La Enfermedad Celíaca

La Enfermedad Celíaca (EC) es la intolerancia alimentaria de orden genético más frecuente de la especie humana. En nuestro Servicio de Gastroenterología hemos diagnosticado más de 1900 casos en los últimos 34 años, y 92 y 73 nuevos casos en los años 2004 y 2005, respectivamente. La EC es el resultado de la interacción entre factores genéticos (constante absoluta) expresados en la mucosa intestinal y la respuesta inmune (constante relativa) por una parte, y factores ambientales y culturales (variable absoluta), como el consumo de trigo en cantidades impensables para la especie humana hace no más de 5.000 años. La hipótesis etiopatogénica más aceptada y extendida de la EC es que resultaría de una respuesta inmune peculiar de la mucosa intestinal al gluten del TACC. En esta revisión analizamos los aspectos históricos de la enfermedad así como información sobre la patogenia y la forma actual de reconocer las características clínicas, de laboratorio, histopatológicas y de tratamiento de la misma. También se analizan la fisiopatología y la experiencia de nuestro grupo, haciendo especial énfasis en el espectro de las enfermedades asociadas.Celiac disease (CD) is the most frequent human genetic food intolerance. In our Gastroenterology Unit we have diagnosed more than 1900 cases in the last 34 years, 92 and 73 new cases in years 2004 and 2005, respectively. CD results from the interaction of genetic factors expressed in the bowel mucosa and immune response on one side and cultural and environmental factors such as the use of extremely large amounts of wheat as food by human beings in the last 5,000 years. The most widely accepted etiopathegenetic hypothesis is that CD results form a peculiar immune response of bowel mucosa to the gluten of wheat ant related grains. In this review we analyze historical data as well as information regarding pathogenesis, up-to-date clinical, laboratory, and histopathological features and treatment modalities of CD. We also present data about the fisiopathology of CD and our experience emphasizing particularly the range of associated diseases

Evaluación de un suplemento probiótico en la recuperación nutricional de pacientes celíacos sometidos a una dieta SIN TACC

Se presentan los resultados del progreso de peso de 45 pacientes celíacos de reciente diagnóstico bajo dieta SIN TACC (sin trigo, avena, cebada y centeno), a 23 de los cuales se les agregó un suplemento probiótico; 22 sirvieron de grupo control. Se analizaron también aspectos ambientales y culturales. Si bien el mayor incremento de peso se observó en el grupo que recibió suplemento en la etapa de la recuperación nutricional, este progreso no mostró diferencias estadísticamente significativas. Creemos que el probiótico, la dosis diaria indicada y el tiempo de administración deben ser variables a estudiar en un futuro próximo. Los grupos fueron similares para otras variables potencialmente confundentes.We are presenting the results of adding probiotics to a group of 23 out of 45 recently diagnosed, previously untreated, celiac patients. All were under gluten-free diet. All the patients were investigated upon their socio-cultural habitat as to not to attribute the success of failure of the therapy to that conditions. Although the group receiving the supplementary probiotic diet showed more weight gain, the difference with the other group was not statistically significant. We speculate that the type of probiotic, the daily doses, and the length of time if its administration as variables which should be studied in future trials

Evaluación ponderal de tres alternativas terapéuticas en niños con diarrea crónica y desnutrición: dieta, hidrolizados y probióticos

Se presenta la evolución clínica de tres grupos de pacientes desnutridos con diarrea crónica en los que se descartaron entidades específicas y que fueron sometidos tres alternativas terapéuticas: dieta hipofermentativa, hidrolizados de leche de vaca y probiótico de uso farmacológico, con un control ponderal durante tres meses. Si bien no hubo diferencias significativas en cuanto al progreso de peso, sí las hubo en cuanto a costos. Palabras clave: alergia a la leche de vaca, desnutrición, diarrea crónica, hidrolizado, probiótico.We are reporting the clinical evolution pattern of three groups of patients with chronic diarrhea not related to specific entities, submitted to three alternative diets, namely hypofermentative diet, cow mil hydrolisates, and probiotics. The patient´s weight was followed for three months. Although there were not significative differences in weight gain, there were indeed as to the costs

The falling in love of Florio and Biancifiore: digital edition of an extract from Boccaccio's Filocolo (MS. Canon. Ital. 28, fols. 18v-21v)

This data set consists of 7 image files in PNG format, and an XML file. These files were created as part of a Digital Editions course, run by the Taylor Institution Library, during Hilary Term 2021. The course required participants to create a digitised version of a printed text. This text is fols. 18v-21v from MS. Canon. Ital. 28. The images of the original text were provided by the Weston Library's special collections scans service. The XML file included here contains an encoded transcription of the original text, created and edited using Oxygen XML Editor, according to Text Encoding Initiative (TEI) guidelines

The Cousa objective: a long-working distance air objective for multiphoton imaging in vivo.

Multiphoton microscopy can resolve fluorescent structures and dynamics deep in scattering tissue and has transformed neural imaging, but applying this technique in vivo can be limited by the mechanical and optical constraints of conventional objectives. Short working distance objectives can collide with compact surgical windows or other instrumentation and preclude imaging. Here we present an ultra-long working distance (20 mm) air objective called the Cousa objective. It is optimized for performance across multiphoton imaging wavelengths, offers a more than 4 mm2 field of view with submicrometer lateral resolution and is compatible with commonly used multiphoton imaging systems. A novel mechanical design, wider than typical microscope objectives, enabled this combination of specifications. We share the full optical prescription, and report performance including in vivo two-photon and three-photon imaging in an array of species and preparations, including nonhuman primates. The Cousa objective can enable a range of experiments in neuroscience and beyond