Power profile generator for the test of microgrid measurement and control systems

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Development and Performance of RFD Crab Cavity Prototypes for HL-LHC AUP

The US will be contributing to the HL-LHC upgrade at CERN with the fabrication and qualification of RFD crabbing cavities in the framework of the HL-LHC Accelerator Upgrade Project (AUP) managed by Fermilab. AUP received Critical Decision 3 (CD-3) approval by DOE in December 2020 launching the project into the production phase. The electro-magnetic design of the cavity was inherited from the LHC Accelerator Research Program (LARP) but needed to be revised to meet new project requirements and to prevent issues encountered during beam tests performed at CERN in the R&D phase. Two prototype cavities were manufactured in industry and cold tested. Challenges specific to the RFD cavity were the stringent interface tolerances, the pole symmetry, and the higher-order-mode impedance spectrum. Chemical processing and heat treatments were performed initially at FNAL/ANL and are now being transferred to industry for the production phase. HOM dampers are manufactured and validated by JLAB. A summary of cold test results with and without HOM dampers is presented.Comment: 21st International Conference on RF Superconductivity (SRF23

Development and Performance of RFD Crab Cavity Prototypes for HL-LHC AUP

The US will be contributing to the HL-LHC upgrade at CERN with the fabrication and qualification of RFD crabbing cavities in the framework of the HL-LHC Accelerator Upgrade Project (AUP) managed by Fermilab. AUP received Critical Decision 3 (CD-3) approval by DOE in December 2020 launching the project into the production phase. The electro-magnetic design of the cavity was inherited from the LHC Accelerator Research Program (LARP) but needed to be revised to meet new project requirements and to prevent issues encountered during beam tests performed at CERN in the R&D phase. Two prototype cavities were manufactured in industry and cold tested. Challenges specific to the RFD cavity were the stringent interface tolerances, the pole symmetry and the higher-order-mode impedance spectrum. Chemical processing and heat treatments were performed initially at FNAL/ANL and are now being transferred to industry for the production phase. HOM dampers are manufactured and validated by JLAB. A summary of cold test results with and without HOM dampers is presented

Association of kidney disease measures with risk of renal function worsening in patients with type 1 diabetes

Background: Albuminuria has been classically considered a marker of kidney damage progression in diabetic patients and it is routinely assessed to monitor kidney function. However, the role of a mild GFR reduction on the development of stage 653 CKD has been less explored in type 1 diabetes mellitus (T1DM) patients. Aim of the present study was to evaluate the prognostic role of kidney disease measures, namely albuminuria and reduced GFR, on the development of stage 653 CKD in a large cohort of patients affected by T1DM. Methods: A total of 4284 patients affected by T1DM followed-up at 76 diabetes centers participating to the Italian Association of Clinical Diabetologists (Associazione Medici Diabetologi, AMD) initiative constitutes the study population. Urinary albumin excretion (ACR) and estimated GFR (eGFR) were retrieved and analyzed. The incidence of stage 653 CKD (eGFR < 60 mL/min/1.73 m2) or eGFR reduction > 30% from baseline was evaluated. Results: The mean estimated GFR was 98 \ub1 17 mL/min/1.73m2 and the proportion of patients with albuminuria was 15.3% (n = 654) at baseline. About 8% (n = 337) of patients developed one of the two renal endpoints during the 4-year follow-up period. Age, albuminuria (micro or macro) and baseline eGFR < 90 ml/min/m2 were independent risk factors for stage 653 CKD and renal function worsening. When compared to patients with eGFR > 90 ml/min/1.73m2 and normoalbuminuria, those with albuminuria at baseline had a 1.69 greater risk of reaching stage 3 CKD, while patients with mild eGFR reduction (i.e. eGFR between 90 and 60 mL/min/1.73 m2) show a 3.81 greater risk that rose to 8.24 for those patients with albuminuria and mild eGFR reduction at baseline. Conclusions: Albuminuria and eGFR reduction represent independent risk factors for incident stage 653 CKD in T1DM patients. The simultaneous occurrence of reduced eGFR and albuminuria have a synergistic effect on renal function worsening

Ten-year incidence of hypertension in a Swiss population-based sample Incidence of hypertension in Switzerland.

