511 research outputs found
TGRS Observations of Positron Annihilation in Classical Novae
The TGRS experiment on board the Wind spacecraft has many advantages as a sky
monitor --- broad field of view (~2 pi) centered on the south ecliptic pole),
long life (1994-present), and stable low background and continuous coverage due
to Wind's high altitude high eccentricity orbit. The Ge detector has sufficient
energy resolution (3-4 keV at 511 keV) to resolve a cosmic positron
annihilation line from the strong background annihilation line from beta-decays
induced by cosmic ray impacts on the instrument, if the cosmic line is
Doppler-shifted by this amount. Such lines (blueshifted) are predicted from
nucleosynthesis in classical novae. We have searched the entire TGRS database
for 1995-1997 for this line, with negative results. In principle such a search
could yield an unbiased upper limit on the highly-uncertain Galactic nova rate.
We carefully examined the times around the known nova events during this
period, also with negative results. The upper limit on the nova line flux in a
6-hr interval is typically <3.8 E-3 photon/(cm2 s) at 4.6 sigma. We performed
the same analysis for times around the outburst of Nova Vel 1999, obtaining a
worse limit due to recent degradation of the detector response caused by cosmic
ray induced damage.Comment: 5 pp. inc. 3 figs. Proc. 5th Compton Symposium (AIP Conf. Series),
ed. M. McConnell, in pres
Transient Gamma Ray Spectrometer Measurements of Gamma-Ray Lines from Novae. I. Limits on the Positron Annihilation Line in Five Individual Novae
The Transient Gamma Ray Spectrometer (TGRS) on board the WIND spacecraft has
spent most of the interval 1995-1997 in a high-altitude orbit where gamma-ray
backgrounds are low. Its high-resolution Ge spectrometer is thus able to detect
weak lines which are slightly offset from stronger background features. One
such line is predicted from nucleosynthesis in classical novae, where
beta-decays on a time-scale of a few hours in an expanding envelope produce
positrons that annihilate to generate a line which is blueshifted by a few keV
away from the background annihilation line at 511 keV. The broad TGRS field of
view contained five known Galactic novae during 1995 January - 1997 June, and
we have searched the spectra taken around the times of these events for the
blueshifted nova annihilation line. Although no definite detections were made,
the method is shown to be sensitive enough to detect novae occurring on
ONeMg-rich white dwarfs out to about 2.5 kpc.Comment: 27 pp. + 10 figs., or offprint mailed by request to
[email protected]
Complex-Temperature Properties of the Ising Model on 2D Heteropolygonal Lattices
Using exact results, we determine the complex-temperature phase diagrams of
the 2D Ising model on three regular heteropolygonal lattices, (kagom\'{e}), , and (bathroom
tile), where the notation denotes the regular -sided polygons adjacent to
each vertex. We also work out the exact complex-temperature singularities of
the spontaneous magnetisation. A comparison with the properties on the square,
triangular, and hexagonal lattices is given. In particular, we find the first
case where, even for isotropic spin-spin exchange couplings, the nontrivial
non-analyticities of the free energy of the Ising model lie in a
two-dimensional, rather than one-dimensional, algebraic variety in the
plane.Comment: 31 pages, latex, postscript figure
Complex-Temperature Singularities in the Ising Model. III. Honeycomb Lattice
We study complex-temperature properties of the uniform and staggered
susceptibilities and of the Ising model on the honeycomb
lattice. From an analysis of low-temperature series expansions, we find
evidence that and both have divergent singularities at the
point (where ), with exponents
. The critical amplitudes at this
singularity are calculated. Using exact results, we extract the behaviour of
the magnetisation and specific heat at complex-temperature
singularities. We find that, in addition to its zero at the physical critical
point, diverges at with exponent , vanishes
continuously at with exponent , and vanishes
discontinuously elsewhere along the boundary of the complex-temperature
ferromagnetic phase. diverges at with exponent
and at (where ) with exponent , and
diverges logarithmically at . We find that the exponent relation
is violated at ; the right-hand side is 4
rather than 2. The connections of these results with complex-temperature
properties of the Ising model on the triangular lattice are discussed.Comment: 22 pages, latex, figures appended after the end of the text as a
