A tutorial task and tertiary courseware model for collaborative learning communities

RAED provides a computerised infrastructure to support the development and administration of Vicarious Learning in collaborative learning communities spread across multiple universities and workplaces. The system is based on the OASIS middleware for Role-based Access Control. This paper describes the origins of the model and the approach to implementation and outlines some of its benefits to collaborative teachers and learners

Direct imaging of a digital-micromirror device for configurable microscopic optical potentials

Programable spatial light modulators (SLMs) have significantly advanced the configurable optical trapping of particles. Typically, these devices are utilized in the Fourier plane of an optical system, but direct imaging of an amplitude pattern can potentially result in increased simplicity and computational speed. Here we demonstrate high-resolution direct imaging of a digital micromirror device (DMD) at high numerical apertures (NA), which we apply to the optical trapping of a Bose-Einstein condensate (BEC). We utilise a (1200 x 1920) pixel DMD and commercially available 0.45 NA microscope objectives, finding that atoms confined in a hybrid optical/magnetic or all-optical potential can be patterned using repulsive blue-detuned (532 nm) light with 630(10) nm full-width at half-maximum (FWHM) resolution, within 5% of the diffraction limit. The result is near arbitrary control of the density the BEC without the need for expensive custom optics. We also introduce the technique of time-averaged DMD potentials, demonstrating the ability to produce multiple grayscale levels with minimal heating of the atomic cloud, by utilising the high switching speed (20 kHz maximum) of the DMD. These techniques will enable the realization and control of diverse optical potentials for superfluid dynamics and atomtronics applications with quantum gases. The performance of this system in a direct imaging configuration has wider application for optical trapping at non-trivial NAs.Comment: 9 page

Dynamic and Energetic Stabilization of Persistent Currents in Bose-Einstein Condensates

We study conditions under which vortices in a highly oblate harmonically trapped Bose-Einstein condensate (BEC) can be stabilized due to pinning by a blue-detuned Gaussian laser beam, with particular emphasis on the potentially destabilizing effects of laser beam positioning within the BEC. Our approach involves theoretical and numerical exploration of dynamically and energetically stable pinning of vortices with winding number up to $S=6$, in correspondence with experimental observations. Stable pinning is quantified theoretically via Bogoliubov-de Gennes excitation spectrum computations and confirmed via direct numerical simulations for a range of conditions similar to those of experimental observations. The theoretical and numerical results indicate that the pinned winding number, or equivalently the winding number of the superfluid current about the laser beam, decays as a laser beam of fixed intensity moves away from the BEC center. Our theoretical analysis helps explain previous experimental observations, and helps define limits of stable vortex pinning for future experiments involving vortex manipulation by laser beams.Comment: 8 pages 5 figure

Enhancement and suppression in a lexical interference fMRI-paradigm

Previous picture-word interference (PWI) fMRI-paradigms revealed ambiguous mechanisms underlying facilitation and inhibition in healthy subjects. Lexical distractors revealed increased (enhancement) or decreased (suppression) activation in language and monitoring/control areas. Performing a secondary examination and data analysis, we aimed to illuminate the relation between behavioral and neural interference effects comparing target-related distractors (REL) with unrelated distractors (UNREL). We hypothesized that interference involves both (A) suppression due to priming and (B) enhancement due to simultaneous distractor and target processing. Comparisons to UNREL should remain distractor unspecific even at a low threshold. (C) Distractor types with common characteristics should reveal overlapping brain areas. In a 3T MRI scanner, participants were asked to name pictures while auditory words were presented (stimulus onset asynchrony [SOA] = –200 msec). Associatively and phonologically related distractors speeded responses (facilitation), while categorically related distractors slowed them down (inhibition) compared to UNREL. As a result, (A) reduced brain activations indeed resembled previously reported patterns of neural priming. Each target-related distractor yielded suppressions at least in areas associated with vision and conflict/competition monitoring (anterior cingulate cortex [ACC]), revealing least priming for inhibitors. (B) Enhancements concerned language-related but distractor-unspecific regions. (C) Some wider brain regions were commonly suppressed for combinations of distractor types. Overlapping areas associated with conceptual priming were found for facilitatory distractors (inferior frontal gyri), and areas related to phonetic/articulatory processing (precentral gyri and left parietal operculum/insula) for distractors sharing feature overlap. Each distractor with semantic relatedness revealed nonoverlapping suppressions in lexical-phonological areas (superior temporal regions). To conclude, interference combines suppression of areas well known from neural priming and enhancement of language-related areas caused by dual activation from target and distractor. Differences between interference and priming need to be taken into account. The present interference paradigm has the potential to reveal the functioning of word-processing stages, cognitive control, and responsiveness to priming at the same time

Characteristics of Two-Dimensional Quantum Turbulence in a Compressible Superfluid

Under suitable forcing a fluid exhibits turbulence, with characteristics strongly affected by the fluid's confining geometry. Here we study two-dimensional quantum turbulence in a highly oblate Bose-Einstein condensate in an annular trap. As a compressible quantum fluid, this system affords a rich phenomenology, allowing coupling between vortex and acoustic energy. Small-scale stirring generates an experimentally observed disordered vortex distribution that evolves into large-scale flow in the form of a persistent current. Numerical simulation of the experiment reveals additional characteristics of two-dimensional quantum turbulence: spontaneous clustering of same-circulation vortices, and an incompressible energy spectrum with $k^{-5/3}$ dependence for low wavenumbers $k$ and $k^{-3}$ dependence for high $k$.Comment: 7 pages, 7 figures. Reference [29] updated for v

Soft X-ray harmonic comb from relativistic electron spikes

We demonstrate a new high-order harmonic generation mechanism reaching the `water window' spectral region in experiments with multi-terawatt femtosecond lasers irradiating gas jets. A few hundred harmonic orders are resolved, giving uJ/sr pulses. Harmonics are collectively emitted by an oscillating electron spike formed at the joint of the boundaries of a cavity and bow wave created by a relativistically self-focusing laser in underdense plasma. The spike sharpness and stability are explained by catastrophe theory. The mechanism is corroborated by particle-in-cell simulations

Phenotype standardization for statin-induced myotoxicity

Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis. Research in this area has been hampered to some extent by the lack of standardized nomenclature and phenotypic definitions. We have used numerical and descriptive classifications and developed an algorithm to define statin-related myotoxicity phenotypes, including myalgia, myopathy, rhabdomyolysis, and necrotizing autoimmune myopathy.</p