Some Thoughts on the Whole Works-in-Progress Thing

Panel: Works in Progres

General practitioners\u27 awareness and management of common psychiatric disorders: a community-based survey from Karachi, Pakistan

This study assessed the knowledge and management of common psychiatric disorders by general practitioners (GPs) in Karachi, Pakistan. Structured interviews were carried out in 2009 with 360 GPs selected by cluster random sampling. Patients with psychiatric disorders were estimated to be up to 10% of the daily caseload according to 71.8% of doctors. Two-thirds of GPs were unaware of the ICD-10 diagnostic criteria for depression and anxiety disorders. Benzodiazepines were the most recognized category of medication (75.3%) and were the most commonly used medication for all mental health conditions. Fewer GPs were familiar with selective serotonin reuptake inhibitors (35.1%) or tricyclic antidepressants (20.2%). Lack of time and patients\u27 financial constraints were reported to be barriers to care. Most GPs (69.2%) had not received any recent medical education about mental health problems. Gaps in GPs\u27 knowledge about the management of mental disorders have implications for the rational use of psychotropic medications in primary care

Calcium pyrophosphate dihydrate deposition disease (CPPD)/Pseudogout of the temporomandibular joint – FNA findings and microanalysis

We report a case of a Calcium pyrophosphate dihydrate deposition disease (CPPD) presenting as a mass in the parotid and temporomandibular joint (TMJ) that simulated a parotid tumor. A 35 year-old man presented with pain in the left ear area. A CT Scan of the area showed a large, calcified mass surrounding the left condylar head, and extending into the infratemporal fossa. FNA of the mass showed birefringent crystals, most of which were rhomboid with occasional ones being needle shaped, embedded in an amorphous pink substance. Scanning electron microscopy (SEM) with energy dispersive x-ray spectroscopy (EDS) of these crystals showed peaks corresponding to calcium and phosphorus. SEM/EDS is a rapid method of diagnosing calcium pyrophosphate dihydrate deposition disease (CPPD) and an alternative to more commonly used method of special staining of cell block sections coupled with polarizing microscopy

Immunohistochemical Estrogen receptor determination in human Breast carcinoma: correlation with histologic differentiation and age of the patients

An immunohistochemical assay for the measurement of estrogen receptor (ER) has been evaluated on 290 consecutive human breast biopsy and mastectomy specimens in the year 1992 at The Aga Khan University Hospital laboratories. Immunohistochemical localization of estrogen receptor on frozen/paraffin section was scored in a semi-quantitative fashion incorporating both the intensity and the distribution of specific staining. Histologic grading of the tumour was performed according to Bloom’s method. In this study, 21% of the tumours were estrogen receptor negative, 15% were weak positive, 25% intermediate positive and 39% strong positive. Fifty percent of the well differentiated tumours showed strong ER positivity against 27% of the poorly differentiated tumours. Seventy eight percent of all negative estrogen receptors were in patients younger than 50 years of age (pre-menopausal group), while 52% of strong estrogen receptor positivity was observed in patients older than 50 years (post- menopausal). This study demonstrates the value of immunohistochemical method to determine the ER status in patients with advanced breast cancer

Iron organic speciation during the LOHAFEX experiment: Iron ligands release under biomass control by copepod grazing

The LOHAFEX iron fertilization experiment consisted in the fertilization of the closed core of a cyclonic eddy located south of the Antarctic Polar Front in the Atlantic sector of the Southern Ocean. This eddy was characterized by high nitrate and low silicate concentrations. Despite a 2.5 fold increase of the chlorophyll-a (Chl-a) concentrations, the composition of the biological community did not change. Phytoplankton biomass was mostly formed by small autotrophic flagellates whereas zooplankton biomass was mostly comprised by the large copepod Calanus simillimus. Efficient recycling of copepod fecal pellets (the main component of the downward flux of organic matter) in the upper 100–150 m of the water column prevented any significant deep export of particulate organic carbon (POC). Before fertilization, dissolved iron (DFe) concentrations in the upper 200 m were low, but not depleted, at ~0.2 nM. High DFe concentrations appeared scattered from day 14 onwards as a result of the grazing activity. A second fertilization on day 21 had no significant effect on the DFe and Chl-a standing stocks. Work with unfiltered samples using different acidification protocols revealed that, by midway of LOHAFEX, rapid recycling of iron-replenished copepod fecal pellets explained the source of bioavailable iron that prolonged the duration of the bloom for many weeks. Here we present the evolution of the organic speciation of iron in the upper 200 m of the water column during LOHAFEX by a Competing Ligand Equilibrium method using voltammetry. During the first 12 days of the experiment, ligands of an affinity for iron similar to the ligands found before fertilization (logK′Fe′L~11.9) accumulated in fertilized waters mostly in the upper 80 m (from ~1 nM to ~2.5 nM). The restriction of ligand accumulation to the depth of Chl-a penetration points to exudation by the growing autotrophic population as the initial source of ligands. From day 5 onwards, we found in many samples a new class of ligands (L1) characterized by a significant higher conditional stability constant than the background complexation (logK′Fe′L1~12.9). During the middle section of the experiment (days 12 to 25) the accumulation of overall ligands and specifically L1, reached an upper limit in surface waters (at ~3 nM). Overall ligands and L1 accumulation was also observed below the mixed layer depth indicating that grazing was the process behind ligand release. During the last 10 days of the experiment ligands kept accumulating in deep waters but suffered a small decrease in the upper 50 m of the water column caused by the vanishing of L1. Ligand removal restricted to the euphotic layer was probably caused by photodegradation. A high correlation between [DFe] and [L1] suggested that recycled iron (released during grazing and copepod fecal pellet cycling) was in the form of FeL1 complexes. We hypothesize that the iron binding ligands released to the dissolved phase during LOHAFEX were mostly photosensitive intracellular ligands rapidly degraded in extracellular conditions (e.g.: pigments). Sloppy feeding by copepods and recycling of cells and cellular material in copepod fecal pellets caused the transfer of particulate ligands to the dissolved phase as zooplankton built up as a response to the blooming community