compressed, uuencoded postscript fil
Transcriptome Analysis of Cardiac Hypertrophic Growth in MYBPC3-Null Mice Suggests Early Responders in Hypertrophic Remodeling
Rationale: With a prevalence of 1 in 200 individuals, hypertrophic cardiomyopathy (HCM) is thought to be the most common genetic cardiac disease, with potential outcomes that include severe hypertrophy, heart failure, and sudden cardiac death (SCD). Though much research has furthered our understanding of how HCM-causing mutations in genes such as cardiac myosin-binding protein C (MYBPC3) impair contractile function, it remains unclear how such dysfunction leads to hypertrophy and/or arrhythmias, which comprise the HCM phenotype. Identification of early response mediators could provide rational therapeutic targets to reduce disease severity. Our goal was to differentiate physiologic and pathophysiologic hypertrophic growth responses and identify early genetic mediators in the development of cardiomegaly in the cardiac myosin-binding protein C-null (cMyBP-C-/-) mouse model of HCM.Methods and Results: We performed microarray analysis on left ventricles of wild-type (WT) and cMyBPC-/- mice (n = 7 each) at postnatal day (PND) 1 and PND 9, before and after the appearance of an overt HCM phenotype. Applying the criteria of ≥2-fold change, we identified genes whose change was exclusive to pathophysiologic growth (n = 61), physiologic growth (n = 30), and genes whose expression changed ≥2-fold in both WT and cMyBP-C-/- hearts (n = 130). Furthermore, we identified genes that were dysregulated in PND1 cMyBP-C-/- hearts prior to hypertrophy, including genes in mechanosensing pathways and potassium channels linked to arrhythmias. One gene of interest, Xirp2, and its protein product, are regulated during growth but also show early, robust prehypertrophic upregulation in cMyBP-C-/- hearts. Additionally, the transcription factor Zbtb16 also shows prehypertrophic upregulation at both gene and protein levels.Conclusion: Our transcriptome analysis generated a comprehensive data set comparing physiologic vs. hypertrophic growth in mice lacking cMyBP-C. It highlights the importance of extracellular matrix pathways in hypertrophic growth and early dysregulation of potassium channels. Prehypertrophic upregulation of Xirp2 in cMyBP-C-/- hearts supports a growing body of evidence suggesting Xirp2 has the capacity to elicit both hypertrophy and arrhythmias in HCM. Dysregulation of Xirp2, as well as Zbtb16, along with other genes associated with mechanosensing regions of the cardiomyocyte implicate stress-sensing in these regions as a potentially important early response in HCM
ToppCluster: a multiple gene list feature analyzer for comparative enrichment clustering and network-based dissection of biological systems
ToppCluster is a web server application that leverages a powerful enrichment analysis and underlying data environment for comparative analyses of multiple gene lists. It generates heatmaps or connectivity networks that reveal functional features shared or specific to multiple gene lists. ToppCluster uses hypergeometric tests to obtain list-specific feature enrichment P-values for currently 17 categories of annotations of human-ortholog genes, and provides user-selectable cutoffs and multiple testing correction methods to control false discovery. Each nameable gene list represents a column input to a resulting matrix whose rows are overrepresented features, and individual cells per-list P-values and corresponding genes per feature. ToppCluster provides users with choices of tabular outputs, hierarchical clustering and heatmap generation, or the ability to interactively select features from the functional enrichment matrix to be transformed into XGMML or GEXF network format documents for use in Cytoscape or Gephi applications, respectively. Here, as example, we demonstrate the ability of ToppCluster to enable identification of list-specific phenotypic and regulatory element features (both cis-elements and 3′UTR microRNA binding sites) among tissue-specific gene lists. ToppCluster’s functionalities enable the identification of specialized biological functions and regulatory networks and systems biology-based dissection of biological states. ToppCluster can be accessed freely at http://toppcluster.cchmc.org
Social presence and dishonesty in retail
