PO-039 Influence of Physical Activity on Aerobic Endurance Capacity on Primary School Students

Objective The physical fitness of primary school students is not optimistic in recent years. The obesity rate and myopia rate have continuously increased, and the aerobic endurance capacity has insistently declined. The aerobic endurance capacity is an important indicator to evaluate the physical fitness of students. This article explores the effects of physical activity(PA) designed by NSPEL on the improvement of aerobic endurance by intervening in the fourth grade students of Shifoying Primary School in Chaoyang District in Beijing, and provides a reference for students' physical fitness promotion. Methods 155 fourth-grade students from Shifoying primary School in Beijing were selected as subjects. They were subjected to PA intervention for 16 weeks and their physical fitness related indicators were evaluated. PA intervention includes in-class and extracurricular sports activities. Physical education was guided by the syllabus. Extracurricular sports activities were mainly activities in break and after-school sports interest classes. The final analysis of the physical fitness assessment scores, BMI, 50m run, 50-meter shuttle run, skipping and sit-up were performed before and after the intervention. Results The average score of physical fitness assessment of students was 79.79 before PA intervention, and the score was significantly increased and increased to 88.12 (10.43%) after the intervention. Physical shape of the students changed significantly after PA intervention. The mean of BMI was within the normal range before and after intervention, and the obesity rate was reduced by 1.29%. The student's speed capacity improved significantly after the intervention, the average score of the 50-meter race increased from 10.22 seconds to 7.90 seconds, the difference was very significant, with an increase of 2.32 seconds after the intervention. The student's aerobic endurance capacity was significantly improved before and after PA intervention. The average score of the 50 meter shuttle run was increased from 2.01 min to 1.74 min, and the result was significantly improved by 13.43%. The average score of sit-up was 21.64, and it increased to 42.30 after the intervention, with an average increase of 20.66. Conclusions Students' physical fitness assessment scores improved significantly after PA in and out of class, suggesting that PA effectively improved the physical fitness status of 11-year-old pupils. Students' 50-meter run, 50 meter shuttle run, skipping, and sit-ups were all significantly improved after PA interventions, suggesting that PA is of great significance for improving aerobic endurance. The combination of activities inside and outside class can be used as a reference mode to improve students' physical fitness (NSFC31401018, SKXJX2014014, [email protected])

Soluble CD83 Alleviates Experimental Autoimmune Uveitis by Inhibiting Filamentous Actin-Dependent Calcium Release in Dendritic Cells

Soluble CD83 (sCD83) is the extracellular domain of the membrane-bound CD83 molecule, and known for its immunoregulatory functions. Whether and how sCD83 participates in the pathogenesis of uveitis, a serious inflammatory disease of the eye that can cause visual disability and blindness, is unknown. By flow cytometry and imaging studies, we show that sCD83 alleviates experimental autoimmune uveitis (EAU) through a novel mechanism. During onset and recovery of EAU, the level of sCD83 rises in the serum and aqueous humor, and CD83+ leukocytes infiltrate the inflamed eye. Systemic or topical application of sCD83 exerts a protective effect by decreasing inflammatory cytokine expression, reducing ocular and splenic leukocyte including CD4+ T cells and dendritic cells (DCs). Mechanistically, sCD83 induces tolerogenic DCs by decreasing the synaptic expression of co-stimulatory molecules and hampering the calcium response in DCs. These changes are caused by a disruption of the cytoskeletal rearrangements at the DC–T cell contact zone, leading to altered localization of calcium microdomains and suppressed T-cell activation. Thus, the ability of sCD83 to modulate DC-mediated inflammation in the eye could be harnessed to develop new immunosuppressive therapeutics for autoimmune uveitis

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Effects of Vanadium Microalloying and Intercritical Annealing on Yield Strength–Ductility Trade-Offs of Medium-Manganese Steels

In this paper, we investigate the effects of vanadium on the strength and ductility of medium-manganese steels by analyzing the microstructural evolution and strain hardening rates and performing quantitative calculations. Two significantly different contents of vanadium, 0.05 and 0.5 wt.%, were independently added to model steel (0.12C-10Mn) and annealed at different intercritical temperatures. The results show that higher vanadium addition increases the yield strength but decreases the ductility. The maximum yield strength can increase from 849 MPa to 1063 MPa at low temperatures. The model calculations reveal that this is due to a precipitation strengthening increment of up to 148 MPa and a dislocation strengthening increment of 50 MPa caused by a higher quantity of V4C3 precipitates. However, the high density of vanadium carbides leads them to easily segregate at grain boundaries or phase interfaces, which prevents strain from uniformly distributing throughout the phases. This results in stress concentrations which cause a high strain hardening rate in the early stages of loading and a delayed transformation-induced plasticity (TRIP) effect. Additionally, the precipitates decrease the austenite proportion and its carbon concentrations, rendering the TRIP effect unsustainable. Accordingly, the ductility of high vanadium steels is relatively low

Synthesis, characterization and microwave dielectric properties of flower - like Co(OH)2/C nanocomposites

Flower - like Co(OH)2/C nanocomposites have been synthesized by a facile hydrothermal method. Flower - like Co(OH)2/C nanocomposites were self - assembled by the nanosheets with the thickness distribution of 50 - 80 nm and abundant flocculent carbon structures. With the help of transmission electron microscopy and energy dispersive spectrometer, nanosheets were observed to have core/shell structure, in which Co(OH)2 worked as cores and amorphous C as shells. When the as - prepared products were heated for 6 h at 180 ºC, the Co(OH)2 cores were amorphous. The heating time increased to 10 h, the Co(OH)2 cores became crystalline. The formation mechanism and the self - assembly evolution process were proposed. The microwave dielectric properties of Co(OH)2/C nanocomposites were investigated in the frequency range of 0.03 - 18 GHz. Compared with the amorphous Co(OH)2/C nanocomposites, crystalline nanocomposites had the better conductivity

Silver-Catalyzed Tandem Hydroazidation/Alkyne–Azide Cycloaddition of Diynes with TMS‑N₃: An Easy Access to 1,5-Fused 1,2,3-Triazole Frameworks

A general cascade hydroazidation and alkyne–azide 1,3-dipolar cycloaddition of diynes using silver catalysis is reported. A wide variety of diynes participated in the reaction with trimethylsilyl azide (TMS-N₃) in the presence of H₂O, affording the corresponding 1,5-fused-1,2,3-triazoles in good-to-excellent yields. This unprecedented protocol is operationally simple with a broad substrate scope, good functional group tolerance, and high reaction efficiency, thus providing easy access to various fused 1,2,3-triazoles