1,337 research outputs found
A Computational Study of a Novel Turbine Rotor Partial Shroud
The over tip leakage (OTL) flow that exists between the stationary casing and the rotor tip of a shroudless HP turbine remains a major source of loss of performance for modern aero gas turbines. To-date the principal approaches to reducing OTL loss have been to minimise the clearance gap and/ or apply a rotating shroud to the rotor. Tip clearance control systems continue to improve, but a practical limit on tip gap remains. A rotating shroud is highly effective but increases the rotor weight forcing it to run more slowly, thus increasing other aerodynamic losses. Additional means of reducing OTL loss are still needed. Partial shrouds (winglets) have been tried but none have entered commercial service to-date. This paper presents a novel design of partial shroud derived from a review of past research. The (arbitrary) objectives were to halve the OTL loss of a shroudless rotor, at less than half the size of a full shroud. This design has been analysed using a steady flow RANS CFD code to qualitatively determine its benefits. Attention has been paid to its validation and a realistic determination of its capabilities. The winglet is predicted to significantly improve the efficiency of a highly loaded HP turbine, by 1.2 -1.8% at 2% tip gap/ span. A detailed understanding of the flow field shows this to be credible
Tau isoform-specific enhancement of L-type calcium current and augmentation of afterhyperpolarization in rat hippocampal neurons
Accumulation of tau is observed in dementia, with human tau displaying 6 isoforms grouped by whether they display either 3 or 4 C-terminal repeat domains (3R or 4R) and exhibit no (0N), one (1N) or two (2N) N terminal repeats. Overexpression of 4R0N-tau in rat hippocampal slices enhanced the L-type calcium (Ca(2+)) current-dependent components of the medium and slow afterhyperpolarizations (AHPs). Overexpression of both 4R0N-tau and 4R2N-tau augmented Ca(V)1.2-mediated L-type currents when expressed in tsA-201 cells, an effect not observed with the third 4R isoform, 4R1N-tau. Current enhancement was only observed when the pore-forming subunit was co-expressed with Ca(V)β3 and not Ca(V)β2a subunits. Non-stationary noise analysis indicated that enhanced Ca(2+) channel current arose from a larger number of functional channels. 4R0N-tau and Ca(V)β3 were found to be physically associated by co-immunoprecipitation. In contrast, the 4R1N-tau isoform that did not augment expressed macroscopic L-type Ca(2+) current exhibited greatly reduced binding to Ca(V)β3. These data suggest that physical association between tau and the Ca(V)β3 subunit stabilises functional L-type channels in the membrane, increasing channel number and Ca(2+) influx. Enhancing the Ca(2+)-dependent component of AHPs would produce cognitive impairment that underlie those seen in the early phases of tauopathies
The IFS for WFIRST CGI: Science Requirements to Design
Direct Imaging of exoplanets using a coronagraph has become a major field of research both on the ground and in space. Key to the science of direct imaging is the spectroscopic capabilities of the instrument, our ability to extract spectra, and measure the abundance of molecular species such as Methane. To take these spectra, the WFIRST coronagraph instrument (CGI) uses an integral field spectrograph (IFS), which encodes the spectrum into a two-dimensional image on the detector. This results in more efficient detection and characterization of targets, and the spectral information is critical to achieving detection limits below the speckle floor of the imager. The CGI IFS operates in two18% bands spanning 600nm to 840nm at a nominal spectral resolution of R50. We present the current science and engineering requirements for the IFS design, the instrument design, anticipated performance, and how the calibration is integrated into the focal plane wavefront control algorithms. We also highlight the role of the Prototype Imaging Spectrograph for Coronagraphic Exoplanet Studies (PISCES) at the JPL High Contrast Imaging Testbed to demonstrate performance and validate calibration methodologies for the flight instrument
Changes in physical activity during hospital admission for chronic respiratory disease: Inpatient step count does not recover
