Innovative development of higher educational institutions of Ukraine as the factor to increase competitiveness

В статті розглянуто проблеми інноваційного розвитку вищих навчальних закладів України, систематизовано чинники формування стратегії інноваційного розвитку ВНЗ в контексті забезпечення їх конкурентоспроможності. Визначено основні форми переходу ВНЗ до інноваційної моделі сучасного університету – інноваційну матричну структуру та створення відокремленого підрозділу управління інноваціями.В статье рассмотрены проблемы инновационного развития высших учебных заведений Украины, систематизированы факторы формирования стратегии инновационного развития вуза в контексте обеспечения их конкурентоспособности. Определены основные формы перехода вузов к инновационной модели современного университета - инновационную матричную структуру и создание обособленного подразделения управления инновациями.The article considers problems of innovative development of higher educational institutions of Ukraine, systemises factors of strategy formation of innovative development at the University in the context of ensuring its competitiveness. There have been defined the basic forms of the universities transition to the innovation model of university - innovative matrix structure and creation of a separate division for managing innovation

The Induction of APC with a Distinct Tolerogenic Phenotype via Contact-Dependent STAT3 Activation

BACKGROUND: Activation of the signal transducer and activator of transcription 3 (STAT3) within antigen presenting cells (APCs) is linked to abnormal APCs differentiation and function. We have previously shown that STAT3 is activated within APC by a novel contact-dependent mechanism, which plays a key role in mediating the immunomodulatory effects of hMSC. In order to better understand the underlying mechanisms that control APC maturation in a contact dependent manner, we extended our observation to tumor cells. Tumors were shown to secrete a variety of tumor-derived factors that activate STAT3 within infiltrating APCs. We now tested whether tumor cells can activate STAT3 within APC using the contact-dependent mechanism, in addition to soluble factors, and compared these two STAT3 activating pathways. PRINCIPAL FINDINGS: We demonstrate that in addition to tumor-derived secreted factors tumor cells activate STAT3 by a mechanism that is based on cell-cell interaction. We further demonstrate that these two STAT3 activating mechanisms differ in their JAK usage and their susceptibility to JSI-124 inhibition thereby representing two distinct pathways. Significantly, although both pathways activate STAT3, they modulate DCs maturation in a different manner that results in disparate phenotypic outcomes. Whereas the soluble-dependent pathway results in an immature phenotype, the contact-dependent pathway results in an apparently mature phenotype. Albeit their mature-like phenotype these latter cells express the tolerogenic markers ILT3 and ILT4 and possess T cell inhibitory activity. SIGNIFICANCE: This data suggests that, in at least certain cellular microenvironments, cell:cell interactions represent a novel way to activate STAT3 signaling, uncouple APC activation events and consequently regulate immunity and tolerance. Significantly, we have now demonstrated that this contact-dependent signaling pathway differs from that mediated by soluble factors and cytokines, inducing disparate phenotypic outcome, suggesting these two mechanisms have different and possibly complementary biological functions

General Motor Skills Dynamics in Preschoolers with Intellectual Development Disorder

Статья посвящена раскрытию особенностей двигательной сферы детей дошкольного возраста с задержкой психического развития и с легкой умственной отсталостью.The article describes the peculiarities of the motor system of children with disorders of psychological development (DPD) and mild intellectual disability brought up in preschool institutions

Biodegradable detergents in household use

The purpose of the study. Compare the composition of biodegradable and non-biodegradable detergents, evaluate the popularity and availability of biodegradable detergents as a substitute for synthetic non-biodegradable products.Цель исследования - сравнить состав биоразлагаемых и небиоразлагаемых моющих средств, оценить популярность и доступность биоразлагаемых моющих средств в качестве замены синтетическим небиоразлагаемым средствам

Antimicrobial activity ofspices

The purpose of the study - to analyze the literature data in the field of antimicrobial activity of spices.Цель исследования –проанализировать данные литературы в области антимикробной активности специй

Hygienic assessment of actual nutrition in preschool and its role in the physical development of preschoolers

The purpose of the study is to analyze nutrition according to menu layouts in preschool and assess its impact on the physical development of children 6-7 years old.Цель исследования – проанализировать питание по меню-раскладкам в ДОУ и оценить его влияние на физическое развитие детей 6-7 лет

Bacterial contamination of food products with violations in the technological process as a factor in the occurrence of acute intestinal infections

The aim of the study – to conduct a hygienic assessment of the results of laboratory studies of finished products (chicken semi–finished products) of the Reftinskaya poultry farm (hereinafter referred to as Reftinskaya PF) conducted within the framework of control and supervisory measures, to assess the frequency of occurrence of OKI depending on the safety of the products used by Reftinskaya PF.Цель исследования – провести гигиеническую оценку результатов лабораторных исследований готовой продукции (куриных полуфабрикатов) птицефабрики «Рефтинская» (далее – ПФ «Рефтинская), проведенных в рамках контрольно-надзорных мероприятий, оценить частоту возникновения ОКИв зависимости отбезопасностиупотребляемой продукции ПФ «Рефтинская»

Hygienic literacy among students of grades 7-11 about the adverse effect of fast food on the body

The purpose of the study is to assess the attitude and awareness about fast food (fast food) among schoolchildren of grades 7-11.Цель исследования – оценить отношение и информированность о фаст-фуде (быстром питании) среди школьников 7-11 классов