362 research outputs found
On noise treatment in radio measurements of cosmic ray air showers
Precise measurements of the radio emission by cosmic ray air showers require
an adequate treatment of noise. Unlike to usual experiments in particle
physics, where noise always adds to the signal, radio noise can in principle
decrease or increase the signal if it interferes by chance destructively or
constructively. Consequently, noise cannot simply be subtracted from the
signal, and its influence on amplitude and time measurement of radio pulses
must be studied with care. First, noise has to be determined consistently with
the definition of the radio signal which typically is the maximum field
strength of the radio pulse. Second, the average impact of noise on radio pulse
measurements at individual antennas is studied for LOPES. It is shown that a
correct treatment of noise is especially important at low signal-to-noise
ratios: noise can be the dominant source of uncertainty for pulse height and
time measurements, and it can systematically flatten the slope of lateral
distributions. The presented method can also be transfered to other experiments
in radio and acoustic detection of cosmic rays and neutrinos.Comment: 4 pages, 6 figures, submitted to NIM A, Proceedings of ARENA 2010,
Nantes, Franc
The LOPES experiment - recent results, status and perspectives
The LOPES experiment at the Karlsruhe Institute of Technology has been taking
radio data in the frequency range from 40 to 80 MHz in coincidence with the
KASCADE-Grande air shower detector since 2003. Various experimental
configurations have been employed to study aspects such as the energy scaling,
geomagnetic dependence, lateral distribution, and polarization of the radio
emission from cosmic rays. The high quality per-event air shower information
provided by KASCADE-Grande has been the key to many of these studies and has
even allowed us to perform detailed per-event comparisons with simulations of
the radio emission. In this article, we give an overview of results obtained by
LOPES, and present the status and perspectives of the ever-evolving experiment.Comment: Proceedings of the ARENA2010 conference, Nantes, Franc
Results from the KASCADE, KASCADE-Grande, and LOPES experiments
The origin of high-energy cosmic rays in the energy range from 10^14 to 10^18
eV is explored with the KASCADE and KASCADE-Grande experiments. Radio signals
from air showers are measured with the LOPES experiment. An overview on results
is given.Comment: Talk at The ninth International Conference on Topics in Astroparticle
and Underground Physics, TAUP 2005, Zaragoza, September 10-14, 200
The Influence of the Human Becoming Theory on Teaching-Learning Stories in Hangzhou, China
MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer
Alterations in epithelial mucin expression are associated with carcinogenesis, but there are few data in biliary tract cancer (BTC). In pancreatic malignancy, MUC4 is a diagnostic and prognostic tumour marker, whereas MUC5AC has been proposed as a sensitive serological marker for BTC. We assessed MUC4 and MUC5AC expression in (i) prospectively collected bile and serum specimens from 72 patients with biliary obstruction (39 BTC) by real-time reverse transcriptase–PCR (qPCR) and western blot analysis, and (ii) 79 archived biliary tissues (69 BTC) by immunohistochemistry. In bile, MUC4 protein was detected in 27% of BTC and 29% of primary sclerosing cholangitis (PSC) cases, but not in other benign and malignant biliary diseases (P<0.01 and P=0.06). qPCR revealed a 1.9-fold increased MUC4 mRNA expression in BTC patients' bile compared with benign disease. In archived tissues, MUC4 protein was detected in 37% of BTC but in none of the benign samples (P=0.03). In serum, MUC5AC was found exclusively in BTC and PSC sera (44% and 13%, respectively; P<0.001 for BTC vs non-BTC) and correlated negatively with BTC survival. Biliary MUC4 and serum MUC5AC are highly specific tumour-associated mucins that may be useful in the diagnosis and formulation of therapeutic strategies in BTC
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Understanding recovery in the context of lived experience of personality disorders: a collaborative, qualitative research study
Background
Concepts of recovery increasingly inform the development and delivery of mental health services internationally. In the UK recent policy advocates the application of recovery concepts to the treatment of personality disorders. However diagnosis and understanding of personality disorders remains contested, challenging any assumption that mainstream recovery thinking can be directly translated into personality disorders services.
Methods
In a qualitative interview-based study understandings of recovery were explored in extended, in-depth interviews with six people purposively sampled from a specialist personality disorders’ service in the UK. An interpretive, collaborative approach to research was adopted in which university-, clinical- and service user (consumer) researchers were jointly involved in carrying out interviews and analysing interview data.
Results
Findings suggested that recovery cannot be conceptualised separately from an understanding of the lived experience of personality disorders. This experience was characterised by a complexity of ambiguous, interrelating and conflicting feelings, thoughts and actions as individuals tried to cope with tensions between internally and externally experienced worlds. Our analysis was suggestive of a process of recovering or, for some, discovering a sense of self that can safely coexist in both worlds.
Conclusions
We conclude that key facilitators of recovery – positive personal relationships and wider social interaction – are also where the core vulnerabilities of individuals with lived experience of personaility disorders can lie. There is a role for personality disorders services in providing a safe space in which to develop positive relationships. Through discursive practice within the research team understandings of recovery were co-produced that responded to the lived experience of personality disorders and were of applied relevance to practitioners
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