Prospects for intermediate mass black hole binary searches with advanced gravitational-wave detectors

We estimated the sensitivity of the upcoming advanced, ground-based gravitational-wave observatories (the upgraded LIGO and Virgo and the KAGRA interferometers) to coalescing intermediate mass black hole binaries (IMBHB). We added waveforms modeling the gravitational radiation emitted by IMBHBs to detectors' simulated data and searched for the injected signals with the coherent WaveBurst algorithm. The tested binary's parameter space covers non-spinning IMBHBs with source-frame total masses between 50 and 1050 $\text{M}_{\odot}$ and mass ratios between $1/6$ and 1$\,$. We found that advanced detectors could be sensitive to these systems up to a range of a few Gpc. A theoretical model was adopted to estimate the expected observation rates, yielding up to a few tens of events per year. Thus, our results indicate that advanced detectors will have a reasonable chance to collect the first direct evidence for intermediate mass black holes and open a new, intriguing channel for probing the Universe over cosmological scales.Comment: 9 pages, 4 figures, corrected the name of one author (previously misspelled

Enhancing the significance of gravitational wave bursts through signal classification

The quest to observe gravitational waves challenges our ability to discriminate signals from detector noise. This issue is especially relevant for transient gravitational waves searches with a robust eyes wide open approach, the so called all- sky burst searches. Here we show how signal classification methods inspired by broad astrophysical characteristics can be implemented in all-sky burst searches preserving their generality. In our case study, we apply a multivariate analyses based on artificial neural networks to classify waves emitted in compact binary coalescences. We enhance by orders of magnitude the significance of signals belonging to this broad astrophysical class against the noise background. Alternatively, at a given level of mis-classification of noise events, we can detect about 1/4 more of the total signal population. We also show that a more general strategy of signal classification can actually be performed, by testing the ability of artificial neural networks in discriminating different signal classes. The possible impact on future observations by the LIGO-Virgo network of detectors is discussed by analysing recoloured noise from previous LIGO-Virgo data with coherent WaveBurst, one of the flagship pipelines dedicated to all-sky searches for transient gravitational waves

The role of spiritual formation in the education of modern human beings : a European Christian perspective

One of the most considerable changes in the contemporary European educational mentality is a person’s disconnection from spiritual life. Christian formation has been replaced with religious pluralism, in terms of syncretism influenced by global economic ideologies. Some consequences are low resilience and low spiritual resistance to contemporary challenges, associated with mental traumas or social behaviour deficits. Is it possible to restore the modern person’s spiritual education? There is no evolution in the modern individual’s social life without a horizon of spiritual expectation and fulfilment, different from the strictly material one. Moreover, conscious education cannot deprive people of cultivating the spiritual part of their consciousness from which the real values of existence are born. A series of arguments for renewing the relation between school and the mature, Scripture-based Christian thinking in the spirit of the European pedagogy are revealed by the factual historical analyses. Both Eastern and Western European experiences have met after 13 years of evolving into two antagonist geopolitical spheres. Their lessons in the education field could be an appropriate model, academically applied at the cultural mentality and the European pedagogy level. CONTRIBUTION : With this study, I want to highlight the historical and conceptual frameworks of the Christian religious education meaning in the context of the rediscovery of Orthodox Christianity by the international theological culture in post-communism. Orthodox Christianity, forgotten in dictionaries and syntheses by the Western theological elite, brings in a spiritualisation of education according to the Lord Jesus Christ’s Gospel and not of the ideological cultural interests.The author is participating as the research associate of Dean Prof. Dr Jerry Pillay, Faculty of Theology and Religion, University of Pretoria.Special Collection: Lucian Blaga University, Sibiu, Romania, sub-edited by Daniel Buda (Lucian Blaga University) and Jerry Pillay (University of Pretoria).http://www.hts.org.zaam2022Dogmatics and Christian Ethic

Эффективность и безопасность длительного применения бронхорасширяющих средств и фенспирида при хронической обструктивной болезни легких

