Non-Cardiogenic Thromboembolism in a Persian Cat with Hypertrophic Cardiomyopathy

Background: Hypertrophic cardiomyopathy is the most common acquired cardiovascular disease in the feline species. A frequent complication of this cardiomyopathy is the development of cardiac congestive failure, left atrial enlargement and subsequent development of arterial thromboembolism. In a significant percentage of affected animals there is progression to congestive heart failure, resulting in cyanosis and dyspnea, often the first clinical signs reported by owners. This is a report of a 10-year-old Persian cat with hypertrophic cardiomyopathy and venous and arterial thromboembolism of non-cardiogenic origin.Case: The patient was referred for cardiac evaluation, arterial thromboembolism was the suspected cause of tetraparesis. On clinical examination, a metacarpal pulse was present in all limbs; there was no cyanosis or peripheral hypothermia thus, ruling out a thromboembolic event in the limbs. Changes consistent with feline asthma and pulmonary edema were seen on radiographs, therefore hypertrophic cardiomyopathy was suspected. Treatment with enalapril (0.25 mg/kg every 12 h) for the heart condition and prednisolone (1 mg/kg every 24 h) for asthma was started. Nine days later, the patient developed mixed dyspnea (inspiratory and expiratory) and was hospitalized with signs consistent with arterial thromboembolism: paralysis and cold extremities in the right and left pelvic limbs. The patient was euthanized due to the poor prognosis. Post mortem and histopathological findings revealed left ventricular concentric hypertrophy, with no valvular changes; disseminated intravascular coagulation, with thrombi in the arterial (iliac arteries, pancreatic and renal vessels) and venous (pulmonary and renal veins) beds; as well as multiple neoplastic lung masses, identified as scirrhous pulmonary adenocarcinoma, responsible for increased interstitial radiopacity. Metastasis was also identified at the tracheal bifurcation, causing radiographic changes similar to the alveolar pattern of pulmonary edema.Discussion: The origin of the concentric left ventricular hypertrophy was not established. Both primary hypertrophy, due to breed-related genetic predisposition or secondary hypertrophy, due to systemic hypertension from chronic kidney disease are possibilities. However, despite the left ventricular concentric hypertrophy and the presence of thrombus under the mitral valve, it was not thought that the patient had cardiogenic thromboembolism, since this would not explain the venous thrombi. The arterial and venous thromboembolism in this case were the result of paraneoplastic syndrome due to pulmonary adenocarcinoma, which was a triggering factor for disseminated intravascular coagulation and multiple thrombus formation, both in arterial and venous beds. Tumor cells may promote direct and indirect modifications in the coagulation cascade and, thus hypercoagulability. The hypercoagulatory state promoted by the tumor associated with the Virchow triad seen in feline species, explains the occurrence of thrombosis in this case report. Sensitive imaging tests, such as computed tomography or magnetic resonance imaging, may be required in middle-aged cats with hypertrophic cardiomyopathy and clinical presentations of thromboembolism or respiratory signs, in order to exclude pulmonary neoplasm as a differential diagnosis for thrombus formation and dyspnea. Furthermore, it is speculated that the antitumor effect of heparin used in the treatment for arterial thromboembolism may delay the diagnosis of lung neoplasia in cats

Phlebotomine sandflies fauna (Diptera: Psychodidae) at rural settlements in the municipality of Cáceres, State of Mato Grosso, Brazil Fauna flebotomínica (Diptera: Psychodidae) em assentamentos rurais no Município de Cáceres, Estado de Mato Grosso, Brasil

