COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report

Background The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, and whether vaccination attenuates infection severity in IEI. Objective To estimate COVID-19 vaccination safety and examine effect on outcomes in patients with IEI. Methods We built a secure registry database in conjunction with the US Immunodeficiency Network to examine vaccination frequency and indicators of safety and effectiveness in IEI patients. The registry opened on January 1, 2022, and closed on August 19, 2022. Results Physicians entered data on 1245 patients from 24 countries. The most common diagnoses were antibody deficiencies (63.7%). At least one COVID-19 vaccine was administered to 806 patients (64.7%), and 216 patients received vaccination prior to the development of COVID-19. The most common vaccines administered were mRNA-based (84.0%). Seventeen patients were reported to seek outpatient clinic or emergency room care for a vaccine-related complication, and one patient was hospitalized for symptomatic anemia. Eight hundred twenty-three patients (66.1%) experienced COVID-19 infection. Of these, 156 patients required hospitalization (19.0%), 47 required ICU care (5.7%), and 28 died (3.4%). Rates of hospitalization (9.3% versus 24.4%, p < 0.001), ICU admission (2.8% versus 7.6%, p = 0.013), and death (2.3% versus 4.3%, p = 0.202) in patients who had COVID-19 were lower in patients who received vaccination prior to infection. In adjusted logistic regression analysis, not having at least one COVID-19 vaccine significantly increased the odds of hospitalization and ICU admission. Conclusion Vaccination for COVID-19 in the IEI population appears safe and attenuates COVID-19 severity

Inborn errors of immunity: Manifestation, treatment, and outcome—an ESID registry 1994–2024 report on 30,628 patients

The European Society for Immunodeficiencies patient registry (ESID-R), established in 1994, is one of the world’s largest databases on inborn errors of immunity (IEI). IEI are genetic disorders predisposing patients to infections, autoimmunity, inflammation, allergies, and malignancies. Treatments include antimicrobial therapy, immunoglobulin replacement, immune modulation, stem cell transplantation, and gene therapy. Data from 194 centers in 33 countries capture clinical manifestations and treatments from birth onward, with annually expected updates. This report reviews the ESID-R’s structure, data content, and impact. The registry includes 30,628 patient datasets (aged 0–97.9 years; median follow-up: 7.2 years; total 825,568.2 patient-years), with 13,550 cases in 15 sub-studies. It has produced 84 peer-reviewed publications (mean citation rate: 95). Findings include real-world observations of IEI diagnoses, genetic causes, clinical manifestations, treatments, and survival trends. The ESID-R fosters global collaboration, advancing IEI research and patient care. This report highlights the key role of the multinational ESID-R, led by an independent medical society, in evidence-based discovery

Ad-Me: A Context-Sensitive Advertising System

Third International Conference on Information Integration and Web-based Applications and Services (iiWAS 2001), Linz, Austria, 10-12 September, 2001The mobile commerce sector and in particular the context sensitive advertising will represent a high yield revenue stream. This paper introduces the Ad-me (Advertising for the Mobile E-commerce user) system. The Ad-me is a mobile tourist guide that proactively delivers advertisements to users based upon perceived individual user needs together with their location. A Multi-Agent Systems (MAS) design philosophy is adopted. In order to achieve maximum content diffusion a range of presentation formats are accommodated including HTML, WML, HDML and iMode.09/07/13 RBCannot find any publisher information - R

Agent-Based Ubiquitous Systems : 9 Lessons Learnt

UbiComp 2003, 5th International Conference on Ubiquitous Computing, UbiSys (System Support for Ubiquitous Computing) Workshop, 12th-15th October, 2003, Seattle, Washington, USAThe recent emergence of agent prototyping environments for developing Java agents (Aglets, JATlite, JACK, Agent Factory) and the availability of the J2ME (Java 2Micro Edition) on light devices (PDAs and cellular phones) provides the ability for strong agenthood to be delivered in the mobile and ubiquitous sector. This is an experience paper that discusses the lessons learnt in the construction of agent-based ubiquitous sytems. Within this paper we consider four such systems namely Ad-me, WAY, Gulliver’s Genie, and Easishop. They all have been developed at UCD. The common denominator for all prototypes is the use of Lightweight BDI agents and the intelligent pre-caching of content.8.7.2013 SB

Ad-me: Intelligent Context-Sensitive Advertising within a Mobile Tourist Guide.

12th Irish Conference on Artificial Intelligence & Cognitive Science 5 September - 7 September, 2001, National University of Ireland (NUI), Maynooth, Co. Kildare, IrelandThe mobile commerce sector is set to witness phenomenal growth. In particular context sensitive advertising will represent a high yield revenue stream. This paper introduces the Ad-me (Advertising for the mobile e-commerce user) system which proactively delivers advertisements to users. Within the context of a mobile tourist guide advertisements are presented relative to user location and perceived needs. It uses Global Positioning System (GPS) and embraces agent-oriented design principles.090713 - R

Ad-me: Wireless Advertising Adapted to the User Location, Device and Emotions

It has been predicted that the next phase of electronic business growth will be in the area of mobile e-commerce. The translation from “e ” to “m ” commerce, however, is not a straightforward task. This paper considers context sensitive advertising. According to analysts, wireless advertising will prove most successful when the advertisements merge seamlessly with the service content provided. This paper discusses key issues in the development of Ad-me (Advertising for the Mobile E-commerce user), a context-sensitive advertising system. Ad-me aims to deliver more palatable, less intrusive and personalized advertisements overlaid upon a mobile tourist guide. This paper describes the design and implementation of Ad-me and subsequently reflects upon the possibility of using user emotion to increase effectiveness of the advertising. The design of Ad-me adopts a Multi-Agent Systems (MAS) philosophy

Effect of lanthanide ions and triazole ligands on the molecular properties, spectroscopy and pharmacological activity

The effect of La, Ce, Pr and Nd ions on four Ln(ligand)3 complexes and at three DFT levels of calculation was analyzed. Four ligands were chosen, three of which were based on the 1,2,3-triazole ring. The DFT methods used were B3LYP, CAM-B3LYP and M06-2X. The relationships established were between the geometric parameters, atomic charges, HOMO-LUMO energies and other molecular properties. These comparisons and trends will facilitate the synthesis of new complexes by selecting the ligand and lanthanide ion best suited to the desired property of the complex. The experimental IR and Raman spectra of Ln(2b')3 complexes where Ln = La, Ce, Pr, Nd, Sm, Gd, Dy, Ho and Er ions have been recorded and compared to know the effect of the lanthanide ion on the complex. The hydration in these complexes was also analyzed. Additionally, the effect of the type of coordination center on the ability of an Ln(ligand)3 complex to participate in electron exchange and hydrogen transfer was investigated using two in vitro model systems-DPPH and ABTS.Unión EuropeaDepto. de Química FísicaFac. de Ciencias QuímicasTRUEpu