Catedra Medicină internă nr. 6, USMF „Nicolae Testemiţanu”, Universitatea Liberă Internaţională a Moldovei, Conferinţa Ştiinţifico-Practică „Medicina modernă, actualităţi şi perspective”, consacrată aniversării de 40 de ani ai Spitalului Clinic al Ministerului Sănătăţii, 27-28 mai, 2010, Chişinău, Republica MoldovaThe study included 60 patients with COPD grade II. In the first stage of the study, the patients were monitored during exacerbation of COPD; in stage 2 – in ambulatory conditions (for 6 months) during clinical remission of the disease. Depending on the administered treatment the patients were randomized into 3 groups. Group I included 20 patients with COPD who administered bronchodilator Salmeterol, group II – 20 patients who received the combined drug Seretide, group III – 20 patients with COPD who received Fenspirid. Administration of Seretide and Fenspirid contributed to a statistically significant decrease of dyspnoea and the concentration of systemic inflammation markers, decreased the frequency of exacerbations, improved the indices of FEV, enhanced the effectiveness of the basic curative therapy and improved patients’ quality of life.Обследовано 60 больных ХОБЛ II степени тяжести. На первом этапе, в период обострения хронической обструктивной болезни легких, проводился мониторинг пациентов в условиях стационара, на втором – в амбулаторных условиях в период клинической ремиссии заболевания (в течение 6 месяцев). В зависимости от метода лечения методом рандомизации были сформированы 3 группы наблюдения. В I группу были включены 20 пациентов с ХОБЛ, получавших бронходилататор Сальметерол, во II группу – 20 пациентов, получавших комбинированный препарат Серетайд, в III группу – 20 пациентов, получавших Фенспирид. Применение в комплексной терапии хронической обструктивной болезни легких препаратов Серетайд и Фенспирид способствовало статистически достоверному уменьшению одышки и концентрации системных маркеров воспаления, улучшению ОФВ1 и снижению частоты обострений

Клинико-фармакологические аспекты гептрала в лечении неалкогольного стеатогепатита

Catedra Farmacologie şi farmacologie clinică, Catedra Medicină internă nr. 6, Catedra Medicină internă nr. 1, USMF „Nicolae Testemiţanu”, Conferinţa Ştiinţifico-Practică „Medicina modernă, actualităţi şi perspective”, consacrată aniversării de 40 de ani ai Spitalului Clinic al Ministerului Sănătăţii, 27-28 mai, 2010, Chişinău, Republica MoldovaThe study included 50 patients with NASH. Among them were 15 men and 35 women. Initially all patients had abdominal type obesity. Overweight body mass was diagnosed in 5 patients, 5 – I degree obesity, 8 – II degree, 7 – degree III and IV. Heptral is a pharmaceutical preparation with positive influence on the main pathogenetic links of steatohepatitis. Including Heptral in the complex therapy of patients with non-alcoholic steatohepatitis decreased the activity of enzymes of cytolysis, significantly improved the lipid peroxidation and hormonal status indices in comparison with the basic therapy. Heptral also improved patients’ quality of life.В исследование были включены 50 пациентов (15 мужчин и 35 женщин) с НАСГ. Первоначально все пациенты имели ожирение брюшного типа. Избыточная масса тела была диагностирована у 5 пациентов: у 5 – I-й, у 8 – II-й, 7 – III-й и IV-й степени ожирения. Включение гептрала в комплексную терапию больных нелкогольным стеатогепатитом позволило значительно уменьшить активность ферментов цитолиза, улучшить показатели перекисного окисления липидов и гормонального статуса

Роль Сумамеда в лечении инфекционных обострений хронической обструктивной болезни легких

Catedra Medicină internă nr. 6, USMF „Nicolae Testemiţanu”The comparative clinical efficiency of different antibacterial remedies was studied in 85 patients with bacterial exacerbations of chronic obstructive lung disease (COLD). It was established that in patients with stage I COLD who were administered Sumamed, the respiratory symptoms reduced in intensity by 4.5 times and by 2.9 times in patients with stage II of COLD, while the therapy with Augmentin reduced the symptomatic by 2.2 times only in patient with COLD stage I, which is 2 times worse than the treatment with Sumamed. Administration of Sumamed resulted in a faster normalization of inflammatory markers in comparison with the control group. The administered therapy resulted in a lasting positive effect in 86.6% of cases 6 to 12 months, while the basic therapy – only in 47.5% cases.У 85 больных хронической обструктивной болезнью легких (ХОБЛ) изучена сравнительная клиническая эффективность Сумамеда и Аугментина в лечении I типа обострений заболевания. Установлено, что у больных ХОБЛ I стадии, принимавших Сумамед, интенсивность респираторных симптомов снизилась в 4,5 раза, при II стадии – в 2,9 раза. Включение Аугментина способствовало снижению респираторных симптомов при I стадии в 2,2 раза, а при II стадии существенной достоверной динамики не отмечено. Применение Сумамеда в комплексной терапии больных ХОБЛ I и II стадии способствовало нормализации биохимических маркеров воспаления в более короткие сроки, чем в группе контроля. После курсового лечения Сумамедом положительный эффект был стабилен в 86,6% случаев на протяжении 6-12 месяцев, в то время как после Аугментина – только в 47,5% случаев

