Biogeochemical properties and transports in the North East Atlantic

The eastern subpolar North Atlantic is a source of nutrients to the Northwest European Shelf and Arctic; however, biogeochemical transports in this important region are unknown. We examine variability in nutrients and carbon at the eastern boundary of the subpolar North Atlantic between 2017 and 2020, and calculate their transport by a branch of the North Atlantic Current and the European Slope Current. By combining observations from moorings and ship-based surveys, we derive novel biogeochemical property transports at high temporal resolution. Data from 63 m provide new evidence of a strong seasonal signal with silicate declining between April and May (−2.3 μmol kg−1) and a concurrent increase in pH (0.04) and oxygen saturation (3.5%). Additionally, pH and oxygen saturation show a secondary peak in October during the autumn bloom. Biogeochemical transports are northwards and highly variable with volume transport dominating the variability over a multi-annual timescale. However, historical data suggests that nitrate and phosphate transports were 15% and 19% lower respectively in the late 2000s when the subpolar gyre circulation was weaker and lower nutrient source waters were dominant. These changes may have been amplified by concurrent reductions in volume transport. Changes in carbon and nutrient transports in the eastern subpolar North Atlantic may propagate downstream with potential effects on the Northwest European Shelf and Eurasian Arctic

Inbred Mouse Populations Exhibit Intergenerational Changes in Intestinal Microbiota Composition and Function Following Introduction to a Facility

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Inbred mice are used to investigate many aspects of human physiology, including susceptibility to disease and response to therapies. Despite increasing evidence that the composition and function of the murine intestinal microbiota can substantially influence a broad range of experimental outcomes, relatively little is known about microbiome dynamics within experimental mouse populations. We investigated changes in the intestinal microbiome between C57BL/6J mice spanning six generations (assessed at generations 1, 2, 3, and 6), following their introduction to a stringently controlled facility. Fecal microbiota composition and function were assessed by 16S rRNA gene amplicon sequencing and liquid chromatography mass spectrometry, respectively. Significant divergence of the intestinal microbiota between founder and second generation mice, as well as continuing inter-generational variance, was observed. Bacterial taxa whose relative abundance changed significantly through time included Akkermansia, Turicibacter, and Bifidobacterium (p < 0.05), all of which are recognized as having the potential to substantially influence host physiology. Shifts in microbiota composition were mirrored by corresponding differences in the fecal metabolome (r = 0.57, p = 0.0001), with notable differences in levels of tryptophan pathway metabolites and amino acids, including glutamine, glutamate and aspartate. We related the magnitude of changes in the intestinal microbiota and metabolome characteristics during acclimation to those observed between populations housed in separate facilities, which differed in regards to husbandry, barrier conditions and dietary intake. The microbiome variance reported here has implications for experimental reproducibility, and as a consequence, experimental design and the interpretation of research outcomes across wide range of contexts

Diffusion Tensor Imaging of Frontal Lobe in Autism Spectrum Disorder

To investigate frontal lobe white matter in children with autism spectrum disorder (ASD), we performed diffusion tensor imaging (DTI) in 50 ASD children (mean age: 57.5 ± 29.2 months, 43 males) and 16 typically developing children (mean age: 82.1 ± 41.4 months, 11 males). The apparent diffusion coefficient (ADC) was significantly higher for whole frontal lobe (P = 0.011), long (P < 0.001) and short range (P = 0.0126) association fibers in ASD group. There was a trend toward statistical significance in the fractional anisotropy (FA) of whole frontal lobe fibers (P = 0.11). FA was significantly lower in ASD group for short range fibers (P = 0.0031) but not for long range fibers (P = not significant [NS]). There was no between-group difference in the number of frontal lobe fibers (short and long) (P = NS). The fiber length distribution was significantly more positively skewed in the normal population than in the ASD group (P < 0.001). The long range association fibers of frontal lobe were significantly longer in ASD group (P = 0.026 for both left and right hemispheres). Abnormal frontal FA and ADC may be due to white matter organization abnormalities in ASD. Lack of evidence for excessive short range connectivity in ASD in this study may need to be re-examined with future advances in DTI technology

The Galaxy Luminosity Function from M_R = -25 to M_R = -9

Redshift surveys like the Sloan Digital Sky Survey (SDSS) have given a very precise measurement of the galaxy luminosity function down to about M_R = -17 (~ M_B = -16). Fainter absolute magnitudes cannot be probed because of the flux limit required for spectroscopy. Wide-field surveys of nearby groups using mosaic CCDs on large telescopes are able to reach much fainter absolute magnitudes, about M_R = -10. These diffuse, spiral-rich groups are thought to be typical environments for galaxies so their luminosity functions should be the same as the field luminosity function. The luminosity function of the groups at the bright end (M_R < -17) is limited by Poisson statistics and is far less precise than that derived from redshift surveys. Here we combine the results of the SDSS and the surveys of nearby groups and supplement the results with studies of Local Group galaxies in order to determine the galaxy luminosity function over the entire range -25 <M_R < -9. The average logarithmic slope of the field luminosity function between M_R = -19 and M_R = -9 is alpha = -1.26, although a single power law is a poor fit to the data over the entire magnitude range. We also determine the luminosity function of galaxy clusters and demonstrate that it is different from the field luminosity function at a high level of significance: there are many more dwarf galaxies in clusters than in the field, due to a rise in the cluster luminosity function of alpha ~ -1.6 between M_R = -17 and M_R = -14.Comment: 11 pages, 9 figures, accepted for publication in MNRA

The Science Performance of JWST as Characterized in Commissioning

This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures; https://iopscience.iop.org/article/10.1088/1538-3873/acb29

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Life-Sustaining Treatment Decisions: A Social Work Response To Meet Needs Of Health Care Surrogates

Surrogates must possess essential patient information prior to legitimately exercising legal and moral obligations to act on patients\u27 medical care preferences. This descriptive, in vivo study examined factors influencing surrogate and proxy decisions (N = 132) following life-sustaining treatment decisions. Patient communication and self-efficacy variables accounted for approximately 38% of the variance in surrogates\u27 perceptions of benefits/barriers associated with decision making. Guided by patients\u27 advanced communication, respondents (97.8%) expressed high self-reliance and significant appreciation of benefits associated with their decisions. Clarifying surrogates\u27 and providers\u27 understanding of patient care preferences during ICU/CCU admission may facilitate better adherence to patient wishes. © Taylor & Francis Group, LLC