Adiciones a la flora navarra.

Se dan a conocer nuevas localidades navarras para 48 especies de fanerógamas, 20 de las cuales se citan por primera vez para la provincia

Damasonium alisma Miller, novedad para el catálogo florístico navarro.

Se cita Damasonium alisma Miller, herborizada en Montiuso, término de Lerín, como novedad para el catálogo florístico de la provincia de Navarra

mBISON: Finding miRNA target over-representation in gene lists from ChIP-sequencing data

BACKGROUND: Over-representation of predicted miRNA targets in sets of genes regulated by a given transcription factor (e.g. as defined by ChIP-sequencing experiments) helps to identify biologically relevant miRNA targets and is useful to get insight into post-transcriptional regulation. FINDINGS: To facilitate the application of this approach we have created the mBISON web-application. mBISON calculates the significance of over-representation of miRNA targets in a given non-ranked gene set. The gene set can be specified either by a list of genes or by one or more ChIP-seq datasets followed by a user-defined peak-gene association procedure. mBISON is based on predictions from TargetScan and uses a randomization step to calculate False-Discovery-Rates for each miRNA, including a correction for gene set specific properties such as 3'UTR length. The tool can be accessed from the following web-resource: http://cbdm.mdc-berlin.de/~mgebhardt/cgi-bin/mbison/home . CONCLUSION: mBISON is a web-application that helps to extract functional information about miRNAs from gene lists, which is in contrast to comparable applications easy to use by everyone and can be applied on ChIP-seq data directly

Paisaje Vegetal y Espectro Ecológico de dos Municipios Navarros (España)

Tomando como referencia el trabajo de BRAUN BLANQUET y 0. DE BOLOS (1957) sobre el Valle del Ebro, se ha realizado un estudio del paisaje vegetal de Marcilla y Milagro, municipios situados en la Ribera de Navarra. Hemos reconocido comunidades vegetales pertenecientes a 14 clases fitosociológicas. Expresamos nuestros resultados mediante dos perfiles fitotopográficos y un espectro ecológico

Corporate blogging in Spanish companies. Design and application of a quality index (ICB)

Blogs have strengthened its position as an online communication tool to increase the dialogue between organizations and their publics, and this thanks to their interactive capacity and easy use. Although blogs didn’t enjoy the popularity and swift penetration of social networks, Spanish companies are gradually incorporating this channel to their Public Relations plans. Thus, it becomes increasingly interesting to develop a quantitative index allowing determining the degree of compliance to excellence criteria. This paper aims to identify the main factors in order to value the quality of a corporate blog, describes the design of the evaluation index and, later, applies this index to study the corporate blogs of the main Spanish companies in order to unveil how they are exploiting its many advantages

CUCUMBER BIOFORTIFICATION WITH POTASSIUM

A few years ago, humans consumed a diet rich in potassium, however, an increased consumption of processed foods and the reduction of the consumption of fruits and vegetables, has meant that potassium intake has been reduced. The aim of this study is to increase potassium content in cucumbers with natural biofortification of the crop, adding an extra amount of potassium sulphate ranging from 0.014 g/l to 4 g/l plus regular fertilization. Fourteen samples were collected at three different times that were analyzed with and without skin. The potassium content was determined by flame photometry. The results show that potassium content has increased over time and the differences initially existing between the cucumbers with and without skin have disappeared

Similarity in targets with REST points to neural and glioblastoma related miRNAs

There are groups of genes that need coordinated repression in multiple contexts, for example if they code for proteins that work together in a pathway or in a protein complex. Redundancy of biological regulatory networks implies that such coordinated repression might occur at both the pre- and post-transcriptional level, though not necessarily simultaneously or under the same conditions. Here, we propose that such redundancy in the global regulatory network can be detected by the overlap between the putative targets of a transcriptional repressor, as identified by a ChIP-seq experiment, and predicted targets of a microRNA (miRNA). To test this hypothesis, we used publicly available ChIP-seq data of the neural transcriptional repressor RE1 silencing transcription factor (REST) from 15 different cell samples. We found 20 miRNAs, each of which shares a significant amount of predicted targets with REST. The set of predicted associations between these 20 miRNAs and the overlapping REST targets is enriched in known miRNA targets. Many of the detected miRNAs have functions related to neural identity and glioblastoma, which could be expected from their overlap in targets with REST. We propose that the integration of experimentally determined transcription factor binding sites with miRNA-target predictions provides functional information on miRNAs

String Indexing for Patterns with Wildcards

We consider the problem of indexing a string $t$ of length $n$ to report the occurrences of a query pattern $p$ containing $m$ characters and $j$ wildcards. Let $occ$ be the number of occurrences of $p$ in $t$, and $\sigma$ the size of the alphabet. We obtain the following results. - A linear space index with query time $O(m+\sigma^j \log \log n + occ)$. This significantly improves the previously best known linear space index by Lam et al. [ISAAC 2007], which requires query time $\Theta(jn)$ in the worst case. - An index with query time $O(m+j+occ)$ using space $O(\sigma^{k^2} n \log^k \log n)$, where $k$ is the maximum number of wildcards allowed in the pattern. This is the first non-trivial bound with this query time. - A time-space trade-off, generalizing the index by Cole et al. [STOC 2004]. We also show that these indexes can be generalized to allow variable length gaps in the pattern. Our results are obtained using a novel combination of well-known and new techniques, which could be of independent interest