Background and objectiveEstablishing the amount of inpatient physical activity (PA) undertaken by individuals hospitalized for chronic respiratory disease is needed to inform interventions. This observational study investigated whether PA changes when a person is an inpatient, how long is required to obtain representative PA measures and whether PA varies within a day and between patients of differing lengths of stay.MethodsA total of 389 participants were recruited as early as possible into their hospitalization. Patients wore a PA monitor from recruitment until discharge. Step count was extracted for a range of wear time criteria. Single‐day intraclass correlation coefficients (ICC) were calculated, with an ICC ≥ 0.80 deemed acceptable.ResultsPA data were available for 259 participants. No changes in daily step count were observed during the inpatient stay (586 (95% CI: 427–744) vs 652 (95% CI: 493–812) steps/day for day 2 and 7, respectively). ICC across all wear time criteria were > 0.80. The most stringent wear time criterion, retaining 80% of the sample, was ≥11 h on ≥1 day. More steps were taken during the morning and afternoon than overnight and evening. After controlling for the Medical Research Council (MRC) grade or oxygen use, there was no difference in step count between patients admitted for 2–3 days (short stay) and those admitted for 7–14 days (long stay).ConclusionPatients move little during their hospitalization, and inpatient PA did not increase during their stay. A wear time criterion of 11 waking hours on any single day was representative of the entire admission whilst retaining an acceptable proportion of the initial sample size. Patients may need encouragement to move more during their hospital stay
Ontogenetic Partial Migration Is Associated with Environmental Drivers and Influences Fisheries Interactions in a Marine Predator
The ability to predict animal movement based on environmental change is essential for understanding the dynamic nature of their spatial ecology, and in turn the effectiveness of conservation strategies. We used a large marine predator that displays partial migration (the tiger shark Galeocerdo cuvier) as a model to test the role of oceanic conditions in predicting the space-use of different size classes. By using generalized additive mixed models (GAMMs), we revealed that environmental variables (sea surface temperature, primary productivity, thermal fronts, and bathymetry) had much greater predictive power for the movements of large, migratory tiger sharks than for small, resident individuals. We also found that coverage of tiger shark movements within “shark sanctuaries” (protected areas specifically for sharks) in the northwest Atlantic could be increased from 12 to 52% through inclusion of Bermuda’s waters. However, as large tiger sharks are migratory, over 80% of potential longline fisheries interactions would still occur outside the boundaries of even the expanded protected areas. This emphasises that management of highly migratory species needs to be dynamic and account for changing interactions with fisheries over time, which in a changing climate may rely on predicting movements based on oceanic conditions to be effective
Repeated, Long-Distance Migrations by a Philopatric Predator Targeting Highly Contrasting Ecosystems
Long-distance movements of animals are an important driver of population spatial dynamics and determine the extent of overlap with area-focused human activities, such as fishing. Despite global concerns of declining shark populations, a major limitation in assessments of population trends or spatial management options is the lack of information on their long-term migratory behaviour. For a large marine predator, the tiger shark Galeocerdo cuvier, we show from individuals satellite-tracked for multiple years (up to 1101 days) that adult males undertake annually repeated, round-trip migrations of over 7,500 km in the northwest Atlantic. Notably, these migrations occurred between the highly disparate ecosystems of Caribbean coral reef regions in winter and high latitude oceanic areas in summer, with strong, repeated philopatry to specific overwintering insular habitat. Partial migration also occurred, with smaller, immature individuals displaying reduced migration propensity. Foraging may be a putative motivation for these oceanic migrations, with summer behaviour showing higher path tortuosity at the oceanic range extremes. The predictable migratory patterns and use of highly divergent ecosystems shown by male tiger sharks appear broadly similar to migrations seen in birds, reptiles and mammals, and highlight opportunities for dynamic spatial management and conservation measures of highly mobile sharks
Space-based research in fundamental physics and quantum technologies
Space-based experiments today can uniquely address important questions
related to the fundamental laws of Nature. In particular, high-accuracy physics
experiments in space can test relativistic gravity and probe the physics beyond
the Standard Model; they can perform direct detection of gravitational waves
and are naturally suited for precision investigations in cosmology and
astroparticle physics. In addition, atomic physics has recently shown
substantial progress in the development of optical clocks and atom
interferometers. If placed in space, these instruments could turn into powerful
high-resolution quantum sensors greatly benefiting fundamental physics.
