Waloryzacja przydatności turystycznej regionu na przykładzie odcinka Wielkiej Pętli Wielkopolski

River valleys and forest areas, are the most useful for the development of tourism and recreation. These areas are particularly important for the tourist potential of the region. This article evaluates the tourist potential of areas along the Great Waterway Loop of Wielkopolska. The study was carried out in accordance with the rules of point bonitation and covered communes located directly and indirectly along the valley of the Warta River, on the section from Konin to Rogalinek. Based on selected criteria, variables and using appropriate statistical methods, individual research units were evaluated and a ranking of tourist usefulness of the studied units was created. Recognizing the diversity in the level of tourist utility of municipalities will enable the correct use of natural resources,in this case the Great Waterway Loop of Wielkopolska and activation of tourism development in the region.Szczególne znaczenie dla potencjału turystycznego regionu mają doliny rzeczne oraz obszary leśne, które są terenami przydatnymi do rozwoju turystyki i rekreacji. W artykule dokonano waloryzacji przydatności turystycznej obszarów położonych wzdłuż Wielkiej Pętli Wielkopolski. Badanie przeprowadzono zgodnie z zasadami bonitacji punktowej i objęto nim gminy zlokalizowane bezpośrednio i pośrednio wzdłuż doliny rzeki Warty, na odcinku od Konina do Rogalinka. Na podstawie wybranych kryteriów, zmiennych i przy użyciu odpowiednich metod statystycznych dokonano oceny poszczególnych jednostek badawczych i utworzono ranking ich przydatności turystycznej. Rozpoznanie zróżnicowania poziomu przydatności turystycznej gmin umożliwi prawidłowe wykorzystanie zasobów przyrodniczych, w tym przypadku Wielkiej Pętli Wielkopolski, i aktywizację rozwoju turystyki w regionie

Construction of bionanoparticles with the use of a recombinant DNA vector-enzymatic system, containing artificial poliepitopic proteins, for the delivery of new generation vaccines

DNA/RNA amplification technologies, such as the Polymerase Chain Reaction have revolutionized modern biology, medical diagnostics and forensic analyses, among others. A number of alternative nucleic acids amplification methods have been developed, tailored to specific applications. Here we present a refined version of a DNA fragment amplification technology, which enables the construction of ordered concatemers in a head-to-tail-orientation. A very high number of DNA segments, at least 500 copies, can be consecutively linked. Other key features include: (i) the application of a dedicated vector-enzymatic system, including selected subtype IIS restriction endonucleases, which has been designed to automatically generate long Open Reading Frames and (ii) an amplification-expression vector with a built-in strong transcription promoter along with optimal translation initiation signals, which allow for a high level of expression of the constructed artificial poliepitopic protein. This highly advanced technology makes it possible to obtain ordered polymers of monomeric, synthetic or natural, DNA far beyond the capabilities of current chemical synthesis methods. The constructed poliepitopic proteins are further used for construction of several types of nanoparticles, including inclusion bodies and bacteriophages, containing multiple genetic fusion with poliepitopic proteins.The technology offers significant advances in a number of scientific, industrial and medical applications, including new vaccines and tissue pro-regenerative methods. The technology is protected by an international patent application and is available for licensing. Acknowledgments: project was supported by National Center for Research and Development, Warsaw, Poland, grant no STRATEGMED1/235077/9/NCBR/2014 and POIG.01.04.00-22-140/12; Jagiellonian Center for Innovation, Krakow, Poland; SATUS VC, Warsaw, Poland and BioVentures Institute Ltd, Poznan, Poland

The influence of interleukin-6 and tumor necrosis factor α gene polymorphisms on bone mineral density in postmenopausal women

