric Analysis

A mixed methods bibliometric analysis was performed to ascertain the characteristic of scientific literature published in a 10-year period (2007–2016) regarding the application of remote sensing data in human health. A search was performed on the Scopus database, followed by manual revision using synthesis studies’ techniques, requiring the authors to sort through more than 8000 medical concepts to create the query, and to manually select relevant papers from over 2000 documents. From the initial 2752 papers identified, 520 articles were selected for analysis, showing that the United States ranked first, with a total of 250 (48.1% of the total) documents, followed by France and the United Kingdom, with 67 (12.9% of the total) and 54 (10.4% of the total) documents, respectively. When considering authorship, the top three authors were Vounatsou P (22 articles), Utzinger J (19 articles), and Vignolles C (13 articles). Regarding disease-specific keywords, malaria, dengue, and schistosomiasis were the most frequent keywords, occurring 142, 34, and 24 times, respectively. For some infectious diseases and other highly pathogenic or emerging infectious diseases, remote sensing has become a very powerful instrument. Also, several studies relate different environmental factors retrieved by remote sensing data with other diseases, such as asthma exacerbations. Health-related remote sensing publications are increasing and this paper highlights the importance of these related technologies toward better information and, ideally, better provision of healthcare. On the other hand, this paper provides an overall picture of the state of the research regarding the application of remote sensing data in human health and identifies the most active stakeholders e.g., authors and institutions in the field, informing possible new collaboration research groups