On Optimal Mechanisms in the Two-Item Single-Buyer Unit-Demand Setting

We consider the problem of designing a revenue-optimal mechanism in the two-item, single-buyer, unit-demand setting when the buyer's valuations, $(z_1, z_2)$, are uniformly distributed in an arbitrary rectangle $[c,c+b_1]\times[c,c+b_2]$ in the positive quadrant. We provide a complete and explicit solution for arbitrary nonnegative values of $(c,b_1,b_2)$. We identify five simple structures, each with at most five (possibly stochastic) menu items, and prove that the optimal mechanism has one of the five structures. We also characterize the optimal mechanism as a function of $b_1, b_2$, and $c$. When $c$ is low, the optimal mechanism is a posted price mechanism with an exclusion region; when $c$ is high, it is a posted price mechanism without an exclusion region. Our results are the first to show the existence of optimal mechanisms with no exclusion region, to the best of our knowledge

Mechanism design for single leader Stackelberg problems and application to procurement auction design

In this paper, we focus on mechanism design for single leader Stackelberg problems, which are a special case of hierarchical decision making problems in which a distinguished agent, known as the leader, makes the first move and this action is followed by the actions of the remaining agents, which are known as the followers. These problems are also known as single leader rest follower (SLRF) problems. There are many examples of such problems in the areas of electronic commerce, supply chain management, manufacturing systems, distributed computing, transportation networks, and multiagent systems. The game induced among the agents for these problems is a Bayesian Stackelberg game, which is more general than a Bayesian game. For this reason, classical mechanism design, which is based on Bayesian games, cannot be applied as is for solving SLRF mechanism design problems. In this paper, we extend classical mechanism design theory to the specific setting of SLRF problems. As a significant application of the theory developed, we explore two examples from the domain of electronic commerce-first-price and second-price electronic procurement auctions with reserve prices. Using an SLRF model for these auctions, we derive certain key results using the SLRF mechanism design framework developed in this paper. The theory developed has many promising applications in modeling and solving emerging game theoretic problems in engineering

Psychopharmacological activities of acorus calamus roots in rat and mice models

Acorus calamus (Araceae) is commonly known in India as sweet flag and has been used in traditional medicine as a remedy for pain, convulsion, inflammation, and ulcer. In the present work, the methanolic extract of Acorus calamus roots (MEAC) was assessed for different psychopharmacological activities in rats and mice by evaluation of general, exploratory behaviour, phenobarbitone sodium-induced sleeping time and muscle relaxant activity. The extract at doses 100 mg/kg and above exhibited a reduction in spontaneous activity and a decrease in exploratory behavioural pattern was observed. Also a significant reduction in muscle relaxant activity and potentiated phenobarbitone sodium-induced sleeping time in mice was noted in MEAC treated groups. From our study, the results indicates that MEAC appears to have effects on alteration in general behavior pattern, evident from the spontaneous activity, sound, touch and pain responses of the MEAC treated groups.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Water-triggered frontal polymerization

A totally new mode of frontal polymerization (FP) of acrylamide is established which is triggered by the simple addition of a minute, specific volume of water. Experimental conditions under which this mode of polymerization yields linear and water-soluble polyacrylamide were carefully established, paving the way to synthesize commercially pertinent homo- and copolymers. A new redox couple was identified to circumvent the imidization and the ensuing gelation, hitherto associated with FP of acrylamide. Effects of reaction variables such as type and concentration of redox couple and volume of water on measurable parameters of FP such as front velocity, front temperature, shape of front and yield have been studied. Two types of redox couples are reported. Nonplanar frontal regime was observed in few redox couples. We could visually observe helical patterns with naked eyes, while layered patterns were observable under SEM. Additionally, micro-phase separation and heterogeneity in the polymer matrix was observed due to unreacted pockets of monomer which evolve via bulk mode. This nonlinear phenomenon is described

PUF Probe: A PUF-based Hardware Authentication Equipment for IEDs

Intelligent Electronic Devices (IEDs) are vital components in modern electrical substations, collectively responsible for monitoring electrical parameters and performing protective functions. As a result, ensuring the integrity of IEDs is an essential criteria. While standards like IEC 61850 and IEC 60870-5-104 establish cyber-security protocols for secure information exchange in IED-based power systems, the physical integrity of IEDs is often overlooked, leading to a rise in counterfeit and tainted electronic products. This paper proposes a physical unclonable function (PUF)-based device (IEDPUF probe) capable of extracting unique hardware signatures from commercial IEDs. These signatures can serve as identifiers, facilitating the authentication and protection of IEDs against counterfeiting. The paper presents the complete hardware architecture of the IEDPUF probe, along with algorithms for signature extraction and authentication. The process involves the central computer system (CCS) initiating IED authentication requests by sending random challenges to the IEDPUF probe. Based on the challenges, the IEDPUF probe generates responses, which are then verified by the CCS to authenticate the IED. Additionally, a two-way authentication technique is employed to ensure that only verified requests are granted access for signature extraction. Experimental results confirm the efficacy of the proposed IEDPUF probe. The results demonstrate its ability to provide real-time responses possessing randomness while uniquely identifying the IED under investigation. The proposed IEDPUF probe offers a simple, cost-effective, accurate solution with minimal storage requirements, enhancing the authenticity and integrity of IEDs within electrical substation

