When good bugs go bad: Epidemiology and antimicrobial resistance profiles of Corynebacterium striatum, an emerging multidrug-resistant, opportunistic pathogen

ABSTRACT Infections with Corynebacterium striatum have been described in the literature over the last 2 decades, with the majority being bacteremia, central line infections, and occasionally, endocarditis. In recent years, the frequency of C. striatum infections appears to be increasing; a factor likely contributing to this is the increased ease and accuracy of the identification of Corynebacterium spp., including C. striatum , from clinical cultures. The objective of this study was to retrospectively characterize C. striatum isolates recovered from specimens submitted as part of routine patient care at a 1,250-bed, tertiary-care academic medical center. Multiple strain types were recovered, as demonstrated by repetitive-sequence-based PCR. Most of the strains of C. striatum characterized were resistant to antimicrobials commonly used to treat Gram-positive organisms, such as penicillin, ceftriaxone, meropenem, clindamycin, and tetracycline. The MIC 50 for ceftaroline was &gt;32 μg/ml. Although there are no interpretive criteria for susceptibility with telavancin, it appeared to have potent in vitro efficacy against this species, with MIC 50 and MIC 90 values of 0.064 and 0.125 μg/ml, respectively. Finally, as previously reported in case studies, we demonstrated rapid in vitro development of daptomycin resistance in 100% of the isolates tested ( n = 50), indicating that caution should be exhibited when using daptomycin for the treatment of C. striatum infections. C. striatum is an emerging, multidrug-resistant pathogen that can be associated with a variety of infection types. </jats:p

Old-fashioned or enlightened? Small retailers' practices in e-procurement.

The paper considers how and why SME retailers use the internet in their procurement processes. Examining retailers' views and reasons, we relate these to existing technology acceptance models, employing a qualitative approach. Although our respondents accepted the pervasion of internet marketing, they believed that a more personalised approach to purchasing was necessary to maintain their competitive advantage. For them, effectiveness in purchasing took priority over efficiency. We argue that this view and the consequent actions were a result of the size of the firm and the nature of the products they sold. Our sample size prevents us from generalising. However, we argue that large scale surveys may miss the nuances of decision-making and that the unique character of SMEs may imply that conventional models of technology acceptance need to be modified to take account of these characteristics. Our findings challenge the assumption that one size theoretically fits all in technology driven procurement

Applying Technology Forecasting to New Product Development Target Setting of LCD Panels

This chapter illustrates the Technology Forecasting using Data Envelopment Analysis (TFDEA) process on Liquid Crystal Display (LCD) performance characteristics from 1997 to 2012. The objective of this study is to forecast future state-of-the-arts (SOAs) specifications as well as to diagnose past technological advancement of the LCD industry. Appropriate characteristics were determined from a group of LCD technologists. Data was gathered from public databases and outlying data points were cross-referenced as a validity check. The TFDEA process is defined and its application to the dataset is described in detail. The results not only provide information on how LCD industry has evolved but also provide an insight on future NPD targets

Holidaying with the family pet: No dogs allowed!

This paper assesses the extent to which dog owners located in Brisbane, Australia, wish to holiday with their pets, and whether there is a gap between this desire and reality. The paper also examines the extent to which this demand is being catered for by the tourism accommodation sector. The need for this study reflects the increasingly significant role dogs are playing in the lives of humans, and the scale of the dog-owning population. The results suggest that, although there is a strong desire among dog owners to take holidays with their pets, the actualisation of this desire is comparatively low. A significant obstacle to the realisation of this desire appears to be a dearth of pet-friendly accommodation. This has implications for the ability of the tourism industry to benefit from this potentially lucrative market, that is, the dog-owning population

Validity of interpretation: a user validity perspective beyond the test score

YesThis paper introduces the concept of user validity and provides a new perspective on the validity of interpretations from tests. Test interpretation is based on outputs such as test scores, profiles, reports, spread-sheets of multiple candidates’ scores, etc. The user validity perspective focuses on the interpretations a test user makes given the purpose of the test and the information provided in the test output. This innovative perspective focuses on how user validity can be extended to content, criterion and to some extent construct-related validity. It provides a basis for researching the validity of interpretations and an improved understanding of the appropriateness of different approaches to score interpretation, as well as how to design test outputs and assessments which are pragmatic and optimal

Cell wall protection by the Candida albicans class I chitin synthases

Open Access funded by Medical Research Council Acknowledgments We thank Kevin Mackenzie in the Microscopy and Histology Core Facility (Institute of Medical Sciences, University of Aberdeen), and Donna MacCallum for helpful statistical advice. This work was supported by grants from the Wellcome Trust (0868827 and 080088) including a Wellcome Trust Strategic Award (097377) and an Investigator Award to NG (101873), an MRC New Investigator Award to ML (MR/J008230/1) and a PhD scholarship awarded to KP from the Ministry of Sciences and Technology and Chiang Mai University, Thailand. Author contributions are as follows: KP constructed strains, performed the majority of the experiments, analyzed the data and contributed to the preparation of the manuscript. JA produced Fig. S1 using the data from the phosphoproteomic analysis conducted by SP and AB. NG conceived and designed experiments, analyzed data and commented on drafts of the manuscript. ML constructed strains, conceived, designed and performed experiments, analyzed data and wrote the manuscript.Peer reviewedPublisher PD

