Social inequalities in early childhood competences, and the relative role of social and emotional versus cognitive skills in predicting adult outcomes

This study draws on the nationally representative British Birth Cohort Study (BCS70) to examine (1) the association between social background and early socio-emotional and cognitive competences at age 5 and (2) the relative and independent contributions of early socio-emotional and cognitive competences to educational and socio-economic attainment in adulthood. A multi-dimensional (multiple exposure, multiple outcome) approach is adopted in conceptualising social background, childhood competences and adult outcomes by age 42. Indicators of social background include parental education, social class, employment status, family income, as well as home ownership, enabling us to test which aspects of socio-economic risk uniquely influence the development of early competences. Indicators of childhood competences include directly assessed cognitive competences (i.e. verbal and visual motor skills), while measures of socio-emotional competences include hyperactivity, good conduct, emotional health and social skills, reported by the child’s mother at age 5. Adult outcomes include highest qualifications, social class and household income by age 42. The findings suggest that multiple indicators of social background are associated with both socio-emotional and cognitive competences, although the associations with socio-emotional competences are less strong than those with cognitive competences. We find significant long-term predictive effects of early cognitive skills on adult outcomes, but also independent effects of socio-emotional competences, in particular self-regulation, over and above the role of family background. The study supports calls for early interventions aiming to reduce family socio-economic risk exposure and supporting the development of cognitive skills and self-regulation (i.e. reducing hyperactivity and conduct problems)

The Reactive Sulfur Species Concept: 15 Years On

Fifteen years ago, in 2001, the concept of “Reactive Sulfur Species” or RSS was advocated as a working hypothesis. Since then various organic as well as inorganic RSS have attracted considerable interest and stimulated many new and often unexpected avenues in research and product development. During this time, it has become apparent that molecules with sulfur-containing functional groups are not just the passive “victims” of oxidative stress or simple conveyors of signals in cells, but can also be stressors in their own right, with pivotal roles in cellular function and homeostasis. Many “exotic” sulfur-based compounds, often of natural origin, have entered the fray in the context of nutrition, ageing, chemoprevention and therapy. In parallel, the field of inorganic RSS has come to the forefront of research, with short-lived yet metabolically important intermediates, such as various sulfur-nitrogen species and polysulfides (Sx2−), playing important roles. Between 2003 and 2005 several breath-taking discoveries emerged characterising unusual sulfur redox states in biology, and since then the truly unique role of sulfur-dependent redox systems has become apparent. Following these discoveries, over the last decade a “hunt” and, more recently, mining for such modifications has begun—and still continues—often in conjunction with new, innovative and complex labelling and analytical methods to capture the (entire) sulfur “redoxome”. A key distinction for RSS is that, unlike oxygen or nitrogen, sulfur not only forms a plethora of specific reactive species, but sulfur also targets itself, as sulfur containing molecules, i.e., peptides, proteins and enzymes, preferentially react with RSS. Not surprisingly, today this sulfur-centred redox signalling and control inside the living cell is a burning issue, which has moved on from the predominantly thiol/disulfide biochemistry of the past to a complex labyrinth of interacting signalling and control pathways which involve various sulfur oxidation states, sulfur species and reactions. RSS are omnipresent and, in some instances, are even considered as the true bearers of redox control, perhaps being more important than the Reactive Oxygen Species (ROS) or Reactive Nitrogen Species (RNS) which for decades have dominated the redox field. In other(s) words, in 2017, sulfur redox is “on the rise”, and the idea of RSS resonates throughout the Life Sciences. Still, the RSS story isn’t over yet. Many RSS are at the heart of “mistaken identities” which urgently require clarification and may even provide the foundations for further scientific revolutions in the years to come. In light of these developments, it is therefore the perfect time to revisit the original hypotheses, to select highlights in the field and to question and eventually update our concept of “Reactive Sulfur Species”

The impact of early life skills on later outcomes

In this report we assess the evidence on the long-run associations between early social, emotional and cognitive skills (focusing on measures before age six) and a range of later outcomes. We summarize these skills under the umbrella term of ‘life skills’ and provide a taxonomy, or descriptive model, of specific skill sets. Regarding outcomes, we focus on educational attainment, employment, income, health, and wellbeing. There are three elements to this report: 1. A definition and taxonomy of key social, emotional, and cognitive skills 2. A literature review of evidence on the relationship between childhood social, emotional and cognitive skills and a range of later outcomes 3. New analysis of the British Cohort Study (BCS) on the long-run benefits and predictive power of early skills, using assessments made at age five and linking them to outcomes later in life, up to age 42

Room temperature thermally evaporated thin Au film on Si suitable for application of thiol self-assembled monolayers in MEMS/NEMS sensors