INTRODUCTION: Leishmaniasis is expanding across Brazil, including the State of Mato Grosso (MT). The aim of this study was to characterize the phlebotomine sandfly fauna at threerural settlements located in the municipality of Cáceres, MT, from August 2010 to July 2011. METHODS: Sandfly captures were conducted at the forest border and in intra and peridomicile areas with automatic light traps, biweekly, from 5pm to 6am. RESULTS: Of the 630 sandflies collected, 348 were female, and 282 were male. Captured specimens were distributed across 11 genera - Brumptomyia, Evandromyia, Expapillata, Lutzomyia, Martinsmyia, Micropygomyia, Nyssomyia, Pintomyia, Psathyromyia, Psychodopygus, and Sciopemyia - and 28 species. Among these, six species had not been marked yet in MT (Brumptomyia avellari, Br. mangabeirai, Evandromyia aldafalcaoae, Micropygomyia echinatopharynx, Micropygomyia peresi, and Pa. campograndensis). Nyssomyia whitmani was the most abundant species across ecotopes at all settlements. Interestingly, Lutzomyia longipalpis and Lutzomyia cruzi were found in sympatry. CONCLUSIONS: The disorganized occupation of the environment that is happening at the rural settlements of Mata Comprida, Laranjeira I and II could provide opportunities for the domiciliation of wild populations of phlebotomine, including vectors of leishmaniasis. Therefore, more studies are needed to understand the epidemiology of the disease in these areas and its impact on the human population.<br>INTRODUÇÃO: As leishmanioses encontram-se em expansão no Brasil, inclusive no Estado de Mato Grosso (MT). A presente pesquisa teve como objetivo estudar a fauna flebotomínica emtrês assentamentos rurais localizados no município de Cáceres, MT, entre agosto de 2010 e julhode 2011. MÉTODOS: As coletas foram realizadas na margem da mata, no intra e peridomicílio com armadilhas automáticas luminosas, quinzenalmente, das 17h às 6h. RESULTADOS: Foram coletados 630 exemplares, sendo 348 fêmeas e 282 machos. Os espécimes foramdistribuídos em 11 gêneros: Brumptomyia, Evandromyia, Expapillata, Lutzomyia, Martinsmyia,Micropygomyia, Nyssomyia, Pintomyia, Psathyromyia, Psychodopygus e Sciopemyia e 28 espécies, sendo que dentre estas, seis não haviam sido assinaladas em MT (Brumptomyia avellari, Br. mangabeirai, Evandromyia aldafalcaoae, Micropygomyia echinatopharynx, Micropygomyia peresi e Pa. campograndensis). Ressalta-se o encontro de Nyssomyia whitmani, espécie mais abundante nos diferentes ecótopos em todos os assentamentos. Destaca-se também a presençadas espécies Lutzomyia longipalpis e Lutzomyia cruzi em simpatria. CONCLUSÕES: A ocupação desordenada do ambiente, como vem ocorrendo nos assentamentos Mata Comprida, LaranjeiraI e II, pode proporcionar a domiciliação de populações selváticas de flebotomíneos, dentre estes os vetores das leishmanioses, tornando-se necessários maiores estudos para entender a dinâmica de transmissão dessas morbidades nestes locais

Phlebotomine sandflies fauna (Diptera: Psychodidae) at rural settlements in the municipality of Cáceres, State of Mato Grosso, Brazil