Few studies assessed incidence and determinants of hypertension. We assessed the incidence and determinants of hypertension in a cohort of healthy adults aged 35-75 years living in Lausanne, Switzerland. Baseline data were collected from 2003 to 2006. Follow-ups were conducted in 2009-2012 and 2014-2017. Incident hypertension, defined as a systolic BP ≥140 mm Hg or a diastolic BP ≥90 mm Hg or anti-hypertensive medication, was assessed at 1) second follow-up only; 2) first and/or second follow-up. After 10.9 years, incident hypertension was 26.8% (analysis 1, N = 3299) and 30.3% (analysis 2, N = 3728). After multivariate adjustment, the variables associated with increased hypertension incidence were male gender [incident-rate ratio (IRR) and (95% confidence interval)]: 1.20 (1.07-1.35) and 1.24 (1.13-1.37) for analyses 1 and 2, respectively; increasing age (p for trend < 0.001) and body mass index (p for trend < 0.001) and history of cardiovascular disease (CVD). Being physically active was negatively associated with incident hypertension: 0.88 (0.78-0.98) and 0.92 (0.83-1.01) for analyses 1 and 2, respectively. Except for male gender, these associations remained after adjusting for baseline BP levels, with incident rate ratios for physical activity of 0.86 (0.77-0.96) and 0.91 (0.83-0.99) for analyses 1 and 2, respectively. No association was found for education, alcohol consumption or smoking status. We conclude that over 10.9 years, between 1/4 and 1/3 of the Swiss population aged 35-75 developed hypertension. Male gender, history of CVD, increasing age and higher BMI increase the risk of hypertension, while being physically active reduces the risk

Discharge information and its relationship to auality of care and transition outcomes following short stay hysterectomy: a pilot study

Vaginal or laparoscopic hysterectomy performed as day surgery has been broadly welcomed but this can diminish the time and opportunity for discharge nursing education leaving patients potentially under prepared to recover at home. It is unknown if the current discharge information and teaching is meeting clients’ needs following short stay hysterectomy and what effect this has on satisfaction with care and recovery outcomes. The purpose of this study was to examine relationships between and among a set of variables: discharge information provided, perception of discharge information received, overall satisfaction with short hospital stay experience, satisfaction with discharge information, perceived confidence in self-care and post-operative recovery following short stay hysterectomy procedures. An integrated model of Donabedian’s Quality of Care Model and Schumacher and Meleis’s Nursing Model of Transitions was the guiding framework for this descriptive correlational study. Fifty one women, aged between 23 and 71, who underwent a short stay hysterectomy procedure, were contacted 48 to 72 hours after discharge for a telephone interview. Quantitative data analysis indicated that most women were satisfied to very satisfied with the short stay experience and with the discharge education they received. There was a high positive correlation between the discharge information provided and the perception of the discharge information received(r = 0.85). Women recovering at home scored themselves as having high levels of self-care confidence but reported varying levels of post-surgical recovery. The best predictor of self-care confidence was satisfaction with discharge information (adjusted R² = 27%) and the best predictor of post-operative recovery was self-care confidence (adjusted R² = 22%). Findings from this study support the important role of discharge teaching for short stay hysterectomy patients. As well, the implications for nursing practice, education and research are discussed

Improving the annotation of unknown metabolites via integration of GCMS and LCMS metabolomics: a close look into the complexity of grapevine glycosides

Every grape cultivar has its own unique genetic characteristics, leading to the production of a different secondary metabolite profile. Volatile compounds in grapes are usually analyzed via GC-MS, while their glycosides are evaluated by indirect methods, after enzymatic or chemical hydrolysis. A common feature of raw data from metabolomics experiments is that they cannot be immediately interpreted as relative concentrations of constituent compounds. A bottleneck here is the signal annotation, which is the process of tentatively associating the pseudospectra found with chemical structure. For the free volatiles, the annotation of large metabolomics dataset can be performed by an automatic pipeline that it is able to focus on hundreds of compounds simultaneously (Wehrens et al., 2014). However, there is scarcity of publications addressing the annotation of the glycosides, which makes the annotation of these compounds a challenging task. In this study we present the molecular profiling of volatile compounds and their precursors in ten selected genotypes, including Vitis vinifera cultivars, American species and interspecific crosses. We tried to “gain from the complexity”, since the difficult task of annotation of the glycosides was achieved through combined use of two orthogonal techniques, GC/MS and LC/HRMS, before and after enzymatic hydrolysis. The results show that both free and glycosidically bound aroma precursors behave differently in each different grape cultivars and species. As many as 66 free aroma volatile molecules (originally existing and released after hydrolysis) were profiled through GC/MS analysis, while 15 glycosides were identified through LC/HRMS and correlation with GC/MS data. Literature Wehrens R., Weingart G., Mattivi F. (2014) MetaMS: An open-source pipeline for GC-MS-based untargeted metabolomics. Journal of Chromatography B, 966, 109–116. Acknowledgements. The project of MG and LN is funded under the International PhD Programme in Genomics and the Molecular Physiology of Fruits (GMPF) by the Fondazione Edmund Mach (FEM), San Michele all’Adige, (TN) Italy. Financial support from the project ADP 2014, by Autonomous Province of Trento, Italy, is greatly acknowledge

On compressed sensing and super-resolution in DFT-based spectral analysis

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