Channel assisted noise propagation in a two-step cascade

Signal propagation in biochemical networks is characterized by the inherent randomness in gene expression and fluctuations of the environmental components, commonly known as intrinsic and extrinsic noise, respectively. We present a theoretical framework for noise propagation in a generic two-step cascade (S$\rightarrow$X$\rightarrow$Y) in terms of intrinsic and extrinsic noise. We identify different channels of noise transmission that regulate the individual as well as the overall noise properties of each component. Our analysis shows that the intrinsic noise of S alleviates the overall noise and information transmission capacity along the cascade. On the other hand, the intrinsic noise of X and Y acts as a bottleneck of information transmission.Comment: 10 pages, 2 figures. Comments are welcom

Interplay of degeneracy and non-degeneracy in fluctuations propagation in coherent feed-forward loop motif

We present a stochastic framework to decipher fluctuations propagation in classes of coherent feed-forward loops. The systematic contribution of the direct (one-step) and indirect (two-step) pathways is considered to quantify fluctuations of the output node. We also consider both additive and multiplicative integration mechanisms of the two parallel pathways (one-step and two-step). Analytical expression of the output node's coefficient of variation shows contributions of intrinsic, one-step, two-step, and cross-interaction in closed form. We observe a diverse range of degeneracy and non-degeneracy in each of the decomposed fluctuations term and their contribution to the overall output fluctuations of each coherent feed-forward loop motif. Analysis of output fluctuations reveals a maximal level of fluctuations of the coherent feed-forward loop motif of type 1.Comment: 20 pages, 4 figure

Bi‐stability of the master gene regulatory network of the common dendritic precursor cell: Implications for cell differentiation

In cell lineage commitment decisions, a gene regulatory network (GRN) consisting of a limited number of transcription factors forms the regulatory pivot. Myeloid lineage dendritic cells or DCs are specialized cells having the antigen‐presenting ability and are of immense importance in immune surveillance. In this report, we analyze the GRN that governs the lineage commitment of Common DC Progenitor (CDP) cells to conventional dendritic cells (cDC) and plasmacytoid dendritic cells (pDC). We have analyzed the quantitative behavior of the master regulatory circuit of CDP that governs the lineage commitment. Simulations showed that the GRN displays a bi‐stable behavior within a range of parameter values. Several transcription factors, PU.1, IRF8, Flt3, and Stat3, whose concentrations vary significantly in the two steady states, appear to be the key players. We hypothesize that the two stable steady states are precursors of cDC and pDC, and the variation of concentration of these key transcription factors in the two states may be responsible for early events in lineage commitment

Measurement of (anti)alpha production in central Pb-Pb collisions at sNN\sqrt{s_{\rm NN}} = 5.02 TeV

International audienceIn this letter, measurements of (anti)alpha production in central (0$-$10%) Pb$-$Pb collisions at a center-of-mass energy per nucleon$-$nucleon pair of $\sqrt{s_{\rm NN}}$ = 5.02 TeV are presented, including the first measurement of an antialpha transverse-momentum spectrum. Owing to its large mass, (anti)alpha production yields and transverse-momentum spectra are of particular interest because they provide a stringent test of particle production models. The averaged antialpha and alpha spectrum is included into a common blast-wave fit with lighter particles, indicating that the (anti)alpha also participates in the collective expansion of the medium created in the collision. A blast-wave fit including only protons, (anti)alpha, and other light nuclei results in a similar flow velocity as the fit that includes all particles. A similar flow velocity, but a significantly larger kinetic freeze-out temperature is obtained when only protons and light nuclei are included in the fit. The coalescence parameter $B_4$ is well described by calculations from a statistical hadronization model but significantly underestimated by calculations assuming nucleus formation via coalescence of nucleons. Similarly, the (anti)alpha-to-proton ratio is well described by the statistical hadronization model. On the other hand, coalescence calculations including approaches with different implementations of the (anti)alpha substructure tend to underestimate the data

Investigating the nature of the K0∗(700)^*_0(700) state with π±\pi^\pmKS0^0_{\rm S} correlations at the LHC

International audienceThe first measurements of femtoscopic correlations with the particle pair combinations $\pi^\pm$K$^0_{\rm S}$ in pp collisions at $\sqrt{s}=13$ TeV at the Large Hadron Collider (LHC) are reported by the ALICE experiment. Using the femtoscopic approach, it is shown that it is possible to study the elusive K$^*_0(700)$ particle that has been considered a tetraquark candidate for over forty years. Boson source parameters and final-state interaction parameters are extracted by fitting a model assuming a Gaussian source to the experimentally measured two-particle correlation functions. The final-state interaction is modeled through a resonant scattering amplitude, defined in terms of a mass and a coupling parameter, decaying into a $\pi^\pm$K$^0_{\rm S}$ pair. The extracted mass and Breit-Wigner width, derived from the coupling parameter, of the final-state interaction are found to be consistent with previous measurements of the K$^*_0(700)$. The small value and increasing behavior of the correlation strength with increasing source size support the hypothesis that the K$^*_0(700)$ is a four-quark state, i.e. a tetraquark state. This latter trend is also confirmed via a simple geometric model that assumes a tetraquark structure of the K$^*_0(700)$ resonance

Emergence of long-range angular correlations in low-multiplicity proton-proton collisions

