Asymptotics of Harish-Chandra expansions, bounded hypergeometric functions associated with root systems, and applications

A series expansion for Heckman-Opdam hypergeometric functions $\varphi_\lambda$ is obtained for all $\lambda \in \mathfrak a^*_{\mathbb C}.$ As a consequence, estimates for $\varphi_\lambda$ away from the walls of a Weyl chamber are established. We also characterize the bounded hypergeometric functions and thus prove an analogue of the celebrated theorem of Helgason and Johnson on the bounded spherical functions on a Riemannian symmetric space of the noncompact type. The $L^p$-theory for the hypergeometric Fourier transform is developed for $0<p<2$. In particular, an inversion formula is proved when $1\leq p <2$

A continuum treatment of growth in biological tissue: The coupling of mass transport and mechanics

Growth (and resorption) of biological tissue is formulated in the continuum setting. The treatment is macroscopic, rather than cellular or sub-cellular. Certain assumptions that are central to classical continuum mechanics are revisited, the theory is reformulated, and consequences for balance laws and constitutive relations are deduced. The treatment incorporates multiple species. Sources and fluxes of mass, and terms for momentum and energy transfer between species are introduced to enhance the classical balance laws. The transported species include: (\romannumeral 1) a fluid phase, and (\romannumeral 2) the precursors and byproducts of the reactions that create and break down tissue. A notable feature is that the full extent of coupling between mass transport and mechanics emerges from the thermodynamics. Contributions to fluxes from the concentration gradient, chemical potential gradient, stress gradient, body force and inertia have not emerged in a unified fashion from previous formulations of the problem. The present work demonstrates these effects via a physically-consistent treatment. The presence of multiple, interacting species requires that the formulation be consistent with mixture theory. This requirement has far-reaching consequences. A preliminary numerical example is included to demonstrate some aspects of the coupled formulation.Comment: 29 pages, 11 figures, accepted for publication in Journal of the Mechanics and Physics of Solids. See journal for final versio

In silico estimates of the free energy rates in growing tumor spheroids

The physics of solid tumor growth can be considered at three distinct size scales: the tumor scale, the cell-extracellular matrix (ECM) scale and the sub-cellular scale. In this paper we consider the tumor scale in the interest of eventually developing a system-level understanding of the progression of cancer. At this scale, cell populations and chemical species are best treated as concentration fields that vary with time and space. The cells have chemo-mechanical interactions with each other and with the ECM, consume glucose and oxygen that are transported through the tumor, and create chemical byproducts. We present a continuum mathematical model for the biochemical dynamics and mechanics that govern tumor growth. The biochemical dynamics and mechanics also engender free energy changes that serve as universal measures for comparison of these processes. Within our mathematical framework we therefore consider the free energy inequality, which arises from the first and second laws of thermodynamics. With the model we compute preliminary estimates of the free energy rates of a growing tumor in its pre-vascular stage by using currently available data from single cells and multicellular tumor spheroids.Comment: 27 pages with 5 figures and 2 tables. Figures and tables appear at the end of the pape

Biological remodelling: Stationary energy, configurational change, internal variables and dissipation

Remodelling is defined as an evolution of microstructure or variations in the configuration of the underlying manifold. The manner in which a biological tissue and its subsystems remodel their structure is treated in a continuum mechanical setting. While some examples of remodelling are conveniently modelled as evolution of the reference configuration (Case I), others are more suited to an internal variable description (Case II). In this paper we explore the applicability of stationary energy states to remodelled systems. A variational treatment is introduced by assuming that stationary energy states are attained by changes in microstructure via one of the two mechanisms--Cases I and II. An example is presented to illustrate each case. The example illustrating Case II is further studied in the context of the thermodynamic dissipation inequality.Comment: 24 pages, 4 figures. Replaced version has corrections to typos in equations, and the corresponding correct plot of the solution--all in Section

Domain-wall fermions with U(1)U(1) dynamical gauge fields

We have carried out a numerical simulation of a domain-wall model in $(2+1)$-dimensions, in the presence of a dynamical gauge field only in an extra dimension, corresponding to the weak coupling limit of a ( 2-dimensional ) physical gauge coupling. Using a quenched approximation we have investigated this model at $\beta_{s} ( = 1 / g^{2}_{s} ) =$ 0.5 ( ``symmetric'' phase), 1.0, and 5.0 (``broken'' phase), where $g_s$ is the gauge coupling constant of the extra dimension. We have found that there exists a critical value of a domain-wall mass $m_{0}^{c}$ which separates a region with a fermionic zero mode on the domain-wall from the one without it, in both symmetric and broken phases. This result suggests that the domain-wall method may work for the construction of lattice chiral gauge theories.Comment: 27 pages (11 figures), latex (epsf style-file needed

On the equisummability of Hermite and Fourier expansions

We prove an equisummability result for the Fourier expansions and Hermite expansions as well as special Hermite expansions. We also prove the uniform boundedness of the Bochner-Riesz means associated to the Hermite expansions for polyradial functions

Spontaneous Flavor and Parity Breaking with Wilson Fermions

We discuss the phase diagram of Wilson fermions in the $m_0$--$g^2$ plane for two-flavor QCD. We argue that, as originally suggested by Aoki, there is a phase in which flavor and parity are spontaneously broken. Recent numerical results on the spectrum of the overlap Hamiltonian have been interpreted as evidence against Aoki's conjecture. We show that they are in fact consistent with the presence of a flavor-parity broken ``Aoki phase''. We also show how, as the continuum limit is approached, one can study the lattice theory using the continuum chiral Lagrangian supplemented by additional terms proportional to powers of the lattice spacing. We find that there are two possible phase structures at non-zero lattice spacing: (1) there is an Aoki phase of width $\Delta m_0 \sim a^3$ with two massless Goldstone pions; (2) there is no symmetry breaking, and all three pions have an equal non-vanishing mass of order $a$. Present numerical evidence suggests that the former option is realized for Wilson fermions. Our analysis then predicts the form of the pion masses and the flavor-parity breaking condensate within the Aoki phase. Our analysis also applies for non-perturbatively improved Wilson fermions.Comment: 22 pages, LaTeX, 5 figures (added several references and a comment