An investigation of the pre-analytical variability in laboratory testing and its influence on result interpretation and patient management

Interpretation of laboratory tests in clinical practice is based on an understanding of the disease process within or between individuals. This is demonstrated by the variability of pathology results as compared to the previous result or against the reference range, made up from the intrinsic pathophysiological changes and also variation associated with the in vitro changes to the sample. My work is on identification and minimisation of the result variation in the pre-analytical phase, accounting for 60-70% of the errors associated with laboratory testing. The first project of my thesis is based on four studies that consider the in vitro stability of parathyroid hormone (PTH) and C-reactive protein (CRP), in which significant sample degradation is observed due to sample tube type, anticoagulant used and time to separation. The second project considers ethnic variation as a source of intra individual variation. Specifically considering intra individual ethnic variation in total cholesterol (TC) and high density lipoprotein cholesterol (HDLC), reporting significant differences were observed between Caucasian Indo-Asians in HDLC, in addition I investigated the relationship between low maternal vitamin B12 concentrations in Caucasian women and cord blood cholesterol. The third project considered the variation in laboratory results due to pre-existing conditions causing interference in common laboratory tests. I published on the effect of lipaemia on common laboratory tests, showing lipaemia does have a significant effect on laboratory tests. The following study found that the raised prolactin seen in rheumatoid arthritis is not artefactual but due to changes in cross reactivity due of prolactin subtypes. The final paper of this project shows, through a collection of case studies falsely elevated serum calcium levels in patients with paraproteinaemia

Paving the way for research in recruitment and selection:Recent developments, challenges and future opportunities

Considered as one of the cornerstones of work and organizational psychology, it is not surprising that the selection and recruitment literature is vast. In this review, we synthesize and integrate the findings from around 40 meta-analyses and literature reviews from the last decade to identify the most recent meta-trends and future research directions in the selection and recruitment research and practice. We organize our key findings around three superordinate areas: a) recent developments in selection research, covering findings on validities of selection methods, expanding the criterion space, and applicant reactions and impression management; b) recent developments in recruitment research, paying attention to the evidence around recruitment methods and applicant attraction; and c) new technology in recruitment and selection. In our call for future research, we delineate a number of substantive issues and the need for more sophisticated theoretical developments in the field as well as methodological challenges that future efforts should address. We concur with the vast literature in that selection and recruitment research is a vibrant field, which we expect will address a number of ongoing political, cultural, technological, societal, and employment regulations-related issues to keep creating impact and providing meaningful findings for recruitment and selection practices in organizations

Salt Dissolution and Surface Subsidence in Central Kansas: A Seismic Investigation of the Anthropogenic and Natural Origin Models

Gradual subsidence in the Punkin Center study area, northeast Reno County, Kansas, has resulted in ponding of surface waters, abandonment of at least one oil well, and damage to county roads. Because the Punkin Center area is within the Burrton oil field and is underlain by the Hutchinson Salt Member, surface subsidence historically has been attributed to salt dissolution of anthropogenic origin. Subsidence that occurred significant distances from any known well sites has been attributed to unrecorded abandoned wells or complex asymmetric patterns of salt dissolution that originated at a drillhole. To ascertain the validity of the widely accepted anthropogenic salt-dissolution model, a 4-km seismic reflection profile was acquired along an east-west-oriented county road adjacent to an abandoned oil well. The expectation was that the residual Hutchinson Salt Member would be anomalously thin where maximum recorded surface subsidence occurred and thicker elsewhere. Contrary to expectations, the residual Hutchinson Salt Member is relatively thick (20-30 m) below areas of significant recent surface subsidence. There is no evidence of recent surface subsidence at those locations along the seismic profile where the rock salt has been totally leached. At these sites dissolution and subsidence is interpreted to predate European settlement in Kansas and to be of natural origin. The presence of dissolution and subsidence features related to natural processes has implications for developing an understanding of the potentially complex relationship between anthropogenic activities and pre-existing geologic conditions. Sinkhole development is apparently a natural and expected process along an irregular salt dissolution front. The geometry of this front may be influenced strongly by geologic factors (e.g., fracture patterns and facies distribution). The results are that not all modern sinkhole development has a clear-cut anthropogenic cause, and the potential for adverse impact resulting from anthropogenic activities will be influenced strongly by pre-existing geologic conditions. Efficient management decisions along the dissolution front related to well location and well-site practices should take into account natural processes that previously have and will continue to have an effect on salt dissolution and surface subsidence