Summary Proinflammatory cytokines, interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α), involved into osteoclastogenesis and responsible for bone resorption process, participate in the pathogenesis of the osteoporosis. In vitro studies have shown that single nucleotide polymorphisms of IL-6 and TNF-α genes could influence the transcription process of the genes and the cytokines level. Aim: Assessment of the influence of IL-6 and TNF-α gene polymorphisms on bone mineral density (BMD) and evaluation of their connection with osteoporosis prevalence in women from Wielkopolska region. Material and methods: In the group of 267 postmenopausal women (average age 58,5+/-5,9 years, average age of last period 49,8+/-3,9 years) bone mineral density in lumbar spine (L2-L4) was performed using dual energy X-ray absorptiometry (DXA). Genotypes frequencies were determined by polymerase chain reaction with restriction fragment length polymorphism (PCR/RFLP) using restriction enzymes Lwe I and Faq I, respectively. The connection between the polymorphisms of investigated genes and body mass index, age of menarche and menopause and length of reproductive age had been analyzed as well. Results: No statistically significant association was found between examined genetic factors and the value of bone mineral density in the investigated group of postmenopausal women. The frequencies of investigated genotypes were in compliance with Hardy-Weinberg equilibrium. The correspondence between evaluated clinical parameters and IL-6 i TNF-α genotypes frequencies has not been proven. Conclusions: The -174G/C polymorphism in the IL-6 and -308G/A polymorphism in TNF-α genes have no influence on bone mineral density value (BMD) in the investigated population of women from Wielkopolska region

Results of the first European Source Apportionment intercomparison for Receptor and Chemical Transport Models

In this study, the performance of the source apportionment model applications were evaluated by comparing the model results provided by 44 participants adopting a methodology based on performance indicators: z-scores and RMSEu, with pre-established acceptability criteria. Involving models based on completely different and independent input data, such as receptor models (RMs) and chemical transport models (CTMs), provided a unique opportunity to cross-validate them. In addition, comparing the modelled source chemical profiles, with those measured directly at the source contributed to corroborate the chemical profile of the tested model results. The most used RM was EPA- PMF5. RMs showed very good performance for the overall dataset (91% of z-scores accepted) and more difficulties are observed with SCE time series (72% of RMSEu accepted). Industry resulted the most problematic source for RMs due to the high variability among participants. Also the results obtained with CTMs were quite comparable to their ensemble reference using all models for the overall average (>92% of successful z-scores) while the comparability of the time series is more problematic (between 58% and 77% of the candidates’ RMSEu are accepted). In the CTM models a gap was observed between the sum of source contributions and the gravimetric PM10 mass likely due to PM underestimation in the base case. Interestingly, when only the tagged species CTM results were used in the reference, the differences between the two CTM approaches (brute force and tagged species) were evident. In this case the percentage of candidates passing the z-score and RMSEu tests were only 50% and 86%, respectively. CTMs showed good comparability with RMs for the overall dataset (83% of the z-scores accepted), more differences were observed when dealing with the time series of the single source categories. In this case the share of successful RMSEu was in the range 25% - 34%.JRC.C.5-Air and Climat

Lying in the workplace

W procesie kłamstwa istotną rolę odgrywa relacja interpersonalna, a także kontekstspołeczny w jakim akt kłamstwa następuje. Kłamstwo w miejscu pracy może przybierać różne formy. Może to być kłamstwo wypowiedziane pracodawcy przez pracownika lub odwrotnie. Może to być kłamstwo w CV lub kłamstwo wypowiedziane podczas rozmowy kwalifikacyjnej, kłamstwo stosowane jako usprawiedliwienie niewywiązania się z powierzonych obowiązków lub tzw. białe kłamstwa, które są związane z utrzymywaniem prawidłowych kontaktów społecznych. Istnieje wiele typów kłamstw i sytuacji, w których pracownicy mogą je stosować. Pracownicy kłamiąc starają się prezentować bardziej efektywnie niż są w rzeczywistości, próbują zamaskować własne niekompetencje i brak sukcesu, często dlatego, że nie mogą zrozumieć, dlaczego nie odnoszą sukcesów i nie wiedzą, jak zmienić swoją sytuację, a w końcu aby być postrzeganym wśród współpracowników jako osoba powszechnie lubiana. Jednak o ile kłamstwo jest rozumiane jako endemiczna cecha społeczeństwa rzadko było centralnym problemem badań organizacji. W artykule zaprezentowano fragment wyników badań własnych przeprowadzonych wśród pracowników z terenu województwa lubuskiego. Celem ogólnym poniższego opracowania jest przedstawienie kłamstwa jako zachowania występującego w miejscu pracy. Podstawę źródłową stanowi analiza literatury przedmiotu oraz analiza fragmentu wyników badań własnych.In the process of lying, an important role is played by the interpersonal relationship as well as the social context in which the act of lying occurs. Lying in the workplace can take many forms. It may be a lie told to the employer by the employee or vice versa. It may be a lie on your CV or a lie said during an interview, a lie used as an excuse for not fulfilling your duties or the so-called white lies that are related to maintaining proper social contacts. There are many types of lies and situations in which employees can apply them. Employees lying, try to present more effectively than they really are, try to mask their own incompetence and lack of success, often because they cannot understand why they are not successful and do not know how to change their situation and finally be perceived among colleagues as a common person liked. However, as far as lying is understood as an endemic trait of society, it has rarely been a central research problem of an organization. The article presents a fragment of the results of own research conducted among employees from the Lubuskie Voivodeship. The general aim of the following study isto present lying as behavior occurring in the workplace. The source basisis an analysis of the literature on the subject and an analysis of a fragment of the results of own research