Self-service checkouts (SCOs) in retail can benefit consumers and retailers, providing control and autonomy to shoppers independent from staff, together with reduced queuing times. Recent research indicates that the absence of staff may provide the opportunity for consumers to behave dishonestly, consistent with a perceived lack of social presence. This study examined whether a social presence in the form of various instantiations of embodied, visual, humanlike SCO interface agents had an effect on opportunistic behaviour. Using a simulated SCO scenario, participants experienced various dilemmas in which they could financially benefit themselves undeservedly. We hypothesised that a humanlike social presence integrated within the checkout screen would receive more attention and result in fewer instances of dishonesty compared to a less humanlike agent. This was partially supported by the results. The findings contribute to the theoretical framework in social presence research. We concluded that companies adopting self-service technology may consider the implementation of social presence in technology applications to support ethical consumer behaviour, but that more research is required to explore the mixed findings in the current study.<br/
Gamma-ray limits on Galactic 60Fe nucleosynthesis and implications on the Origin of the 26Al emission
The Gamma Ray Imaging Spectrometer (GRIS) recently observed the gamma-ray
emission from the Galactic center region. We have detected the 1809 keV
Galactic 26Al emission at a significance level of 6.8-sigma but have found no
evidence for emission at 1173 keV and 1332 keV, expected from the decay chain
of the nucleosynthetic 60Fe. The isotopic abundances and fluxes are derived for
different source distribution models. The resulting abundances are between
2.6+-0.4 and 4.5+-0.7 Solar Masses for 26Al and a 2-sigma upper limit for 60Fe
between 1.7 and 3.1 Solar Masses. The measured 26Al emission flux is
significantly higher than that derived from the CGRO/COMPTEL 1.8 MeV sky map.
This suggests that a fraction of the 26Al emission may come from extended
sources with a low surface brightness that are invisible to COMPTEL. We obtain
a 60Fe to 26Al flux ratio 2-sigma upper limit of 0.14, which is slightly lower
than the 0.16 predicted from current nucleosynthesis models assuming that SNII
are the major contributors to the galactic 26Al. Since the uncertainties in the
predicted fluxes are large (up to a factor of 2), our measurement is still
compatible with the theoretical expectations.Comment: to be published in Astroph. Journal Letters, 12 pages, 3 Postscript
figures; added reference for introduction, typos adde
Selection for growth is associated in gilthead sea bream (Sparus aurata) with diet flexibility, changes in growth patterns and higher intestine plasticity
Farmed gilthead sea bream (Sparus aurata) is able to grow efficiently with new feed formulations based on plant ingredients. Here, two experimental diets with standard and high inclusion levels of plant ingredients were formulated to assess the suited use of plant-based diets in fish with different growth genetic backgrounds. To pursue this issue, a long-term feeding trial (12-months) was conducted with fish (17 g initial body weight) of 16 families coming from the broodstock of PROGENSA project, that were grown communally in the IATS-CSIC experimental facilities. All fish in the study (2545) were PIT-tagged, and their pedigree was re-constructed with 96% success by using a SMsa1 multiplex of 11 microsatellites, which revealed the main parents contributions of 5 females and 6 males. Each diet was randomly assigned to replicate 3000 L tanks, gathering each replicate a similar family composition through all the feeding trial. Data on growth performance highlighted a strong ge- netic effect on growth trajectories, associated with enhanced growth during winter in fish selected for faster growth. No main dietary effects were found on growth rates or condition factor, and regression-correlation analyses of growth rates across families on both diets suggest that genome by diet interaction was weak, while genetic variation accounted for most of the growth phenotypic variation. Hepatosomatic index (HSI) and me- senteric fat index (MSI) of five families, covering the growth variability of the population, were regulated nu- tritionally and genetically, but without statistically significant genome by diet interactions. Fish from faster growing families showed shorter intestines after being fed the control diet, but this phenotype was masked by the enriched plant-based diet. Collectively, the results demonstrate that selection for faster growth is associated in gilthead sea bream with different growth trajectories and a high diet flexibility and intestine plasticity.Versión del editor2,04
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