International audienceThis Letter presents the measurement of near-side associated per-trigger yields, denoted ridge yields, from the analysis of angular correlations of charged hadrons in proton-proton collisions at $\sqrt{s}$ = 13 TeV. Long-range ridge yields are extracted for pairs of charged particles with a pseudorapidity difference of $1.4 < |\Delta\eta| < 1.8$ and a transverse momentum of $1 < p_{\rm T} < 2$ GeV/$c$, as a function of the charged-particle multiplicity measured at midrapidity. This study extends the measurements of the ridge yield to the low multiplicity region, where in hadronic collisions it is typically conjectured that a strongly-interacting medium is unlikely to be formed. The precision of the new results allows for the first direct quantitative comparison with the results obtained in $\mathrm {e^{+}e^{-}}$ collisions at $\sqrt{s}$ = 91 GeV, where initial-state effects such as pre-equilibrium dynamics and collision geometry are not expected to play a role. In the multiplicity range where the $\mathrm {e^{+}e^{-}}$ results have good precision, the measured ridge yields in pp collisions are substantially larger than the limits set in $\mathrm {e^{+}e^{-}}$ annihilations. Consequently, the findings presented in this Letter suggest that the processes involved in $\mathrm {e^{+}e^{-}}$ annihilations do not contribute significantly to the emergence of long-range correlations in pp collisions

Investigating the nature of the K0∗^*_0(700) state with π±\pi^\pmKS0^0_{\rm S} correlations at the LHC

The first measurements of femtoscopic correlations with the particle pair combinations $\pi^\pm$K$^0_{\rm S}$ in pp collisions at $\sqrt{s}=13$ TeV at the Large Hadron Collider (LHC) are reported by the ALICE experiment. Using the femtoscopic approach, it is shown that it is possible to study the elusive K$^*_0(700)$ particle that has been considered a tetraquark candidate for over forty years. Boson source parameters and final-state interaction parameters are extracted by fitting a model assuming a Gaussian source to the experimentally measured two-particle correlation functions. The final-state interaction is modeled through a resonant scattering amplitude, defined in terms of a mass and a coupling parameter, decaying into a $\pi^\pm$K$^0_{\rm S}$ pair. The extracted mass and Breit--Wigner width, derived from the coupling parameter, of the final-state interaction are found to be consistent with previous measurements of the K$^*_0(700)$. The small value and increasing behavior of the correlation strength with increasing source size support the hypothesis that the K$^*_0(700)$ is a four-quark state, i.e. a tetraquark state. This latter trend is also confirmed via a simple geometric model that assumes a tetraquark structure of the K$^*_0(700)$ resonance.The first measurements of femtoscopic correlations with the particle pair combinations $\pi^\pm$K$^0_{\rm S}$ in pp collisions at $\sqrt{s}=13$ TeV at the Large Hadron Collider (LHC) are reported by the ALICE experiment. Using the femtoscopic approach, it is shown that it is possible to study the elusive K$^*_0(700)$ particle that has been considered a tetraquark candidate for over forty years. Boson source parameters and final-state interaction parameters are extracted by fitting a model assuming a Gaussian source to the experimentally measured two-particle correlation functions. The final-state interaction is modeled through a resonant scattering amplitude, defined in terms of a mass and a coupling parameter, decaying into a $\pi^\pm$K$^0_{\rm S}$ pair. The extracted mass and Breit-Wigner width, derived from the coupling parameter, of the final-state interaction are found to be consistent with previous measurements of the K$^*_0(700)$. The small value and increasing behavior of the correlation strength with increasing source size support the hypothesis that the K$^*_0(700)$ is a four-quark state, i.e. a tetraquark state. This latter trend is also confirmed via a simple geometric model that assumes a tetraquark structure of the K$^*_0(700)$ resonance

Systematic study of flow vector decorrelation in sNN=5.02\mathbf{\sqrt{\textit{s}_{_{\bf NN}}}=5.02} TeV Pb-Pb collisions

International audienceMeasurements of the $p_{\rm T}$-dependent flow vector fluctuations in Pb-Pb collisions at $\sqrt{s_{_{\rm NN}}} = 5.02~\mathrm{TeV}$ using azimuthal correlations with the ALICE experiment at the LHC are presented. A four-particle correlation approach [1] is used to quantify the effects of flow angle and magnitude fluctuations separately. This paper extends previous studies to additional centrality intervals and provides measurements of the $p_{\rm T}$-dependent flow vector fluctuations at $\sqrt{s_{_{\rm NN}}} = 5.02~\mathrm{TeV}$ with two-particle correlations. Significant $p_{\rm T}$-dependent fluctuations of the $\vec{V}_{2}$ flow vector in Pb-Pb collisions are found across different centrality ranges, with the largest fluctuations of up to $\sim$15% being present in the 5% most central collisions. In parallel, no evidence of significant $p_{\rm T}$-dependent fluctuations of $\vec{V}_{3}$ or $\vec{V}_{4}$ is found. Additionally, evidence of flow angle and magnitude fluctuations is observed with more than $5\sigma$ significance in central collisions. These observations in Pb-Pb collisions indicate where the classical picture of hydrodynamic modeling with a common symmetry plane breaks down. This has implications for hard probes at high $p_{\rm T}$, which might be biased by $p_{\rm T}$-dependent flow angle fluctuations of at least 23% in central collisions. Given the presented results, existing theoretical models should be re-examined to improve our understanding of initial conditions, quark--gluon plasma (QGP) properties, and the dynamic evolution of the created system