Multiattribute electronic procurement using goal programming

One of the key challenges of current day electronic procurement systems is to enable procurement decisions transcend beyond a single attribute such as cost. Consequently, multiattribute procurement have emerged as an important research direction. In this paper, we develop a multiattribute e-procurement system for procuring large volume of a single item. Our system is motivated by an industrial procurement scenario for procuring raw material. The procurement scenario demands multiattribute bids, volume discount cost functions, inclusion of business constraints, and consideration of multiple criteria in bid evaluation. We develop a generic framework for an e-procurement system that meets the above requirements. The bid evaluation problem is formulated as a mixed linear integer multiple criteria optimization problem and goal programming is used as the solution technique. We present a case study for which we illustrate the proposed approach and a heuristic is proposed to handle the computational complexity arising out of the cost functions used in the bids

Preferred reporting items for studies mapping onto preference-based outcome measures: The MAPS statement

'Mapping' onto generic preference-based outcome measures is increasingly being used as a means of generating health utilities for use within health economic evaluations. Despite publication of technical guides for the conduct of mapping research, guidance for the reporting of mapping studies is currently lacking. The MAPS (MApping onto Preference-based measures reporting Standards) statement is a new checklist, which aims to promote complete and transparent reporting of mapping studies. The primary audiences for the MAPS statement are researchers reporting mapping studies, the funders of the research, and peer reviewers and editors involved in assessing mapping studies for publication. A de novo list of 29 candidate reporting items and accompanying explanations was created by a working group comprised of six health economists and one Delphi methodologist. Following a two-round, modified Delphi survey with representatives from academia, consultancy, health technology assessment agencies and the biomedical journal editorial community, a final set of 23 items deemed essential for transparent reporting, and accompanying explanations, was developed. The items are contained in a user friendly 23 item checklist. They are presented numerically and categorised within six sections, namely: (i) title and abstract; (ii) introduction; (iii) methods; (iv) results; (v) discussion; and (vi) other. The MAPS statement is best applied in conjunction with the accompanying MAPS explanation and elaboration document. It is anticipated that the MAPS statement will improve the clarity, transparency and completeness of reporting of mapping studies. To facilitate dissemination and uptake, the MAPS statement is being co-published by eight health economics and quality of life journals, and broader endorsement is encouraged. The MAPS working group plans to assess the need for an update of the reporting checklist in five years' time. This statement was published jointly in Applied Health Economics and Health Policy, Health and Quality of Life Outcomes, International Journal of Technology Assessment in Health Care, Journal of Medical Economics, Medical Decision Making, PharmacoEconomics, and Quality of Life Research

Psychopharmacological activities of acorus calamus roots in rat and mice models

Acorus calamus (Araceae) is commonly known in India as sweet flag and has been used in traditional medicine as a remedy for pain, convulsion, inflammation, and ulcer. In the present work, the methanolic extract of Acorus calamus roots (MEAC) was assessed for different psychopharmacological activities in rats and mice by evaluation of general, exploratory behaviour, phenobarbitone sodium-induced sleeping time and muscle relaxant activity. The extract at doses 100 mg/kg and above exhibited a reduction in spontaneous activity and a decrease in exploratory behavioural pattern was observed. Also a significant reduction in muscle relaxant activity and potentiated phenobarbitone sodium-induced sleeping time in mice was noted in MEAC treated groups. From our study, the results indicates that MEAC appears to have effects on alteration in general behavior pattern, evident from the spontaneous activity, sound, touch and pain responses of the MEAC treated groups.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Average flow constraints and stabilizability in uncertain production-distribution systems

We consider a multi-inventory system with controlled flows and uncertain demands (disturbances) bounded within assigned compact sets. The system is modelled as a first-order one integrating the discrepancy between controlled flows and demands at different sites/nodes. Thus, the buffer levels at the nodes represent the system state. Given a long-term average demand, we are interested in a control strategy that satisfies just one of two requirements: (i) meeting any possible demand at each time (worst case stability) or (ii) achieving a predefined flow in the average (average flow constraints). Necessary and sufficient conditions for the achievement of both goals have been proposed by the authors. In this paper, we face the case in which these conditions are not satisfied. We show that, if we ignore the requirement on worst case stability, we can find a control strategy driving the expected value of the state to zero. On the contrary, if we ignore the average flow constraints, we can find a control strategy that satisfies worst case stability while optimizing any linear cost on the average control. In the latter case, we provide a tight bound for the cost