5 research outputs found
Cancer treatment delays among cancer patients living with HIV during the COVIDâ19 pandemic in the United States
Abstract Background The COVIDâ19 pandemic led to care disruptions across the cancer continuum. It is unknown if immunosuppressed patients with cancer, who may be at higher risk for complications of SARSâCoVâ2 infection, are disproportionately impacted. Thus, we aimed to compare delays in cancer treatment initiation between people living with HIV (PLWH) and cancer, the general cancer population (GCP), and patients with cancer and a history of solid organ transplant (SOT). Comparisons were made across the period 2âyears preceding the pandemic versus the first year of the pandemic. Methods We used data from a realâworld electronic health recordâderived deâidentified database (2018â2021) comprised of US patients with cancer from 800 sites of care across the country. We included patients with 19 different cancer types. We calculated time to cancer treatment initiation (TTI) as the difference between the date of cancer diagnosis and the earliest date that cancer treatment was recorded. Results The sample included 181 PLWH, 65,073 GCP patients, and 195 patients with a SOT. Differenceâinâdifference regression models adjusted for age, sex, and presence of metastatic disease at cancer diagnosis revealed a significant increase in delayed TTI among PLWH compared to the GCP during COVIDâ19 versus prior to COVIDâ19, with delays increasing by approximately 1âmonth during the pandemic (DID: 32.6âdays [8.9â56.3]; pâ=â0.007). The increase in TTI for PLWH was observed across treatment modalities, including surgery (DID: 55.1 [28.8â81.3], pâ<â0.001) and systemic therapy (DID: 30.4 [4.6â56.3], pâ=â0.021). Conclusions/Relevance PLWH experienced significant delays in cancer treatment initiation after diagnosis during the first year of COVIDâ19, delays that may negatively impact cancer outcomes. These data warrant patient and provider attention as the pandemic continues to impact the US healthcare system
Measurement of D-s(+) and D-s(*+) production in B meson decays and from continuum e(+)e(-) annihilation at root s=10.6 GeV
New measurements of D-s(+) and D-s(*+) meson production rates from B decays and from q(q) over bar continuum events near the Y(4S) resonance are presented. Using 20.8 fb(-1) of data on the Y(4S) resonance and 2.6 fb(-1) off-resonance, we find the inclusive branching fractions B(B-->Ds+X) = (10.93+/-0.19+/-0.58+/-2.73)% and B(B-->Ds*+X) = (7.9+/-0.8+/-0.7+/-2.0)%, where the first error is statistical, the second is systematic, and the third is due to the D-s(+)-->phipi(+) branching fraction uncertainty. The production cross sections sigma(e(+)e(-)-->Ds+X)xB(D-s(+)-->phipi(+)) = 7.55+/-0.20+/-0.34 pb and sigma(e(+)e(-)-->Ds*+/-X)xB(D-s(+)-->phipi(+)) = 5.8+/-0.7+/-0.5 pb are measured at center-of-mass energies about 40 MeV below the Y(4S) mass. The branching fractions SigmaB(B-->D-s((*)+)(D) over bar ((*))) = (5.07+/-0.14+/-0.30+/-1.27)% and SigmaB(B-->D-s(*+)(D) over bar ((*))) = (4.1+/-0.2+/-0.4+/-1.0)% are determined from the D-s((*)+) momentum spectra. The mass difference m(D-s(+)) -m(D+) = 98.4+/-0.1+/-0.3 MeV/c(2) is also measured
Measurement of Ds+ and Ds*+ production in B meson decays and from continuum e+e- annihilation at âs=10.6 GeV
New measurements of Ds+ and Ds*+ meson production rates from B decays and from qqÌ
continuum events near the ΄(4S) resonance are presented. Using 20.8 fb-1 of data on the ΄(4S) resonance and 2.6 fb-1 off-resonance, we find the inclusive branching fractions B(BâDs+X)=(10.93±0.19±0.58±2.73)% and B(BâDs*+X)=(7.9±0.8±0.7±2.0)%, where the first error is statistical, the second is systematic, and the third is due to the Ds+âÏÏ+ branching fraction uncertainty. The production cross sections Ï(e+e-âDs+X)ĂB(Ds+âÏÏ+)=7.55±0.20±0.34pb and Ï(e+e-âDs*±X)ĂB(Ds+âÏÏ+)=5.8±0.7±0.5pb are measured at center-of-mass energies about 40 MeV below the ΄(4S) mass. The branching fractions ÎŁB(BâDs(*)+D(*))=(5.07±0.14±0.30±1.27)% and ÎŁB(BâDs*+D(*))=(4.1±0.2±0.4±1.0)% are determined from the Ds(*)+ momentum spectra. The mass difference m(Ds+)-m(D+)=98.4±0.1±0.3MeV/c2 is also measured
Measurement of D+(s) and D*+(s) production in B meson decays and from continuum e+ e- annihilations at s**(1/2) = 10.6-GeV.
