Cerebrospinal fluid biomarker candidates associated with human WNV neuroinvasive disease

During the last decade, the epidemiology of WNV in humans has changed in the southern regions of Europe, with high incidence of West Nile fever (WNF) cases, but also of West Nile neuroinvasive disease (WNND). The lack of human vaccine or specific treatment against WNV infection imparts a pressing need to characterize indicators associated with neurological involvement. By its intimacy with central nervous system (CNS) structures, modifications in the cerebrospinal fluid (CSF) composition could accurately reflect CNS pathological process. Until now, few studies investigated the association between imbalance of CSF elements and severity of WNV infection. The aim of the present study was to apply the iTRAQ technology in order to identify the CSF proteins whose abundances are modified in patients with WNND. Forty-seven proteins were found modified in the CSF of WNND patients as compared to control groups, and most of them are reported for the first time in the context of WNND. On the basis of their known biological functions, several of these proteins were associated with inflammatory response. Among them, Defensin-1 alpha (DEFA1), a protein reported with anti-viral effects, presente

Value co-creation in service interactions: dimensions and antecedents

Contains fulltext : 119106.pdf (publisher's version ) (Open Access)The purpose of this article is to further develop the conceptualization of value co-creation and discuss its dimensions and antecedents. We propose that in service interactions, value co-creation should be understood as a joint collaborative activity between service employees and customers consisting of six dimensions, which correspond to simpler joint actions (individuated, relational, empowered, ethical, developmental and concerted joint actions). Furthermore, we address communicating, relating and knowing as antecedents of value co-creation. This article is among the first to propose an analytical framework for the study of value co-creation and can drive both future research and guide managers interested in implementing the service logic principles.Quis Conference, 10 juni 201

Value cocreation in service interactions:Dimensions and antecedents

The purpose of this article is to further develop the conceptualization of value cocreation by discussing its dimensions and antecedents. We propose that in service interactions, value cocreation should be understood as a joint collaborative activity between service employees and customers, consisting of six dimensions, which correspond to simpler joint actions (individuating, relating, empowering, ethical, developmental, and concerted joint actions). Furthermore, we derive propositions about nine antecedents of value cocreation labeled as communicating, relating, and knowing factors. This article is among the first to propose a conceptually richer understanding of value cocreation illustrated via an analytical framework, which can drive both future research and guide managers interested in implementing the service-dominant logic (S-D logic) principles within their service providing firms. </jats:p

Hydatidosis of the central nervous system in central and Eastern Europe

Hydatidosis (also known as echinococcosis or hydatid disease) is one of Europe's neglected infections of poverty. Cystic echinococcosis (CE) is endemic in Southwestern and Eastern parts of Europe. Although alveolar echinococcosis was considered a rare disease in Central Europe, recent studies have shown its emerging nature and demonstrated that the endemic areas for this parasite are broader than previously thought. This chapter aims not only to review but also to bring to light new epidemiological and clinical data regarding hydatidosis of the central nervous system (CNS) in the countries of Eastern and Central Europe where information was available. At the same time, we intend to shed light on particular or interesting cases reported in the literature. Special emphasis will be given to the casuistic from Romania, listed in 1995 among the countries with the highest prevalence of CE worldwide and where, in the past, at least one person from 45.5 % of its localities underwent surgery for CE. Although rare in Central and Eastern Europe, hydatidosis of the CNS should always be considered in the differential diagnosis of any patient with seizures, focal neurological deficits, and symptoms of increased intracranial pressure, especially when that person comes from regions with high disease prevalence