Regioselective zincation of indazoles using TMP2Zn and Negishi cross-coupling with aryl and heteroaryl iodides.

The metalation of various SEM-protected functionalized indazoles with TMP2Zn provides 3-zincated indazoles which undergo palladium-catalyzed Negishi cross-couplings in good yields

Precision study of B^* B\pi coupling for the static heavy-light meson

We compute the B^*B\pi coupling \hat{g}_{\infty} for static heavy-light meson using all-to-all propagators. It is shown that low-mode averaging with 100 low-lying eigenmodes indeed improves the signal for the 2-point and 3-point functions for heavy-light meson significantly. Our study suggests that the all-to-all propagator will be a very efficient method for high precision computation of the B^*B\pi coupling especially in unquenched QCD where the number of configurations is limited.Comment: 30 pages, 25 figures, typos correcte

Model of the Classification of English Vowels by Spanish Speakers

A number of models of single language vowel classification based on formant representations have been proposed. We propose a new model that explicitly predicts vowel perception by second language (L2) learners based on the phonological map of their native language (Ll). The model represents the vowels using polar coordinates in the F l-F2 formant space. Boundaries bisect the angles made by two adjacent category centroids. An L2 vowel is classified with the closest Ll vowel with a probability based on the angular difference of the L2 vowel and the Ll vowel boundary. The polar coordinate model is compared with other vowel classification models, such as the quadratic discriminant analysis method used by Hillenbrand and Gay vert [J. Speech Hear. Research, 36, 694-700, 1993] and the logistic regression analysis method adopted by Nearey [J. Phonetics, 18, 347-373, 1990]. All models were trained on Spanish vowel data and tested on English vowels. The results were compared with behavioral data obtained by Flege [Q. J. Exp. Psych., 43 A(3), 701-731 (1991)] for Spanish monolingual speakers identifying English vowels. The polar coordinate model outperformed the other models in matching its predictions most closely with the behavioral data.National Institute on Deafness and other Communication Disorders (R29 02852); Alfred P. Sloan Foundatio

Phenylpropanoid 2,3-dioxygenase involved in the cleavage of the ferulic acid side chain to form vanillin and glyoxylic acid in Vanilla planifolia

Enzyme catalyzing the cleavage of the phenylpropanoid side chain was partially purified by ion exchange and gel filtration column chromatography after (NH4)2SO4 precipitation. Enzyme activities were dependent on the concentration of dithiothreitol (DTT) or glutathione (GSH) and activated by addition of 0.5 mM Fe2+. Enzyme activity for ferulic acid was as high as for 4-coumaric acid in the presence of GSH, suggesting that GSH acts as an endogenous reductant in vanillin biosynthesis. Analyses of the enzymatic reaction products with quantitative NMR (qNMR) indicated that an amount of glyoxylic acid (GA) proportional to vanillin was released from ferulic acid by the enzymatic reaction. These results suggest that phenylpropanoid 2,3-dioxygenase is involved in the cleavage of the ferulic acid side chain to form vanillin and GA in Vanilla planifolia

Smallness of a commodity and partial equilibrium analysis

Partial equilibrium analysis has a conceptual dilemma that its object should be negligibly small in order to be free from income effect but then the consumer does not care for it and the notion of willingness to pay for it does not make sense. In the setting of a continuum of commodities, we propose a limiting procedure which transforms the general many-commodity framework into a partial single-commodity framework. In the limit, willingness to pay for a commodity is established as a density notion and it is shown to be free from income effect. This pins down an exact relationship between general equilibrium analysis and partial equilibrium analysis

Picard-Fuchs equations of the Dwork family

We give explicitly the Picard-Fuchs equations for every cohomology class of the Dwork family. The proof is done by showing that periods satisfy suitable GKZ hypergeometric systems.Comment: 8 page