A Surveillance System for Enhancing the Safety of Rescue Teams

The article summarizes preliminary results of the research and development of a system focused on enhancing the safety of teams participating in the integrated rescue system managing extraordinary events or crisis situations (fire, mass disaster, release of harmful industrial substances), and on the support in the course of training. Individual partial technical solutions are mentioned, which should lead to providing automatized telemetric monitoring equipment in a more resistant form making it possible to recognize the nature and intensity of the motion, including the determination of the topical and total energy outputs, monitoring of environmental parameters (temperature, smoke, etc.) and back analysis of the intervention course or training in real time, and the monitoring of health-physiological parameters and signalling risk conditions (physical exhaustion, stress, overheating, etc.) under extreme measures

Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration

Mitochondria generate energy and building blocks required for cellular growth and function. The notion that mitochondria are not involved in the cancer growth has been challenged in recent years together with the emerging idea of mitochondria as a promising therapeutic target for oncologic diseases. Pentamethinium salts, cyan dyes with positively charged nitrogen on the benzothiazole or indole part of the molecule, were originally designed as mitochondrial probes. In this study, we show that pentamethinium salts have a strong effect on mitochondria, suppressing cancer cell proliferation and migration. This is likely linked to the strong inhibitory effect of the salts on dihydroorotate dehydrogenase (DHODH)-dependent respiration that has a key role in the de novo pyrimidine synthesis pathway. We also show that pentamethinium salts cause oxidative stress, redistribution of mitochondria, and a decrease in mitochondria mass. In conclusion, pentamethinium salts present novel anti-cancer agents worthy of further studies.SCOPUS: ar.jinfo:eu-repo/semantics/publishe