Determination of Acute Toxicity of Copper and Cobalt for \u3cem\u3eTilapia nilotica\u3c/em\u3e

During the present investigation, the 96-hr LC50 and lethal concentrations of copper and cobalt for Tilapia nilotica were determined under controlled laboratory conditions at constant pH (7.25), total hardness (255 mgL-1) and temperature (30 °C). During acute toxicity studies, the physico-chemical parameters of water viz. temperature, pH, dissolved oxygen, electrical conductivity, carbon dioxide, total ammonia, calcium, sodium, magnesium, potassium and total hardness were monitored at 12-hr intervals for each test. Fish were exposed to different concentrations of copper and cobalt, separately, starting from zero with an increment of 0.05 and 0.5 mgL-1. After 96-hr exposure of various concentrations of each metal, the fish mortality data were recorded with three replicates for each concentration. The 96-hr LC50 and lethal concentrations for each metal was computed by using Probit analyses method at 95% confidence interval. The 96-hr LC50 and lethal concentrations of copper for Tilapia nilotica were computed as 25.00±0.65 and 47.56±1.18 mg L-1, respectively. However, the tolerance limits of fish for cobalt, in terms of 96-hr LC50 and lethal concentrations were calculated as 96.14±0.58 and 178.46±2.04, respectively. The tolerance limits of fish for both copper and cobalt varied significantly in terms of 96-hr LC50 and lethal concentrations. However, fish were significantly more tolerant to cobalt than that of copper. With the increase in metallic ion concentration of the test media (water), the level of ammonia and carbon dioxide increased, while that of dissolved oxygen decreased constantly. Total ammonia of the test media showed significantly direct relationship with carbon dioxide while the same remained significantly negative with dissolved oxygen indicating decrease in oxygen consumption by the fish under metallic ion stress, at different concentrations of copper and cobalt that enhanced the ammonia excretion by the fish

Sports Achievement Motivation and Sports Competition Anxiety: A Relationship Study

Anxiety and Motivation are important psychological variables in sports and its need to achieve high level of competition. Without knowledge of these two variables athletes cannot give best in competition. The aim of study was to find out the relationship between Anxiety and Motivation of intervarsity Badminton players. The total sample consisted of twenty players age ranged from 17 to 25 years. Sport Competition Anxiety Test (SCAT) and Sports Achievement Motivation Test was administered to collect the data. Mean, standard deviation, and Pearsion Product Moment Correlation were computed to analyze the data at .05 level of significant. It was found that significant negative relationship between Achievement Motivation and Anxiety

Developing a Prototype to Translate Pakistan Sign Language into Text and Speech While Using Convolutional Neural Networking

The purpose of the study is to provide a literature review of the work done on sign language in Pakistan and the world. This study also provides a framework of an already developed prototype to translate Pakistani sign language into speech and text while using convolutional neural networking (CNN) to facilitate unimpaired teachers to bridge the communication gap among the deaf learners and unimpaired teachers. Due to the lack of sign language teaching, unimpaired teachers face difficulty in communicating with impaired learners. This communication gap can be filled with the help of this translation tool. Research indicates that a prototype has been evolved that can translate the English textual content into sign language and highlighted that there is a need for translation tool which can translate the signs into English text. The current study will provide an architectural framework of the Pakistani sign language to English text translation tool that how different components of technology like deep learning, convolutional neural networking, python, tensor Flow, and NumPy, InceptionV3 and transfer learning, eSpeak text to speech help in the development of a translation tool prototype. Keywords: Pakistan sign language (PSL), sign language (SL), translation, deaf, unimpaired, convolutional neural networking (CNN). DOI: 10.7176/JEP/10-15-18 Publication date:May 31st 201

Prevalence of non-communicable diseases and their risk factors at a semi-urban community, Pakistan