We discuss the current status of space-based research in fundamental physics,
its discovery potential, and its importance for modern science. We offer a set
of recommendations to be considered by the upcoming National Academy of
Sciences' Decadal Survey in Astronomy and Astrophysics. In our opinion, the
Decadal Survey should include space-based research in fundamental physics as
one of its focus areas. We recommend establishing an Astronomy and Astrophysics
Advisory Committee's interagency ``Fundamental Physics Task Force'' to assess
the status of both ground- and space-based efforts in the field, to identify
the most important objectives, and to suggest the best ways to organize the
work of several federal agencies involved. We also recommend establishing a new
NASA-led interagency program in fundamental physics that will consolidate new
technologies, prepare key instruments for future space missions, and build a
strong scientific and engineering community. Our goal is to expand NASA's
science objectives in space by including ``laboratory research in fundamental
physics'' as an element in agency's ongoing space research efforts.Comment: a white paper, revtex, 27 pages, updated bibliograph
Global patterns and environmental controls of perchlorate and nitrate co-occurrence in arid and semi-arid environments
Natural perchlorate (ClO4-) is of increasing interest due to its wide-spread occurrence on Earth and Mars, yet little information exists on the relative abundance of ClO4- compared to other major anions, its stability, or long-term variations in production that may impact the observed distributions. Our objectives were to evaluate the occurrence and fate of ClO4- in groundwater and soils/caliche in arid and semi-arid environments (southwestern United States, southern Africa, United Arab Emirates, China, Antarctica, and Chile) and the relationship of ClO4- to the more well-studied atmospherically deposited anions NO3- and Cl- as a means to understand the prevalent processes that affect the accumulation of these species over various time scales. ClO4- is globally distributed in soil and groundwater in arid and semi-arid regions on Earth at concentrations ranging from 10-1 to 106 µg/kg. Generally, the ClO4- concentration in these regions increases with aridity index, but also depends on the duration of arid conditions. In many arid and semi-arid areas, NO3- and ClO4- co-occur at molar ratios (NO3-/ClO4-) that vary between ~104 and 105. We hypothesize that atmospheric deposition ratios are largely preserved in hyper-arid areas that support little or no biological activity (e.g. plants or bacteria), but can be altered in areas with more active biological processes including N2 fixation, N mineralization, nitrification, denitrification, and microbial ClO4- reduction, as indicated in part by NO3- isotope data. In contrast, much larger ranges of Cl-/ClO4- and Cl-/NO3- ratios indicate Cl- varies independently from both ClO4- and NO3-. The general lack of correlation between Cl- and ClO4- or NO3- implies that Cl- is not a good indicator of co-deposition and should be used with care when interpreting oxyanion cycling in arid systems. The Atacama Desert appears to be unique compared to all other terrestrial locations having a NO3-/ClO4- molar ratio ~103. The relative enrichment in ClO4- compared to Cl- or NO3- and unique isotopic composition of Atacama ClO4- may reflect either additional in-situ production mechanism(s) or higher relative atmospheric production rates in that specific region or in the geological past. Elevated concentrations of ClO4- reported on the surface of Mars, and its enrichment with respect to Cl- and NO3-, could reveal important clues regarding the climatic, hydrologic, and potentially biologic evolution of that planet. Given the highly conserved ratio of NO3-/ClO4- in non-biologically active areas on Earth, it may be possible to use alterations of this ratio as a biomarker on Mars and for interpreting major anion cycles and processes on both Mars and Earth, particularly with respect to the less-conserved NO3- pool terrestrially
Global patterns and environmental controls of perchlorate and nitrate co-occurrence in arid and semi-arid environments
Natural perchlorate (ClO4-) is of increasing interest due to its wide-spread occurrence on Earth and Mars, yet little information exists on the relative abundance of ClO4- compared to other major anions, its stability, or long-term variations in production that may impact the observed distributions. Our objectives were to evaluate the occurrence and fate of ClO4- in groundwater and soils/caliche in arid and semi-arid environments (southwestern United States, southern Africa, United Arab Emirates, China, Antarctica, and Chile) and the relationship of ClO4- to the more well-studied atmospherically deposited anions NO3- and Cl- as a means to understand the prevalent processes that affect the accumulation of these species over various time scales. ClO4- is globally distributed in soil and groundwater in arid and semi-arid regions on Earth at concentrations ranging from 10-1 to 106 µg/kg. Generally, the ClO4- concentration in these regions increases with aridity index, but also depends on the duration of arid conditions. In many arid and semi-arid areas, NO3- and ClO4- co-occur at molar ratios (NO3-/ClO4-) that vary between ~104 and 105. We hypothesize that atmospheric deposition ratios are largely preserved in hyper-arid areas that support little or no biological activity (e.g. plants or bacteria), but can be altered in areas with more active biological processes including N2 fixation, N mineralization, nitrification, denitrification, and microbial ClO4- reduction, as indicated in part by NO3- isotope data. In contrast, much larger ranges of Cl-/ClO4- and Cl-/NO3- ratios indicate Cl- varies independently from both ClO4- and NO3-. The general lack of correlation between Cl- and ClO4- or NO3- implies that Cl- is not a good indicator of co-deposition and should be used with care when interpreting oxyanion cycling in arid systems. The Atacama Desert appears to be unique compared to all other terrestrial locations having a NO3-/ClO4- molar ratio ~103. The relative enrichment in ClO4- compared to Cl- or NO3- and unique isotopic composition of Atacama ClO4- may reflect either additional in-situ production mechanism(s) or higher relative atmospheric production rates in that specific region or in the geological past. Elevated concentrations of ClO4- reported on the surface of Mars, and its enrichment with respect to Cl- and NO3-, could reveal important clues regarding the climatic, hydrologic, and potentially biologic evolution of that planet. Given the highly conserved ratio of NO3-/ClO4- in non-biologically active areas on Earth, it may be possible to use alterations of this ratio as a biomarker on Mars and for interpreting major anion cycles and processes on both Mars and Earth, particularly with respect to the less-conserved NO3- pool terrestrially
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