Submitted by Nuzia Santos ([email protected]) on 2014-02-19T13:46:55Z No. of bitstreams: 1 cáceres.pdf: 1674264 bytes, checksum: 12b917a1e84341d079e52137732df29f (MD5)Made available in DSpace on 2014-02-19T13:46:55Z (GMT). No. of bitstreams: 1 cáceres.pdf: 1674264 bytes, checksum: 12b917a1e84341d079e52137732df29f (MD5) Previous issue date: 2012Universidade Federal do Mato Grosso do Sul. Programa de Pós-Graduação em Doenças Infecciosas e Parasitárias. Campo Grande, MS, BrasilUniversidade Federal do Mato Grosso do Sul. Centro de Ciências Biológicas e da Saúde. Laboratório de Parasitologia Humana. Campo Grande, MS, BrasilUniversidade Estadual de Mato Grosso. Curso de Ciências Biológicas. Cáceres, MT, BrasilUniversidade Estadual de Mato Grosso. Curso de Ciências Biológicas. Cáceres, MT, BrasilUniversidade Federal do Mato Grosso do Sul. Centro de Ciências Biológicas e da Saúde. Laboratório de Parasitologia Humana. Campo Grande, MS, BrasilUniversidade Federal do Mato Grosso do Sul. Centro de Ciências Biológicas e da Saúde. Laboratório de Parasitologia Humana. Campo Grande, MS, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Referência Nacional e Internacional para Flebotomíneos. Coleção de Flebotomíneos. Belo Horizonte, MG, BrasilUniversidade Federal do Mato Grosso do Sul. Programa de Pós-Graduação em Doenças Infecciosas e Parasitárias. Campo Grande, MS, Brasil/Universidade Federal do Mato Grosso do Sul. Centro de Ciências Biológicas e da Saúde. Laboratório de Parasitologia Humana. Campo Grande, MS, BrasilINTRODUÇÃO: As leishmanioses encontram-se em expansão no Brasil, inclusive no Estado de Mato Grosso (MT). A presente pesquisa teve como objetivo estudar a fauna flebotomínica emtrês assentamentos rurais localizados no município de Cáceres, MT, entre agosto de 2010 e julhode 2011. MÉTODOS: As coletas foram realizadas na margem da mata, no intra e peridomicílio com armadilhas automáticas luminosas, quinzenalmente, das 17h às 6h. RESULTADOS: Foram coletados 630 exemplares, sendo 348 fêmeas e 282 machos. Os espécimes foramdistribuídos em 11 gêneros: Brumptomyia, Evandromyia, Expapillata, Lutzomyia, Martinsmyia,Micropygomyia, Nyssomyia, Pintomyia, Psathyromyia, Psychodopygus e Sciopemyia e 28 espécies, sendo que dentre estas, seis não haviam sido assinaladas em MT (Brumptomyia avellari, Br. mangabeirai, Evandromyia aldafalcaoae, Micropygomyia echinatopharynx, Micropygomyia peresi e Pa. campograndensis). Ressalta-se o encontro de Nyssomyia whitmani, espécie mais abundante nos diferentes ecótopos em todos os assentamentos. Destaca-se também a presençadas espécies Lutzomyia longipalpis e Lutzomyia cruzi em simpatria. CONCLUSÕES: A ocupação desordenada do ambiente, como vem ocorrendo nos assentamentos Mata Comprida, LaranjeiraI e II, pode proporcionar a domiciliação de populações selváticas de flebotomíneos, dentre estes os vetores das leishmanioses, tornando-se necessários maiores estudos para entender a dinâmica de transmissão dessas morbidades nestes locais.INTRODUCTION: Leishmaniasis is expanding across Brazil, including the State of Mato Grosso (MT). The aim of this study was to characterize the phlebotomine sandfly fauna at threerural settlements located in the municipality of Cáceres, MT, from August 2010 to July 2011. METHODS: Sandfly captures were conducted at the forest border and in intra and peridomicile areas with automatic light traps, biweekly, from 5pm to 6am. RESULTS: Of the 630 sandflies collected, 348 were female, and 282 were male. Captured specimens were distributed across 11 genera - Brumptomyia, Evandromyia, Expapillata, Lutzomyia, Martinsmyia, Micropygomyia, Nyssomyia, Pintomyia, Psathyromyia, Psychodopygus, and Sciopemyia - and 28 species. Among these, six species had not been marked yet in MT (Brumptomyia avellari, Br. mangabeirai, Evandromyia aldafalcaoae, Micropygomyia echinatopharynx, Micropygomyia peresi, and Pa. campograndensis). Nyssomyia whitmani was the most abundant species across ecotopes at all settlements. Interestingly, Lutzomyia longipalpis and Lutzomyia cruzi were found in sympatry. CONCLUSIONS: The disorganized occupation of the environment that is happening at the rural settlements of Mata Comprida, Laranjeira I and II could provide opportunities for the domiciliation of wild populations of phlebotomine, including vectors of leishmaniasis. Therefore, more studies are needed to understand the epidemiology of the disease in these areas and its impact on the human population