none622Bernard Aubert; D. Boutigny; J.M. Gaillard; A. Hicheur; Y. Karyotakis; J.P. Lees; P. Robbe; V. Tisserand; A. Palano; G.P. Chen; J.C. Chen; N.D. Qi; G. Rong; P. Wang; Y.S. Hz; G. Eigen; P.L. Reinertsen; B. Stugu; B. Abbott; G.S. Abrams; A.W. Borgland; A.B. Breon; David Nathan Brown; Janice Button-Shafer; R.N. Cahn; A.R. Clark; M.S. Gill; A.V. Gritsan; Y. Groysman; R.G. Jacobsen; R.W. Kadel; J. Kadyk; L.T. Kerth; S. Kluth; Yu.G. Kolomensky; J.F. Kral; C. LeClerc; M.E. Levi; T. Liu; G. Lynch; A.B. Meyer; M. Momayezi; P.J. Oddone; A. Perazzo; M. Pripstein; N.A. Roe; A. Romosan; M.T. Ronan; V.G. Shelkov; A.V. Telnov; W.A. Wenzel; P.G. Bright-Thomas; T.J. Harrison; C.M. Hawkes; D.J. Knowles; S.W. O'Neale; R.C. Penny; A.T. Watson; N.K Watson; T. Deppermann; K. Goetzen; H. Koch; J. Krug; M. Kunze; B. Lewandowski; K. Peters; H. Schmuecker; M. Steinke; J.C. Andress; N.R. Barlow; W. Bhimji; N. Chevalier; P.J. Clark; W.N. Cottingham; N. De Groot; N. Dyce; B. Foster; J.D. McFall; D. Wallom; F.F. Wilson; K. Abe; C. Hearty; T.S. Mattison; J.A. McKenna; D. Thiessen; S. Jolly; A.K. McKemey; Jane S. Tinslay; V.E. Blinov; A.D. Bukin; D.A. Bukin; A.R. Buzykaev; V.B. Golubev; V.N. Ivanchenko; A.A. Korol; E.A. Kravchenko; A.P. Onuchin; A.A. Salnikov; S.I. Serednyakov; Yu.I. Skovpen; Valery I. Telnov; A.N. Yushkov; D. Best; A.J. Lankford; M. Mandelkern; S. McMahon; D.P. Stoker; A. Ahsan; K. Arisaka; C. Buchanan; S. Chun; J.G. Branson; D.B. MacFarlane; Soeren A. Prell; S. Rahatlou; G. Raven; V. Sharma; C. Campagnari; B. Dahmes; P.A. Hart; N. Kuznetsova; S.L. Levy; O. Long; A. Lu; J.D. Richman; W. Verkerke; Michael S. Witherell; S. Yellin; J. Beringer; D.E. Dorfan; A.M. Eisner; A. Frey; A.A. Grillo; M. Grothe; C.A. Heusch; R.P. Johnson; W. Kroeger; William S. Lockman; T. Pulliam; H. Sadrozinski; T. Schalk; R.E. Schmitz; B.A. Schumm; A. Seiden; M. Turri; W. Walkowiak; D.C. Williams; M.G. Wison; E. Chen; G.P. Dubois-Felsmann; A. Dvoretskii; D.G. Hitlin; S. Metzler; J. Oyang; F.C. Porter; A. Ryd; A. Samuel; M. Weaver; S. Yang; R.Y. Zhu; S. Devmal; T.L. Geld; S. Jayatilleke; G. Mancinelli; B.T. Meadows; M.D. Sokoloff; T. Barillari; P. Bloom; M.O. Dima; S. Fahey; William T. Ford; D.R. Johnson; U. Nauenberg; A. Olivas; H. Park; P. Rankin; J. Roy; S. Sen; James G. Smith; W.C. van Hoek; D.L. Wagner; J. Blouw; John L. Harton; M. Krishnamurthy; A. Soffer; W.H. Toki; R.J. Wilson; J. Zhang; T. Brandt; J. Brose; T. Colberg; G. Dahlinger; M. Dickopp; R.S. Dubitzky; A. Hauke; E. Maly; R. Muller-Pfefferkorn; S. Otto; Klaus R. Schubert; R. Schwierz; B. Spaan; L. Wilden; L. Behr; Denis Bernard; 1; G.R. Bonneaud; F. Brochard; J. Cohen-Tanugi; S. Ferrag; E. Roussot; S. T'Jampens; C. Thiebaux; G. Vasileiadis; M. Verderi; A. Anjomshoaa; R. Bernet; A. Khan; D. Lavin; F. Muheim; S. Playfer; J.E. Swain; M. Falbo; C. Borean; C. Bozzi; S. Dittongo; M. Folegani; L. Piemontese; E. Treadwell; F. Anulli; R. Baldini-Ferroli; A. Calcaterra; R. de Sangro; D. Falciai; G. 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Measurement of the CP violating asymmetry amplitude sin 2beta
We present results on time-dependent CP-violating asymmetries in neutral B
decays to several CP eigenstates. The measurements use a data sample of about
88 million Y(4S) --> B Bbar decays collected between 1999 and 2002 with the
BABAR detector at the PEP-II asymmetric-energy B Factory at SLAC. We study
events in which one neutral B meson is fully reconstructed in a final state
containing a charmonium meson and the other B meson is determined to be either
a B0 or B0bar from its decay products. The amplitude of the CP-violating
asymmetry, which in the Standard Model is proportional to sin2beta, is derived
from the decay-time distributions in such events. We measure sin2beta = 0.741
+/- 0.067 (stat) +/- 0.034 (syst) and |lambda| = 0.948 +/- 0.051 (stat) +/-
0.030 (syst). The magnitude of lambda is consistent with unity, in agreement
with the Standard Model expectation of no direct CP violation in these modes.Comment: 7 pages, 2 postscript figures, submitted to PR