Клиническая эффективность лозартана, лизиноприла и их сочетание в лечении хронической сердечной недостаточности

Catedra Farmacologie şi farmacie clinică, USMF „Nicolae Testemiţanu”, Catedra Boli interne nr. 6, USMF „Nicolae Testemiţanu”, Spitalul Clinic al Ministerului Sănătăţii, Conferinţa Ştiinţifico-Practică „Medicina modernă, actualităţi şi perspective”, consacrată aniversării de 40 de ani ai Spitalului Clinic al Ministerului Sănătăţii, 27-28 mai, 2010, Chişinău, Republica MoldovaThe study included 60 patients with stable symptomatic CHF of II-IV functional class and ejection fraction (EF) of the left ventricle ≤ 45%. All patients completed a set of diagnostic procedures to determine the diagnosis and received severity of hemodynamic disorders and were divided into 3 groups. Group I included 20 patients receiving Losartan, group II (n = 20) Lisinopril, and group III (n = 20) received combined therapy Losartan + Lisinopril. Monitoring of the patients lasted 24 weeks. It was established that the combined therapy of Losartan and Lisinopril determined a quicker (3-4 days) diminishing of clinical symptoms of CHF compared to monotherapy. The effects of Losartan, Lisinopril and their combination on morpho-functional indices of the heart manifested by decreasing the size of the left heart chambers and improving the contractile function of left ventricle myocardium, the prevalence of these changes related more to the combined therapy.В исследование включено 60 больных со стабильными симптомами ХСН и фракцией выброса (ФВ) левого желудочка ≤ 45%. Все обследованные больные методом рандомизации были распределены на 3 группы. Первая группа включала 20 пациентов, получавших лозартан, II группа (n = 20) – лизиноприл и III группа (n = 20) комбинированную терапию – лизиноприл + лозартан. Мониторинг пациентов продолжался в течение 24 недель. Было установлено, что комбинированная терапия способствовала более быстрому купированию клинических симптомов ХСН по сравнению с монотерапией. Влияние лозартана, лизиноприла и их сочетание на морфофункциональные показатели сердца проявилось в уменьшении размеров левых камер сердца и улучшении сократительной функции миокарда левого желудочка

Отечественный препарат Биозар – эффективное средство в лечении стеатогепатита

Department of Internal Medicine, Medical Clinic of Occupational Diseases Nicolae Testemitanu State Medical and Pharmaceutical UniversityThe local drug Biozar – an efficient remedy in the treatment of steatohepatitis 60 patients with non-alcoholic steatohepatitis associated with acalculous cholecystitis were randomly grouped according to the type of treatment. The study group consisted of 35 patients who received local standard therapy and Biozar and the control group, 25 patients who received only standard therapy. In the 8-week program the complex treatment coupled with Biozar showed a positive influence on the dyspeptic and pain syndromes, each showing a severity status 1,2 times lower than the control group, clearly improved liver function and normalized the lipid components helping to reduce the aterogenity index. В исследование были включены 60 пациентов с неалкогольным стеатогепатитом ассоциированным с калькулезным холециститом. В зависимости от применяемого лечения методом случайного отбора, больные были разделены на две группы: основная – 35 пациентов, которые получали базисную терапию и Biozar; контрольная группа – 25 пациентов, которые получали только базисную терапию. Лечение продолжалось в течение 8 недель. Комплексное лечение с включением Biozar повлияло более значимо на болезненный и диспепсический синдромы (средняя степень тяжести обоих синдромов было в 1,2 раза ниже по сравнению с контрольной группой), что способствовало улучшению функционального состояния печени и коррекции липидных компонентов сыворотки, что способствовало достоверному уменьшению индекса атерогенности

Semantic Web Tools and Decision-Making

Semantic Web technologies are intertwined with decision-making processes. In this paper the general objectives of the semantic web tools are reviewed and characterized, as well as the categories of decision support tools, in order to establish an intersection of utility and use. We also elaborate on actual and foreseen possibilities for a deeper integration, considering the actual implementation, opportunities and constraints in the decision-making context.info:eu-repo/semantics/publishedVersio