Squamous cell carcinoma antigen suppresses radiation-induced cell death

Previous study has demonstrated that squamous cell carcinoma antigen (SCCA) 1 attenuates apoptosis induced by TNFα, NK cell or anticancer drug. In this study, we have examined the effect of SCCA2, which is highly homologous to SCCA1, but has different target specificity, against radiation-induced apoptosis, together with that of SCCA1. We demonstrated that cell death induced by radiation treatment was remarkably suppressed not only in SCCA1 cDNA-transfected cells, but also in SCCA2 cDNA-transfected cells. In these transfectants, caspase 3 activity and the expression of activated caspase 9 after radiation treatment were suppressed. Furthermore, the expression level of phosphorylated p38 mitogen-activated protein kinase (p38 MAPK) was suppressed compared to that of the control cells. The expression level of upstream stimulator of p38 MAPK, phosphorylated MKK3/MKK6, was also suppressed in the radiation-treated cells. Thus, both SCCA1 and SCCA2 may contribute to survival of the squamous cells from radiation-induced apoptosis by regulating p38 MAPK pathway. © 2001 Cancer Research Campaign http://www.bjcancer.co

Super-A-polynomials for Twist Knots

We conjecture formulae of the colored superpolynomials for a class of twist knots $K_p$ where p denotes the number of full twists. The validity of the formulae is checked by applying differentials and taking special limits. Using the formulae, we compute both the classical and quantum super-A-polynomial for the twist knots with small values of p. The results support the categorified versions of the generalized volume conjecture and the quantum volume conjecture. Furthermore, we obtain the evidence that the Q-deformed A-polynomials can be identified with the augmentation polynomials of knot contact homology in the case of the twist knots.Comment: 22+16 pages, 16 tables and 5 figures; with a Maple program by Xinyu Sun and a Mathematica notebook in the ancillary files linked on the right; v2 change in appendix B, typos corrected and references added; v3 change in section 3.3; v4 corrections in Ooguri-Vafa polynomials and quantum super-A-polynomials for 7_2 and 8_1 are adde

Cartan subalgebras and the UCT problem, II

We show that outer approximately represenbtable actions of a finite cyclic group on UCT Kirchberg algebras satisfy a certain quasi-freeness type property if the corresponding crossed products satisfy the UCT and absorb a suitable UHF algebra tensorially. More concretely, we prove that for such an action there exists an inverse semigroup of homogeneous partial isometries that generates the ambient C*-algebra and whose idempotent semilattice generates a Cartan subalgebra. We prove a similar result for actions of finite cyclic groups with the Rokhlin property on UCT Kirchberg algebras absorbing a suitable UHF algebra. These results rely on a new construction of Cartan subalgebras in certain inductive limits of Cartan pairs. We also provide a characterisation of the UCT problem in terms of finite order automorphisms, Cartan subalgebras and inverse semigroups of partial isometries of the Cuntz algebra $\mathcal{O}_2$. This generalizes earlier work of the authors.Comment: minor revisions; final version, accepted for publication in Math. Ann.; 26 page

Brane cosmological solutions in six-dimensional warped flux compactifications

We study cosmology on a conical brane in the six-dimensional Einstein-Maxwell-dilaton system, where the extra dimensions are compactified by a magnetic flux. We systematically construct exact cosmological solutions using the fact that the system is equivalently described by (6+n)-dimensional pure Einstein-Maxwell theory via dimensional reduction. In particular, we find a power-law inflationary solution for a general dilatonic coupling. When the dilatonic coupling is given by that of Nishino-Sezgin chiral supergravity, this reduces to the known solution which is not inflating. The power-law solution is shown to be the late-time attractor. We also investigate cosmological tensor perturbations in this model using the (6+n)-dimensional description. We obtain the separable equation of motion and find that there always exist a zero mode, while tachyonic modes are absent in the spectrum. The mass spectrum of Kaluza-Klein modes is obtained numerically.Comment: 12 pages, 2 figures; v2: references added; v3: version published in JCA

Constraints on chiral operators in N=2 SCFTs

Open Access, © The Authors. Article funded by SCOAP3. This article is distributed under the terms of the Creative Commons Attribution License ( CC-BY 4.0 ), which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited

Localization of N=4 Superconformal Field Theory on S^1 x S^3 and Index

We provide the geometrical meaning of the ${\cal N}=4$ superconformal index. With this interpretation, the ${\cal N}=4$ superconformal index can be realized as the partition function on a Scherk-Schwarz deformed background. We apply the localization method in TQFT to compute the deformed partition function since the deformed action can be written as a $\delta_\epsilon$-exact form. The critical points of the deformed action turn out to be the space of flat connections which are, in fact, zero modes of the gauge field. The one-loop evaluation over the space of flat connections reduces to the matrix integral by which the ${\cal N}=4$ superconformal index is expressed.Comment: 42+1 pages, 2 figures, JHEP style: v1.2.3 minor corrections, v4 major revision, conclusions essentially unchanged, v5 published versio