Hábitos de sueño y problemas relacionados con el sueño en adolescentes: relación con el rendimiento escolar

ObjetivoConocer la prevalencia de trastornos de sueño en los adolescentes. Describir los hábitos de sueño de los adolescentes y su relación con los trastornos del sueño y los factores asociados. Conocer la relación entre los trastornos del sueño y/o los hábitos de sueño inadecuados con el rendimiento escolar.DiseñoEstudio observacional, descriptivo y transversal.EmplazamientoInstitutos de enseñanza secundaria obligatoria (ESO) de la ciudad de Cuenca.ParticipantesUn total de 1.293 alumnos escolarizados en primero y cuarto cursos de ESO.Mediciones principalesHábitos de sueño en días lectivos y fines de semana y prevalencia de trastornos del sueño medidos mediante un cuestionario estructurado con preguntas abiertas y cerradas, autoadministrado y anónimo. Se determinó el rendimiento escolar de los alumnos y su relación con los hábitos y trastornos de sueño.ResultadosDe los 1.293 alumnos matriculados, completaron la encuesta 1.155 (89,33%), 537 (45,9%) chicos y 618 (54,1%) chicas, con una media de edad de 14 años (rango, 11-18 años). Los días laborables se acuestan en promedio a las 23.17 y se levantan a las 7.46 (tiempo medio, 8 h y 18 min) y los fines de semana se acuestan a la 1.02 y se levantan a las 10.42 (tiempo medio, 9 h y 40 min). El 45,4% declara dormir mal la noche del domingo al lunes. El promedio de asignaturas suspendidas es mayor en los adolescentes con queja de sueño (2,28 frente a 1,91; p = 0,04), los que se levantan cansados (2,17 frente a 1,97; p = 0,048) y los que tienen somnolencia diurnal (2,17 frente a 1,75; p = 0,004).ConclusionesEl horario escolar conlleva deuda de sueño durante la semana que se recupera parcialmente el fin de semana. En los fines de semana se produce una rotura en los hábitos de sueño de los adolescentes. Los adolescentes con problemas relacionados con el sueño muestran peor rendimiento escolar.ObjectiveTo determine the prevalence of sleep disorders in adolescence.To describe sleeping habits of adolescents in relation to sleep disorders and associated factors. To determine the relation between sleep disorders/inappropiate sleeping habits and school performance.DesignObservational, descriptive, crosssectional study.SettingSecondary school of Cuenca (city in Spain).Participants1293 school children of first and fourth curses of secondary education.Main measuresStructured questionnaire with opened and closed questions on sleeping habits during weekdays and at weekends and sleep disorders to be answered by the adolescents anonymously and on their own. Student's school performance with relation with to sleeping habits and sleep disorders were determined.Results1155 students out of 1293 (response rate 89.33%) answered the questionnaire, 537 (45.9%) boys and 618 (54.1%) girls, 14 years old on average (between 11-18 years). On weekdays students went to bed at 23.17 h and got up at 7.46 h (average sleeping time =8 hours and 18 minutes). At weekends they went to bed at 1.02 h and got up at 10.42 h (average sleeping time =9 hours and 40 minutes). 45.4% of students said to sleep badly on Sunday night's.On average the number of subjects failed in class is higher with adolescents who complain about sleep (2.28 vs 1.91; P=.04), who are tired at waking up time (2.17 vs 1.97; P=.048) and who have morning sleepiness (2.17 vs 1.75; P=.004).ConclusionsSchools hours cause deficitsleeping time during weekdays which is partly made up for at weekend. At weekends there is an interruption of the adolescent's sleeping habits. School performance of adolescents with sleep disorders is lower

Influence of palliative care training on nurses’ attitudes towards end-of-life care during the COVID-19 pandemic in Spain

Aim: This study aims to assess the influence of training on nurses’ attitudes toward end-of-life care during the COVID-19 pandemic alarm state in Spain. Design: Cross-sectional descriptive study. Data collection was carried out by means of an ad hoc questionnaire using Google Forms in April and May 2020. The score of attitudes toward end-of-life care was used, to which sociodemographic variables and training in palliative care were added. Methods: Data were collected from 238 nursing professionals who had cared for COVID-19 and non-COVID-19 adult patients at the end-of-life stage in a hospital or nursing home. Results: Results showed that 51% of the nurses in the sample had training in palliative care. However, the percentage decreased to 38.5% among those who cared for COVID-19 patients and to 44.5% in those who cared for non-COVID-19 patients. In relation to attitudes about end-of-life care, more positive attitudes and a higher mean score were found in the trained group. Conclusions: Palliative care training is a key element in end-of-life care and is even more important in times of COVID-19. Impact: Although end-of-life accompaniment has been studied, few studies have included the influence of training on this during the pandemic. This study identifies key elements of accompaniment and training in a comparison of COVID-19 and non-COVID-19 patients during the pandemic. In relation to attitudes toward end-of-life care, the results showed a more positive attitude and a higher mean score in the trained group (3.43 ± 0.37 versus 3.21 ± 0.32), the difference being statistically significant (p < 0.001)