Meditation effects within the hippocampal complex revealed by voxel-based morphometry and cytoarchitectonic probabilistic mapping.

Scientific studies addressing anatomical variations in meditators' brains have emerged rapidly over the last few years, where significant links are most frequently reported with respect to gray matter (GM). To advance prior work, this study examined GM characteristics in a large sample of 100 subjects (50 meditators, 50 controls), where meditators have been practicing close to 20 years, on average. A standard, whole-brain voxel-based morphometry approach was applied and revealed significant meditation effects in the vicinity of the hippocampus, showing more GM in meditators than in controls as well as positive correlations with the number of years practiced. However, the hippocampal complex is regionally segregated by architecture, connectivity, and functional relevance. Thus, to establish differential effects within the hippocampal formation (cornu ammonis, fascia dentata, entorhinal cortex, subiculum) as well as the hippocampal-amygdaloid transition area, we utilized refined cytoarchitectonic probabilistic maps of (peri-) hippocampal subsections. Significant meditation effects were observed within the subiculum specifically. Since the subiculum is known to play a key role in stress regulation and meditation is an established form of stress reduction, these GM findings may reflect neuronal preservation in long-term meditators-perhaps due to an attenuated release of stress hormones and decreased neurotoxicity

Does wrinkle ridge formation on Mars involve most of the lithosphere

Recent work on the origin of wrinkle ridges suggests that they are compressional tectonic features whose subsurface structure is not understood. Some characteristics of Martian wrinkle ridges are reviewed which suggest that they are the surface expression of thrust faults that extend through much of the lithosphere

Electroconvulsive therapy mediates neuroplasticity of white matter microstructure in major depression.

Whether plasticity of white matter (WM) microstructure relates to therapeutic response in major depressive disorder (MDD) remains uncertain. We examined diffusion tensor imaging (DTI) correlates of WM structural connectivity in patients receiving electroconvulsive therapy (ECT), a rapidly acting treatment for severe MDD. Tract-Based Spatial Statistics (TBSS) applied to DTI data (61 directions, 2.5 mm(3) voxel size) targeted voxel-level changes in fractional anisotropy (FA), and radial (RD), axial (AD) and mean diffusivity (MD) in major WM pathways in MDD patients (n=20, mean age: 41.15 years, 10.32 s.d.) scanned before ECT, after their second ECT and at transition to maintenance therapy. Comparisons made at baseline with demographically similar controls (n=28, mean age: 39.42 years, 12.20 s.d.) established effects of diagnosis. Controls were imaged twice to estimate scanning-related variance. Patients showed significant increases of FA in dorsal fronto-limbic circuits encompassing the anterior cingulum, forceps minor and left superior longitudinal fasciculus between baseline and transition to maintenance therapy (P<0.05, corrected). Decreases in RD and MD were observed in overlapping regions and the anterior thalamic radiation (P<0.05, corrected). Changes in DTI metrics associated with therapeutic response in tracts showing significant ECT effects differed between patients and controls. All measures remained stable across time in controls. Altered WM microstructure in pathways connecting frontal and limbic areas occur in MDD, are modulated by ECT and relate to therapeutic response. Increased FA together with decreased MD and RD, which trend towards normative values with treatment, suggest increased fiber integrity in dorsal fronto-limbic pathways involved in mood regulation

Korruption in Deutschland - der Normalfall?

In der letzten Zeit häuften sich auch in Deutschland Vorfälle, die in der Öffentlichkeit den Verdacht aufkommen lassen, es sei Korruption involviert. Dass Korruption in Deutschland zum Normalfall wird, lässt sich zwar nach Ansicht von Prof. Dr. Christian Watrin, Universität zu Köln, nicht ausschließen: »Aber solange für das politische und wirtschaftliche Handeln das Leitbild einer Offenen Gesellschaft bestimmend ist, ist Pessimismus nicht angesagt.« Für Prof. Dr. Dieter Biallas, Transparency International, steht fest ..., »dass sich die verantwortlichen Personen in diesem Land zwar, auch unter dem Druck der Ereignisse, von der Vorstellung verabschieden, Korruption sei vorwiegend ein Problem anderer Länder, man sich aber des Eindrucks nicht erwehren kann, der letzte Wille zu durchgreifenden Reformen sei noch nicht vorhanden, dass vielmehr oft nur auf Skandale reagiert wird.« Impulse für den Kampf gegen die Korruption müssten daher, seiner Meinung nach, auch »von unten« kommen, von Bürgern und Unternehmern, die das Thema zur Sprache bringen und Lösungsvorschläge beisteuern. Für Prof. Dr. Wolf-Dieter Narr, Freie Universität Berlin, ist »korruptiöse Politik ... nicht eine Frage ›schlechten‹ Charakters dieses oder jenes Politikers. Sie ist Ausdruck, Politik mangelhaft zu organisieren.«Korruption, Deutschland

Soliton Dynamics in Computational Anatomy

Computational anatomy (CA) has introduced the idea of anatomical structures being transformed by geodesic deformations on groups of diffeomorphisms. Among these geometric structures, landmarks and image outlines in CA are shown to be singular solutions of a partial differential equation that is called the geodesic EPDiff equation. A recently discovered momentum map for singular solutions of EPDiff yields their canonical Hamiltonian formulation, which in turn provides a complete parameterization of the landmarks by their canonical positions and momenta. The momentum map provides an isomorphism between landmarks (and outlines) for images and singular soliton solutions of the EPDiff equation. This isomorphism suggests a new dynamical paradigm for CA, as well as new data representation.Comment: published in NeuroImag

Inter and intra-hemispheric structural imaging markers predict depression relapse after electroconvulsive therapy: a multisite study.