Introduction: Pakistan is currently facing the double burden of communicable (38%) and non- communicable diseases (49%) according to WHO NCD Country Profiles 2014. About 50% of all deaths are attributed to NCD's. The objective of this study was to determine the burden of noncommunicable diseases in semi urban community of Islamabad. Methods: We carried a cross sectional study to estimate the burden of noncommunicable diseases in an urban setting, a community based cross sectional survey covering 1210 households was carried out over a period of three months. Households were selected through consecutive non-probability sampling, among which adult females and males who were permanent resident of the community were interviewed through a structured questionnaire in urdu language. SPSS version 21 was used to analyze the data. Descriptive statistics were calculated. Results: About 38.7% individuals had High BP / IHD, 34.4% had oro-dental health problems, 24.3% were physically disabled and 14.6% had diabetes. Among the risk factors, 48.2% were tobacco user, 13.60% were drug abuser and 1.8% alcoholics. Conclusion: We conclude that the prevalence of non-communicable diseases is quite high in the above setting as compared to the National indicators, which demands timely intervention to curtail the existing burden of NCD.Pan African Medical Journal 2016; 2

Association of 25 Hydroxy Vitamin D Levels with Age in Community Acquired Pneumonia

Background : To determine association of 25 hydroxy vitamin D deficiency with age in patients with community acquired pneumonia (CAP). Methods: In this descriptive study 150 diagnosed patients of community-acquired pneumonia based on the CURB-65 scoring criteria were enrolled. The 25 hydroxy vitamin D levels were recorded in all patients. Patients were divided into three groups according to their age. Effect modifiers like gender were controlled by stratification. Post stratification chi square test was applied. A p value of 0.05 was considered significant. Results: Mean age of the patients was 40.05 ± 14.33 years (mean ± SD). Out of 150 patients 54.7% (n=82) were males while the 45.3% (n=68) were females. The mean level of vitamin D was 18.43 ± 5.005 (mean ± SD) ng/ml. When the cut off value for deficiency was applied i.e. 20 ng/ml, the 60% (n=90) patients were found deficient while 40% (n=60) patients had normal values. The p value was significant only for the age group to 35 to 50 years. Independent sample t test showed that the difference is statistically significant (p=0.003) in age groups between 35 to 50 years. Conclusions: Lower concentrations of vitamin D might be associated with CAP particularly in age group between 35 to 50 years

Comparison of Vitamin D Levels in Patients with Dengue Haemorrhagic Fever and Dengue Fever

Background: To compare vitamin D levels in patients of dengue hemorrhagic fever with dengue feverMethods: A total of 50 patients with diagnosed dengue fever, who fulfilled the inclusion criteria were enrolled in the study. Patients were divided into two groups having 25 participants each; one group had Dengue fever (DF) while the other was suffering from dengue hemorrhagic fever (DHF). Vitamin D was estimated by the chemiluminescence method. Pearson’s Chi-square was applied to compare the proportion of patients in each study group. Relative Risk was measured along with 95% confidence interval. Significant p-value was < 0.05.Results: Mean age of patients was 37.79 ± 15.2 years (range: 16-90 years). There were 74% males and 26% females. Mean vitamin D levels in dengue fever patients were higher (21.5 ± 13.6 ng/ml) as compared to Dengue hemorrhagic fever (12.4 ± 5.6 ng/ml). The difference was statistically significant (p=0.003).Conclusions: Vitamin D may have a role in the management of dengue fever. Low levels of vitamin D might be associated with dengue hemorrhagic fever

Hybrid management of a spontaneous ilio-iliac arteriovenous fistula: a case report

<p>Abstract</p> <p>Introduction</p> <p>Spontaneous iliac arteriovenous fistulae are a rare clinical entity. Such localized fistulation is usually a result of penetrating traumatic or iatrogenic injury. Clinical presentation can vary greatly but commonly includes back pain, high-output congestive cardiac failure and the presence of an abdominal bruit. Diagnosis, therefore, is often incidental or delayed.</p> <p>Case presentation</p> <p>We report a case of a spontaneous ilio-iliac arteriovenous fistula in a 68-year-old Caucasian man detected following presentation with unilateral claudication and congestive cardiac failure. Following computed tomography evaluation, the fistula was successfully treated with a combined endovascular (aorto-uni-iliac device) and open (femoro-femoral crossover) approach.</p> <p>Conclusion</p> <p>Endovascular surgery has revolutionized the management of such fistulae and we report an interesting case of a high-output iliac arteriovenous fistulae successfully treated with a hybrid vascular approach.</p

