Probing early supermassive black hole growth and quasar evolution with near-infrared spectroscopy of 37 reionization-era quasars at 6.3 < z < 7.64

Galaxie

Discovery of 24 radio-bright quasars at 4.9 <= z <= 6.6 using low-frequency radio observations

Galaxie

A dusty proto-cluster surrounding the binary galaxy HerBS-70 at z = 2.3

We report on deep SCUBA-2 observations at 850 μm and NOEMA spectroscopic measurements at 2 mm of the environment surrounding the luminous, massive (M* ≈ 2 × 1011 M⊙) Herschel-selected source HerBS-70. This source was revealed by previous NOEMA observations to be a binary system of dusty star-forming galaxies at z = 2.3, with the East component (HerBS-70E) hosting an Active Galactic Nucleus (AGN). The SCUBA-2 observations detected, in addition to the binary system, twenty-one sources at >3.5σ over an area of ∼25 square comoving Mpc with a sensitivity of 1σ850 = 0.75 mJy. The surface density of continuum sources around HerBS-70 is three times higher than for field galaxies. The NOEMA spectroscopic measurements confirm the protocluster membership of three of the nine brightest sources through their CO(4–3) line emission, yielding a volume density 36 times higher than for field galaxies. All five confirmed sub-mm galaxies in the HerBS-70 system have relatively short gas depletion times (80 − 500 Myr), indicating the onset of quenching for this protocluster core due to the depletion of gas. The dark matter halo mass of the HerBS-70 system is estimated around 5 × 1013 M⊙, with a projected current-day mass of 1015 M⊙, similar to the local Virgo and Coma clusters. These observations support the claim that DSFGs, in particular the ones with observed multiplicity, can trace cosmic overdensities

Management of Delirium in Palliative Care: a review

Delirium is a complex but common disorder in palliative care with a prevalence between 13% to 88% but a particular frequency at the end of life (terminal delirium). By reviewing the most relevant studies (MEDLINE, EMBASE, PsycLit, PsycInfo, Cochrane Library), a correct assessment to make the diagnosis (e.g. DSM-5, delirium assessment tools), the identification of the possible etiological factors, and the application of multicomponent and integrated intervention, were reported as the correct steps to effectively manage delirium in palliative care. In terms of medications, both conventional (namely haloperidol) and atypical antipsychotics (e.g. olanzapine, risperidone, quetiapine, aripiprazole), were shown to be equally effective in the treatment of delirium. No recommendation was possible in palliative care regarding the use of other drugs (e.g. α-2 receptors agonists, psychostimulants, cholinesterase inhinbitors, melatonergic drugs). Non-pharmacological intervention (e.g. behavioral and educational) were also shown to be important in the management of delirium. More research is necessary to clarify how to more thoroughly manage delirium in palliative care

An approach to the development of a national strategy for controlling invasive alien plant species: the case of parthenium hysterophorus in South Africa

Invasive alien species require co-ordinated management if negative impacts are to be effectively avoided. Here we describe a strategy for the management of Parthenium hysterophorus L.(Asteraceae) in South Africa. P.Hysterophorus is an annual herb native to tropical America, which has become invasive in over 30 countries. The strategy sets goals for (1) the prevention of spread to new areas; (2) local eradication of isolated populations; (3) containment in areas where eradication is not possible; and (4) actions to protect assets where containment is no longer an option. We developed both a national strategy to set policy and to monitor progress towards goals at a national level and an implementation plan to set goals and timeframes for their achievement at local levels. It is not clear, at this stage, whether of not the goals of the strategy are achievable because implementation will face many challenges arising from ecological features of the target plant, social and cultural practices that will influence management, inadequate levels of funding and multiple political considerations. Our strategy proposes regular assessment using high-level indicators, a practice that is widely recognised as essential but seldom implemented at a national scale. Because the outcomes are uncertain, it is vital that regular monitoring of outcomes should be instituted from the start, so that both appropriate adjustments can be made to the strategy and lessons for the implementation of similar strategies elsewhere can be derived

Consultation-Liaison Psychiatry in the General hospital. The experience of UK, Italy and Japan

Consultation-Liaison Psychiatry (CLP), as a specific psychiatric area dealing with the psychological care of medically ill patients and the relation between medical and psychiatric disorders, has remarkably developed over the last 30 years in many countries. Some issues related to its relationship with psychosomatic medicine, the sparse application of CLP guidelines and result have been to objects of investigation and the different organization in different countries remain unsolved problems. The paper examines the recent progress and challenges of CLP in the United Kingdom, Italy and Japan. The experience in specific areas of CLP are described in these three countries, particularly in the settings of general hospital psychiatry (e.g. psychiatric consultation and liaison in medical and surgical wards), CLP in emergency unit (e.g. self-harm), psychiatric and psychosocial care in oncology (e.g. psycho-oncology) and palliative care liaison psychiatry. In all three countries, however, it is considered that the provision of CLP service is insufficient, and the application of officially acknowledged standards of care is necessary

Bioprinting and plastic compression of large pigmented and vascularized human dermo-epidermal skin substitutes by means of a new robotic platform

Extensive availability of engineered autologous dermo-epidermal skin substitutes (DESS) with functional and structural properties of normal human skin represents a goal for the treatment of large skin defects such as severe burns. Recently, a clinical phase I trial with this type of DESS was successfully completed, which included patients own keratinocytes and fibroblasts. Yet, two important features of natural skin were missing: pigmentation and vascularization. The first has important physiological and psychological implications for the patient, the second impacts survival and quality of the graft. Additionally, accurate reproduction of large amounts of patient's skin in an automated way is essential for upscaling DESS production. Therefore, in the present study, we implemented a new robotic unit (called SkinFactory) for 3D bioprinting of pigmented and pre-vascularized DESS using normal human skin derived fibroblasts, blood- and lymphatic endothelial cells, keratinocytes, and melanocytes. We show the feasibility of our approach by demonstrating the viability of all the cells after printing in vitro, the integrity of the reconstituted capillary network in vivo after transplantation to immunodeficient rats and the anastomosis to the vascular plexus of the host. Our work has to be considered as a proof of concept in view of the implementation of an extended platform, which fully automatize the process of skin substitution: this would be a considerable improvement of the treatment of burn victims and patients with severe skin lesions based on patients own skin derived cells.ISSN:2041-731

U.S. National Accelerator R&D Program on Future Colliders

Future colliders are an essential component of a strategic vision for particle physics. Conceptual studies and technical developments for several exciting future collider options are underway internationally. In order to realize a future collider, a concerted accelerator R&D program is required. The U.S. HEP accelerator R&D program currently has no direct effort in collider-specific R&D area. This shortcoming greatly compromises the U.S. leadership role in accelerator and particle physics. In this white paper, we propose a new national accelerator R&D program on future colliders and outline the important characteristics of such a program