74 research outputs found

    Deterministic Modeling for Evaluating Consumers’ Attitude towards Telecommunication Service in Bangladesh

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    This study is conducted empirically for measuring consumers’ attitude towards telecommunication service in Bangladesh. A conceptual model has been developed based on two constructs. Telecommunication service related intrinsic and intrinsic constructs where five individual attributes (network availability, service quality, service charge strategies, offered value, brand image) are included. A series of analysis technique (arithmetic means) are used to find out the weighted average of intrinsic & extrinsic attributes, which are considered by Bangladeshi consumers for using telecommunication service. Fishbein’s Multiattribute Attitude Model has been used for measuring the overall attitude of consumers toward telecommunication service in Bangladesh, which could help for successful business operations, management, and long-term sustainability of attitude measurement in order to improve product or service quality as per consumer expectation leve

    Host and microbiome features of secondary infections in lethal covid-19

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    Secondary infections contribute significantly to covid-19 mortality but driving factors remain poorly understood. Autopsies of 20 covid-19 cases and 14 controls from the first pandemic wave complemented with microbial cultivation and RNA-seq from lung tissues enabled description of major organ pathologies and specification of secondary infections. Lethal covid-19 segregated into two main death causes with either dominant diffuse alveolar damage (DAD) or secondary pneumonias. The lung microbiome in covid-19 showed a reduced biodiversity and increased prototypical bacterial and fungal pathogens in cases of secondary pneumonias. RNA-seq distinctly mirrored death causes and stratified DAD cases into subgroups with differing cellular compositions identifying myeloid cells, macrophages and complement C1q as strong separating factors suggesting a pathophysiological link. Together with a prominent induction of inhibitory immune-checkpoints our study highlights profound alterations of the lung immunity in covid-19 wherein a reduced antimicrobial defense likely drives development of secondary infections on top of SARS-CoV-2 infection

    The Relationship of Maternal Prepregnancy Body Mass Index and Pregnancy Weight Gain to Neurocognitive Function at Age 10 Years among Children Born Extremely Preterm

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    OBJECTIVE: To assess the association between maternal prepregnancy body mass index and adequacy of pregnancy weight gain in relation to neurocognitive function in school-aged children born extremely preterm. STUDY DESIGN: Study participants were 535 ten-year-old children enrolled previously in the prospective multicenter Extremely Low Gestational Age Newborns cohort study who were products of singleton pregnancies. Soon after delivery, mothers provided information about prepregnancy weight. Prepregnancy body mass index and adequacy of weight gain were characterized based on this information. Children underwent a neurocognitive evaluation at 10 years of age. RESULTS: Maternal prepregnancy obesity was associated with increased odds of a lower score for Differential Ability Scales-II Verbal IQ, for Developmental Neuropsychological Assessment-II measures of processing speed and visual fine motor control, and for Wechsler Individual Achievement Test-III Spelling. Children born to mothers who gained an excessive amount of weight were at increased odds of a low score on the Oral and Written Language Scales Oral Expression assessment. Conversely, children whose mother did not gain an adequate amount of weight were at increased odds of a lower score on the Oral and Written Language Scales Oral Expression and Wechsler Individual Achievement Test-III Word Reading assessments. CONCLUSION: In this cohort of infants born extremely preterm, maternal obesity was associated with poorer performance on some assessments of neurocognitive function. Our findings are consistent with the observational and experimental literature and suggest that opportunities may exist to mitigate risk through education and behavioral intervention before pregnancy

    Extremely low gestational age and very low birthweight for gestational age are risk factors for autism spectrum disorder in a large cohort study of 10-year-old children born at 23-27 weeks’ gestation

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    No prospective cohort study of high-risk children has used rigorous exposure assessment and optimal diagnostic procedures to examine the perinatal antecedents of autism spectrum disorder (ASD), separately among those with and without cognitive impairment

    Estimation of the electron temperature in a Li2C03 ablative capillary discharge

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    The electron temperature in a Li2CO3 ablative capillary discharge has been estimated on the base of soft x-ray spectral line intensity measurements and of evaluations of steady-state ionization and population fractions for the mixture of lithium, carbon and oxygen. The discrepancy in the peak temperatures, estimated from spectral measurements and calculated by one-dimensional MHD and time dependent collisional-radiative codes, is explained by an initial overheating of the plasma electrons
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