The action of psilocybin on the serotonergic system

Psylocybina jest psychoaktywnym związkiem występującym w ponad dwustu gatunkach grzybów halucynogennych i to właśnie ona jest odpowiedzialna za ich działanie na zwierzęta i na ludzi. W obecnych czasach poświęca jej się co raz więcej uwagi i dostrzega się jej terapeutyczny potencjał. Jest to również jeden z najbardziej popularnych i często używanych halucynogenów zaraz obok LSD i meskaliny. Za działanie psylocybiny w naszym organizmie odpowiadają receptory układu serotoninergicznego 5HT2A/2C. Intensywność efektów psylocybiny jest zależna od dawki, nastawienia i otoczenia pacjenta (set & setting) oraz indywidualnej fizjologii organizmu. Ta praca ma na celu przedstawić efekty działania psylocybiny, jej powiązanie z receptorami układu serotoninergicznego oraz zwrócić uwagę na szeroki zakres jej zastosowania terapeutycznego.Psilocybin is an alkaloid that occurs naturally in more than two hundred species of mushrooms. It has hallucinogenic effects on animals and humans. It is also one of the most commonly used hallucinogen next to mescaline and LSD. In the presented paper I review the history of psilocybin usage and the mechanisms of its action in the brain, with particular emphasis on serotonergic system (psilocybin acts on serotonin receptors 5-HT2A or 5-HT2C type). Finally, because several recent studies have revealed the therapeutic potential of psilocybin, I discuss the possible application of this alkaloid in medicine

9,10-Dioxoanthracenyldithiocarbamates effectively inhibit the proliferation of non-small cell lung cancer by targeting multiple protein tyrosine kinases

AbstractAnthraquinones have attracted considerable interest in the realm of cancer treatment owing to their potent anticancer properties. This study evaluates the potential of a series of new anthraquinone derivatives as anticancer agents for non-small-cell lung cancer (NSCLC). The compounds were subjected to a range of tests to assess their cytotoxic and apoptotic properties, ability to inhibit colony formation, pro-DNA damage functions, and capacity to inhibit the activity of tyrosine kinase proteins (PTKs). Based on the research findings, it has been discovered that most active derivatives (i84, i87, and i90) possess a substantial capability to impede the viability of NSCLC while having mostly a negligible effect on the human kidney cell line. Moreover, the anthraquinones displayed pro-apoptotic and genotoxic attributes while blocking the phosphorylation of multiple PTKs. Collectively, our findings indicate that these derivatives may demonstrate promising potential as effective anticancer agents for lung cancer treatment

Effect of Television on Obesity and Excess of Weight and Consequences of Health

The epidemic nature of obesity in industrialized countries is a serious health and social concern. The number of obese people has significantly increased in the past 20 years. In Poland excess weight and obesity are a serious epidemiological concern. In terms of the number of overweight people, Poland is a leader in Europe. Therefore, indicating many serious health concerns that are the natural consequences of this phenomenon has become important from the point of view of public health. This work identifies numerous diseases which are a direct consequence of obesity due to bad eating habits and lack of physical exercise among Poles. It discusses the negative effect of television and food commercials contributing to an increase in obesity, not only among adults but also among children. This is an overview forming grounds for further studies into ways of preventing the development of diseases due to obesity, both in Poland and in the world