Inter-band B(E2) transition strengths in odd-mass heavy deformed nuclei

Inter-band B(E2) transition strengths between different normal parity bands in 163Dy and 165Er are described using the pseudo-SU(3) model. The Hamiltonian includes Nilsson single-particle energies, quadrupole-quadrupole and pairing interactions with fixed, parametrized strengths, and three extra rotor terms used to fine tune the energy spectra. In addition to inter-band transitions, the energy spectra and the ground state intra-band B(E2) strengths are reported. The results show the pseudo-SU(3) shell model to be a powerful microscopic theory for a description of the normal parity sector in heavy deformed odd-A nuclei.Comment: 4 figures, 2 table

Depth Dependence Radon Study in Indian Tube-Wells

Radon a radioactive gas arising from decay of 226 Ra, has been recognized to be one of the major contributors to the natural radiation. In the present investigations, measurements of radon and its progeny were carried out under ground in Indian tube-wells at different depths situated at A.M.U., Aligarh (U.P) India. The twin chamber dosimeter cups were fixed for exposure at a depth of 5 to 35 feet with difference of 5 feet from the surface at three different locations. After exposure, the detectors were retrieved, etched and analyzed in the laboratory for the calculation of radon and its progeny. All the values of the radon concentration presents in this paper are higher than the action level (200-600 Bq.m -3 ) as recommended by ICRP

A flexible and pattern reconfigurable antenna with small dimensions and simple layout for wireless communication systems operating over 1.65–2.51 ghz

This research article proposes a compact frequency and pattern reconfigurable flexible antenna for heterogeneous applications. A triangular monopole antenna with a semicircular stub is made frequency and pattern tunable by connecting and disconnecting two inverted L-shaped stubs utilizing diodes. When either of the stubs is connected to the radiator, a relative phase difference happens at both ends of the radiator that changes the direction of the electromagnetic radiations, consequently pattern reconfigurability can be obtain. Besides that, because of the reactive load introduced by the stubs, the antenna's effective length has changed and, as a result, the frequency reconfigurability can be attained. The antenna features a compact size of 40 x 50 x 0.254 mm(3) corresponding to 0.22 lambda(o) x 0.27 lambda(o) x 0.001 lambda(o), where lambda(o) is free-space wavelength at 1.65 GHz, while its operational bandwidth is from 1.65 GHz to 2.51 GHz, with an average gain and radiation efficiency of better than 2.2 dBi and 80%, exhibiting a pattern reconfigurability of 180 degrees in the E-plane. The frequency of the proposed antenna can be switched from 2.1 GHz to 1.8 GHz by switching the state of both diodes in OFF and ON-state, respectively. The fabricated prototype of the antenna is tested to verify its performance parameters. In addition, to validate the proposed design, it has been compared with prior arts in terms of the overall size, reconfigurability type, flexibility, radio frequency (RF) switch type used for reconfigurability, and frequency bandwidth. The proposed antenna provides smaller size with a large bandwidth coverage alongside with discrete RF switch type with the advantages of flexibility and both frequency and pattern reconfigurability. As a result, the proposed compact flexible and pattern reconfigurable antenna is a promising candidate for heterogeneous applications, including the global system for mobile (GSM) band (1800 and 1900 MHz) and industrial, scientific and medical (ISM) band (2.4 GHz) along with well-known cellular communication bands of 3G, 4G, and long term evolution (LTE) bands ranging from 1700-2300 MHz around the globe

An integrated antenna system for 4G and millimeter-wave 5G future handheld devices

In this work, an integrated antenna system with Defected Ground Structure (DGS) is presented for Fourth Generation (4G) and millimeter (mm)-wave Fifth Generation (5G) wireless applications and handheld devices. The proposed design with overall dimensions of 110 mm × 75 mm is modeled on 0.508 mm thick Rogers RT/Duroid 5880 substrate. Radiating structure consists of antenna arrays excited by the T-shape 1 × 2 power divider/combiner. Dual bands for 4G centered at 3.8 GHz and 5.5 GHz are attained, whereas the 10-dB impedance bandwidth of 24.4 - 29.3 GHz is achieved for the 5G antenna array. In addition, a peak gain of 5.41 dBi is demonstrated across the operating bandwidth of the 4G antenna array. Similarly, for the 5G mm-wave configuration the attained peak gain is 10.29 dBi. Moreover, significant isolation is obtained between the two antenna modules ensuring efficient dual-frequency band operation using a single integrated solution. To endorse the concept, antenna prototype is fabricated and far-field measurements are procured. Simulated and measured results exhibit coherence. Also the proposed design is investigated for the beam steering capability of the mm-wave 5G antenna array using CST®MWS®. The demonstrated structure offers various advantages including compactness, wide bandwidth, high gain, and planar configuration. Hence, the attained radiation characteristics prove the suitability of the proposed design for the current and future wireless handheld devices