Developing local guidelines for management of sepsis in adults: sepsis guidelines for Pakistan (SGP)

Background: The purpose of developing ‘Sepsis Guidelines for Pakistan’ (SGP) is to provide clinicians practicing in local hospitals with a framework to aid timely recognition and management of adult patients in sepsis by adopting evidence-based recommendations of Surviving Sepsis Campaign (SSC) tailored to available resources. These recommendations are not meant to replace the SSC Guidelines. Methodology: SGP is an initiative of Pakistan Society of Critical Care Medicine (PSCCM). Four key decision points to be addressed in the guidelines were identified by a thirteen member multidisciplinary committee i.e., grading the hospitals in the country, recognition of sepsis and associated organ dysfunction, essential interventions to manage sepsis, and general measures for provision of a comprehensive care to patients in sepsis according to the level of education and training of healthcare providers and facilities and resources available in different levels of hospitals. The draft was presented at the 3rd Sepsis Symposium held on 13th September, 2014 in Karachi. The final document was approved by a panel of experts from across the country, representatives of relevant societies and Global Sepsis Alliance (GSA). Recommendations: Hospitals are divided into basic, intermediate and tertiary depending on the availability of diagnostic facilities and training of the medical personnel. Modified definitions of sepsis, severe sepsis, and septic shock are used given the lack of facilities to diagnose sepsis according to international definitionsand criteria in Pakistan. Essential interventions include fluid resuscitation, vasopressors to support the circulation, maintaining oxygen saturation ≥ 90% with oxygen, non-invasive ventilation or mechanical ventilation with lung protective strategies, prompt administration of antibiotics as recommended by the Medical Microbiology & Infectious Diseases Society of Pakistan (MMIDSP) and early source control. It is recommended to avoid starvation, keep an upper blood glucose ≤180 mg/dL, use daily pharmacoprophylaxis against venous thromboembolism (VTE), use stress ulcer prophylaxis, target haemoglobin of 7-9 g/dl in the absence of ischaemic heart disease, avoid sodium bicarbonate therapy as long as pH \u3e 7.20, avoid fresh frozen plasma in the absence of bleeding, transfuse platelets if indicated, not use intravenous immunoglobulins and avoid neuromuscular blocking agents (NMBAs) in the absence of ARDS, target specific titration endpoints when continuous or intermittent sedation is required in mechanically ventilated patients and use continuous renal replacement therapy (CRRT) to facilitate management of fluid balance in hemodynamically unstable septic patients in tertiary care centers. In addition a comprehensive, meticulous and multidisciplinary general care is required to improve outcome of sepsis by reinforcing hand hygiene and other infection control measures, adequate monitoring and documentation tailored to the available resources. Goals of care and prognosis should be discussed with patients and families early and either shifting the patient to a hospital with better facilities or limiting or withdrawing therapy in case of poor prognosis should be considered

Palula Vocabulary

The main purpose of this volume is to provide a complement to Towards a grammatical description of Palula (Liljegren 2008). The 1460 main entries included in the present work are limited to those lexical items that are cited or exemplified in the aforementioned work. The work is the result of linguistic research in and with the Palula community (Pakistan). It contains much of the basic vocabulary used in today's Palula, presented along with illustrative example sentences, grammatical information, and comments on word origins. Henrik Liljegren is a field linguist at Stockholm University, Sweden, and Naseem Haider, himself a native speaker of Palula, is a local researcher with the Forum for Language Initiatives in Islamabad.The book can be ordered from the Forum for Language Initiatives, see www.fli-online.org</p