Şanlıurfa'daki Birinci Trimester Gebelerde Hemoglobin, Ferritin, B12, Folat ve D Vitamini Seviyeleri

Amaç: Gebelerdeki vitamin takviyesi obstetrik sonuçlar açısından önemlidir. Beslenme alışkanlıkları et ağırlıklı olan ve bol güneşli ilimizdeki gebelerin ulusal kılavuzlarda önerilen takviyelere olan gerçek ihtiyacı bilinmemektedir. Bu yüzden çalışmamızda, ilimizdeki gebelerin hemoglobin, ferritin, B12, folat ve D vitamini seviyeleri ve desteğe olan ihtiyaçları araştırıldı.Gereç ve Yöntem: Haziran 2018 ve Aralık 2018 tarihleri arasında kadın doğum polikliniğine başvuran 17845 gebenin verisi incelendi. Hastalardan takviye ilaç kullanmayan ve birinci trimesterde hemoglobin, ferritin, B12, folat ve D vitamini istenen 200 gebe çalışmaya dahil edildi. Gebelerin demografik özellikleri tanımlayıcı istatistiksel yöntemlerle belirlendi. Çalışma grubumuzdaki gebeler iki doğum arasındaki süreye göre ve hemoglobin, ferritin, B12, folat ve D vitamini konsantrasyonlarının seviyelerine göre gruplandırılarak sonuçları incelendi.Bulgular: Hastaların hemogram, ferritin, vitamin B12 ve folat konsantrasyonları normal sınırlarda iken, çalışmaya dahil edilen tüm gebelerde bir önceki gebeliği ile mevcut gebeliği arasındaki süre dikkate alınmadan D vitamini düzeyleri ciddi düşük 20 ng/mL’nin altında bulundu. İlaveten yaşı 26’nın altında olan gebelerde B12 seviyeleri anlamlı olarak daha düşüktü. Sonuç: D Vitamini eksikliği ilimizde sık görülen bir sağlık sorunudur ve güneşli günlerin yaygın olduğu bölgemizde yaşayan gebeler için gizli bir risk faktörüdür. İlaveten nöral tüp defekti etiyolojisinde rol oynadığından özellikle daha genç hasta grubunda B12 vitamini takviyesi, hayvansal temelli diyetin yaygın olduğu yerlerde bile prekonsepsiyonel olarak değerlendirilmelidi

Clinical Characteristics and Visual Outcomes of Pediatric Optic Neuritis: A Single Center Experience

INTRODUCTION: The aim of this study was to describe the clinical characteristics, visual outcomes of pediatric patients presenting with first-episode of optic neuritis. METHODS: We reviewed medical records of the patients newly diagnosed with optic neuritis younger than 18 years between January 2014 and December 2018 retrospectively. RESULTS: Twenty-eight patients were included to this study. The mean age at first onset of optic neuritis was 13.2+-3.1 years (range 6.2-17.3 years). The mean follow-up period was 4.2+-3.2 (range 0.6-13.08) years. 7 of 28 (25%) patients had recurrent optic neuritis. Optic neuritis involvement was unilateral in 17 of 28 (60%) patients. Forty percent of the patients had idiopathic optic neuritis. Of the six patients with demyelinating lesions in cranial magnetic resonance imaging (MRI) at the first admission, three were diagnosed with multiple sclerosis (MS) at the time of first optic neuritis attack, and three were diagnosed within 13.4+-4.8 months after the first episode. Eight of 21 optic neuritis patients (38%) had oligoclonal band positivity and the incidence of MS was significantly higher in these patients (p=0.014). The mean visual acuity at nadir was 0.48+-0.27 at admission. Whereas it was 0.74+-0.31 and 0.76+-0.33 at 1 and 6 months respectively. There was a strong correlation between first and sixth-month visual acuity (r=0.98, p=0.00). DISCUSSION AND CONCLUSION: Our study demonstrated that poor visual acuity (worse than 0.5) at 1 month can predict poor vision at 6 months. The patients with demyelinating lesions in cranial MRI at their first optic neuritis episode, are more likely to develop MS during the follow-up

The interrelations of radiologic findings and mechanical ventilation in community acquired pneumonia patients admitted to the intensive care unit: a multicentre retrospective study

BACKGROUND: We evaluated patients admitted to the intensive care units with the diagnosis of community acquired pneumonia (CAP) regarding initial radiographic findings. METHODS: A multicenter retrospective study was held. Chest x ray (CXR) and computerized tomography (CT) findings and also their associations with the need of ventilator support were evaluated. RESULTS: A total of 388 patients were enrolled. Consolidation was the main finding on CXR (89%) and CT (80%) examinations. Of all, 45% had multi-lobar involvement. Bilateral involvement was found in 40% and 44% on CXR and CT respectively. Abscesses and cavitations were rarely found. The highest correlation between CT and CXR findings was observed for interstitial involvement. More than 80% of patients needed ventilator support. Noninvasive mechanical ventilation (NIV) requirement was seen to be more common in those with multi-lobar involvement on CXR as 2.4-fold and consolidation on CT as 47-fold compared with those who do not have these findings. Invasive mechanical ventilation (IMV) need increased 8-fold in patients with multi-lobar involvement on CT. CONCLUSION: CXR and CT findings correlate up to a limit in terms of interstitial involvement but not in high percentages in other findings. CAP patients who are admitted to the ICU are severe cases frequently requiring ventilator support. Initial CT and CXR findings may indicate the need for ventilator support, but the assumed ongoing real practice is important and the value of radiologic evaluation beyond clinical findings to predict the mechanical ventilation need is subject for further evaluation with large patient series