Gold is a standard surface for attachment of thiol-based self-assembled monolayers (SAMs). To achieve uniform defect free SAM coatings, which are essential for bio/chemical sensing applications, the gold surface must have low roughness, and be highly orientated. These requirements are normally achieved by either heating during Au deposition or post deposition Au surface annealing. This paper shows that room temperature deposited gold, can afford equivalent gold surfaces, if the gold deposition parameters are carefully controlled. This observation is an important result as heating (or annealing) of the deposited gold can have a detrimental effect on the mechanical properties of the silicon on which the gold is deposited used in microsensors. The paper presents the investigation of the morphology and crystalline structure of Au film prepared by thermal evaporation at room temperature on silicon. The effect of gold deposition rate is studied, and it is shown that by increasing the deposition rate from 0.02 nm s-1 to 0.14 nm s-1 the gold surface RMS roughness decreases, whereas the grain size of the deposited gold is seen to follow a step function decreasing suddenly between 0.06 and 0.10 nm s-1. The XRD intensity of the preferentially [111] orientated gold crystallites is also seen to increase as the deposition rate increases up to a deposition rate of 0.14 nm s-1. Formation and characterization of 1-dodecanethiol on these Au coated samples is also studied using contact angle. It is shown that by increasing the Au deposition rate the contact angle hysteresis (CAH) decreases until it plateaus, for a deposition rate greater than 0.14 nm s-1, where the CAH is smaller than 9 degrees which is an indication of homogeneous SAM formation, on a smooth surface

EFFECT OF PREHARVEST RAINS ON QUALIlY CHARACTERISTICS OF SOME PAKISTANI COMMERCIAL WHEAT VARIETIES

Eight commercial wheat varieties were harvested in two sets, i.e. pre-rain and post-rain. All the varieties were grown in field of National Agricultural Research Centre, Islamabad. Pre-rain harvested samples were without any sign of visible sprouting while post-rain harvested samples showed 6.0 to 21.5% sprouting depending upon variety. There was a decrease in thousand kernel weight and Ilour yield in sprouted samples of four varieties. Test weight was lower in sprouted samples than unsprouted samples of all the varieties except Faisalabad 83. Protein and gluten contents showed a considerable decrease in sprouted samples. Falling number values decreased considerably ranging from 290 to 367 seconds and from 164 to 288 seconds for sound aad sprouted samples, respectively. Dough characteristics such as water absorption, dough development time, stability and time to break down as derived from farinograms were lower in sprouted samples

Effect of n-hexane extract of Nigella sativa on gentamicin-induced nephrotoxicity in rats

The present study investigated whether the administration of the n-hexane extract of the Nigella sativa Linn. (kalajira) ameliorates gentamicin-induced nephrotoxicity in rats. Gentamicin (100 mg/kg/day for 7 days) was administered and nephrotoxicity was evaluated biochemically (significantly decreased reduced glutathione in renal cortex and significantly increased serum creatinine and serum urea) and histologically (moderate degree of proximal tubular damage). The n-hexane extract of N. sativa (5 mL/kg/day) was administered as pre-, post- and concomitant treatment for 7 days in the nephrotoxic rats. Statistically significant amelioration in all the biochemical parameters supported by significantly improved renal cortical histology was observed in the n-hexane extract of N. sativa treated nephrotoxic rats, which was more evident in the post-treatment group than the pre-treatment and the concomitantly-treated group. It is suggested that some ingredients contained in the n-hexane extract of N. sativa effected in ameliorating the signs of nephrotoxicity and that the specific active principle of the n-hexane extract of N. sativa responsible for this amelioration if obtained, would be more useful

The QGP phase in relativistic heavy-ion collisions

The dynamics of partons, hadrons and strings in relativistic nucleus-nucleus collisions is analyzed within the novel Parton-Hadron-String Dynamics (PHSD) transport approach, which is based on a dynamical quasiparticle model for partons (DQPM) matched to reproduce recent lattice-QCD results - including the partonic equation of state - in thermodynamic equilibrium. The transition from partonic to hadronic degrees of freedom is described by covariant transition rates for the fusion of quark-antiquark pairs or three quarks (antiquarks), respectively, obeying flavor current-conservation, color neutrality as well as energy-momentum conservation. The PHSD approach is applied to nucleus-nucleus collisions from low SIS to RHIC energies. The traces of partonic interactions are found in particular in the elliptic flow of hadrons as well as in their transverse mass spectra.Comment: To be published by Springer in Proceedings of the International Symposium on `Exciting Physics', Makutsi-Range, South Africa, 13-20 November, 201

Synthesis of some new 3-(chlorophenyl)isocoumarins and their conversion to 3,4-dihydro derivatives

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