Relapse of depression following treatment is high. Biomarkers predictive of an individual's relapse risk could provide earlier opportunities for prevention. Since electroconvulsive therapy (ECT) elicits robust and rapidly acting antidepressant effects, but has a >50% relapse rate, ECT presents a valuable model for determining predictors of relapse-risk. Although previous studies have associated ECT-induced changes in brain morphometry with clinical response, longer-term outcomes have not been addressed. Using structural imaging data from 42 ECT-responsive patients obtained prior to and directly following an ECT treatment index series at two independent sites (UCLA: n = 17, age = 45.41±12.34 years; UNM: n = 25; age = 65.00±8.44), here we test relapse prediction within 6-months post-ECT. Random forests were used to predict subsequent relapse using singular and ratios of intra and inter-hemispheric structural imaging measures and clinical variables from pre-, post-, and pre-to-post ECT. Relapse risk was determined as a function of feature variation. Relapse was well-predicted both within site and when cohorts were pooled where top-performing models yielded balanced accuracies of 71-78%. Top predictors included cingulate isthmus asymmetry, pallidal asymmetry, the ratio of the paracentral to precentral cortical thickness and the ratio of lateral occipital to pericalcarine cortical thickness. Pooling cohorts and predicting relapse from post-treatment measures provided the best classification performances. However, classifiers trained on each age-disparate cohort were less informative for prediction in the held-out cohort. Post-treatment structural neuroimaging measures and the ratios of connected regions commonly implicated in depression pathophysiology are informative of relapse risk. Structural imaging measures may have utility for devising more personalized preventative medicine approaches

Preliminary prediction of individual response to electroconvulsive therapy using whole-brain functional magnetic resonance imaging data.

Electroconvulsive therapy (ECT) works rapidly and has been widely used to treat depressive disorders (DEP). However, identifying biomarkers predictive of response to ECT remains a priority to individually tailor treatment and understand treatment mechanisms. This study used a connectome-based predictive modeling (CPM) approach in 122 patients with DEP to determine if pre-ECT whole-brain functional connectivity (FC) predicts depressive rating changes and remission status after ECT (47 of 122 total subjects or 38.5% of sample), and whether pre-ECT and longitudinal changes (pre/post-ECT) in regional brain network biomarkers are associated with treatment-related changes in depression ratings. Results show the networks with the best predictive performance of ECT response were negative (anti-correlated) FC networks, which predict the post-ECT depression severity (continuous measure) with a 76.23% accuracy for remission prediction. FC networks with the greatest predictive power were concentrated in the prefrontal and temporal cortices and subcortical nuclei, and include the inferior frontal (IFG), superior frontal (SFG), superior temporal (STG), inferior temporal gyri (ITG), basal ganglia (BG), and thalamus (Tha). Several of these brain regions were also identified as nodes in the FC networks that show significant change pre-/post-ECT, but these networks were not related to treatment response. This study design has limitations regarding the longitudinal design and the absence of a control group that limit the causal inference regarding mechanism of post-treatment status. Though predictive biomarkers remained below the threshold of those recommended for potential translation, the analysis methods and results demonstrate the promise and generalizability of biomarkers for advancing personalized treatment strategies

Korruption in Deutschland - der Normalfall?

In der letzten Zeit häuften sich auch in Deutschland Vorfälle, die in der Öffentlichkeit den Verdacht aufkommen lassen, es sei Korruption involviert. Dass Korruption in Deutschland zum Normalfall wird, lässt sich zwar nach Ansicht von Prof. Dr. Christian Watrin, Universität zu Köln, nicht ausschließen: »Aber solange für das politische und wirtschaftliche Handeln das Leitbild einer Offenen Gesellschaft bestimmend ist, ist Pessimismus nicht angesagt.« Für Prof. Dr. Dieter Biallas, Transparency International, steht fest ..., »dass sich die verantwortlichen Personen in diesem Land zwar, auch unter dem Druck der Ereignisse, von der Vorstellung verabschieden, Korruption sei vorwiegend ein Problem anderer Länder, man sich aber des Eindrucks nicht erwehren kann, der letzte Wille zu durchgreifenden Reformen sei noch nicht vorhanden, dass vielmehr oft nur auf Skandale reagiert wird.« Impulse für den Kampf gegen die Korruption müssten daher, seiner Meinung nach, auch »von unten« kommen, von Bürgern und Unternehmern, die das Thema zur Sprache bringen und Lösungsvorschläge beisteuern. Für Prof. Dr. Wolf-Dieter Narr, Freie Universität Berlin, ist »korruptiöse Politik ... nicht eine Frage ›schlechten‹ Charakters dieses oder jenes Politikers. Sie ist Ausdruck, Politik mangelhaft zu organisieren.

Parasagittal Asymmetries of the Corpus Callosum

Significant relationships have been reported between midsagittal areas of the corpus callosum and the degree of interhemispheric transfer, functional lateralization and structural brain asymmetries. No study, however, has examined whether parasagittal callosal asymmetries (i.e. those close to the midline of the brain), which may be of specific functional consequence, are present in the human brain. Thus, we applied magnetic resonance imaging and novel computational surface-based methods to encode hemispheric differences in callosal thickness at a very high resolution. Discrete callosal areas were also compared between the hemispheres. Furthermore, acknowledging the frequently reported sex differences in callosal morphology, parasagittal callosal asymmetries were examined within each gender. Results showed significant rightward asymmetries of callosal thickness predominantly in the anterior body and anterior third of the callosum, suggesting a more diffuse functional organization of callosal projections in the right hemisphere. Asymmetries were increased in men, supporting the assumption of a sexually dimorphic organization of male and female brains that involves hemispheric relations and is reflected in the organization and distribution of callosal fiber