5 research outputs found
The Determinants of Bank Deposit Variability: A Developing Country Case
This paper reports on an analysis of deposit variability in the branch banking system of Bangladesh. As expected, deposit variability is greatest for small, rural branches. It declines with increases in branch size, the share of long-term fixed deposits, and number of types of deposits in a branch
Simplified Dosing of Gentamicin for Treatment of Sepsis in Bangladeshi Neonates
Extended-interval dosing of gentamicin has several advantages over conventional multiple-daily dosing for the treatment of sepsis. The study was conducted to evaluate the pharmacokinetics of gentamicin for the treatment of neonatal sepsis in predetermined doses at 24- or 48-hour intervals, according to weight category, and to develop a simplified protocol for use in peripheral healthcare settings in developing countries. This prospective observational study was conducted among 59 neonates admitted to the Special Care Nursery at Dhaka Shishu Hospital, Bangladesh, with suspected sepsis and treated with antibiotics, including gentamicin. Intravenous dosing of gentamicin according to weight category was: 10 mg every 48 hours if the infant weighed <2,000 g (n=23), 10 mg every 24 hours if the infant weighed 2,000–2,249 g (n=12), or 13.5 mg every 24 hours if the infant weighed 2,500–3,000 g (n=24). Peak and trough concentrations of gentamicin and the presence of signs of nephrotoxicity and ototoxicity were determined. The mean±standard deviation peak concentration of gentamicin was 12.3±3.7 µg/mL in infants weighing <2,000 g, 9.6±3.1 µg/mL in infants 2,000–2,249 g, and 10.0±3.4 µg/mL in infants 2,500–3,000 g. Initial peak concentration of gentamicin was >12 µg/mL in 28.8% and initial trough concentration was >2 µg/mL in 6.8% of the subjects. No signs of nephrotoxicity or ototoxicity were detected. Favourable pharmacokinetic parameters found with the simplified dosing regimen suggest that it is safe for the treatment of neonatal sepsis
Simplified Dosing of Gentamicin for Treatment of Sepsis in Bangladeshi Neonates
Extended-interval dosing of gentamicin has several advantages over
conventional multiple-daily dosing for the treatment of sepsis. The
study was conducted to evaluate the pharmacokinetics of gentamicin for
the treatment of neonatal sepsis in predetermined doses at 24- or
48-hour intervals, according to weight category, and to develop a
simplified protocol for use in peripheral healthcare settings in
developing countries. This prospective observational study was
conducted among 59 neonates admitted to the Special Care Nursery at
Dhaka Shishu Hospital, Bangladesh, with suspected sepsis and treated
with antibiotics, including gentamicin. Intravenous dosing of
gentamicin according to weight category was: 10 mg every 48 hours if
the infant weighed <2,000 g (n=23), 10 mg every 24 hours if the
infant weighed 2,000-2,249 g (n=12), or 13.5 mg every 24 hours if the
infant weighed 2,500-3,000 g (n=24). Peak and trough concentrations of
gentamicin and the presence of signs of nephrotoxicity and ototoxicity
were determined. The mean\ub1standard deviation peak concentration of
gentamicin was 12.3\ub13.7 \u3bcg/mL in infants weighing <2,000
g, 9.6\ub13.1 \u3bcg/mL in infants 2,000-2,249 g, and 10.0\ub13.4
\u3bcg/mL in infants 2,500-3,000 g. Initial peak concentration of
gentamicin was >12 \u3bcg/mL in 28.8% and initial trough
concentration was >2 \u3bcg/mL in 6.8% of the subjects. No signs of
nephrotoxicity or ototoxicity were detected. Favourable pharmacokinetic
parameters found with the simplified dosing regimen suggest that it is
safe for the treatment of neonatal sepsis
The determinants of currency demand: A cross country study.
The determinants of currency demand: A cross country study