Recent history of the agriculture of the Brazilian Amazon Basin : prospects for sustainable development and a first look at the biogeochemical consequences of pasture reformation

Land-use change for human settlement and agricultural purposes, especially pasture establishment, has caused major impacts on the Amazon Basin's environment. Development of strategies for reformation and restoration of already degraded pastures constitutes the main goal of the authors' research work. For some of this work, a homogeneous area of land in terms of soil characteristics was selected at Nova Vida ranch in Rondônia state to conduct a multidisciplinary experiment, which included agronomic, environmental and economic analyses. Since July 2001, the authors have monitored five treatments: control, herbicide, tillage, no-till rice and no-till soybean, arranged in four blocks. Early results on carbon and nitrogen stocks, nitrogen mineralization, trace-gas fluxes, dissolved organic carbon and microbial biomass are briefly presented

A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction

The CHRNA5 gene encodes a neurotransmitter receptor subunit involved in multiple processes, including cholinergic autonomic nerve activity and inflammation. Common variants in CHRNA5 have been linked with atherosclerotic cardiovascular disease. Association of variation in CHRNA5 and specific haplotypes with cardiovascular outcomes has not been described. The aim of this study was to examine the association of CHRNA5 haplotypes with gene expression and mortality among patients with acute myocardial infarction (AMI) and explore potential mechanisms of this association. Patients (N = 2054) hospitalized with AMI were genotyped for two common variants in CHRNA5. Proportional hazard models were used to estimate independent association of CHRNA5 haplotype with 1-year mortality. Both individual variants were associated with mortality (p = 0.0096 and 0.0004, respectively) and were in tight LD (D' = 0.99). One haplotype, HAP3, was associated with decreased mortality one year after AMI (adjusted HR = 0.42, 95% CI 0.26, 0.68; p = 0.0004). This association was validated in an independent cohort (N = 637) of post-MI patients (adjusted HR = 0.23, 95% CI 0.07, 0.79; p = 0.019). Differences in CHRNA5 expression by haplotype were investigated in human heart samples (n = 28). Compared with non-carriers, HAP3 carriers had threefold lower cardiac CHRNA5 mRNA expression (p = 0.023). Circulating levels of the inflammatory marker hsCRP were significantly lower in HAP3 carriers versus non-carriers (3.43 ± 4.2 versus 3.91 ± 5.1; p = 0.0379). Activation of the inflammasome, an important inflammatory complex involved in cardiovascular disease that is necessary for release of the pro-inflammatory cytokine IL-1 β, was assessed in bone marrow-derived macrophages (BMDM) from CHRNA5 knockout mice and wild-type controls. In BMDM from CHRNA5 knockout mice, IL-1β secretion was reduced by 50% compared to wild-type controls (p = 0.004). Therefore, a common haplotype of CHRNA5 that results in reduced cardiac expression of CHRNA5 and attenuated macrophage inflammasome activation is associated with lower mortality after AMI. These results implicate CHRNA5 and the cholinergic anti-inflammatory pathway in survival following AMI.Edward D. Coverstone, Richard G. Bach, LiShiun Chen, Laura J. Bierut, Allie Y. Li, Petra A. Lenzini ... et al

The confusion effect--from neural networks to reduced predation risk

The confusion effect is often cited as an antipredatory benefit of group living and has been demonstrated by numerous studies across a range of taxa. However, there have been relatively few studies examining the mechanisms behind the effect and no experimental test of its supposed theoretical basis (information degradation in neural networks) using a natural predator--prey pairing. In agreement with other studies, we demonstrate that attack success of the three-spined stickleback (Gasterosteus aculeatus L.) is reduced by an increase in Daphnia magna group size. Neural network models attempt to explain this trend with multiple prey inducing poor neural mapping of target prey, thus leading to an increase in the spatial error of each attack. We explicitly tested this prediction and demonstrate that the decrease in attack success by sticklebacks does correspond to an increase in spatial targeting error with larger prey group size. Finally, we show that the number of targets, rather than the density or area occupied by the group, has the greatest effect on reducing the rate of attack. These results are discussed in the context of the information processing constraints of predators, the ultimate cause of the confusion effect. Copyright 2008, Oxford University Press.