Synthesis, structural characterization and DNA interaction of zinc complex from 2,6-diacetylpyridine dihydrazone and {4-[(2E)-2-(hydroxyimino)acetyl]phenoxy} acetic acid

WOS: 000351800900007PubMed: 25704313A new water soluble zinc complex has been prepared and structurally characterized. The Zn(II) complex was synthesized by the reaction of 2,6-diacetylpyridine dihydrazone (dph) with {4-[(2E)-2-(hydroxyimino) acetyl]phenoxy} acetic acid (H2L) in the presence of zinc(II) acetate. Single crystal X-ray diffraction study revealed that the zinc ion is situated in distorted trigonal-bipyramidal environment where the equatorial position is occupied by the nitrogen atom of pyridine ring and the oxygen atoms of acetate groups of two oxime ligands (H2L) whereas the axial positions of the zinc complex are occupied by the imine nitrogen atoms of dph ligand. Characterization of the complex with FTIR, H-1 and C-13 NMR, UV-vis and elemental analysis also confirmed the proposed structure. Interaction of the Zn(II) complex with calf-thymus DNA (CT-DNA) was investigated through UV-vis spectroscopy and viscosity measurements. The results suggest that the complex preferably bind to DNA through the groove binding mode. The zinc complex cleaves plasmid pBR 322 DNA in the presence and absence of an oxidative agent (H2O2), possibly through a hydrolytic pathway which is also supported by DNA cleave experiments in the presence of different radical scavengers. The nuclease activity of the zinc complex significantly depends on concentration of the complex and incubation time both in the presence and absence of H2O2. DNA cleave activity is inhibited in the presence of methyl green indicating that the zinc complex seems to bind the major groove of DNA. (C) 2015 Elsevier B.V. All rights reserved.Scientific and Technological Research Council of Turkey - Turkey (TUBITAK) [TBAG-112T315]; Aksaray University, Science and Technology Application and Research Center, Turkey (State of Planning Organization) [2010K120480]This work was funded by the Scientific and Technological Research Council of Turkey - Turkey (TUBITAK, TBAG-112T315). The authors acknowledge the Aksaray University, Science and Technology Application and Research Center, Turkey, for the use of the Bruker Smart Breeze CCD diffractometer (purchased under-grant 2010K120480 of the State of Planning Organization)

Seven coordinated cobalt(II) complexes with 2,6-diacetylpyridine bis(4-acylhydrazone) ligands: Synthesis, characterization, DNA-binding and nuclease activity

WOS: 000355127300028A new series of pentadentate 2,6-diacetylpyridine bis(4-acylhydrazone)s (H2L1 and H2L2) based seven-coordinated cobalt(II) complexes, [Co(L-n)X-2] (n = 1 and X = DMF for (1); n = 2 and X = H2O for (2)); [Co(H2Ln)Y-2] (n = 1 or 2; Y = N-3 or NCS ), has been synthesized and characterized by using spectroscopic techniques. Single crystal X-ray study of [Co(L-1)(DMF)(2)] (1) complex exhibits pentagonal-bipyramidal coordination geometry where the pentadentate N3O2 ligand in the equatorial plane of the bipyramid and two dimethylformamide molecules in the axial area. Interaction of the cobalt(II) complexes with CT DNA has been investigated by absorption titration method and viscosity measurements which reveal that the cobalt(II) complexes could bind with CT DNA through intercalation. Cleavage activity of the complexes (1) and (2) with pBR 322 plasmid DNA was evaluated by agarose gel electrophoresis demonstrating that the ability of the complexes to cleave the pBR 322 plasmid DNA via oxidative pathway, possibly due to the involvement of a diffusible hydroxyl radical mechanism in presence and absence of an oxidative agent. The nuclease activity of the Co(II) complexes has strong dependence on the concentration of complex and reaction time, both in presence and absence of hydrogen peroxide.Scientific and Technological Research Council of Turkey (TUBITAK) [TBAG-112T315]This work was funded by the Scientific and Technological Research Council of Turkey (TUBITAK, TBAG-112T315)

4-Butoxy-N′-[1-(4-methylphenyl)ethylidene]benzohydrazide

The molecule of the title compound, C20H24N2O2, exists in a trans conformation with respect to the C=N bond. The dihedral angle between the benzene rings is 79.0 (1)°. In the crystal, N—H...O hydrogen bonds link the molecules into chains propagating in [001]. Two weak C—H...O interactions also occur

