704 research outputs found
Integrating fish farming with growing olives in Wadi Natrun, Egypt : a pre-feasibility study done for EMCCO
Investigation of external refrigeration systems for long term cryogenic storage
Selection and optimization of space cryogenic storage tank
Investigation of external refrigeration systems for long term cryogenic storage Final report
Data on external refrigeration systems for space storage of cryogens for long period
Investigation of external refrigeration systems for long-term cryogenic storage
Evaluation of cryogenic refrigeration systems for space application
Comparison of guidelines for the management of patients with highârisk and advanced cutaneous squamous cell carcinoma â a systematic review
The management of highârisk cutaneous squamous cell carcinoma (cSCC) can be a challenge as evidence from high quality clinical trials is rare. Guideline developers are challenged to provide practical and useful guidance for clinicians even in the absence of good evidence. In order to compare treatment recommendations for highârisk and advanced cSCC among national and international guidelines and to extract the most precise guidance provided, a systematic search was carried out in guideline databases Medline and Embase with a cutoff of 4 March 2019. Treatment recommendations for predefined clinical scenarios were extracted from selected guidelines and compared qualitatively. Five guidelines published from 2015 to 2018 were included. Excision of highârisk tumours with margin assessment was recommended in all guidelines. A safety margin of at least 6 mm was suggested in four guidelines. There was no clear recommendation to perform a sentinel lymph node biopsy in any guideline. Lymph node dissection was uniformly recommended in the presence of nodal disease. Treatment for metastatic cSCC was poorly characterized and restricted to the use of chemotherapy and epidermal growth factor receptor inhibitors. Recommendations for the management of highârisk and advanced cSCC were limited. We propose that guidelines should be updated to reflect recent advances in checkpoint blockade for metastatic cSCC
Revolving Asset-Based Lending Contracts and the Resolution of Debt-Related Agency Problems
Small firms that do not have access to organized financial markets must often rely on secured commercial loans for their debt financing. In large firms, debt-related agency problems are often resolved through the bond pricing process in the formal debt markets. When these same debt-related agency problems arise in small, private firms, the structure of the secured lending agreement must resolve these problems. This study identifies debt-related agency problems as they exist in private firms and examines howf the lending agreement resolves these problems
The role of lysosomal cysteine proteinases as markers of macrophage activation and as non-specific mediators of inflammation
Handbook of external refrigeration systems for long term cryogenic storage
Handbook of external refrigeration systems for long term cryogenic storag
Indigenous knowledges and development: a postcolonial caution
As a result of the failure of formal top-down development, there has recently been increased interest in the possibilities of drawing upon the indigenous knowledges of those in the communities involved, in an attempt to produce more effective development strategies. The concept of indigenous knowledge calls for the inclusion of local voices and priorities, and promises empowerment through ownership of the process. However, there has been little critical examination of the ways in which indigenous knowledges have been included in the development process. Drawing upon postcolonial theory, this article suggests that indigenous knowledges are often drawn into development by both theorists and development institutions in a very limited way, failing to engage with other ways of perceiving development, and thus missing the possibility of devising more challenging alternatives
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