Landrace added value and accessibility in Europe: what a collection of case studies tells us

In the actual climate change scenario, in situ conservation of plant genetic resources for food and agriculture can significantly contribute broadening the diversity of our food system as well as increasing its resilience; nevertheless, landrace cultivation has been dramatically reduced in the last decades all over Europe. One of the most effective approaches to counteract the loss of landrace diversity in situ is facilitating its use. Aims of this study were to (i) describe how in situ maintenance of landraces occurs in different agro-environmental conditions in Europe and (ii) identify the main factors influencing landrace added values and accessibility as means to increase their adoption by new farmers. To the purpose, a collection of 95 case studies of both garden and open field landraces maintained in situ was analysed. A first description was obtained by classifying the information into 18 purposely defined categories. Data on landraces added values and accessibility were further transformed into weighted variables; the derived quantitative scores were then used as dependent variables in univariate and multivariate analyses. Results showed that farmers alone are still the main actors maintaining landraces in situ across different European biogeographical regions, mainly carrying out their activity under organic or low-input conditions, often in marginal areas. Results of the multivariate analysis showed that (i) type of actor involved in the multiplication, (ii) the main use of the product and (iii) presence of promotion actions significantly affect garden landraces added value and accessibility; presence of promotion actions was the only factor affecting added value of open field entries. Evidence arising from this work can contribute to the establishment of a fruitful ground of discussion for future European policies and strategies to protect and increase landrace use

The LAUE project for broadband gamma-ray focusing lenses

We present the LAUE project devoted to develop an advanced technology for building a high focal length Laue lens for soft gamma--ray astronomy (80-600 keV). The final goal is to develop a focusing optics that can improve the current sensitivity in the above energy band by 2 orders of magnitude.Comment: 7 pages, 6 figures, presented at the SPIE conference on "Optics for EUV, X-ray, and Gamma-ray Astronomy". To be published in the Proceedings of SPIE, vol.8147, 201

Development status of the LAUE project

We present the status of LAUE, a project supported by the Italian Space Agency (ASI), and devoted to develop Laue lenses with long focal length (up to 100 meters), for hard X--/soft gamma--ray astronomy (80-600 keV). Thanks to their focusing capability, the design goal is to improve the sensitivity of the current instrumention in the above energy band by 2 orders of magnitude, down to a few times $10^{-8}$ photons/(cm$^2$ s keV).Comment: 9 pages, 9 figures, presented at the Space Telescopes and Instrumentation Symposium in Amsterdam, 2012: Ultraviolet to Gamma Ray Conference. Published in the Proceedings of the SPIE, Volume 8443, id. 84430B-84430B-9 (2012

Therapeutic potential of endothelial colony‐forming cells in ischemic disease: Strategies to improve their regenerative efficacy

Cardiovascular disease (CVD) comprises a range of major clinical cardiac and circulatory diseases, which produce immense health and economic burdens worldwide. Currently, vascular regenerative surgery represents the most employed therapeutic option to treat ischemic disorders, even though not all the patients are amenable to surgical revascularization. Therefore, more efficient therapeutic approaches are urgently required to promote neovascularization. Therapeutic angiogenesis represents an emerging strategy that aims at reconstructing the damaged vascular network by stimulating local angiogenesis and/or promoting de novo blood vessel formation according to a process known as vasculogenesis. In turn, circulating endothelial colony‐forming cells (ECFCs) represent truly endothelial precursors, which display high clonogenic potential and have the documented ability to originate de novo blood vessels in vivo. Therefore, ECFCs are regarded as the most promising cellular candidate to promote therapeutic angiogenesis in patients suffering from CVD. The current briefly summarizes the available information about the origin and characterization of ECFCs and then widely illustrates the preclinical studies that assessed their regenerative efficacy in a variety of ischemic disorders, including acute myocardial infarction, peripheral artery disease, ischemic brain disease, and retinopathy. Then, we describe the most common pharmacological, genetic, and epigenetic strategies employed to enhance the vasoreparative potential of autologous ECFCs by manipulating crucial pro‐angiogenic signaling pathways, e.g., extracellular‐signal regulated kinase/Akt, phosphoinositide 3‐kinase, and Ca2+ signaling. We conclude by discussing the possibility of targeting circulating ECFCs to rescue their dysfunctional phenotype and promote neovascularization in the presence of CVD

The WINPack 1 a novel wearable system for heart rate and vital signs monitoring

n/

Scientific prospects in soft gamma-ray astronomy enabled by the LAUE project

This paper summarizes the development of a successful project, LAUE, supported by the Italian Space Agency (ASI) and devoted to the development of long focal length (up to 100 m) Laue lenses for hard X--/soft gamma--ray astronomy (80-600 keV). The apparatus is ready and the assembling of a prototype lens petal is ongoing. The great achievement of this project is the use of bent crystals. From measurements obtained on single crystals and from simulations, we have estimated the expected Point Spread Function and thus the sensitivity of a lens made of petals. The expected sensitivity is a few $\times10^{-8}$ photons cm$^{-2}$ s$^{-1}$ keV$^{-1}$. We discuss a number of open astrophysical questions that can settled with such an instrument aboard a free-flying satellite.Comment: 17 pages, 18 figures, published in Proceedings of the SPIE, Volume 8861, id. 886106 17 pp. (2013