One-pot synthesis of a new 2-substituted 1,2,3-triazole 1-oxide derivative from dipyridyl ketone and isonitrosoacetophenone hydrazone: Nickel(II) complex, DNA binding and cleavage properties

WOS: 000404534300033PubMed: 28285876An efficient and simple one-pot synthesis of a new 1,2,3-triazole-1-oxide via reaction between isonitrosoacetophenone hydrazone and dipyridyl ketone in the EtOH/AcOH at room temperature has been developed smoothly in high yield. The reaction proceeds via metal salt free, in-situ formation of asymmetric azine followed by cyclization to provide 1,2,3-triazole 1-oxide compound. It has been structurally characterized. The 1:1 ratio reaction of the 1,2,3-triazole 1-oxide ligand with nickel(II) chloride gives the mononuclear complex [Ni(L)(DMF)Cl-2], hexa-coordinated within an octahedral geometry. Characterization of the 1,2,3-triazole compound and its Ni(II) complex with FTIR, H-1 and C-13 NMR, UV-vis and elemental analysis also confirms the proposed structures of the compounds. The interactions of the compounds with Calf thymus DNA (CT-DNA) have been investigated by UV-visible spectra and viscosity measurements. The results suggested that both ligand and Ni(II) complex bind to DNA in electrostatic interaction and/or groove binding, also with a slight partial intercalation in the case of ligand. DNA cleavage experiments have been also investigated by agarose gel electrophoresis in the presence and absence of an oxidative agent (H2O2). Both 1,2,3-triazole 1-oxide ligand and its nickel(II) complex show nuclease activity in the presence of hydrogen peroxide. DNA binding and cleavage affinities of the 1,2,3-triazole 1-oxide ligand is stronger than that of the Ni(II) complex.Scientific Research Projects Foundation of Mugla Sitki Kocman University (BAP) [13-169]We thank the Scientific Research Projects Foundation of Mugla Sitki Kocman University for financial support of this work (BAP No: 13-169)

Seven-coordinated cobalt(II) complexes with 2,6-diacetylpyridine bis(4-hydroxybenzoylhydrazone): synthesis, characterisation, DNA binding and cleavage properties

WOS: 000362878300001Synthesis and characterisation of three seven-coordinated cobalt(II) complexes of 2,6-diacetylpyridine bis(4-hydroxybenzoylhydrazone) (H4L) ligand, [Co(H2L)(H2O)(2)] (1), [Co(H4L)(N-3)(2)] (2) and [Co(H4L)(NCS)(2)] (3) are described. The structures of the complexes were characterised by elemental analysis, IR, UV-vis and magnetic susceptibility measurement. The molecular structure of the [Co(H4L)(NCS)(2)] (3) was also determined by X-ray crystallography. Single crystal X-ray revealed that the Co(II) complex (3) has a pentagonal-bipyramidal coordination geometry, with pentadentate N3O2 ligand in the equatorial plane of the bipyramid and two isothiocyanato groups in the axial area. Interaction of the cobalt(II) complexes with CT-DNA was investigated by absorption titration method and viscosity measurements. Cleavage activity of the complexes with pBR 322 plasmid DNA was evaluated by agarose gel electrophoresis in presence and absence of an oxidative agent, and the mechanism of DNA cleavage was investigated. The results suggest that the cobalt(II) complexes bind effectively and they exhibit nuclease activity, which has strong dependence on the concentration of complex and reaction time, both in presence and absence of hydrogen peroxide.Scientific and Technological Research Council of Turkey [TUBITAK] [TBAG-112T315]This work was funded by the Scientific and Technological Research Council of Turkey [TUBITAK, TBAG-112T315]

Crystal structure of (2E)-1-(4-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one

The compound, C16H14O3, (except H atoms) is almost planar [r.m.s. deviations for all non-H atoms = 0.001 Å] and the dihedral angle between the aromatic rings is 9.35 (7)°. In the crystal, molecules are linked by intermolecular O—H···O and C—H···O hydrogen bonds, forming a three-dimensional network structure. Furthermore, a weak π-π stacking interactions [centroid-to-centroid distance = 3.7055 (9) Å] contributes to the stabilization of the molecular packing. Crystal Data for C16H14O3 (M = 254.27 g/mol): Orthorhombic, space group Pbca (no. 61), a = 13.4563(16) Å, b = 11.4986(14) Å, c = 16.720(2) Å, V = 2587.1(5) Å3, Z = 8, T = 296(2) K, μ(MoKα) = 0.090 mm-1, Dcalc = 1.306 g/cm3, 61402 reflections measured (4.88° ≤ 2Θ ≤ 56.76°), 3240 unique (Rint = 0.0334, Rsigma = 0.0120) which were used in all calculations. The final R1 was 0.0438 (I≥2σ(I)) and wR2 was 0.1228 (all data)