Serotonin receptor agonists in the acute treatment of migraine. a review on their therapeutic potential

Migraine is an important socioeconomic burden and is ranked the sixth cause of years of life lost because of disability in the general population and the third cause of years of life lost in people younger than 50 years. The cornerstone of pharmacological treatment is represented by the acute therapy. The serotonin (5-hydroxytryptamine [5-HT]) receptor subtype 1B/1D agonists, called triptans, are nowadays the first-line acute therapy for patients who experience moderate-to-severe migraine attacks. Unfortunately, a high percentage of patients are not satisfied with this acute treatment, either for lack of response or side effects. Moreover, their mechanism of action based on vasoconstriction makes them unsuitable for patients with previous cardio- and cerebrovascular diseases and for those with uncontrolled hypertension. Since the introduction of triptans, no other acute drug class has passed all developmental stages. The research for a new drug lacking vasoconstrictive effects led to the development of lasmiditan, a highly selective 5-HT1F receptor agonist with minimized interactions with other 5-HT receptor subtypes. Lasmiditan is considered to be the first member of a new drug category, the neurally acting anti-migraine agent (NAAMA). Phase II and III trials had shown superiority compared to placebo and absence of typical triptan-associated adverse events (AEs). Most of the AEs were related to the central nervous system, depending on the high permeability through the blood-brain barrier and mild to moderate severity. The results of ongoing long-term Phase III trials will determine whether lasmiditan will become available in the market, and then active triptan comparator studies will assess patients’ preference. Future studies could then explore the safety during pregnancy and breastfeeding or the risk that overuse of lasmiditan leads to medication overuse headache

Anyons, group theory and planar physics

Relativistic and nonrelativistic anyons are described in a unified formalism by means of the coadjoint orbits of the symmetry groups in the free case as well as when there is an interaction with a constant electromagnetic field. To deal with interactions we introduce the extended Poincar\'e and Galilei Maxwell groups.Comment: 22 pages, journal reference added, bibliography update

The use of FRPs in seismic repair and retrofit: experimental verification

The application of FRPs in the seismic repair and retrofit of structures is addressed. The results from a few tests on full-scale structures, repaired and/or retrofitted with composites, performed at the ELSA laboratory are presented and discussed

Intertwining Symmetry Algebras of Quantum Superintegrable Systems

We present an algebraic study of a kind of quantum systems belonging to a family of superintegrable Hamiltonian systems in terms of shape-invariant intertwinig operators, that span pairs of Lie algebras like $(su(n),so(2n))$ or $(su(p,q),so(2p,2q))$. The eigenstates of the associated Hamiltonian hierarchies belong to unitary representations of these algebras. It is shown that these intertwining operators, related with separable coordinates for the system, are very useful to determine eigenvalues and eigenfunctions of the Hamiltonians in the hierarchy. An study of the corresponding superintegrable classical systems is also included for the sake of completness

Susceptibility of the QCD vacuum to CP-odd electromagnetic background fields

We investigate two flavor QCD in presence of CP-odd electromagnetic background fields and determine, by means of lattice QCD simulations, the induced effective theta term to the first order in the scalar product of E and B. We employ a rooted staggered discretization and study lattice spacings down to 0.1 fm and Goldstone pion masses around 480 MeV. In order to deal with a positive measure, we consider purely imaginary electric fields and real magnetic fields, then exploiting analytic continuation. Our results are relevant to a description of the effective pseudoscalar QED-QCD interactions.Comment: 5 pages, 4 figures, 1 table. New data and references added. Matches the published versio

A Christian Negro to Dear Sir (12 October 1962)

https://egrove.olemiss.edu/mercorr_pro/2143/thumbnail.jp